Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils
Grund T, Teuchert-Noodt G, Busche A, Neddens J, Brurnmelte S, Moll GH, Dawirs RR (2007)
BRAIN RESEARCH 1176: 124-132.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Grund, Thorsten;
Teuchert-Noodt, GertraudUniBi;
Busche, Andrea;
Neddens, Joerg;
Brurnmelte, Susanne;
Moll, Gunther H.;
Dawirs, Ralph R.
Einrichtung
Abstract / Bemerkung
The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the development of DA fiber innervation in control animals sensitive to a clinically relevant subchronic treatment with MP? (2) Is the development of DA fiber innervation in the forebrain altered by a single early MA challenge? (3) if so, might the subsequent institution of a therapeutically relevant MP application scheme interfere with such early induced alternative developmental trajectories for DA fiber innervation? For this purpose, gerbils pretreated both with saline and MA (50 mg/kg, i. p.) on day 14 received either H2O or MP (5 mg/kg) orally on days 30 to 60. On day 90, DA fibers were immunohistochemically detected and quantified. As a result, MP on its own did not have any significant influence on the postnatal development of the DA fiber systems, whereas it prevented a previously MA triggered suppressive development of DA fiber innervation in the prefrontal cortex and amygdala complex (30% less fiber innervation in both areas). Thus, MP prevented previously initiated miswiring of DA fibers from actually being implemented in the gerbil forebrain. During earlier studies, rather complex miswiring has been documented in response to an early preweaning MA challenge. This miswiring was associated with functional deficits resembling some of the symptoms of patients with ADHD. Therefore, morphogenetic properties of MP need further attention. (C) 2007 Elsevier B.V. All rights reserved.
Stichworte
attention deficit hyperactivity;
disorder;
ADHD;
methamphetamine;
Ritalin (R);
dopamine
Erscheinungsjahr
2007
Zeitschriftentitel
BRAIN RESEARCH
Band
1176
Seite(n)
124-132
ISSN
0006-8993
Page URI
https://pub.uni-bielefeld.de/record/1631295
Zitieren
Grund T, Teuchert-Noodt G, Busche A, et al. Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils. BRAIN RESEARCH. 2007;1176:124-132.
Grund, T., Teuchert-Noodt, G., Busche, A., Neddens, J., Brurnmelte, S., Moll, G. H., & Dawirs, R. R. (2007). Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils. BRAIN RESEARCH, 1176, 124-132. https://doi.org/10.1016/j.brainres.2007.06.107
Grund, Thorsten, Teuchert-Noodt, Gertraud, Busche, Andrea, Neddens, Joerg, Brurnmelte, Susanne, Moll, Gunther H., and Dawirs, Ralph R. 2007. “Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils”. BRAIN RESEARCH 1176: 124-132.
Grund, T., Teuchert-Noodt, G., Busche, A., Neddens, J., Brurnmelte, S., Moll, G. H., and Dawirs, R. R. (2007). Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils. BRAIN RESEARCH 1176, 124-132.
Grund, T., et al., 2007. Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils. BRAIN RESEARCH, 1176, p 124-132.
T. Grund, et al., “Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils”, BRAIN RESEARCH, vol. 1176, 2007, pp. 124-132.
Grund, T., Teuchert-Noodt, G., Busche, A., Neddens, J., Brurnmelte, S., Moll, G.H., Dawirs, R.R.: Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils. BRAIN RESEARCH. 1176, 124-132 (2007).
Grund, Thorsten, Teuchert-Noodt, Gertraud, Busche, Andrea, Neddens, Joerg, Brurnmelte, Susanne, Moll, Gunther H., and Dawirs, Ralph R. “Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils”. BRAIN RESEARCH 1176 (2007): 124-132.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
7 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats.
Izquierdo A, Pozos H, Torre Ade L, DeShields S, Cevallos J, Rodriguez J, Stolyarova A., Behav Brain Res 308(), 2016
PMID: 27091300
Izquierdo A, Pozos H, Torre Ade L, DeShields S, Cevallos J, Rodriguez J, Stolyarova A., Behav Brain Res 308(), 2016
PMID: 27091300
Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function.
van der Marel K, Klomp A, Meerhoff GF, Schipper P, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L., Neuropsychopharmacology 39(2), 2014
PMID: 23851400
van der Marel K, Klomp A, Meerhoff GF, Schipper P, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L., Neuropsychopharmacology 39(2), 2014
PMID: 23851400
Effects of adolescent social defeat on adult amphetamine-induced locomotion and corticoaccumbal dopamine release in male rats.
