Helicobacter exploits integrin for type IV secretion and kinase activation

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Koenig W, Backert S (2007)
NATURE 449(7164): 862-866.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Kwok, Terry; Zabler, Dana; Urman, Sylwia; Rohde, Manfred; Hartig, Roland; Wessler, Silja; Misselwitz, Rolf; Berger, Juergen; Sewald, NorbertUniBi ; Koenig, Wolfgang; Backert, Steffen
Abstract / Bemerkung
Integrins are important mammalian receptors involved in normal cellular functions as well as pathogenesis of chronic inflammation and cancer. We propose that integrins are exploited by the gastric pathogen and type-1 carcinogen Helicobacter pylori for injection of the bacterial oncoprotein cytotoxin-associated gene A (CagA) into gastric epithelial cells. Virulent H. pylori express a type-IV secretion pilus that injects CagA into the host cell; CagA then becomes tyrosine-phosphorylated by Src family kinases. However, the identity of the host cell receptor involved in this process has remained unknown. Here we show that the H. pylori CagL protein is a specialized adhesin that is targeted to the pilus surface, where it binds to and activates integrin alpha(5)beta(1) receptor on gastric epithelial cells through an arginine-glycine-aspartate motif. This interaction triggers CagA delivery into target cells as well as activation of focal adhesion kinase and Src. Our findings provide insights into the role of integrins in H.-pylori-induced pathogenesis. CagL may be exploited as a new molecular tool for our further understanding of integrin signalling.
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Kwok T, Zabler D, Urman S, et al. Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE. 2007;449(7164):862-866.
Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., et al. (2007). Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE, 449(7164), 862-866. https://doi.org/10.1038/nature06187
Kwok, Terry, Zabler, Dana, Urman, Sylwia, Rohde, Manfred, Hartig, Roland, Wessler, Silja, Misselwitz, Rolf, et al. 2007. “Helicobacter exploits integrin for type IV secretion and kinase activation”. NATURE 449 (7164): 862-866.
Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Koenig, W., et al. (2007). Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE 449, 862-866.
Kwok, T., et al., 2007. Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE, 449(7164), p 862-866.
T. Kwok, et al., “Helicobacter exploits integrin for type IV secretion and kinase activation”, NATURE, vol. 449, 2007, pp. 862-866.
Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Koenig, W., Backert, S.: Helicobacter exploits integrin for type IV secretion and kinase activation. NATURE. 449, 862-866 (2007).
Kwok, Terry, Zabler, Dana, Urman, Sylwia, Rohde, Manfred, Hartig, Roland, Wessler, Silja, Misselwitz, Rolf, Berger, Juergen, Sewald, Norbert, Koenig, Wolfgang, and Backert, Steffen. “Helicobacter exploits integrin for type IV secretion and kinase activation”. NATURE 449.7164 (2007): 862-866.

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Wroblewski LE, Peek RM., Gastroenterol Clin North Am 42(2), 2013
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Helicobacter pylori initiates a mesenchymal transition through ZEB1 in gastric epithelial cells.
Baud J, Varon C, Chabas S, Chambonnier L, Darfeuille F, Staedel C., PLoS One 8(4), 2013
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Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in a region at high risk of gastric cancer.
Wang MY, Chen C, Gao XZ, Li J, Yue J, Ling F, Wang XC, Shao SH., Microb Pathog 59-60(), 2013
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Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori.
Salama NR, Hartung ML, Müller A., Nat Rev Microbiol 11(6), 2013
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Genome sequences of 65 Helicobacter pylori strains isolated from asymptomatic individuals and patients with gastric cancer, peptic ulcer disease, or gastritis.
Blanchard TG, Czinn SJ, Correa P, Nakazawa T, Keelan M, Morningstar L, Santana-Cruz I, Maroo A, McCracken C, Shefchek K, Daugherty S, Song Y, Fraser CM, Fricke WF., Pathog Dis 68(2), 2013
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Delineating breast cancer cell interactions with engineered bone microenvironments.
Taubenberger AV, Quent VM, Thibaudeau L, Clements JA, Hutmacher DW., J Bone Miner Res 28(6), 2013
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A systematic approach toward stabilization of CagL, a protein antigen from Helicobacter pylori that is a candidate subunit vaccine.
Choudhari SP, Pendleton KP, Ramsey JD, Blanchard TG, Picking WD., J Pharm Sci 102(8), 2013
PMID: 23794457
Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor.
Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, Salama N, Churin Y, Meyer TF., Cell Microbiol 15(11), 2013
PMID: 23782461
Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice.
Krueger S, Bernhardt A, Kalinski T, Baldensperger M, Zeh M, Teller A, Adolf D, Reinheckel T, Roessner A, Kuester D., PLoS One 8(7), 2013
PMID: 23936173
Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.
Tegtmeyer N, Rivas Traverso F, Rohde M, Oyarzabal OA, Lehn N, Schneider-Brachert W, Ferrero RL, Fox JG, Berg DE, Backert S., PLoS One 8(8), 2013
PMID: 23940723
Helicobacter pylori downregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion.
Patel SR, Smith K, Letley DP, Cook KW, Memon AA, Ingram RJ, Staples E, Backert S, Zaitoun AM, Atherton JC, Robinson K., Cell Microbiol 15(12), 2013
PMID: 23870035
Dynamics of the Cag-type IV secretion system of Helicobacter pylori as studied by bacterial co-infections.
Jiménez-Soto LF, Clausen S, Sprenger A, Ertl C, Haas R., Cell Microbiol 15(11), 2013
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Inflammation, immunity, vaccines for Helicobacter pylori infection.
Koch M, Meyer TF, Moss SF., Helicobacter 18 Suppl 1(), 2013
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ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population.
Yim DH, Zhang YW, Eom SY, Moon SI, Yun HY, Song YJ, Youn SJ, Hyun T, Park JS, Kim BS, Lee JY, Kim YD, Kim H., World J Gastroenterol 19(35), 2013
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Cag type IV secretion system: CagI independent bacterial surface localization of CagA.
Kumar N, Shariq M, Kumari R, Tyagi RK, Mukhopadhyay G., PLoS One 8(9), 2013
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A helical RGD motif promoting cell adhesion: crystal structures of the Helicobacter pylori type IV secretion system pilus protein CagL.
Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH., Structure 21(11), 2013
PMID: 24076404
Cytokinins secreted by Agrobacterium promote transformation by repressing a plant myb transcription factor.
Sardesai N, Lee LY, Chen H, Yi H, Olbricht GR, Stirnberg A, Jeffries J, Xiong K, Doerge RW, Gelvin SB., Sci Signal 6(302), 2013
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Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1.
Conradi J, Huber S, Gaus K, Mertink F, Royo Gracia S, Strijowski U, Backert S, Sewald N., Amino Acids 43(1), 2012
PMID: 21915696
Characterization of CagI in the cag pathogenicity island of Helicobacter pylori.
Wang H, Han J, Chen D, Duan X, Gao X, Wang X, Shao S., Curr Microbiol 64(2), 2012
PMID: 22109855
In vivo expression of Helicobacter pylori virulence genes in patients with gastritis, ulcer, and gastric cancer.
Avilés-Jiménez F, Reyes-Leon A, Nieto-Patlán E, Hansen LM, Burgueño J, Ramos IP, Camorlinga-Ponce M, Bermúdez H, Blancas JM, Cabrera L, Ribas-Aparicio RM, Solnick JV, Torres-López J., Infect Immun 80(2), 2012
PMID: 22124657
The Helicobacter pylori cag Pathogenicity Island.
Noto JM, Peek RM., Methods Mol Biol 921(), 2012
PMID: 23015490
Variations in Helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention.
Rizzato C, Torres J, Plummer M, Muñoz N, Franceschi S, Camorlinga-Ponce M, Fuentes-Pananá EM, Canzian F, Kato I., PLoS One 7(1), 2012
PMID: 22235308
Alterations in Helicobacter pylori triggered by contact with gastric epithelial cells.
Johnson EM, Gaddy JA, Cover TL., Front Cell Infect Microbiol 2(), 2012
PMID: 22919609
Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm.
Cinghu S, Goh YM, Oh BC, Lee YS, Lee OJ, Devaraj H, Bae SC., J Cell Physiol 227(3), 2012
PMID: 21567391
c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains.
Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S., J Clin Invest 122(4), 2012
PMID: 22378042
Effects of cholesterol on Helicobacter pylori growth and virulence properties in vitro.
Jiménez-Soto LF, Rohrer S, Jain U, Ertl C, Sewald X, Haas R., Helicobacter 17(2), 2012
PMID: 22404444
CagI is an essential component of the Helicobacter pylori Cag type IV secretion system and forms a complex with CagL.
