Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients

Ingman T, Tervahartiala T, Ding YL, Tschesche H, Haerian A, Kinane DF, Konttinen YT, Sorsa T (1996)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Ingman, T; Tervahartiala, T; Ding, YL; Tschesche, HaraldUniBi; Haerian, A; Kinane, DF; Konttinen, YT; Sorsa, T
Abstract / Bemerkung
Matrix metalloproteinases (MMPs) and serine proteinases seem to be related to tissue destruction in periodontitis. The presence of MMPs in gingival crevicular fluid (GCF) and saliva, however, has not been studied comprehensively with the enzyme-linked immunosorbent assay (ELISA)-technique, We therefore examined the levels of MMP-1, -3, -8 and -9, and their endogenous inhibitor, tissue inhibitor of matrix metalloproteinases (TIMP-1), in GCF and saliva of patients with adult periodontitis (AP) and localized juvenile periodontitis (LJP). Elevated levels of MMP-1 were detected in LJP GCF compared to AP and control GCE Elevated levels of TIMP-1 were also detected in LJP GCF in comparison to AP and control GCE Higher MMP-8 levels were detected in AP GCF compared to LJP and control GCE The relative low levels of MMP-3 were present in all studied GCF samples. Elevated levels of MMP-8 were further detected in saliva of AP compared to LJP and the controls. Both MMP-1 and TIMP-1 were detected in all studied saliva samples, but not significant differences were detected between the studied groups. Our ELISA-results confirm that (i) PMN MMP-8 and MMP-9 are the main collagenase and gelatinase in AP GCF, whereas GCF collagenase in LJP seems to be of the MMP-1-type; (ii) only low levels of TIMP-1, endogenous MMP-inhibitor, are present in AP GCE which emphasises the importance of doxycycline as a possible adjunctive drug in the treatment of AP patients; (iii) tests based on specific antibodies against PMN MMPs, especially MMP-8, might serve as a reliable method of measuring and monitoring enzyme levels in GCF from different periodontitis patients.
gingival crevicular fluid; localized; juvenile periodontitis; matrix metalloproteinases; saliva; tissue; ELISA; adult periodontitis; inhibitor of matrix metalloproteinases
Page URI


Ingman T, Tervahartiala T, Ding YL, et al. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. JOURNAL OF CLINICAL PERIODONTOLOGY. 1996;23(12):1127-1132.
Ingman, T., Tervahartiala, T., Ding, Y. L., Tschesche, H., Haerian, A., Kinane, D. F., Konttinen, Y. T., et al. (1996). Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. JOURNAL OF CLINICAL PERIODONTOLOGY, 23(12), 1127-1132.
Ingman, T, Tervahartiala, T, Ding, YL, Tschesche, Harald, Haerian, A, Kinane, DF, Konttinen, YT, and Sorsa, T. 1996. “Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients”. JOURNAL OF CLINICAL PERIODONTOLOGY 23 (12): 1127-1132.
Ingman, T., Tervahartiala, T., Ding, Y. L., Tschesche, H., Haerian, A., Kinane, D. F., Konttinen, Y. T., and Sorsa, T. (1996). Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. JOURNAL OF CLINICAL PERIODONTOLOGY 23, 1127-1132.
Ingman, T., et al., 1996. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. JOURNAL OF CLINICAL PERIODONTOLOGY, 23(12), p 1127-1132.
T. Ingman, et al., “Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients”, JOURNAL OF CLINICAL PERIODONTOLOGY, vol. 23, 1996, pp. 1127-1132.
Ingman, T., Tervahartiala, T., Ding, Y.L., Tschesche, H., Haerian, A., Kinane, D.F., Konttinen, Y.T., Sorsa, T.: Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. JOURNAL OF CLINICAL PERIODONTOLOGY. 23, 1127-1132 (1996).
Ingman, T, Tervahartiala, T, Ding, YL, Tschesche, Harald, Haerian, A, Kinane, DF, Konttinen, YT, and Sorsa, T. “Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients”. JOURNAL OF CLINICAL PERIODONTOLOGY 23.12 (1996): 1127-1132.

169 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Associations of oral fluid MMP-8 with periodontitis in Swiss adult subjects.