Burke AR, Forster GL, Novick AM, Roberts CL, Watt MJ., Neuropharmacology 67(), 2013
PMID: 23220295
Burke AR, Forster GL, Novick AM, Roberts CL, Watt MJ., Neuropharmacology 67(), 2013
PMID: 23220295
Is the treatment with psychostimulants in children and adolescents with attention deficit hyperactivity disorder harmful for the dopaminergic system?
Gerlach M, Grünblatt E, Lange KW., Atten Defic Hyperact Disord 5(2), 2013
PMID: 23605387
Gerlach M, Grünblatt E, Lange KW., Atten Defic Hyperact Disord 5(2), 2013
PMID: 23605387
Developmental chlorpyrifos and methyl parathion exposure alters radial-arm maze performance in juvenile and adult rats.
Johnson FO, Chambers JE, Nail CA, Givaruangsawat S, Carr RL., Toxicol Sci 109(1), 2009
PMID: 19293373
Johnson FO, Chambers JE, Nail CA, Givaruangsawat S, Carr RL., Toxicol Sci 109(1), 2009
PMID: 19293373
Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur J Pharmacol 616(1-3), 2009
PMID: 19540225
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur J Pharmacol 616(1-3), 2009
PMID: 19540225
Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils.
Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR., J Negat Results Biomed 7(), 2008
PMID: 18485211
Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR., J Negat Results Biomed 7(), 2008
PMID: 18485211
65 References
Daten bereitgestellt von Europe PubMed Central.
Stimulants and the developing brain.
Andersen SL., Trends Pharmacol. Sci. 26(5), 2005
PMID: 15860370
Andersen SL., Trends Pharmacol. Sci. 26(5), 2005
PMID: 15860370
Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugs.
Andersen SL, Navalta CP., Int. J. Dev. Neurosci. 22(5-6), 2004
PMID: 15380841
Andersen SL, Navalta CP., Int. J. Dev. Neurosci. 22(5-6), 2004
PMID: 15380841
The effects of haloperidol on synaptic patterns in the rat striatum.
Benes FM, Paskevich PA, Davidson J, Domesick VB., Brain Res. 329(1-2), 1985
PMID: 3978446
Benes FM, Paskevich PA, Davidson J, Domesick VB., Brain Res. 329(1-2), 1985
PMID: 3978446
Pathologies of brain attentional networks.
Berger A, Posner MI., Neurosci Biobehav Rev 24(1), 2000
PMID: 10654653
Berger A, Posner MI., Neurosci Biobehav Rev 24(1), 2000
PMID: 10654653
Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus).
Blaesing B, Nossoll M, Teuchert-Noodt G, Dawirs RR., J Neural Transm (Vienna) 108(1), 2001
PMID: 11261741
Blaesing B, Nossoll M, Teuchert-Noodt G, Dawirs RR., J Neural Transm (Vienna) 108(1), 2001
PMID: 11261741
Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood.
Bolanos CA, Barrot M, Berton O, Wallace-Black D, Nestler EJ., Biol. Psychiatry 54(12), 2003
PMID: 14675795
Bolanos CA, Barrot M, Berton O, Wallace-Black D, Nestler EJ., Biol. Psychiatry 54(12), 2003
PMID: 14675795
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
Brummelte S, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 114(5), 2007
PMID: 17195918
Brummelte S, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 114(5), 2007
PMID: 17195918
Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus).
Busche A, Neddens J, Dinter C, Dawirs RR, Teuchert-Noodt G., Dev. Neurosci. 24(6), 2002
PMID: 12697989
Busche A, Neddens J, Dinter C, Dawirs RR, Teuchert-Noodt G., Dev. Neurosci. 24(6), 2002
PMID: 12697989
Enduring behavioral effects of early exposure to methylphenidate in rats.
Carlezon WA Jr, Mague SD, Andersen SL., Biol. Psychiatry 54(12), 2003
PMID: 14675796
Carlezon WA Jr, Mague SD, Andersen SL., Biol. Psychiatry 54(12), 2003
PMID: 14675796
Methylphenidate: its pharmacology and uses.
