Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer

Kubben FJGM, Sier CFM, Hawinkels LJAC, Tschesche H, van Duijn W, Zuidwijk K, van der Reijden JJ, Hanemaaijer R, Griffioen G, Lamers CBHW, Verspaget HW (2007)
EUROPEAN JOURNAL OF CANCER 43(12): 1869-1876.

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Abstract / Bemerkung
Recently, complexes of matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) with lipocalin-2 (neutrophil gelatinase-associated lipocalin) were found in the urine obtained from breast cancer patients, while these were completely absent in that obtained from healthy controls. In vitro data suggested a possible role for lipocalin-2 in the protection of MMP-9 against autolysis. To establish this effect in vivo, we determined the presence of MMP-9, lipocalin-2 and their complex in tumour tissue from 81 gastric cancer patients. The effect of the presence of the individual parameters, the complexes, and the inhibitors TIMP-1 and TIMP-2 on MMP-9 activity was evaluated with a bioactivity assay Immuno-histochemical (double) staining identified epithelial cells as the most likely cellular source. Finally, evaluation of all these parameters with clinicopathological scores revealed that tumour MMP-9/lipocalin-2 complexes were significantly related with the classifications of Lauren and WHO, and highly associated with worse survival in Cox's univariate (HR 2.087, P = 0.006) and multivariate analyses (HR 2.095, P = 0.025). (C) 2007 Elsevier Ltd. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
EUROPEAN JOURNAL OF CANCER
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43
Ausgabe
12
Seite(n)
1869-1876
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Kubben FJGM, Sier CFM, Hawinkels LJAC, et al. Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer. EUROPEAN JOURNAL OF CANCER. 2007;43(12):1869-1876.
Kubben, F. J. G. M., Sier, C. F. M., Hawinkels, L. J. A. C., Tschesche, H., van Duijn, W., Zuidwijk, K., van der Reijden, J. J., et al. (2007). Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer. EUROPEAN JOURNAL OF CANCER, 43(12), 1869-1876. doi:10.1016/j.ejca.2007.05.013
Kubben, F. J. G. M., Sier, C. F. M., Hawinkels, L. J. A. C., Tschesche, H., van Duijn, W., Zuidwijk, K., van der Reijden, J. J., Hanemaaijer, R., Griffioen, G., Lamers, C. B. H. W., et al. (2007). Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer. EUROPEAN JOURNAL OF CANCER 43, 1869-1876.
Kubben, F.J.G.M., et al., 2007. Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer. EUROPEAN JOURNAL OF CANCER, 43(12), p 1869-1876.
F.J.G.M. Kubben, et al., “Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer”, EUROPEAN JOURNAL OF CANCER, vol. 43, 2007, pp. 1869-1876.
Kubben, F.J.G.M., Sier, C.F.M., Hawinkels, L.J.A.C., Tschesche, H., van Duijn, W., Zuidwijk, K., van der Reijden, J.J., Hanemaaijer, R., Griffioen, G., Lamers, C.B.H.W., Verspaget, H.W.: Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer. EUROPEAN JOURNAL OF CANCER. 43, 1869-1876 (2007).
Kubben, Frank J. G. M., Sier, Cornelis F. M., Hawinkels, Lukas J. A. C., Tschesche, Harald, van Duijn, Wim, Zuidwijk, Kim, van der Reijden, Johan J., Hanemaaijer, Roeland, Griffioen, Gerrit, Lamers, Cornelis B. H. W., and Verspaget, Hein W. “Clinical evidence for a protective role of lipocalin-2 against MDAP-9 autodegradation and the impact for gastric cancer”. EUROPEAN JOURNAL OF CANCER 43.12 (2007): 1869-1876.

74 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer.
Li W, Ng JM, Wong CC, Ng EKW, Yu J., Oncogene 37(36), 2018
PMID: 29795331
Expression of uterine lipocalin 2 and its receptor during early- to mid-pregnancy period in mares.
Haneda S, Nagaoka K, Nambo Y, Kikuchi M, Nakano Y, Li J, Matsui M, Miyake YI, Imakawa K., J Reprod Dev 63(2), 2017
PMID: 27980236
Matrix-metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression.
Isaacson KJ, Martin Jensen M, Subrahmanyam NB, Ghandehari H., J Control Release 259(), 2017
PMID: 28153760
Lipocalin-2 and iron trafficking in the tumor microenvironment.