Pham KT, Weiss E, Jiménez Soto LF, Breithaupt U, Haas R, Fischer W., PLoS One 7(4), 2012
PMID: 22493745
How Helicobacter pylori infection controls gastric acid secretion.
Smolka AJ, Backert S., J Gastroenterol 47(6), 2012
PMID: 22565637
An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA.
Conradi J, Tegtmeyer N, Woźna M, Wissbrock M, Michalek C, Gagell C, Cover TL, Frank R, Sewald N, Backert S., Front Cell Infect Microbiol 2(), 2012
PMID: 22919661
Live Helicobacter pylori in the root canal of endodontic-infected deciduous teeth.
Hirsch C, Tegtmeyer N, Rohde M, Rowland M, Oyarzabal OA, Backert S., J Gastroenterol 47(8), 2012
PMID: 22722905
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system.
Walldén K, Williams R, Yan J, Lian PW, Wang L, Thalassinos K, Orlova EV, Waksman G., Proc Natl Acad Sci U S A 109(28), 2012
PMID: 22745169
Helicobacter pylori CagA tertiary structure reveals functional insights.
Backert S, Tegtmeyer N., Cell Host Microbe 12(1), 2012
PMID: 22817982
Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA.
Hayashi T, Senda M, Morohashi H, Higashi H, Horio M, Kashiba Y, Nagase L, Sasaya D, Shimizu T, Venugopalan N, Kumeta H, Noda NN, Inagaki F, Senda T, Hatakeyama M., Cell Host Microbe 12(1), 2012
PMID: 22817985
Exploitation of integrin function by pathogenic microbes.
Hauck CR, Borisova M, Muenzner P., Curr Opin Cell Biol 24(5), 2012
PMID: 22884865
Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin.
Kaplan-Türköz B, Jiménez-Soto LF, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R, Terradot L., Proc Natl Acad Sci U S A 109(36), 2012
PMID: 22908298
Subversion of phagocytosis for pathogen survival.
Sarantis H, Grinstein S., Cell Host Microbe 12(4), 2012
PMID: 23084912
Life at the margins: modulation of attachment proteins in Helicobacter pylori.
Moore ME, Borén T, Solnick JV., Gut Microbes 2(1), 2011
PMID: 21637017
A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.
Pelz C, Steininger S, Weiss C, Coscia F, Vogelmann R., J Biol Chem 286(11), 2011
PMID: 21212271
Architecture of the Helicobacter pylori Cag-type IV secretion system.
Terradot L, Waksman G., FEBS J 278(8), 2011
PMID: 21352491
Molecular cross-talk between Helicobacter pylori and human gastric mucosa.
Ricci V, Romano M, Boquet P., World J Gastroenterol 17(11), 2011
PMID: 21472096
Integrin-mediated type IV secretion by Helicobacter: what makes it tick?
Schuelein R, Everingham P, Kwok T., Trends Microbiol 19(5), 2011
PMID: 21371889
Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions.
Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, Slaughter JC, Perez-Perez G, Israel DA, Peek RM., Am J Pathol 178(4), 2011
PMID: 21406172
Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cells.
Schneider S, Carra G, Sahin U, Hoy B, Rieder G, Wessler S., Infect Immun 79(6), 2011
PMID: 21402757
Control of host cell phosphorylation by legionella pneumophila.
Haenssler E, Isberg RR., Front Microbiol 2(), 2011
PMID: 21747787
BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity.
Ishijima N, Suzuki M, Suzuki M, Ashida H, Ichikawa Y, Kanegae Y, Saito I, Borén T, Haas R, Sasakawa C, Mimuro H., J Biol Chem 286(28), 2011
PMID: 21596743
Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.
Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez-Quiles N, Backert S., Cell Host Microbe 9(6), 2011
PMID: 21669400
Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling.
Tabassam FH, Graham DY, Yamaoka Y., Am J Physiol Gastrointest Liver Physiol 301(4), 2011
PMID: 21757638
Dual roles of CagA protein in Helicobacterpylori-induced chronic gastritis in mice.
Kido M, Watanabe N, Aoki N, Iwamoto S, Nishiura H, Maruoka R, Ikeda A, Azuma T, Chiba T., Biochem Biophys Res Commun 412(2), 2011
PMID: 21820415
Helicobacter pylori activates calpain via toll-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells.
O'Connor PM, Lapointe TK, Jackson S, Beck PL, Jones NL, Buret AG., Infect Immun 79(10), 2011
PMID: 21825064
Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain.
