Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners

Neumeyer-Gromen A, Razum O, Kersten N, Seidler A, Zeeb H (2009)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Neumeyer-Gromen, Angela; Razum, OliverUniBi; Kersten, Norbert; Seidler, Andreas; Zeeb, Hajo
Abstract / Bemerkung
International health authorities have graded diesel motor emissions (DME) as probably cancerogenic in human beings. There are gaps in epidemiological evidence regarding exact exposure quantification, confounder control and the investigation of highly exposed populations. We investigated the association of DME ana lung cancer mortality in a historical cohort study of 5,862 German potash miners who were followed from 1970 to 2001. Cumulative exposure (CE) was measured by representative concentrations of total carbon multiplied with exposure years from the mines' medical records. Exposure and smoking behavior were validated by interviews of 3,087 participants. We computed standardized mortality ratios (SMR, external comparison) and performed Cox regression (internal comparison). The relative risk estimates (RR) with 95%-confidence intervals were adjusted for age and smoking. Vital status and causes of death were confirmed for 98.1% of participants. Sixty-one lung cancer deaths occurred. SMR-analysis showed lower than expected lung cancer mortality (healthy-worker-effect). Internal comparisons revealed risk elevations from moderate to risk doubling depending oil the exposure categories used (dichotomized: up to RR 1.43[0.67-3.03] for a CE of 4.90[mg/m(3)]*years as compared with less exposure; quintiles: RR 1.13[0.46-2.75], 2.47[1.02-6.02], 1.50[0.56-4.04] and 2.28[0.87-5.97] for a CE up to 2.04, 2.73, 3.90 and >3.90, respectively, as compared with the reference of <1.29[mg/m(3)] *years). Additional adjustment of length of follow-up leads to further RR increases and indicates healthy-worker-survivor-phenomena. The analyses of a sub-cohort (n = 3,335) with particularly accurate exposure measurement revealed a nonsignificant dose-response-relationship. Our results support an association of DME and lung cancer mortality. (C) 2008 Wiley-Liss, Inc.
diesel motor emissions; potash mining; study; cohort; lung cancer mortality
Page URI


Neumeyer-Gromen A, Razum O, Kersten N, Seidler A, Zeeb H. Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER. 2009;124(8):1900-1906.
Neumeyer-Gromen, A., Razum, O., Kersten, N., Seidler, A., & Zeeb, H. (2009). Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER, 124(8), 1900-1906. https://doi.org/10.1002/ijc.24127
Neumeyer-Gromen, A., Razum, O., Kersten, N., Seidler, A., and Zeeb, H. (2009). Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER 124, 1900-1906.
Neumeyer-Gromen, A., et al., 2009. Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER, 124(8), p 1900-1906.
A. Neumeyer-Gromen, et al., “Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners”, INTERNATIONAL JOURNAL OF CANCER, vol. 124, 2009, pp. 1900-1906.
Neumeyer-Gromen, A., Razum, O., Kersten, N., Seidler, A., Zeeb, H.: Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners. INTERNATIONAL JOURNAL OF CANCER. 124, 1900-1906 (2009).
Neumeyer-Gromen, Angela, Razum, Oliver, Kersten, Norbert, Seidler, Andreas, and Zeeb, Hajo. “Diesel motor emissions and lung cancer mortality-Results of the second follow-up of a cohort study in potash miners”. INTERNATIONAL JOURNAL OF CANCER 124.8 (2009): 1900-1906.