Jung M, Mertens C, Bauer R, Rehwald C, Brüne B., Pharmacol Res 120(), 2017
PMID: 28342790
S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2.
Syed SN, Jung M, Weigert A, Brüne B., Mediators Inflamm 2017(), 2017
PMID: 28804221
The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice.
Garay J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, Zabaleta J., Cancer Lett 371(1), 2016
PMID: 26639196
Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye.
Bian F, Pelegrino FS, Henriksson JT, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS., Ocul Surf 14(2), 2016
PMID: 26772899
Diagnostic value of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 pathway in transitional cell carcinoma of the bladder.
Candido S, Di Maso M, Serraino D, McCubrey JA, Bortolus R, Zanin M, Battiston M, Salemi R, Libra M, Polesel J., Tumour Biol 37(7), 2016
PMID: 26810191
A role for novel adipose tissue-secreted factors in obesity-related carcinogenesis.
Cabia B, Andrade S, Carreira MC, Casanueva FF, Crujeiras AB., Obes Rev 17(4), 2016
PMID: 26914773
Neutrophil gelatinase-associated lipocalin in dogs with chronic kidney disease, carcinoma, lymphoma and endotoxaemia.
Cobrin AR, Blois SL, Abrams-Ogg AC, Kruth SA, Dewey C, Holowaychuk MK, Gauthier V., J Small Anim Pract 57(6), 2016
PMID: 27112380
Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis.
Lin CW, Yang WE, Lee WJ, Hua KT, Hsieh FK, Hsiao M, Chen CC, Chow JM, Chen MK, Yang SF, Chien MH., Carcinogenesis 37(7), 2016
PMID: 27207653
Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis.
Ören B, Urosevic J, Mertens C, Mora J, Guiu M, Gomis RR, Weigert A, Schmid T, Grein S, Brüne B, Jung M., J Pathol 239(3), 2016
PMID: 27038000
iTRAQ-Based Proteomics Screen identifies LIPOCALIN-2 (LCN-2) as a potential biomarker for colonic lateral-spreading tumors.
Wang X, Li A, Guo Y, Wang Y, Zhao X, Xiang L, Han Z, Li Y, Xu W, Zhuang K, Yan Q, Zhong J, Xiong J, Liu S., Sci Rep 6(), 2016
PMID: 27339395
Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening.
Kalanxhi E, Hektoen HH, Meltzer S, Dueland S, Flatmark K, Ree AH., BMC Cancer 16(), 2016
PMID: 27461255
Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy.
Asimakopoulou A, Weiskirchen S, Weiskirchen R., Front Physiol 7(), 2016
PMID: 27729871
Diverse functional roles of lipocalin-2 in the central nervous system.
Jha MK, Lee S, Park DH, Kook H, Park KG, Lee IK, Suk K., Neurosci Biobehav Rev 49(), 2015
PMID: 25511817
Lipocalin-2 and matrix metalloproteinase-9 expression in high-grade endometrial cancer and their prognostic value.
Srdelić Mihalj S, Kuzmić-Prusac I, Zekić-Tomaš S, Šamija-Projić I, Čapkun V., Histopathology 67(2), 2015
PMID: 25522256
[Effect of Inhibiting NGAL Gene Expression on A549 Lung Cancer Cell Migration and Invasion].
Tang J, Li J, Li S, Li J, Yu C, Wei C., Zhongguo Fei Ai Za Zhi 18(4), 2015
PMID: 25936881
Role of lipocalin-2 in brain injury after intracerebral hemorrhage.
Ni W, Zheng M, Xi G, Keep RF, Hua Y., J Cereb Blood Flow Metab 35(9), 2015
PMID: 25853903
Overexpression of SPAG9 in human gastric cancer is correlated with poor prognosis.
Miao ZF, Wang ZN, Zhao TT, Xu YY, Wu JH, Liu XY, Xu H, You Y, Xu HM., Virchows Arch 467(5), 2015
PMID: 26293216
Serum Neutrophil Gelatinase B-associated Lipocalin and Matrix Metalloproteinase-9 Complex as a Surrogate Marker for Mucosal Healing in Patients with Crohn's Disease.
de Bruyn M, Arijs I, De Hertogh G, Ferrante M, Van Assche G, Rutgeerts P, Vermeire S, Opdenakker G., J Crohns Colitis 9(12), 2015
PMID: 26351381
Matrix Metalloproteinase-9/Neutrophil Gelatinase-Associated Lipocalin Complex Activity in Human Glioma Samples Predicts Tumor Presence and Clinical Prognosis.