Mauramo M, Ramseier AM, Mauramo E, Buser A, Tervahartiala T, Sorsa T, Waltimo T., Oral Dis 24(3), 2018
PMID: 28889479
The Effect of Chemically Modified Tetracycline-3 on the Progression of Dental Caries in Rats.
Xu J, Miao C, Tian Z, Li J, Zhang C, Yang D., Caries Res 52(4), 2018
PMID: 29408826
Targeted Proteomics Guided by Label-free Quantitative Proteome Analysis in Saliva Reveal Transition Signatures from Health to Periodontal Disease.
Bostanci N, Selevsek N, Wolski W, Grossmann J, Bao K, Wahlander A, Trachsel C, Schlapbach R, Öztürk VÖ, Afacan B, Emingil G, Belibasakis GN., Mol Cell Proteomics 17(7), 2018
PMID: 29610270
Salivary Diagnostics-Point-of-Care diagnostics of MMP-8 in dentistry and medicine.
Rathnayake N, Gieselmann DR, Heikkinen AM, Tervahartiala T, Sorsa T., Diagnostics (Basel) 7(1), 2017
PMID: 28117682
Quantitative proteomic analysis of gingival crevicular fluids from deciduous and permanent teeth.
Moriya Y, Obama T, Aiuchi T, Sugiyama T, Endo Y, Koide Y, Noguchi E, Ishizuka M, Inoue M, Itabe H, Yamamoto M., J Clin Periodontol 44(4), 2017
PMID: 28092104
Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases.
Sorsa T, Gursoy UK, Nwhator S, Hernandez M, Tervahartiala T, Leppilahti J, Gursoy M, Könönen E, Emingil G, Pussinen PJ, Mäntylä P., Periodontol 2000 70(1), 2016
PMID: 26662488
Salivary Markers for Periodontal and General Diseases.
Podzimek S, Vondrackova L, Duskova J, Janatova T, Broukal Z., Dis Markers 2016(), 2016
PMID: 27143814
A meta-analysis of MMP-9 promoter -1562 C/T polymorphism on susceptibility of chronic periodontitis.
Ajmera DH, Singh P, Zhu Y, Li W, Song J., Springerplus 5(), 2016
PMID: 27186490
Rapid assessment of salivary MMP-8 and periodontal disease using lateral flow immunoassay.
Johnson N, Ebersole JL, Kryscio RJ, Danaher RJ, Dawson D, Al-Sabbagh M, Miller CS., Oral Dis 22(7), 2016
PMID: 27273425
Matrix metalloproteinase-2, -9, and tissue inhibitor of MMP-2 gene polymorphisms in Taiwanese periodontitis patients.
Hsiao YF, Yang LC, Chou YS, Ho YP, Lin YC, Ho KY, Wu YM, Tsai CC., J Dent Sci 11(4), 2016
PMID: 30895006
Incipient periodontitis and salivary molecules among Korean adults: association and screening ability.
Kim HD, Shin MS, Kim HT, Kim MS, Ahn YB., J Clin Periodontol 43(12), 2016
PMID: 27487155
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis.
Gupta N, Gupta ND, Gupta A, Khan S, Bansal N., Front Med 9(1), 2015
PMID: 25098434
Proteomics - The research frontier in periodontics.
Gupta A, Govila V, Saini A., J Oral Biol Craniofac Res 5(1), 2015
PMID: 25853048
Significance of circulating and crevicular matrix metalloproteinase-9 in rheumatoid arthritis-chronic periodontitis association.
Silosi I, Cojocaru M, Foia L, Boldeanu MV, Petrescu F, Surlin P, Biciusca V., J Immunol Res 2015(), 2015
PMID: 25821836
TNF-α stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38 MAPK pathway in a murine cementoblast cell line.
Sanchavanakit N, Saengtong W, Manokawinchoke J, Pavasant P., Arch Oral Biol 60(7), 2015
PMID: 25956994
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
Rathnayake N, Gustafsson A, Norhammar A, Kjellström B, Klinge B, Rydén L, Tervahartiala T, Sorsa T, PAROKRANK Steering Group., PLoS One 10(7), 2015
PMID: 26132583
Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy.
Fenol A, Peter MR, Perayil J, Vyloppillil R, Bhaskar A., Int J Chronic Dis 2014(), 2014
PMID: 26464855
Immunohistochemical analysis of matrix metalloproteinase-13 in human caries dentin.