18 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

[Occupational risk factors for lung cancer].
Delva F, Andujar P, Lacourt A, Brochard P, Pairon JC., Rev Mal Respir 33(6), 2016
PMID: 26572259
Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts.
Vermeulen R, Silverman DT, Garshick E, Vlaanderen J, Portengen L, Steenland K., Environ Health Perspect 122(2), 2014
PMID: 24273233
Diesel exhaust exposure and the risk of lung cancer--a review of the epidemiological evidence.
Sun Y, Bochmann F, Nold A, Mattenklott M., Int J Environ Res Public Health 11(2), 2014
PMID: 24473109
Real-time diesel particulate monitor for underground mines.
Noll J, Janisko S, Mischler SE., Anal Methods 2013(5), 2013
PMID: 26180555
Diesel motor exhaust and lung cancer mortality: reanalysis of a cohort study in potash miners.
Möhner M, Kersten N, Gellissen J., Eur J Epidemiol 28(2), 2013
PMID: 23420499
The Diesel Exhaust in Miners study: a cohort mortality study with emphasis on lung cancer.
Attfield MD, Schleiff PL, Lubin JH, Blair A, Stewart PA, Vermeulen R, Coble JB, Silverman DT., J Natl Cancer Inst 104(11), 2012
PMID: 22393207
The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaust.
Silverman DT, Samanic CM, Lubin JH, Blair AE, Stewart PA, Vermeulen R, Coble JB, Rothman N, Schleiff PL, Travis WD, Ziegler RG, Wacholder S, Attfield MD., J Natl Cancer Inst 104(11), 2012
PMID: 22393209
Lung cancer and elemental carbon exposure in trucking industry workers.
Garshick E, Laden F, Hart JE, Davis ME, Eisen EA, Smith TJ., Environ Health Perspect 120(9), 2012
PMID: 22739103
Lung cancer and diesel exhaust: an updated critical review of the occupational epidemiology literature.
Gamble JF, Nicolich MJ, Boffetta P., Crit Rev Toxicol 42(7), 2012
PMID: 22656672
Health effects research and regulation of diesel exhaust: an historical overview focused on lung cancer risk.
Hesterberg TW, Long CM, Bunn WB, Lapin CA, McClellan RO, Valberg PA., Inhal Toxicol 24 Suppl 1(), 2012
PMID: 22663144
Diesel exhaust in miners study: how to understand the findings?
Morfeld P., J Occup Med Toxicol 7(1), 2012
PMID: 22676299
Biology of diesel exhaust effects on allergic pulmonary inflammation.
Inoue K, Takano H., Yakugaku Zasshi 131(3), 2011
PMID: 21372531
Research recommendations for selected IARC-classified agents.
Ward EM, Schulte PA, Straif K, Hopf NB, Caldwell JC, Carreón T, DeMarini DM, Fowler BA, Goldstein BD, Hemminki K, Hines CJ, Pursiainen KH, Kuempel E, Lewtas J, Lunn RM, Lynge E, McElvenny DM, Muhle H, Nakajima T, Robertson LW, Rothman N, Ruder AM, Schubauer-Berigan MK, Siemiatycki J, Silverman D, Smith MT, Sorahan T, Steenland K, Stevens RG, Vineis P, Zahm SH, Zeise L, Cogliano VJ., Environ Health Perspect 118(10), 2010
PMID: 20562050

50 References

Daten bereitgestellt von Europe PubMed Central.

World, 2005

Positive gesundheitliche Auswirkungen des Einsatzes von Partikelfiltern bei Dieselfahrzeugen-Risikoabschätzung für die Mortalität in Deutschland
Wichmann, Umweltmed Forsch Prax 2(), 2004
Oxidative stress-induced DNA damage by particulate air pollution.
Risom L, Moller P, Loft S., Mutat. Res. 592(1-2), 2005
PMID: 16085126
Inhaled particles and lung cancer. Part A: Mechanisms.
Knaapen AM, Borm PJ, Albrecht C, Schins RP., Int. J. Cancer 109(6), 2004
PMID: 15027112

IARC, 1989

Health, 1995
Historical estimation of diesel exhaust exposure in a cohort study of U.S. railroad workers and lung cancer.
Laden F, Hart JE, Eschenroeder A, Smith TJ, Garshick E., Cancer Causes Control 17(7), 2006
PMID: 16841258
Smoking imputation and lung cancer in railroad workers exposed to diesel exhaust.
Garshick E, Laden F, Hart JE, Smith TJ, Rosner B., Am. J. Ind. Med. 49(9), 2006
PMID: 16767725
Occupational exposure to diesel and gasoline engine exhausts and risk of lung cancer among Finnish workers.
Guo J, Kauppinen T, Kyyronen P, Lindbohm ML, Heikkila P, Pukkala E., Am. J. Ind. Med. 45(6), 2004
PMID: 15164392
Mortality and cancer incidence of workers in Finnish road paving companies.
Kauppinen T, Heikkila P, Partanen T, Virtanen SV, Pukkala E, Ylostalo P, Burstyn I, Ferro G, Boffetta P., Am. J. Ind. Med. 43(1), 2003
PMID: 12494421
Lung and bladder cancer among Danish urban bus drivers and tramway employees: a nested case-control study.
Soll-Johanning H, Bach E, Jensen SS., Occup Med (Lond) 53(1), 2003
PMID: 12576562
Cohort mortality study of Philadelphia firefighters.
Baris D, Garrity TJ, Telles JL, Heineman EF, Olshan A, Zahm SH., Am. J. Ind. Med. 39(5), 2001
PMID: 11333408
Occupational exposure to diesel engine emissions and risk of cancer in Swedish men and women.
Boffetta P, Dosemeci M, Gridley G, Bath H, Moradi T, Silverman D., Cancer Causes Control 12(4), 2001
PMID: 11456233
Occupational risk factors for kidney cancer: a cohort study in Sweden.
Ji J, Granstrom C, Hemminki K., World J Urol 23(4), 2005
PMID: 16133557
Occupational exposure to diesel exhausts and risk for lung cancer in a population-based case-control study in Italy.
Richiardi L, Mirabelli D, Calisti R, Ottino A, Ferrando A, Boffetta P, Merletti F., Ann. Oncol. 17(12), 2006
PMID: 16971668
Occupational exposure and lung cancer risk: a population-based case-referent study in Sweden.
Gustavsson P, Jakobsson R, Nyberg F, Pershagen G, Jarup L, Scheele P., Am. J. Epidemiol. 152(1), 2000
PMID: 10901327
Diesel exhaust.
Frumkin H, Thun MJ., CA Cancer J Clin 51(3), 2001
PMID: 11577496
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE Initiative., BMJ 335(7624), 2007
PMID: 17947786
Diesel exhaust and lung cancer mortality in potash mining.
Saverin R, Braunlich A, Dahmann D, Enderlein G, Heuchert G., Am. J. Ind. Med. 36(4), 1999
PMID: 10470006