Liu MF, Hu YY, Jin T, Xu K, Wang SH, Du GZ, Wu BL, Li LY, Xu LY, Li EM, Xu HX., Dis Markers 2015(), 2015
PMID: 26663949
Evaluation of NGAL TestTM on Cobas 6000.
Hansen YB, Damgaard A, Poulsen JH., Scand J Clin Lab Invest 74(1), 2014
PMID: 24228725
Stromal expression of neutrophil gelatinase-associated lipocalin correlates with poor differentiation and adverse prognosis in oral squamous cell carcinoma.
Shinriki S, Jono H, Ueda M, Obayashi K, Nakamura T, Ota K, Ota T, Sueyoshi T, Guo J, Hayashi M, Hiraki A, Nakayama H, Yamashita S, Shinohara M, Ando Y., Histopathology 64(3), 2014
PMID: 24118080
New markers in pelvic inflammatory disease.
Yang SF, Wu TF, Tsai HT, Lin LY, Wang PH., Clin Chim Acta 431(), 2014
PMID: 24525211
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer.
Candido S, Maestro R, Polesel J, Catania A, Maira F, Signorelli SS, McCubrey JA, Libra M., Oncotarget 5(6), 2014
PMID: 24742531
Neutrophil gelatinase B-associated lipocalin and matrix metalloproteinase-9 complex as a surrogate serum marker of mucosal healing in ulcerative colitis.
de Bruyn M, Arijs I, Wollants WJ, Machiels K, Van Steen K, Van Assche G, Ferrante M, Rutgeerts P, Vermeire S, Opdenakker G., Inflamm Bowel Dis 20(7), 2014
PMID: 24871805
Lipocalin 2 performs contrasting, location-dependent roles in APCmin tumor initiation and progression.
Reilly PT, Teo WL, Low MJ, Amoyo-Brion AA, Dominguez-Brauer C, Elia AJ, Berger T, Greicius G, Pettersson S, Mak TW., Oncogene 32(10), 2013
PMID: 22614012
Circulating levels of neutrophil gelatinase-associated lipocalin (NGAL) correlate with the presence and severity of preeclampsia.
Kim SM, Park JS, Norwitz ER, Jung HJ, Kim BJ, Park CW, Jun JK., Reprod Sci 20(9), 2013
PMID: 23439619
Knockdown of lipocalin-2 suppresses the growth and invasion of prostate cancer cells.
Tung MC, Hsieh SC, Yang SF, Cheng CW, Tsai RT, Wang SC, Huang MH, Hsieh YH., Prostate 73(12), 2013
PMID: 23775308
Circulating level of lipocalin 2 as a predictor of severity in patients with community-acquired pneumonia.
Yeh YH, Chang JL, Hsiao PC, Tsao SM, Lin CH, Kao SJ, Chou MC, Yang SF, Chien MH., J Clin Lab Anal 27(4), 2013
PMID: 23852780
Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis.
Decicco-Skinner KL, Jung SA, Tabib T, Gwilliam JC, Alexander H, Goodheart SE, Merchant AS, Shan M, Garber C, Wiest JS., Carcinogenesis 34(12), 2013
PMID: 24067898
Imatinib mesylate therapy induces reduction in neutrophil gelatinase-associated lipocalin serum levels and increase in leptin concentrations in chronic myeloid leukemia patients in molecular remission.
Alonci A, Allegra A, Russo S, Penna G, Bellomo G, D'Angelo A, Campo S, Cannavò A, Centorrino R, Musolino C., Acta Haematol 127(1), 2012
PMID: 21986252
Screening and identification of distant metastasis-related differentially expressed genes in human squamous cell lung carcinoma.
Wang N, Zhou F, Xiong H, Du S, Ma J, Okai I, Wang J, Suo J, Hao L, Song Y, Hu J, Shao S., Anat Rec (Hoboken) 295(5), 2012
PMID: 22419659
Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer.
Lin CW, Tseng SW, Yang SF, Ko CP, Lin CH, Wei LH, Chien MH, Hsieh YS., Oral Dis 18(8), 2012
PMID: 22533572
The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer.