Loreto C, Galanti C, Musumeci G, Rusu MC, Leonardi R., Eur J Histochem 58(1), 2014
PMID: 24704999
Protein biomarkers of periodontitis in saliva.
Taylor JJ., ISRN Inflamm 2014(), 2014
PMID: 24944840
Estimation of tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment.
Reddy NR, Deepa A, Madhu Babu DS, Chandra NS, Subba Reddy CV, Kumar AK., J Indian Soc Periodontol 18(3), 2014
PMID: 25024541
Inhibition of endogenous human dentin MMPs by Gluma.
Sabatini C, Scheffel DL, Scheffel RH, Agee KA, Rouch K, Takahashi M, Breschi L, Mazzoni A, Tjäderhane L, Tay FR, Pashley DH., Dent Mater 30(7), 2014
PMID: 24846803
The effect of adjunctive chlorhexidine mouthrinse on GCF MMP-8 and TIMP-1 levels in gingivitis: a randomized placebo-controlled study.
Türkoğlu O, Becerik S, Tervahartiala T, Sorsa T, Atilla G, Emingil G., BMC Oral Health 14(), 2014
PMID: 24886536
Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis.
Nędzi-Góra M, Kostrzewa-Janicka J, Górska R., Cent Eur J Immunol 39(3), 2014
PMID: 26155148
Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis.
Gursoy UK, Könönen E, Huumonen S, Tervahartiala T, Pussinen PJ, Suominen AL, Sorsa T., J Clin Periodontol 40(1), 2013
PMID: 23078613
Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.
Gonçalves PF, Huang H, McAninley S, Alfant B, Harrison P, Aukhil I, Walker C, Shaddox LM., J Periodontol 84(12), 2013
PMID: 23537121
Peri-implant versus periodontal wound healing.
Emecen-Huja P, Eubank TD, Shapiro V, Yildiz V, Tatakis DN, Leblebicioglu B., J Clin Periodontol 40(8), 2013
PMID: 23772674
Matrix metalloproteinase-8 expression in periodontal tissues surgically removed from diabetic and non-diabetic patients with periodontal disease.
Hardy DC, Ross JH, Schuyler CA, Leite RS, Slate EH, Huang Y., J Clin Periodontol 39(3), 2012
PMID: 22092744
Analysis of proteins in human gingival crevicular fluid by mass spectrometry.
Kido J, Bando M, Hiroshima Y, Iwasaka H, Yamada K, Ohgami N, Nambu T, Kataoka M, Yamamoto T, Shinohara Y, Sagawa I, Nagata T., J Periodontal Res 47(4), 2012
PMID: 22220998
MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.
Letra A, Silva RM, Rylands RJ, Silveira EM, de Souza AP, Wendell SK, Garlet GP, Vieira AR., J Clin Periodontol 39(8), 2012
PMID: 22671570
Matrix metalloproteinase-8 is the major potential collagenase in active peri-implantitis.
Arakawa H, Uehara J, Hara ES, Sonoyama W, Kimura A, Kanyama M, Matsuka Y, Kuboki T., J Prosthodont Res 56(4), 2012
PMID: 23083963
Acute myocardial infarction is reflected in salivary matrix metalloproteinase-8 activation level.
Buduneli E, Mäntylä P, Emingil G, Tervahartiala T, Pussinen P, Barış N, Akıllı A, Atilla G, Sorsa T., J Periodontol 82(5), 2011
PMID: 21091346
Salivary biomarkers for periodontal disease diagnostics.
Brinkmann O, Zhang L, Giannobile WV, Wong DT., Expert Opin Med Diagn 5(1), 2011
PMID: 23484474
Effect of non-surgical treatment on chronic and aggressive periodontitis: clinical, immunologic, and microbiologic findings.
Rosalem W, Rescala B, Teles RP, Fischer RG, Gustafsson A, Figueredo CM., J Periodontol 82(7), 2011
PMID: 21309718
Impact of orthodontic retainers on periodontal health status assessed by biomarkers in gingival crevicular fluid.
