Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana

Devkota KP, Lenta BN, Choudhary MI, Naz Q, Fekam FB, Rosenthal PJ, Sewald N (2007)
Chemical & Pharmaceutical Bulletin 55(9): 1397-1401.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide 1 (2), along with three known alkaloids N-a-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC50 2.9-34.1 mu M) and butyryleholinesterase (IC50 0.3-3.6/mu M). These compounds also showed moderate antiplasmodial activity (IC50 2.4-10.3 mu m) against the Plasmodium falciparum chloroquine resistant W2 strain.
Stichworte
sarcococca hookeriana; Alzheimer's disease; antiplasmodial; cholinesterase inhibition; steroidal alkaloid
Erscheinungsjahr
2007
Zeitschriftentitel
Chemical & Pharmaceutical Bulletin
Band
55
Ausgabe
9
Seite(n)
1397-1401
ISSN
0009-2363
eISSN
1347-5223
Page URI
https://pub.uni-bielefeld.de/record/1631653

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Devkota KP, Lenta BN, Choudhary MI, et al. Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin. 2007;55(9):1397-1401.
Devkota, K. P., Lenta, B. N., Choudhary, M. I., Naz, Q., Fekam, F. B., Rosenthal, P. J., & Sewald, N. (2007). Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin, 55(9), 1397-1401. doi:10.1248/cpb.55.1397
Devkota, K. P., Lenta, B. N., Choudhary, M. I., Naz, Q., Fekam, F. B., Rosenthal, P. J., and Sewald, N. (2007). Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin 55, 1397-1401.
Devkota, K.P., et al., 2007. Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin, 55(9), p 1397-1401.
K.P. Devkota, et al., “Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana”, Chemical & Pharmaceutical Bulletin, vol. 55, 2007, pp. 1397-1401.
Devkota, K.P., Lenta, B.N., Choudhary, M.I., Naz, Q., Fekam, F.B., Rosenthal, P.J., Sewald, N.: Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chemical & Pharmaceutical Bulletin. 55, 1397-1401 (2007).
Devkota, Krishna Prasad, Lenta, Bruno Ndjakou, Choudhary, Muhammad Iqbal, Naz, Qamar, Fekam, Fabrice Boyom, Rosenthal, Philip Joseph, and Sewald, Norbert. “Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana”. Chemical & Pharmaceutical Bulletin 55.9 (2007): 1397-1401.

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