Sung H, Choi JY, Lee SA, Lee KM, Han S, Jeon S, Song M, Lee Y, Park SK, Yoo KY, Noh DY, Ahn SH, Kang D., BMC Cancer 12(), 2012
PMID: 22640376
No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.
Cramer EP, Glenthøj A, Häger M, Juncker-Jensen A, Engelholm LH, Santoni-Rugiu E, Lund LR, Laerum OD, Cowland JB, Borregaard N., PLoS One 7(6), 2012
PMID: 22737251
Lipocalin2 promotes invasion, tumorigenicity and gemcitabine resistance in pancreatic ductal adenocarcinoma.
Leung L, Radulovich N, Zhu CQ, Organ S, Bandarchi B, Pintilie M, To C, Panchal D, Tsao MS., PLoS One 7(10), 2012
PMID: 23056397
Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer.
Wenners AS, Mehta K, Loibl S, Park H, Mueller B, Arnold N, Hamann S, Weimer J, Ataseven B, Darb-Esfahani S, Schem C, Mundhenke C, Khandan F, Thomssen C, Jonat W, Holzhausen HJ, von Minckwitz G, Denkert C, Bauer M., PLoS One 7(10), 2012
PMID: 23056218
Increased serum levels of neutrophil gelatinase-associated lipocalin in patients with essential thrombocythemia and polycythemia vera.
Allegra A, Alonci A, Bellomo G, Campo S, Cannavò A, Penna G, Russo S, Centorrino R, Gerace D, Petrungaro A, Musolino C., Leuk Lymphoma 52(1), 2011
PMID: 21133718
Nitroglycerin alters matrix remodeling proteins in THP-1 human macrophages and plasma metalloproteinase activity in rats.
Krishnatry AS, Fung SM, Brazeau DA, Soda D, Fung HL., Nitric Oxide 24(2), 2011
PMID: 21156214
NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis.
Liu MF, Jin T, Shen JH, Shen ZY, Zheng ZC, Zhang ZL, Xu LY, Li EM, Xu HX., J Neurooncol 104(1), 2011
PMID: 21184133
Relationships of lipocalin 2 with breast tumorigenesis and metastasis.
Leng X, Wu Y, Arlinghaus RB., J Cell Physiol 226(2), 2011
PMID: 20857428
Neutrophil gelatinase-associated lipocalin in gastric carcinoma cells and its induction by TPA are controlled by C/EBPβ.
Du ZP, Yuan HM, Wu BL, Chang JX, Lv Z, Shen J, Wu JY, Chen HB, Li EM, Xu LY., Biochem Cell Biol 89(3), 2011
PMID: 21612443
NGAL expression is elevated in both colorectal adenoma-carcinoma sequence and cancer progression and enhances tumorigenesis in xenograft mouse models.
Sun Y, Yokoi K, Li H, Gao J, Hu L, Liu B, Chen K, Hamilton SR, Fan D, Sun B, Zhang W., Clin Cancer Res 17(13), 2011
PMID: 21622717
Elevated levels of neutrophil gelatinase-associated lipocalin in bile from patients with malignant pancreatobiliary disease.
Zabron AA, Horneffer-van der Sluis VM, Wadsworth CA, Laird F, Gierula M, Thillainayagam AV, Vlavianos P, Westaby D, Taylor-Robinson SD, Edwards RJ, Khan SA., Am J Gastroenterol 106(9), 2011
PMID: 21670771
Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene.
Bolignano D, Donato V, Lacquaniti A, Fazio MR, Bono C, Coppolino G, Buemi M., Cancer Lett 288(1), 2010
PMID: 19540040
Neutrophil gelatinase-associated lipocalin induces the expression of heme oxygenase-1 and superoxide dismutase 1, 2.
Bahmani P, Halabian R, Rouhbakhsh M, Roushandeh AM, Masroori N, Ebrahimi M, Samadikuchaksaraei A, Shokrgozar MA, Roudkenar MH., Cell Stress Chaperones 15(4), 2010
PMID: 19904630
[Matrix metalloproteases as molecular markers in gastric cancer].
de la Peña S, Sampieri CL, León-Córdoba K., Med Clin (Barc) 134(3), 2010
PMID: 19944435
Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.