Rody WJ, Akhlaghi H, Akyalcin S, Wiltshire WA, Wijegunasinghe M, Filho GN., Angle Orthod 81(6), 2011
PMID: 21657829
Salivary tissue inhibitor of metalloproteinases-1 localization and glycosylation profile analysis.
Holten-Andersen L, Thaysen-Andersen M, Jensen SB, Buchwald C, Højrup P, Offenberg H, Nielsen HJ, Brünner N, Nauntofte B, Reibel J., APMIS 119(11), 2011
PMID: 21995626
MMP-8 -799 C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese.
Chou YH, Ho YP, Lin YC, Hu KF, Yang YH, Ho KY, Wu YM, Hsi E, Tsai CC., J Clin Periodontol 38(12), 2011
PMID: 22092455
Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy.
Marcaccini AM, Meschiari CA, Zuardi LR, de Sousa TS, Taba M, Teofilo JM, Jacob-Ferreira AL, Tanus-Santos JE, Novaes AB, Gerlach RF., J Clin Periodontol 37(2), 2010
PMID: 19995403
Relationships among gingival crevicular fluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota.
Teles R, Sakellari D, Teles F, Konstantinidis A, Kent R, Socransky S, Haffajee A., J Periodontol 81(1), 2010
PMID: 20059421
Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis.
Skurska A, Pietruska MD, Paniczko-Drężek A, Dolińska E, Zelazowska-Rutkowska B, Zak J, Pietruski J, Milewski R, Wysocka J., Adv Med Sci 55(2), 2010
PMID: 21097444
Current developments in salivary diagnostics.
Miller CS, Foley JD, Bailey AL, Campell CL, Humphries RL, Christodoulides N, Floriano PN, Simmons G, Bhagwandin B, Jacobson JW, Redding SW, Ebersole JL, McDevitt JT., Biomark Med 4(1), 2010
PMID: 20387312
Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes.
Costa PP, Trevisan GL, Macedo GO, Palioto DB, Souza SL, Grisi MF, Novaes AB, Taba M., J Periodontol 81(3), 2010
PMID: 20192865
Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics.
Kardeşler L, Biyikoğlu B, Cetinkalp S, Pitkala M, Sorsa T, Buduneli N., Oral Dis 16(5), 2010
PMID: 20233316
MMP-9/TIMP-1 imbalance induced in human dendritic cells by Porphyromonas gingivalis.
Jotwani R, Eswaran SV, Moonga S, Cutler CW., FEMS Immunol Med Microbiol 58(3), 2010
PMID: 20030715
Longitudinal study of salivary proteinases during pregnancy and postpartum.
Gürsoy M, Könönen E, Tervahartiala T, Gürsoy UK, Pajukanta R, Sorsa T., J Periodontal Res 45(4), 2010
PMID: 20412421
Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis.
Gursoy UK, Könönen E, Pradhan-Palikhe P, Tervahartiala T, Pussinen PJ, Suominen-Taipale L, Sorsa T., J Clin Periodontol 37(6), 2010
PMID: 20507371
The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescents.
Vokurka J, Klapusová L, Pantuckova P, Kukletova M, Kukla L, Holla LI., Arch Oral Biol 54(2), 2009
PMID: 18930181
Salivary biomarkers for clinical applications.
Zhang L, Xiao H, Wong DT., Mol Diagn Ther 13(4), 2009
PMID: 19712004
Assessment of aprotinin influence on periodontal clinical status and matrix metalloproteinases 1, 2 and their tissue inhibitors saliva concentrations in patients with chronic periodontitis.
Pietruska M, Pietruski J, Skurska A, Bernaczyk A, Zak J, Zelazowska B, Dolińska E, Paniczko-Drezek A, Wysocka J., Adv Med Sci 54(2), 2009
PMID: 19758971
The clinical value of salivary biomarkers for periodontal disease.
Zhang L, Henson BS, Camargo PM, Wong DT., Periodontol 2000 51(), 2009
PMID: 19878467
Anti-inflammatory effect of peroxisome proliferator activated receptor gamma on human dental pulp cells.
Yu MK, Lee JC, Kim JH, Lee YH, Jeon JG, Jhee EC, Yi HK., J Endod 35(4), 2009
PMID: 19345798
Immunolocalization of matrix metalloproteinases-2 and -9 during apical periodontitis development.