Challman TD, Lipsky JJ., Mayo Clin. Proc. 75(7), 2000
PMID: 10907387
Challman TD, Lipsky JJ., Mayo Clin. Proc. 75(7), 2000
PMID: 10907387
Effects of early methylphenidate exposure on morphine- and sucrose-reinforced behaviors in adult rats: relationship to dopamine D2 receptors.
Crawford CA, Villafranca SW, Cyr MC, Farley CM, Reichel CM, Gheorghe SL, Krall CM, McDougall SA., Brain Res. 1139(), 2007
PMID: 17274963
Crawford CA, Villafranca SW, Cyr MC, Farley CM, Reichel CM, Gheorghe SL, Krall CM, McDougall SA., Brain Res. 1139(), 2007
PMID: 17274963
Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescence.
Cunningham MG, Bhattacharyya S, Benes FM., J. Comp. Neurol. 453(2), 2002
PMID: 12373778
Cunningham MG, Bhattacharyya S, Benes FM., J. Comp. Neurol. 453(2), 2002
PMID: 12373778
The postnatal maturation of dopamine innervation in the prefrontal cortex of gerbils (Meriones unguiculatus) is sensitive to an early single dose of methamphetamine. A quantitative immunocytochemical study.
Dawirs RR, Teuchert-Noodt G, Czaniera R., J Hirnforsch 35(2), 1994
PMID: 8064138
Dawirs RR, Teuchert-Noodt G, Czaniera R., J Hirnforsch 35(2), 1994
PMID: 8064138
Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus).
Dawirs RR, Teuchert-Noodt G, Czaniera R., J Neural Transm (Vienna) 103(11), 1996
PMID: 9013410
Dawirs RR, Teuchert-Noodt G, Czaniera R., J Neural Transm (Vienna) 103(11), 1996
PMID: 9013410
Stimulant effects in attention deficit hyperactivity disorder: theoretical and empirical issues.
Denney CB., J Clin Child Psychol 30(1), 2001
PMID: 11294083
Denney CB., J Clin Child Psychol 30(1), 2001
PMID: 11294083
Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration.
Ding YS, Gatley SJ, Thanos PK, Shea C, Garza V, Xu Y, Carter P, King P, Warner D, Taintor NB, Park DJ, Pyatt B, Fowler JS, Volkow ND., Synapse 53(3), 2004
PMID: 15236349
Ding YS, Gatley SJ, Thanos PK, Shea C, Garza V, Xu Y, Carter P, King P, Warner D, Taintor NB, Park DJ, Pyatt B, Fowler JS, Volkow ND., Synapse 53(3), 2004
PMID: 15236349
Adult attention-deficit/hyperactivity disorder: neuropsychological correlates and clinical presentation.
Dinn WM, Robbins NC, Harris CL., Brain Cogn 46(1-2), 2001
PMID: 11527308
Dinn WM, Robbins NC, Harris CL., Brain Cogn 46(1-2), 2001
PMID: 11527308
Neural substrates of decision making in adults with attention deficit hyperactivity disorder.
Ernst M, Kimes AS, London ED, Matochik JA, Eldreth D, Tata S, Contoreggi C, Leff M, Bolla K., Am J Psychiatry 160(6), 2003
PMID: 12777263
Ernst M, Kimes AS, London ED, Matochik JA, Eldreth D, Tata S, Contoreggi C, Leff M, Bolla K., Am J Psychiatry 160(6), 2003
PMID: 12777263
Actions of methylphenidate on dopaminergic neurons of the ventral midbrain.
Federici M, Geracitano R, Bernardi G, Mercuri NB., Biol. Psychiatry 57(4), 2005
PMID: 15705351
Federici M, Geracitano R, Bernardi G, Mercuri NB., Biol. Psychiatry 57(4), 2005
PMID: 15705351
The prefrontal cortex and its relation to behavior.
Fuster JM., Prog. Brain Res. 87(), 1991
PMID: 1907745
Fuster JM., Prog. Brain Res. 87(), 1991
PMID: 1907745
Pharmacotherapy of adolescent attention deficit hyperactivity disorder: challenges, choices and caveats.
Garland EJ., J. Psychopharmacol. (Oxford) 12(4), 1998
PMID: 10065914
Garland EJ., J. Psychopharmacol. (Oxford) 12(4), 1998
PMID: 10065914
Comparison between intraperitoneal and oral methylphenidate administration: A microdialysis and locomotor activity study.