Berger T, Cheung CC, Elia AJ, Mak TW., Proc Natl Acad Sci U S A 107(7), 2010
PMID: 20133630
Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis.
Sampieri CL, de la Peña S, Ochoa-Lara M, Zenteno-Cuevas R, León-Córdoba K., World J Gastroenterol 16(12), 2010
PMID: 20333791
Up-regulation of lipocalin 2 is associated with high-risk human papillomavirus and grade of cervical lesion at baseline but does not predict outcomes of infections or incident cervical intraepithelial neoplasia.
Syrjänen S, Naud P, Sarian L, Derchain S, Roteli-Martins C, Tatti S, Branca M, Erzen M, Hammes LS, Costa S, Longatto-Filho A, Syrjänen K., Am J Clin Pathol 134(1), 2010
PMID: 20551266
Neutrophil gelatinase-associated lipocalin immunoexpression in colorectal carcinoma: A stage-specific prognostic factor?
Barresi V, Lucianò R, Vitarelli E, Labate A, Tuccari G, Barresi G., Oncol Lett 1(6), 2010
PMID: 22870118
Expressions of neutrophil gelatinase-associated lipocalin in gastric cancer: a potential biomarker for prognosis and an ancillary diagnostic test.
Wang HJ, He XJ, Ma YY, Jiang XT, Xia YJ, Ye ZY, Zhao ZS, Tao HQ., Anat Rec (Hoboken) 293(11), 2010
PMID: 20730863
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection.
Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T, Mak TW, Clifton MC, Strong RK, Ray P, Kolls JK., J Immunol 182(8), 2009
PMID: 19342674
Clinical significance of Neutrophil gelatinase-associated lipocalin(NGAL) expression in primary rectal cancer.
Zhang XF, Zhang Y, Zhang XH, Zhou SM, Yang GG, Wang OC, Guo GL, Yang GY, Hu XQ., BMC Cancer 9(), 2009
PMID: 19419554
Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease.
Provatopoulou X, Gounaris A, Kalogera E, Zagouri F, Flessas I, Goussetis E, Nonni A, Papassotiriou I, Zografos G., BMC Cancer 9(), 2009
PMID: 19889214
MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
Langers AM, Sier CF, Hawinkels LJ, Kubben FJ, van Duijn W, van der Reijden JJ, Lamers CB, Hommes DW, Verspaget HW., Br J Cancer 98(11), 2008
PMID: 18506186
VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.
Hawinkels LJ, Zuidwijk K, Verspaget HW, de Jonge-Muller ES, van Duijn W, Ferreira V, Fontijn RD, David G, Hommes DW, Lamers CB, Sier CF., Eur J Cancer 44(13), 2008
PMID: 18691882
Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue.
Sabo E, Meitner PA, Tavares R, Corless CL, Lauwers GY, Moss SF, Resnick MB., Clin Cancer Res 14(20), 2008
PMID: 18927283

32 References

Daten bereitgestellt von Europe PubMed Central.

The lipocalin protein family: a role in cell regulation.
Flower DR., FEBS Lett. 354(1), 1994
PMID: 7957904
Lipocalins as biochemical markers of disease.
Xu S, Venge P., Biochim. Biophys. Acta 1482(1-2), 2000
PMID: 11058770
A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase.
Triebel S, Blaser J, Reinke H, Tschesche H., FEBS Lett. 314(3), 1992
PMID: 1281792
Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha.
Cowland JB, Sorensen OE, Sehested M, Borregaard N., J. Immunol. 171(12), 2003
PMID: 14662866
Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases.
Nielsen BS, Borregaard N, Bundgaard JR, Timshel S, Sehested M, Kjeldsen L., Gut 38(3), 1996
PMID: 8675096
Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin.
Mallbris L, O'Brien KP, Hulthen A, Sandstedt B, Cowland JB, Borregaard N, Stahle-Backdahl M., Exp. Dermatol. 11(6), 2002
PMID: 12473066
Heterogeneous expression of the lipocalin NGAL in primary breast cancers.
Stoesz SP, Friedl A, Haag JD, Lindstrom MJ, Clark GM, Gould MN., Int. J. Cancer 79(6), 1998
PMID: 9842963
Urinary type IV collagenase: elevated levels are associated with bladder transitional cell carcinoma.