Corotti MV, Zambuzzi WF, Paiva KB, Menezes R, Pinto LC, Lara VS, Granjeiro JM., Arch Oral Biol 54(8), 2009
PMID: 19497558
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Biyikoğlu B, Buduneli N, Kardeşler L, Aksu K, Pitkala M, Sorsa T., J Periodontol 80(8), 2009
PMID: 19656031
Localization of matrix metalloproteinases (MMPs-2, 8, 9 and 20) in normal and carious dentine.
Shimada Y, Ichinose S, Sadr A, Burrow MF, Tagami J., Aust Dent J 54(4), 2009
PMID: 20415934
Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis.
Gürkan A, Emingil G, Saygan BH, Atilla G, Cinarcik S, Köse T, Berdeli A., Arch Oral Biol 53(4), 2008
PMID: 18155181
Identifying sources and estimating glandular output of salivary TIMP-1.
Holten-Andersen L, Jensen SB, Bardow A, Harslund J, Thaysen-Andersen M, Lademann U, Usher PA, Offenberg H, Højrup P, Reibel J, Nielsen HJ, Brünner N, Nauntofte B., Scand J Clin Lab Invest 68(7), 2008
PMID: 18609089
The influence of type I diabetes mellitus on the expression and activity of gelatinases (matrix metalloproteinases-2 and -9) in induced periodontal disease.
Silva JA, Lorencini M, Peroni LA, De La Hoz CL, Carvalho HF, Stach-Machado DR., J Periodontal Res 43(1), 2008
PMID: 18230106
Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells.
Guan SM, Shu L, Fu SM, Liu B, Xu XL, Wu JZ., FEMS Microbiol Lett 283(1), 2008
PMID: 18400000
Gelatinolytic activity in gingival crevicular fluid from teeth with periapical lesions.
Belmar MJ, Pabst C, Martínez B, Hernández M., Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(6), 2008
PMID: 18439854
Expression of metalloproteinases and their tissue inhibitors in inflamed gingival biopsies.
Gonçalves LD, Oliveira G, Hurtado PA, Feitosa A, Takiya CM, Granjeiro JM, Trackman PC, Otazú I, Feres-Filho EJ., J Periodontal Res 43(5), 2008
PMID: 18624953
Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis.
Pirhan D, Atilla G, Emingil G, Sorsa T, Tervahartiala T, Berdeli A., J Clin Periodontol 35(10), 2008
PMID: 18710412
Matrix metalloproteases: underutilized targets for drug delivery.
Vartak DG, Gemeinhart RA., J Drug Target 15(1), 2007
PMID: 17365270
The role of matrix metalloproteinases in the oral environment.
Hannas AR, Pereira JC, Granjeiro JM, Tjäderhane L., Acta Odontol Scand 65(1), 2007
PMID: 17354089
The effect of chemical inhibition of matrix metalloproteinases on the size of experimentally induced apical periodontitis.
Tjäderhane L, Hotakainen T, Kinnunen S, Ahonen M, Salo T., Int Endod J 40(4), 2007
PMID: 17298412
Microfluidic immunoassays as rapid saliva-based clinical diagnostics.
Herr AE, Hatch AV, Throckmorton DJ, Tran HM, Brennan JS, Giannobile WV, Singh AK., Proc Natl Acad Sci U S A 104(13), 2007
PMID: 17374724
Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin.
Mazzoni A, Mannello F, Tay FR, Tonti GA, Papa S, Mazzotti G, Di Lenarda R, Pashley DH, Breschi L., J Dent Res 86(5), 2007
PMID: 17452564
A potential role of EMMPRIN by regulating ECM degradation in periodontitis.
Cao Z, Xiang J, Li C., Med Hypotheses 69(5), 2007
PMID: 17493767
Matrix metalloproteinase-2, -9, and -12 gene polymorphisms in generalized aggressive periodontitis.
Gürkan A, Emingil G, Saygan BH, Atilla G, Cinarcik S, Köse T, Berdeli A., J Periodontol 78(12), 2007
PMID: 18052707
The role of matrix metalloproteinases (MMPs) in human caries.
Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S., J Dent Res 85(1), 2006
PMID: 16373676
Gingival tissue and crevicular fluid co-operation in adult periodontitis.
