Single-molecule force spectroscopy: Practical limitations beyond Bell's model

Getfert S, Evstigneev M, Reimann P (2009)
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 388(7): 1120-1132.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Single-molecule force spectroscopy experiments, and a number of other physical systems, are governed by thermally activated transitions out of a metastable state under the action of a steadily increasing external force. The main observable in such experiments is the distribution of the forces, at which the escape events occur. The challenge in interpreting the experimental data is to relate them to the microscopic system properties. We work out a maximum likelihood approach and show that it is the optimal method to tackle this problem. When fitting actual experimental data it is unavoidable to assume some functional form for the force-dependent escape rate. Focusing on escape processes over a single activation barrier, we consider a quite general and common such functional form and demonstrate by means of data from a realistic computer experiment that the maximum number of fit parameters that can be determined reliably is three. They are related to the force-free escape rate and the position and height of the activation barrier. Furthermore, the results for the first two of these fit parameters show little dependence on the assumption about the manner in which the barrier decreases with the applied force, while the last one, the barrier height in the absence of force, depends strongly on this assumption. (C) 2009 Elsevier B.V. All rights reserved.
Stichworte
Dynamic force spectroscopy; Thermally; Maximum likelihood method; activated escape
Erscheinungsjahr
2009
Zeitschriftentitel
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
Band
388
Ausgabe
7
Seite(n)
1120-1132
ISSN
0378-4371
Page URI
https://pub.uni-bielefeld.de/record/1635235

Zitieren

Getfert S, Evstigneev M, Reimann P. Single-molecule force spectroscopy: Practical limitations beyond Bell's model. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS. 2009;388(7):1120-1132.
Getfert, S., Evstigneev, M., & Reimann, P. (2009). Single-molecule force spectroscopy: Practical limitations beyond Bell's model. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 388(7), 1120-1132. https://doi.org/10.1016/j.physa.2008.12.053
Getfert, S., Evstigneev, M., and Reimann, P. (2009). Single-molecule force spectroscopy: Practical limitations beyond Bell's model. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 388, 1120-1132.
Getfert, S., Evstigneev, M., & Reimann, P., 2009. Single-molecule force spectroscopy: Practical limitations beyond Bell's model. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 388(7), p 1120-1132.
S. Getfert, M. Evstigneev, and P. Reimann, “Single-molecule force spectroscopy: Practical limitations beyond Bell's model”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, vol. 388, 2009, pp. 1120-1132.
Getfert, S., Evstigneev, M., Reimann, P.: Single-molecule force spectroscopy: Practical limitations beyond Bell's model. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS. 388, 1120-1132 (2009).
Getfert, Sebastian, Evstigneev, Mykhaylo, and Reimann, Peter. “Single-molecule force spectroscopy: Practical limitations beyond Bell's model”. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 388.7 (2009): 1120-1132.

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arXiv: 0805.2849

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