Margulies IM, Hoyhtya M, Evans C, Stracke ML, Liotta LA, Stetler-Stevenson WG., Cancer Epidemiol. Biomarkers Prev. 1(6), 1992
PMID: 1302559
Activity and cellular origin of gelatinases in patients with colon and rectal carcinoma differential activity of matrix metalloproteinase-9.
Roeb E, Dietrich CG, Winograd R, Arndt M, Breuer B, Fass J, Schumpelick V, Matern S., Cancer 92(10), 2001
PMID: 11745204
Assessment of the clinical significance of serum matrix metalloproteinases MMP-2 and MMP-9 in patients with various chronic liver diseases and hepatocellular carcinoma.
Kuyvenhoven JP, van Hoek B, Blom E, van Duijn W, Hanemaaijer R, Verheijen JH, Lamers CB, Verspaget HW., Thromb. Haemost. 89(4), 2003
PMID: 12669127
Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: a comparison with clinically used tumor markers.
Sier CF, Casetta G, Verheijen JH, Tizzani A, Agape V, Kos J, Blasi F, Hanemaaijer R., Clin. Cancer Res. 6(6), 2000
PMID: 10873084
Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma.
Sier CF, Kubben FJ, Ganesh S, Heerding MM, Griffioen G, Hanemaaijer R, van Krieken JH, Lamers CB, Verspaget HW., Br. J. Cancer 74(3), 1996
PMID: 8695357
Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer.
Kubben FJ, Sier CF, van Duijn W, Griffioen G, Hanemaaijer R, van de Velde CJ, van Krieken JH, Lamers CB, Verspaget HW., Br. J. Cancer 94(7), 2006
PMID: 16538217
A sandwich enzyme immunoassay for the determination of neutrophil lipocalin in body fluids.
Blaser J, Triebel S, Tschesche H., Clin. Chim. Acta 235(2), 1995
PMID: 7554268
Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase.
Bergmann U, Michaelis J, Oberhoff R, Knauper V, Beckmann R, Tschesche H., J. Clin. Chem. Clin. Biochem. 27(6), 1989
PMID: 2547014
Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer.
Kubben FJ, Sier CF, van Duijn W, Griffioen G, Hanemaaijer R, van de Velde CJ, van Krieken JH, Lamers CB, Verspaget HW., Br. J. Cancer 94(7), 2006
PMID: 16538217
Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease.
Kruidenier L, Kuiper I, Van Duijn W, Mieremet-Ooms MA, van Hogezand RA, Lamers CB, Verspaget HW., J. Pathol. 201(1), 2003
PMID: 12950013
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Sier CF, Zuidwijk K, Zijlmans HJ, Hanemaaijer R, Mulder-Stapel AA, Prins FA, Dreef EJ, Kenter GG, Fleuren GJ, Gorter A., Int. J. Cancer 118(12), 2006
PMID: 16425263
Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells.
Hanai J, Mammoto T, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP., J. Biol. Chem. 280(14), 2005
PMID: 15691834
Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface.
Mira E, Lacalle RA, Buesa JM, de Buitrago GG, Jimenez-Baranda S, Gomez-Mouton C, Martinez-A C, Manes S., J. Cell. Sci. 117(Pt 9), 2004
PMID: 15075244
Progelatinase B forms from human neutrophils. Complex formation of monomer/lipocalin with TIMP-1
Kolkenbrock, Biol Chem 377(7–8), 1996
92 kDa type IV collagenase (MMP-9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer.
Nielsen BS, Timshel S, Kjeldsen L, Sehested M, Pyke C, Borregaard N, Dano K., Int. J. Cancer 65(1), 1996
PMID: 8543396
Prognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy.
Caruso RA, Bellocco R, Pagano M, Bertoli G, Rigoli L, Inferrera C., Mod. Pathol. 15(8), 2002
PMID: 12181268
The role of proteolytic enzymes in cancer invasion and metastasis.
Duffy MJ., Clin. Exp. Metastasis 10(3), 1992
PMID: 1582084
Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach.
Sier CF, Verspaget HW, Griffioen G, Ganesh S, Vloedgraven HJ, Lamers CB., Gut 34(1), 1993
PMID: 8432457
Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion.
Zhang H, Xu L, Xiao D, Xie J, Zeng H, Wang Z, Zhang X, Niu Y, Shen Z, Shen J, Wu X, Li E., J. Clin. Pathol. 60(5), 2007
PMID: 17412867

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