Beklen A, Tüter G, Sorsa T, Hanemaaijer R, Virtanen I, Tervahartiala T, Konttinen YT., J Dent Res 85(1), 2006
PMID: 16373682
Role of bacteria in health and disease of periodontal tissues.
Feng Z, Weinberg A., Periodontol 2000 40(), 2006
PMID: 16398685
Host-mediated resolution of inflammation in periodontal diseases.
Kantarci A, Hasturk H, Van Dyke TE., Periodontol 2000 40(), 2006
PMID: 16398691
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.
Sorsa T, Tjäderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mäntylä P., Ann Med 38(5), 2006
PMID: 16938801
Salivary proteinase activity: a potential biomarker for preterm premature rupture of the membranes.
Menon R, McIntyre JO, Matrisian LM, Fortunato SJ., Am J Obstet Gynecol 194(6), 2006
PMID: 16731078
Increased local matrix metalloproteinase-8 expression in the periodontal connective tissues of smokers with periodontal disease.
Liu KZ, Hynes A, Man A, Alsagheer A, Singer DL, Scott DA., Biochim Biophys Acta 1762(8), 2006
PMID: 16928431
Association of matrix metalloproteinase-9 promoter gene polymorphism with chronic periodontitis.
Keles GC, Gunes S, Sumer AP, Sumer M, Kara N, Bagci H, Koprulu H., J Periodontol 77(9), 2006
PMID: 16945027
Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases.
Ilgenli T, Vardar-Sengul S, Gürkan A, Sorsa T, Stackelberg S, Köse T, Atilla G., Oral Dis 12(6), 2006
PMID: 17054770
Functional polymorphisms in the matrix metalloproteinase-9 gene in relation to severity of chronic periodontitis.
Holla LI, Fassmann A, Muzík J, Vanek J, Vasku A., J Periodontol 77(11), 2006
PMID: 17076610
Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test.
Mäntylä P, Stenman M, Kinane D, Salo T, Suomalainen K, Tikanoja S, Sorsa T., J Periodontal Res 41(6), 2006
PMID: 17076774
Gingival crevicular fluid matrix metalloproteinase (MMP)-7, extracellular MMP inducer, and tissue inhibitor of MMP-1 levels in periodontal disease.
Emingil G, Tervahartiala T, Mãntylã P, Määttä M, Sorsa T, Atilla G., J Periodontol 77(12), 2006
PMID: 17209789
Histochemical and immunohistochemical evaluation of gingival collagen and metalloproteinases in peri-implantitis.
Borsani E, Salgarello S, Mensi M, Boninsegna R, Stacchiotti A, Rezzani R, Sapelli P, Bianchi R, Rodella LF., Acta Histochem 107(3), 2005
PMID: 16054676
Host response modulation in the management of periodontal diseases.
Salvi GE, Lang NP., J Clin Periodontol 32 Suppl 6(), 2005
PMID: 16128833
Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis.
de Souza AP, Trevilatto PC, Scarel-Caminaga RM, de Brito RB, Barros SP, Line SR., J Clin Periodontol 32(2), 2005
PMID: 15691353
Diagnostic biomarkers for oral and periodontal diseases.
Taba M, Kinney J, Kim AS, Giannobile WV., Dent Clin North Am 49(3), 2005
PMID: 15978241
Effect of E. faecalis on the release of serine proteases elastase and cathepsin G, and collagenase-2 (MMP-8) by human polymorphonuclear leukocytes (PMNs).
Reynaud af Geijersstam A, Sorsa T, Stackelberg S, Tervahartiala T, Haapasalo M., Int Endod J 38(9), 2005
PMID: 16104981
Peptides of human gingival crevicular fluid determined by HPLC-ESI-MS.
Pisano E, Cabras T, Montaldo C, Piras V, Inzitari R, Olmi C, Castagnola M, Messana I., Eur J Oral Sci 113(6), 2005
PMID: 16324135
The IGF-I/IGFBP-3 system in gingival crevicular fluid and dependence on application of fixed force.
Toia M, Galazzo R, Maioli C, Granata R, Scarlatti F., J Endocrinol Invest 28(11), 2005
PMID: 16483180
Advances in periodontal disease markers.
Ozmeric N., Clin Chim Acta 343(1-2), 2004
PMID: 15115674
Matrix metalloproteinases (MMPs) in oral diseases.