Lai CH, Wang HJ, Chang YC, Hsieh WC, Lin HJ, Tang CH, Sheu JJ, Lin CJ, Yang MS, Tseng SF, Wang WC., FEMS Microbiol Lett 323(2), 2011
PMID: 22092715
Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface.
Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL., PLoS Pathog 7(9), 2011
PMID: 21909278
Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration.
Banerjee A, Kim BJ, Carmona EM, Cutting AS, Gurney MA, Carlos C, Feuer R, Prasadarao NV, Doran KS., Nat Commun 2(), 2011
PMID: 21897373
Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression.
Belair C, Baud J, Chabas S, Sharma CM, Vogel J, Staedel C, Darfeuille F., Silence 2(1), 2011
PMID: 22027184
"Targeted disruption of the epithelial-barrier by Helicobacter pylori".
Wroblewski LE, Peek RM., Cell Commun Signal 9(1), 2011
PMID: 22044698
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1.
Boehm M, Krause-Gruszczynska M, Rohde M, Tegtmeyer N, Takahashi S, Oyarzabal OA, Backert S., Front Cell Infect Microbiol 1(), 2011
PMID: 22919583
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Krause-Gruszczynska M, Boehm M, Rohde M, Tegtmeyer N, Takahashi S, Buday L, Oyarzabal OA, Backert S., Cell Commun Signal 9(), 2011
PMID: 22204307
Helicobacter pylori CagA upregulation of CIP2A is dependent on the Src and MEK/ERK pathways.
Zhao D, Liu Z, Ding J, Li W, Sun Y, Yu H, Zhou Y, Zeng J, Chen C, Jia J., J Med Microbiol 59(pt 3), 2010
PMID: 19959630
Helicobacter pylori colonization of the human gastric epithelium: a bug's first step is a novel target for us.
Sheu BS, Yang HB, Yeh YC, Wu JJ., J Gastroenterol Hepatol 25(1), 2010
PMID: 20136973
Bacterial contact-dependent delivery systems.
Hayes CS, Aoki SK, Low DA., Annu Rev Genet 44(), 2010
PMID: 21047256
Role of Helicobacter pylori infection in gastric cancer pathogenesis: a chance for prevention.
Malfertheiner P, Bornschein J, Selgrad M., J Dig Dis 11(1), 2010
PMID: 20132425
PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function.
Backert S, Kenny B, Gerhard R, Tegtmeyer N, Brandt S., Gut Microbes 1(2), 2010
PMID: 21326916
Surreptitious manipulation of the human host by Helicobacter pylori.
Israel DA, Peek RM., Gut Microbes 1(2), 2010
PMID: 20976041
Helicobacter pylori induces miR-155 in T cells in a cAMP-Foxp3-dependent manner.
Fassi Fehri L, Koch M, Belogolova E, Khalil H, Bolz C, Kalali B, Mollenkopf HJ, Beigier-Bompadre M, Karlas A, Schneider T, Churin Y, Gerhard M, Meyer TF., PLoS One 5(3), 2010
PMID: 20209161
Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit.
Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ., Gastroenterology 139(1), 2010
PMID: 20303353
Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam.
Nguyen LT, Uchida T, Tsukamoto Y, Trinh TD, Ta L, Mai HB, Le HS, Ho DQ, Hoang HH, Matsuhisa T, Okimoto T, Kodama M, Murakami K, Fujioka T, Yamaoka Y, Moriyama M., Eur J Clin Microbiol Infect Dis 29(6), 2010
PMID: 20372956
Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen.
Guang W, Ding H, Czinn SJ, Kim KC, Blanchard TG, Lillehoj EP., J Biol Chem 285(27), 2010
PMID: 20430889
Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein.
Murata-Kamiya N, Kikuchi K, Hayashi T, Higashi H, Hatakeyama M., Cell Host Microbe 7(5), 2010
PMID: 20478541
A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation.
Tegtmeyer N, Hartig R, Delahay RM, Rohde M, Brandt S, Conradi J, Takahashi S, Smolka AJ, Sewald N, Backert S., J Biol Chem 285(30), 2010
PMID: 20507990
Helicobacter pylori: gastric cancer and beyond.
Polk DB, Peek RM., Nat Rev Cancer 10(6), 2010
PMID: 20495574
Integrin receptors play a role in the internalin B-dependent entry of Listeria monocytogenes into host cells.
Auriemma C, Viscardi M, Tafuri S, Pavone LM, Capuano F, Rinaldi L, Della Morte R, Iovane G, Staiano N., Cell Mol Biol Lett 15(3), 2010
PMID: 20526749
Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa.