Gerasimov MR, Franceschi M, Volkow ND, Gifford A, Gatley SJ, Marsteller D, Molina PE, Dewey SL., J. Pharmacol. Exp. Ther. 295(1), 2000
PMID: 10991960
Gerasimov MR, Franceschi M, Volkow ND, Gifford A, Gatley SJ, Marsteller D, Molina PE, Dewey SL., J. Pharmacol. Exp. Ther. 295(1), 2000
PMID: 10991960
Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association.
Goldman LS, Genel M, Bezman RJ, Slanetz PJ., JAMA 279(14), 1998
PMID: 9546570
Goldman LS, Genel M, Bezman RJ, Slanetz PJ., JAMA 279(14), 1998
PMID: 9546570
A single neonatal dose of methamphetamine suppresses dentate granule cell proliferation in adult gerbils which is restored to control values by acute doses of haloperidol.
Hildebrandt K, Teuchert-Noodt G, Dawirs RR., J Neural Transm (Vienna) 106(5-6), 1999
PMID: 10443557
Hildebrandt K, Teuchert-Noodt G, Dawirs RR., J Neural Transm (Vienna) 106(5-6), 1999
PMID: 10443557
Methylphenidate-induced plasticity: what should we be looking for?
Hyman SE., Biol. Psychiatry 54(12), 2003
PMID: 14675793
Hyman SE., Biol. Psychiatry 54(12), 2003
PMID: 14675793
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking.
Ikemoto S, Panksepp J., Brain Res. Brain Res. Rev. 31(1), 1999
PMID: 10611493
Ikemoto S, Panksepp J., Brain Res. Brain Res. Rev. 31(1), 1999
PMID: 10611493
Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): implications and applications for primary care providers.
Jensen PS, Hinshaw SP, Swanson JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn JH, Severe JB, Vitiello B, Wells K, Wigal T., J Dev Behav Pediatr 22(1), 2001
PMID: 11265923
Jensen PS, Hinshaw SP, Swanson JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn JH, Severe JB, Vitiello B, Wells K, Wigal T., J Dev Behav Pediatr 22(1), 2001
PMID: 11265923
The neuroscience of natural rewards: relevance to addictive drugs.
Kelley AE, Berridge KC., J. Neurosci. 22(9), 2002
PMID: 11978804
Kelley AE, Berridge KC., J. Neurosci. 22(9), 2002
PMID: 11978804
Attention-deficit/hyperactivity disorder: a therapeutic update.
Kirby K, Rutman LE, Bernstein H., Curr. Opin. Pediatr. 14(2), 2002
PMID: 11981298
Kirby K, Rutman LE, Bernstein H., Curr. Opin. Pediatr. 14(2), 2002
PMID: 11981298
Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine.
Kuczenski R, Segal DS., J. Neurochem. 68(5), 1997
PMID: 9109529
Kuczenski R, Segal DS., J. Neurochem. 68(5), 1997
PMID: 9109529
Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine.
Kuczenski R, Segal DS., J. Pharmacol. Exp. Ther. 296(3), 2001
PMID: 11181919
Kuczenski R, Segal DS., J. Pharmacol. Exp. Ther. 296(3), 2001
PMID: 11181919
Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine.
Kuczenski R, Segal DS., J. Neurosci. 22(16), 2002
PMID: 12177221
Kuczenski R, Segal DS., J. Neurosci. 22(16), 2002
PMID: 12177221
Serotonin fibre densities in subcortical areas: differential effects of isolated rearing and methamphetamine.
Lehmann K, Lesting J, Polascheck D, Teuchert-Noodt G., Brain Res. Dev. Brain Res. 147(1-2), 2003
PMID: 14741759
Lehmann K, Lesting J, Polascheck D, Teuchert-Noodt G., Brain Res. Dev. Brain Res. 147(1-2), 2003
PMID: 14741759
The acetylcholine fiber density of the neocortex is altered by isolated rearing and early methamphetamine intoxication in rodents.
Lehmann K, Hundsdorfer B, Hartmann T, Teuchert-Noodt G., Exp. Neurol. 189(1), 2004
PMID: 15296843
Lehmann K, Hundsdorfer B, Hartmann T, Teuchert-Noodt G., Exp. Neurol. 189(1), 2004
PMID: 15296843
Hemisphere-specific effects on serotonin but not dopamine innervation in the nucleus accumbens of gerbils caused by isolated rearing and a single early methamphetamine challenge.
