Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica

Krämer A, Maloney EM, Morgan OSC, Rodgers-Johnson P, Manns A, Murphy EL, Larsen SA, Cranston B, Murphy JO, Benichou J, Blattner WA (1995)
American Journal of Epidemiology 142(11): 1212-1220.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Krämer, AlexanderUniBi ; Maloney, E. M.; Morgan, O. St. C.; Rodgers-Johnson, P.; Manns, A.; Murphy, E. L.; Larsen, S. A.; Cranston, B.; Murphy, J. O.; Benichou, J.; Blattner, W. A.
Abstract / Bemerkung
Human T-cell lymphotropic virus type I (HTLV-I) has been etiologically associated with a neurologic syndrome called HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) as well as with adult T-cell leukemia/lymphoma. The authors sought to quantify the risk in Jamaica of HAM/TSP associated with HTLV-I infection and cofactors associated with this disease among infected individuals. Between 1988 and 1989, prevalent and incident HAM/TSP patients and controls with other neurologic diseases were enrolled in a retrospective study. A second control group was composed of HTLV-I-seropositive, asymptomatic carriers in Jamaica, ascertained in a separate study conducted in 1988. Although HTLV-I seropositivity was not a component of the case definition for HAM/TSP, all 43 HAM/TSP patients were HTLV-I seropositive compared with two (4.0%) of the controls with other neurologic diseases. Given HTLV-I seropositivity, one cofactor associated with the risk of HAM/TSP was young age at initial heterosexual intercourse (odds ratio = 4.00, 95% confidence interval 1.29-12.46 for individuals aged less than or equal to 15; odds ratio = 4.26, 95% confidence interval 1.41-12.90 for individuals aged 16-17 years at initial intercourse). Among individuals who reported this early age at initial sexual intercourse, an increased risk of HAM/TSP was associated with having reported more than five lifetime sexual partners (odds ratio = 2.88, 95% confidence interval 0.90-8.70). Neither an early age at initial sexual intercourse or the number of lifetime sexual partners was a risk factor for adult T-cell leukemia/lymphoma. These data support the hypothesis that HAM/TSP is associated with sexually acquired HTLV-I infection, whereas adult T-cell leukemia/lymphoma is not.
Stichworte
T-CELL; PARAPARESIS; TROPICAL SPASTIC; TRANSMITTED DISEASES; SEXUALLY; HTLV-I; LYMPHOMA
Erscheinungsjahr
1995
Zeitschriftentitel
American Journal of Epidemiology
Band
142
Ausgabe
11
Seite(n)
1212-1220
ISSN
0002-9262
Page URI
https://pub.uni-bielefeld.de/record/1629330

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Krämer A, Maloney EM, Morgan OSC, et al. Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology. 1995;142(11):1212-1220.
Krämer, A., Maloney, E. M., Morgan, O. S. C., Rodgers-Johnson, P., Manns, A., Murphy, E. L., Larsen, S. A., et al. (1995). Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology, 142(11), 1212-1220.
Krämer, Alexander, Maloney, E. M., Morgan, O. St. C., Rodgers-Johnson, P., Manns, A., Murphy, E. L., Larsen, S. A., et al. 1995. “Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica”. American Journal of Epidemiology 142 (11): 1212-1220.
Krämer, A., Maloney, E. M., Morgan, O. S. C., Rodgers-Johnson, P., Manns, A., Murphy, E. L., Larsen, S. A., Cranston, B., Murphy, J. O., Benichou, J., et al. (1995). Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology 142, 1212-1220.
Krämer, A., et al., 1995. Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology, 142(11), p 1212-1220.
A. Krämer, et al., “Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica”, American Journal of Epidemiology, vol. 142, 1995, pp. 1212-1220.
Krämer, A., Maloney, E.M., Morgan, O.S.C., Rodgers-Johnson, P., Manns, A., Murphy, E.L., Larsen, S.A., Cranston, B., Murphy, J.O., Benichou, J., Blattner, W.A.: Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica. American Journal of Epidemiology. 142, 1212-1220 (1995).
Krämer, Alexander, Maloney, E. M., Morgan, O. St. C., Rodgers-Johnson, P., Manns, A., Murphy, E. L., Larsen, S. A., Cranston, B., Murphy, J. O., Benichou, J., and Blattner, W. A. “Risk factors and cofactors for HTLV-I associated myelopathy / tropical spastic paraparesis (HAM/TSP) in Jamaica”. American Journal of Epidemiology 142.11 (1995): 1212-1220.