Säverin, 1998
Bewertung des aktuellen wissenschaftlichen Kenntnisstandes zur gesundheitlichen Wirkung von Partikeln in der Luft. Umweltmed
Arbeitsgruppe, Forsch Prax 8(), 2003

Hripcsak, 2002

Checkoway, 2004
Graphical assessment of the Cox proportional hazards assumption
Garrett, Stata Tech Bull 35(), 1997

Saracci, 1994

Dupont, 2004
Diesel exhaust exposure and mortality among males in the American Cancer Society prospective study.
Boffetta P, Stellman SD, Garfinkel L., Am. J. Ind. Med. 14(4), 1988
PMID: 3189356
Mortality among members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions.
Wong O, Morgan RW, Kheifets L, Larson SR, Whorton MD., Br J Ind Med 42(7), 1985
PMID: 2410010
Lung cancer and exposure to diesel exhaust among bus garage workers.
Gustavsson P, Plato N, Lidstrom EB, Hogstedt C., Scand J Work Environ Health 16(5), 1990
PMID: 1701566
A follow-up study on the mortality of truck drivers.
Hansen ES., Am. J. Ind. Med. 23(5), 1993
PMID: 7685146
Occupation and male lung cancer: a case-control study in northern Sweden.
Damber LA, Larsson LG., Br J Ind Med 44(7), 1987
PMID: 3620367
Diesel exhaust and lung cancer in the trucking industry: exposure-response analyses and risk assessment.
Steenland K, Deddens J, Stayner L., Am. J. Ind. Med. 34(3), 1998
PMID: 9698990
Lung cancer risk in male workers occupationally exposed to diesel motor emissions in Germany.
Bruske-Hohlfeld I, Mohner M, Ahrens W, Pohlabeln H, Heinrich J, Kreuzer M, Jockel KH, Wichmann HE., Am. J. Ind. Med. 36(4), 1999
PMID: 10470005
Occupational lung cancer risk for men in Germany: results from a pooled case-control study.
Bruske-Hohlfeld I, Mohner M, Pohlabeln H, Ahrens W, Bolm-Audorff U, Kreienbrock L, Kreuzer M, Jahn I, Wichmann HE, Jockel KH., Am. J. Epidemiol. 151(4), 2000
PMID: 10695597
Diversity in the association between occupation and lung cancer among black and white men.
Swanson GM, Lin CS, Burns PB., Cancer Epidemiol. Biomarkers Prev. 2(4), 1993
PMID: 8348054
Respiratory health risks among nonmetal miners.
Short SR, Petsonk EL., Occup Med 8(1), 1993
PMID: 8456349
Bias in occupational epidemiology studies.
Pearce N, Checkoway H, Kriebel D., Occup Environ Med 64(8), 2006
PMID: 17053019
Smoking and occupation from the European Community Respiratory Health Survey.
McCurdy SA, Sunyer J, Zock JP, Anto JM, Kogevinas M; European Community Respiratory Health Survey Study Group., Occup Environ Med 60(9), 2003
PMID: 12937184

Negative bias in exposure-response trends in occupational studies: modeling the healthy workers survivor effect.
Steenland K, Deddens J, Salvan A, Stayner L., Am. J. Epidemiol. 143(2), 1996
PMID: 8546122

Australian, 2006
The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks.
Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, Howe G, Kaldor J, Muirhead CR, Schubauer-Berigan M, Yoshimura T, Bermann F, Cowper G, Fix J, Hacker C, Heinmiller B, Marshall M, Thierry-Chef I, Utterback D, Ahn YO, Amoros E, Ashmore P, Auvinen A, Bae JM, Bernar J, Biau A, Combalot E, Deboodt P, Diez Sacristan A, Eklof M, Engels H, Engholm G, Gulis G, Habib RR, Holan K, Hyvonen H, Kerekes A, Kurtinaitis J, Malker H, Martuzzi M, Mastauskas A, Monnet A, Moser M, Pearce MS, Richardson DB, Rodriguez-Artalejo F, Rogel A, Tardy H, Telle-Lamberton M, Turai I, Usel M, Veress K., Radiat. Res. 167(4), 2007
PMID: 17388693

Clayton, 1993

Conditions for bias from differential left truncation.
Howards PP, Hertz-Picciotto I, Poole C., Am. J. Epidemiol. 165(4), 2006
PMID: 17150983


Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®


PMID: 19123464
PubMed | Europe PMC

Suchen in

Google Scholar