Lesting J, Neddens J, Busche A, Teuchert-Noodt G., Brain Res. 1035(2), 2005
PMID: 15722056
Lesting J, Neddens J, Busche A, Teuchert-Noodt G., Brain Res. 1035(2), 2005
PMID: 15722056
Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons.
Lidow MS, Song ZM., J. Comp. Neurol. 435(3), 2001
PMID: 11406810
Lidow MS, Song ZM., J. Comp. Neurol. 435(3), 2001
PMID: 11406810
Arousal systems.
Marrocco RT, Witte EA, Davidson MC., Curr. Opin. Neurobiol. 4(2), 1994
PMID: 7913640
Marrocco RT, Witte EA, Davidson MC., Curr. Opin. Neurobiol. 4(2), 1994
PMID: 7913640
The amygdala modulates the consolidation of memories of emotionally arousing experiences.
McGaugh JL., Annu. Rev. Neurosci. 27(), 2004
PMID: 15217324
McGaugh JL., Annu. Rev. Neurosci. 27(), 2004
PMID: 15217324
Attention deficit/hyperactivity disorders.
Miller KJ, Castellanos FX., Pediatr Rev 19(11), 1998
PMID: 9805463
Miller KJ, Castellanos FX., Pediatr Rev 19(11), 1998
PMID: 9805463
From motivation to action: functional interface between the limbic system and the motor system.
Mogenson GJ, Jones DL, Yim CY., Prog. Neurobiol. 14(2-3), 1980
PMID: 6999537
Mogenson GJ, Jones DL, Yim CY., Prog. Neurobiol. 14(2-3), 1980
PMID: 6999537
Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters.
Moll GH, Hause S, Ruther E, Rothenberger A, Huether G., J Child Adolesc Psychopharmacol 11(1), 2001
PMID: 11322741
Moll GH, Hause S, Ruther E, Rothenberger A, Huether G., J Child Adolesc Psychopharmacol 11(1), 2001
PMID: 11322741
Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment.
Nakamura S., Prog. Brain Res. 88(), 1991
PMID: 1667552
Nakamura S., Prog. Brain Res. 88(), 1991
PMID: 1667552
An early methamphetamine challenge suppresses the maturation of dopamine fibres in the nucleus accumbens of gerbils: on the significance of rearing conditions.
Neddens J, Lesting J, Dawirs RR, Teuchert-Noodt G., J Neural Transm (Vienna) 109(2), 2002
PMID: 12075854
Neddens J, Lesting J, Dawirs RR, Teuchert-Noodt G., J Neural Transm (Vienna) 109(2), 2002
PMID: 12075854
Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge.
Neddens J, Bagorda F, Busche A, Horstmann S, Moll GH, Dawirs RR, Teuchert-Noodt G., Brain Res. Dev. Brain Res. 146(1-2), 2003
PMID: 14643018
Neddens J, Bagorda F, Busche A, Horstmann S, Moll GH, Dawirs RR, Teuchert-Noodt G., Brain Res. Dev. Brain Res. 146(1-2), 2003
PMID: 14643018
Postnatal maturation of cortical serotonin lateral asymmetry in gerbils is vulnerable to both environmental and pharmacological epigenetic challenges.
Neddens J, Dawirs RR, Bagorda F, Busche A, Horstmann S, Teuchert-Noodt G., Brain Res. 1021(2), 2004
PMID: 15342268
Neddens J, Dawirs RR, Bagorda F, Busche A, Horstmann S, Teuchert-Noodt G., Brain Res. 1021(2), 2004
PMID: 15342268
A single dose of methamphetamine in neonatal gerbils affects adult prefrontal gamma-aminobutyric acid innervation.
Nossoll M, Teuchert-Noodt G, Dawirs RR., Eur. J. Pharmacol. 340(2-3), 1997
PMID: 9537803
Nossoll M, Teuchert-Noodt G, Dawirs RR., Eur. J. Pharmacol. 340(2-3), 1997
PMID: 9537803
The control of responsiveness in ADHD by catecholamines: evidence for dopaminergic, noradrenergic and interactive roles.
Oades RD, Sadile AG, Sagvolden T, Viggiano D, Zuddas A, Devoto P, Aase H, Johansen EB, Ruocco LA, Russell VA., Dev Sci 8(2), 2005
PMID: 15720370
Oades RD, Sadile AG, Sagvolden T, Viggiano D, Zuddas A, Devoto P, Aase H, Johansen EB, Ruocco LA, Russell VA., Dev Sci 8(2), 2005
PMID: 15720370
Remodeling of neural networks in the anterior forebrain of an animal model of hyperactivity and attention deficits as monitored by molecular imaging probes.