Sorsa T, Tjäderhane L, Salo T., Oral Dis 10(6), 2004
PMID: 15533204
MMP-2 activation by Actinobacillus actinomycetemcomitans supernatant in human PDL cells was corresponded with reduction of TIMP-2.
Tiranathanagul S, Pattamapun K, Yongchaitrakul T, Pavasant P., Oral Dis 10(6), 2004
PMID: 15533216
Proteolytic host cell enzymes in gingival crevice fluid.
Uitto VJ, Overall CM, McCulloch C., Periodontol 2000 31(), 2003
PMID: 12656997
MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population.
de Souza AP, Trevilatto PC, Scarel-Caminaga RM, Brito RB, Line SR., J Clin Periodontol 30(2), 2003
PMID: 12622858
The effects of progesterone on matrix metalloproteinases in cultured human gingival fibroblasts.
Lapp CA, Lohse JE, Lewis JB, Dickinson DP, Billman M, Hanes PJ, Lapp DF., J Periodontol 74(3), 2003
PMID: 12710746
Inhibitory effect of procyanidin oligomer from elm cortex on the matrix metalloproteinases and proteases of periodontopathogens.
Song SE, Choi BK, Kim SN, Yoo YJ, Kim MM, Park SK, Roh SS, Kim CK., J Periodontal Res 38(3), 2003
PMID: 12753366
Effect of hydroxamic acid-based matrix metalloproteinase inhibitors on human gingival cells and Porphyromonas gingivalis.
Yoshioka M, Yokoyama N, Masuda K, Honna T, Hinode D, Nakamura R, Rouabhia M, Mayrand D, Grenier D., J Periodontol 74(8), 2003
PMID: 14514237
Effect of tobacco smoking on neutrophil activity following periodontal surgery.
Persson L, Bergström J, Gustafsson A., J Periodontol 74(10), 2003
PMID: 14653394
Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives.
Grenier D, Plamondon P, Sorsa T, Lee HM, McNamara T, Ramamurthy NS, Golub LM, Teronen O, Mayrand D., J Periodontol 73(1), 2002
PMID: 11846203
Signal pathways involved in the production of MMP-1 and MMP-3 in human gingival fibroblasts.
Domeij H, Yucel-Lindberg T, Modéer T., Eur J Oral Sci 110(4), 2002
PMID: 12206592
Etiopathogenesis of periodontitis in children and adolescents.
Kinane DF, Podmore M, Murray MC, Hodge PJ, Ebersole J., Periodontol 2000 26(), 2001
PMID: 11452906
Matrix metalloproteinases and their inhibitors in oral lichen planus.
Zhou XJ, Sugerman PB, Savage NW, Walsh LJ., J Cutan Pathol 28(2), 2001
PMID: 11168755
Expression of matrix metalloproteinases in healthy and diseased human gingiva.
Dahan M, Nawrocki B, Elkaïm R, Soell M, Bolcato-Bellemin AL, Birembaut P, Tenenbaum H., J Clin Periodontol 28(2), 2001
PMID: 11168737
Inhibition of human gelatinases by metals released from dental amalgam.
Souza AP, Gerlach RF, Line SR., Biomaterials 22(14), 2001
PMID: 11426881
The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis.
Park JS, Romero R, Yoon BH, Moon JB, Oh SY, Han SY, Ko EM., Am J Obstet Gynecol 185(5), 2001
PMID: 11717650
Activation of matrix metalloproteinase-2 by a novel oral spirochetal species Treponema lecithinolyticum.
Choi BK, Jung JH, Suh HY, Yoo YJ, Cho KS, Chai JK, Kim CK., J Periodontol 72(11), 2001
PMID: 11759872
Inhibition of human gingival gelatinases (MMP-2 and MMP-9) by metal salts.
de Souza AP, Gerlach RF, Line SR., Dent Mater 16(2), 2000
PMID: 11203530
Use of a fluorogenic septapeptide matrix metalloproteinase assay to assess responses to periodontal treatment.
Bhide VM, Smith L, Overall CM, Birek P, McCulloch CA., J Periodontol 71(5), 2000
PMID: 10872948
Collagenases in different categories of peri-implant vertical bone loss.