Saha A, Hammond CE, Beeson C, Peek RM, Smolka AJ., Gut 59(7), 2010
PMID: 20581234
Bacterial interactions with the host epithelium.
Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa C., Cell Host Microbe 8(1), 2010
PMID: 20638639
Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
Peek RM, Fiske C, Wilson KT., Physiol Rev 90(3), 2010
PMID: 20664074
Type IV secretion systems: versatility and diversity in function.
Wallden K, Rivera-Calzada A, Waksman G., Cell Microbiol 12(9), 2010
PMID: 20642798
Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis.
Acosta N, Quiroga A, Delgado P, Bravo MM, Jaramillo C., World J Gastroenterol 16(31), 2010
PMID: 20712055
Biochemical and functional characterization of Helicobacter pylori vesicles.
Olofsson A, Vallström A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN, Gröbner G, Arnqvist A., Mol Microbiol 77(6), 2010
PMID: 20659286
Helicobacter pylori exploits cholesterol-rich microdomains for induction of NF-kappaB-dependent responses and peptidoglycan delivery in epithelial cells.
Hutton ML, Kaparakis-Liaskos M, Turner L, Cardona A, Kwok T, Ferrero RL., Infect Immun 78(11), 2010
PMID: 20713621
A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island.
Olbermann P, Josenhans C, Moodley Y, Uhr M, Stamer C, Vauterin M, Suerbaum S, Achtman M, Linz B., PLoS Genet 6(8), 2010
PMID: 20808891
The coupling protein Cagbeta and its interaction partner CagZ are required for type IV secretion of the Helicobacter pylori CagA protein.
Jurik A, Hausser E, Kutter S, Pattis I, Prassl S, Weiss E, Fischer W., Infect Immun 78(12), 2010
PMID: 20876293
Integrins as therapeutic targets: lessons and opportunities.
Cox D, Brennan M, Moran N., Nat Rev Drug Discov 9(10), 2010
PMID: 20885411
Mechanisms of disease: Helicobacter pylori virulence factors.
Yamaoka Y., Nat Rev Gastroenterol Hepatol 7(11), 2010
PMID: 20938460
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation.
Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM., Gastroenterology 136(1), 2009
PMID: 18996125
The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion.
Cendron L, Couturier M, Angelini A, Barison N, Stein M, Zanotti G., J Mol Biol 386(1), 2009
PMID: 19109970
Helicobacter pylori virulence factors in gastric carcinogenesis.
Wen S, Moss SF., Cancer Lett 282(1), 2009
PMID: 19111390
The type VI secretion system: translocation of effectors and effector-domains.
Pukatzki S, McAuley SB, Miyata ST., Curr Opin Microbiol 12(1), 2009
PMID: 19162533
Expression of Helicobacter pylori CagA domains by library-based construct screening.
Angelini A, Tosi T, Mas P, Acajjaoui S, Zanotti G, Terradot L, Hart DJ., FEBS J 276(3), 2009
PMID: 19143840
NF-kappaB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65.
Takeshima E, Tomimori K, Kawakami H, Ishikawa C, Sawada S, Tomita M, Senba M, Kinjo F, Mimuro H, Sasakawa C, Fujita J, Mori N., BMC Microbiol 9(), 2009
PMID: 19216748
Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils.
Wiedemann T, Loell E, Mueller S, Stoeckelhuber M, Stolte M, Haas R, Rieder G., PLoS One 4(3), 2009
PMID: 19270747
Selective upregulation of endothelial E-selectin in response to Helicobacter pylori-induced gastritis.
Svensson H, Hansson M, Kilhamn J, Backert S, Quiding-Järbrink M., Infect Immun 77(7), 2009
PMID: 19414551
Helicobacter pylori in health and disease.
Cover TL, Blaser MJ., Gastroenterology 136(6), 2009
PMID: 19457415
Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells.
Magalhães A, Marcos NT, Carvalho AS, David L, Figueiredo C, Bastos J, David G, Reis CA., FEMS Immunol Med Microbiol 56(3), 2009
PMID: 19519784
Bacterial adhesins in host-microbe interactions.
Kline KA, Fälker S, Dahlberg S, Normark S, Henriques-Normark B., Cell Host Microbe 5(6), 2009
PMID: 19527885
Bacterial type IV secretion systems in human disease.
Llosa M, Roy C, Dehio C., Mol Microbiol 73(2), 2009
PMID: 19508287
Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori.