27 Zitationen in Europe PMC

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Mother-to-Child HTLV-1 Transmission: Unmet Research Needs.
Rosadas C, Taylor GP., Front Microbiol 10(), 2019
PMID: 31134031
Association Between HTLV-1 Genotypes and Risk of HAM/TSP.
Saito M., Front Microbiol 10(), 2019
PMID: 31156605
HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil.
Nunes D, Boa-Sorte N, Grassi MF, Taylor GP, Teixeira MG, Barreto ML, Dourado I, Galvão-Castro B., PLoS One 12(2), 2017
PMID: 28158226
Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status.
Shiohama Y, Naito T, Matsuzaki T, Tanaka R, Tomoyose T, Takashima H, Fukushima T, Tanaka Y, Saito M., Virol J 14(1), 2017
PMID: 28716148
Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran.
Shoeibi A, Rafatpanah H, Azarpazhooh A, Mokhber N, Hedayati-Moghaddam MR, Amiri A, Hashemi P, Foroghipour M, Hoseini RF, Bazarbachi A, Azarpazhooh MR., Acta Neurol Belg 113(4), 2013
PMID: 23568138
Early neurologic abnormalities associated with human T-cell lymphotropic virus type 1 infection in a cohort of Peruvian children.
Kendall EA, González E, Espinoza I, Tipismana M, Verdonck K, Clark D, Vermund SH, Gotuzzo E., J Pediatr 155(5), 2009
PMID: 19628219
Autonomous proliferation of HTLV-CD4+ T cell clones derived from human T cell leukemia virus type I (HTLV-I)-associated myelopathy patients.
Miyano-Kurosaki N, Kira J, Barnor JS, Maeda N, Misawa N, Kawano Y, Tanaka Y, Yamamoto N, Koyanagi Y., Microbiol Immunol 51(2), 2007
PMID: 17310092
The HTLV-1 neurological complex.
Araujo AQ, Silva MT., Lancet Neurol 5(12), 2006
PMID: 17110288
Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia/lymphoma.
Arnulf B, Thorel M, Poirot Y, Tamouza R, Boulanger E, Jaccard A, Oksenhendler E, Hermine O, Pique C., Leukemia 18(1), 2004
PMID: 14574331
Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers.
Santos SB, Porto AF, Muniz AL, de Jesus AR, Magalhães E, Melo A, Dutra WO, Gollob KJ, Carvalho EM., BMC Infect Dis 4(), 2004
PMID: 15070424
Peripheral neuropathy in HTLV-I infected individuals without tropical spastic paraparesis/HTLV-I-associated myelopathy.
Leite AC, Silva MT, Alamy AH, Afonso CR, Lima MA, Andrada-Serpa MJ, Nascimento OJ, Araújo AQ., J Neurol 251(7), 2004
PMID: 15258793
Neuropsychological assessment in HTLV-1 infection: a comparative study among TSP/HAM, asymptomatic carriers, and healthy controls.
Silva MT, Mattos P, Alfano A, Araújo AQ., J Neurol Neurosurg Psychiatry 74(8), 2003
PMID: 12876239
Human T-cell lymphotropic virus-I in Latin America.
Gotuzzo E, Arango C, de Queiroz-Campos A, Istúriz RE., Infect Dis Clin North Am 14(1), 2000
PMID: 10738680
HTLV-1 and HIV infections of the central nervous system in tropical areas.
Cabre P, Smadja D, Cabié A, Newton CR., J Neurol Neurosurg Psychiatry 68(5), 2000
PMID: 10766881
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy.
Jeffery KJ, Usuku K, Hall SE, Matsumoto W, Taylor GP, Procter J, Bunce M, Ogg GS, Welsh KI, Weber JN, Lloyd AL, Nowak MA, Nagai M, Kodama D, Izumo S, Osame M, Bangham CR., Proc Natl Acad Sci U S A 96(7), 1999
PMID: 10097126
Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil.
Gomes I, Melo A, Proietti FA, Moreno-Carvalho O, Loures LA, Dazza MC, Said G, Larouzé B, Galvão-Castro B., J Neurol Sci 165(1), 1999
PMID: 10426153
Incidence of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica and Trinidad.
Maloney EM, Cleghorn FR, Morgan OS, Rodgers-Johnson P, Cranston B, Jack N, Blattner WA, Bartholomew C, Manns A., J Acquir Immune Defic Syndr Hum Retrovirol 17(2), 1998
PMID: 9473019
Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a Black population.
Manns A, Hanchard B, Morgan OS, Wilks R, Cranston B, Nam JM, Blank M, Kuwayama M, Yashiki S, Fujiyoshi T, Blattner W, Sonoda S., J Natl Cancer Inst 90(8), 1998
PMID: 9554445
Laboratory test differences associated with HTLV-I and HTLV-II infection. Retrovirus Epidemiology Donor Study Investigators.
Murphy EL, Glynn S, Watanabe K, Fridey J, Smith J, Sacher R, Wright D, Schreiber G, Luban N., J Acquir Immune Defic Syndr Hum Retrovirol 17(4), 1998
PMID: 9525434
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