Papa M, Sellitti S, Sadile AG., Neurosci Biobehav Rev 24(1), 2000
PMID: 10654672
Papa M, Sellitti S, Sadile AG., Neurosci Biobehav Rev 24(1), 2000
PMID: 10654672
Paxinos, 1986
Connectivity of the rat amygdaloid complex
Pitkanen, 2000
Pitkanen, 2000
Neurobehavioural mechanisms of reward and motivation.
Robbins TW, Everitt BJ., Curr. Opin. Neurobiol. 6(2), 1996
PMID: 8725965
Robbins TW, Everitt BJ., Curr. Opin. Neurobiol. 6(2), 1996
PMID: 8725965
Cocaine decreases cell survival and inhibits neurite extension of rat locus coeruleus neurons.
Snow DM, Smith JD, Booze RM, Welch MA, Mactutus CF., Neurotoxicol Teratol 23(3), 2001
PMID: 11418264
Snow DM, Smith JD, Booze RM, Welch MA, Mactutus CF., Neurotoxicol Teratol 23(3), 2001
PMID: 11418264
Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration.
Solanto MV., Behav. Brain Res. 94(1), 1998
PMID: 9708845
Solanto MV., Behav. Brain Res. 94(1), 1998
PMID: 9708845
Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder.
Sowell ER, Thompson PM, Welcome SE, Henkenius AL, Toga AW, Peterson BS., Lancet 362(9397), 2003
PMID: 14643117
Sowell ER, Thompson PM, Welcome SE, Henkenius AL, Toga AW, Peterson BS., Lancet 362(9397), 2003
PMID: 14643117
Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle.
Spencer T, Biederman J, Wilens T, Harding M, O'Donnell D, Griffin S., J Am Acad Child Adolesc Psychiatry 35(4), 1996
PMID: 8919704
Spencer T, Biederman J, Wilens T, Harding M, O'Donnell D, Griffin S., J Am Acad Child Adolesc Psychiatry 35(4), 1996
PMID: 8919704
Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans.
Srinivas NR, Hubbard JW, Korchinski ED, Midha KK., Pharm. Res. 10(1), 1993
PMID: 8430051
Srinivas NR, Hubbard JW, Korchinski ED, Midha KK., Pharm. Res. 10(1), 1993
PMID: 8430051
Valverde, 1998
The effects of chronic haloperidol administration on GABA-immunoreactive axon terminals in rat medial prefrontal cortex.
Vincent SL, Adamec E, Sorensen I, Benes FM., Synapse 17(1), 1994
PMID: 8042144
Vincent SL, Adamec E, Sorensen I, Benes FM., Synapse 17(1), 1994
PMID: 8042144
Psychopharmacology for young children: clinical needs and research opportunities.
Vitiello B., Pediatrics 108(4), 2001
PMID: 11581454
Vitiello B., Pediatrics 108(4), 2001
PMID: 11581454
What are the long-term effects of methylphenidate treatment?
Volkow ND, Insel TR., Biol. Psychiatry 54(12), 2003
PMID: 14675792
Volkow ND, Insel TR., Biol. Psychiatry 54(12), 2003
PMID: 14675792
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.
Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Logan J, Ding YS, Hitzemann R, Pappas N., Am J Psychiatry 155(10), 1998
PMID: 9766762
Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Logan J, Ding YS, Hitzemann R, Pappas N., Am J Psychiatry 155(10), 1998
PMID: 9766762
Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain.
Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L, Ding Y, Gatley SJ, Gifford A, Franceschi D., J. Neurosci. 21(2), 2001
PMID: 11160455
Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L, Ding Y, Gatley SJ, Gifford A, Franceschi D., J. Neurosci. 21(2), 2001
PMID: 11160455
Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life.
Wegerer V, Moll GH, Bagli M, Rothenberger A, Ruther E, Huether G., J Child Adolesc Psychopharmacol 9(1), 1999
PMID: 10357514
Wegerer V, Moll GH, Bagli M, Rothenberger A, Ruther E, Huether G., J Child Adolesc Psychopharmacol 9(1), 1999
PMID: 10357514
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 17900540
PubMed | Europe PMC
Suchen in