Mullaney E, Brown PA, Smith SM, Botting CH, Yamaoka YY, Terres AM, Kelleher DP, Windle HJ., Proteomics Clin Appl 3(7), 2009
PMID: 21136987
Comparative genomics of Helicobacter pylori.
Dong QJ, Wang Q, Xin YN, Li N, Xuan SY., World J Gastroenterol 15(32), 2009
PMID: 19705492
Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship.
Belair C, Darfeuille F, Staedel C., Clin Microbiol Infect 15(9), 2009
PMID: 19702585
The structural biology of type IV secretion systems.
Fronzes R, Christie PJ, Waksman G., Nat Rev Microbiol 7(10), 2009
PMID: 19756009
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.
Lindén SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA., PLoS Pathog 5(10), 2009
PMID: 19816567
Biological diversity of prokaryotic type IV secretion systems.
Alvarez-Martinez CE, Christie PJ., Microbiol Mol Biol Rev 73(4), 2009
PMID: 19946141
A novel diagnostic monoclonal antibody specific for Helicobacter pylori CagA of East Asian type.
Yasuda A, Uchida T, Nguyen LT, Kawazato H, Tanigawa M, Murakami K, Kishida T, Fujioka T, Moriyama M., APMIS 117(12), 2009
PMID: 20078554
Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner.
Jiménez-Soto LF, Kutter S, Sewald X, Ertl C, Weiss E, Kapp U, Rohde M, Pirch T, Jung K, Retta SF, Terradot L, Fischer W, Haas R., PLoS Pathog 5(12), 2009
PMID: 19997503
Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studies.
Kutter S, Buhrdorf R, Haas J, Schneider-Brachert W, Haas R, Fischer W., J Bacteriol 190(6), 2008
PMID: 18178731
Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Backert S, Feller SM, Wessler S., Trends Biochem Sci 33(2), 2008
PMID: 18182299
Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner.
Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins CL, Solnick JV., Gastroenterology 134(4), 2008
PMID: 18395086
SagA of CagA in Helicobacter pylori pathogenesis.
Hatakeyama M., Curr Opin Microbiol 11(1), 2008
PMID: 18243773
Role of type IV secretion in Helicobacter pylori pathogenesis.
Backert S, Selbach M., Cell Microbiol 10(8), 2008
PMID: 18410539
Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells.
Lai CH, Chang YC, Du SY, Wang HJ, Kuo CH, Fang SH, Fu HW, Lin HH, Chiang AS, Wang WC., Infect Immun 76(7), 2008
PMID: 18443091
Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence.
Juhas M, Crook DW, Hood DW., Cell Microbiol 10(12), 2008
PMID: 18549454
Mechanism for gastric cancer development by Helicobacter pylori infection.
Chiba T, Marusawa H, Seno H, Watanabe N., J Gastroenterol Hepatol 23(8 pt 1), 2008
PMID: 18637055
Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor.
O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM., J Biol Chem 283(35), 2008
PMID: 18579524
Helicobacter pylori produces unique filaments upon host contact in vitro.
Couturier MR, Stein M., Can J Microbiol 54(7), 2008
PMID: 18641700
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.
Wessler S, Backert S., Trends Microbiol 16(8), 2008
PMID: 18619844
Differential phosphoproteome profiling reveals a functional role for VASP in Helicobacter pylori-induced cytoskeleton turnover in gastric epithelial cells.
Knauer O, Binai NA, Carra G, Beckhaus T, Hanschmann KM, Renné T, Backert S, Karas M, Wessler S., Cell Microbiol 10(11), 2008
PMID: 18637808
p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7.
Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM., Mol Biol Cell 19(10), 2008
PMID: 18653469
The role of viral and bacterial pathogens in gastrointestinal cancer.
Selgrad M, Malfertheiner P, Fini L, Goel A, Boland CR, Ricciardiello L., J Cell Physiol 216(2), 2008
PMID: 18338378
Targeting focal adhesions:Helicobacter pylori-host communication in cell migration.
Schneider S, Weydig C, Wessler S., Cell Commun Signal 6(), 2008
PMID: 18684322
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?
Backert S, Fronzes R, Waksman G., Trends Microbiol 16(9), 2008
PMID: 18706815
Cooperation of Salmonella pathogenicity islands 1 and 4 is required to breach epithelial barriers.
Gerlach RG, Cláudio N, Rohde M, Jäckel D, Wagner C, Hensel M., Cell Microbiol 10(11), 2008
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