Ma J, Kitti U, Teronen O, Sorsa T, Husa V, Laine P, Rönkä H, Salo T, Lindqvist C, Konttinen YT., J Dent Res 79(11), 2000
PMID: 11145357
The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis.
Tervahartiala T, Pirilä E, Ceponis A, Maisi P, Salo T, Tuter G, Kallio P, Törnwall J, Srinivas R, Konttinen YT, Sorsa T., J Dent Res 79(12), 2000
PMID: 11201047
Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine.
Gendron R, Grenier D, Sorsa T, Mayrand D., Clin Diagn Lab Immunol 6(3), 1999
PMID: 10225852
Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease.
Sorsa T, Mäntylä P, Rönkä H, Kallio P, Kallis GB, Lundqvist C, Kinane DF, Salo T, Golub LM, Teronen O, Tikanoja S., Ann N Y Acad Sci 878(), 1999
PMID: 10415725
Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases.
Mancini S, Romanelli R, Laschinger CA, Overall CM, Sodek J, McCulloch CA., J Periodontol 70(11), 1999
PMID: 10588492
The association between smoking cessation and periodontal status and salivary proteinase levels.
Liede KE, Haukka JK, Hietanen JH, Mattila MH, Rönkä H, Sorsa T., J Periodontol 70(11), 1999
PMID: 10588500
Dissolution of type I collagen fibrils by gingival fibroblasts isolated from patients of various periodontitis categories.
Havemose-Poulsen A, Holmstrup P, Stoltze K, Birkedal-Hansen H., J Periodontal Res 33(5), 1998
PMID: 9777595
The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions.
Tjäderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T., J Dent Res 77(8), 1998
PMID: 9719036
Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate.
Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Sorsa T., J Dent Res 76(9), 1997
PMID: 9294486
Human neutrophil gelatinase and associated lipocalin in adult and localized juvenile periodontitis.
Westerlund U, Ingman T, Lukinmaa PL, Salo T, Kjeldsen L, Borregaard N, Tjäderhane L, Konttinen YT, Sorsa T., J Dent Res 75(8), 1996
PMID: 8906123

44 References

Daten bereitgestellt von Europe PubMed Central.

Lactoferrin in the gingival crevice as a marker of polymorphonuclear leucocytes in periodontal diseases.
Adonogianaki E, Moughal NA, Kinane DF., J. Clin. Periodontol. 20(1), 1993
PMID: 8421112
The case for periodontosis as a clinical entity.
Baer PN., J. Periodontol. 42(8), 1971
PMID: 5284178
Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase.
Bergmann U, Michaelis J, Oberhoff R, Knauper V, Beckmann R, Tschesche H., J. Clin. Chem. Clin. Biochem. 27(6), 1989
PMID: 2547014
Role of matrix metalloproteinases in human periodontal diseases.
Birkedal-Hansen H., J. Periodontol. 64(5 Suppl), 1993
PMID: 8315570
Immunoassays for the detection of human collagenase, stromelysin, tissue inhibitor of metalloproteinases (TIMP) and enzyme-inhibitor complexes.
Cooksley S, Hipkiss JB, Tickle SP, Holmes-Ievers E, Docherty AJ, Murphy G, Lawson AD., Matrix 10(5), 1990
PMID: 1964712

Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases.
Ding Y, Uitto VJ, Firth J, Salo T, Haapasalo M, Konttinen YT, Sorsa T., Oral Dis 1(4), 1995
PMID: 8705837

Ding, J. Clin. Periodontol. (), 1996

Ding, J. Dent. Res. (), 1996

Golub, Journal of Clinical Periodontology 21(), 1995
Characterization of matrix metalloproteinase (MMP-8 and -9) activities in the saliva and in gingival crevicular fluid of children with Down's syndrome.
Halinen S, Sorsa T, Ding Y, Ingman T, Salo T, Konttinen YT, Saari H., J. Periodontol. 67(8), 1996
PMID: 8866313
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Ingman T, Sorsa T, Konttinen YT, Liede K, Saari H, Lindy O, Suomalainen K., Oral Microbiol. Immunol. 8(5), 1993
PMID: 8265204
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article.
Ingman T, Sorsa T, Suomalainen K, Halinen S, Lindy O, Lauhio A, Saari H, Konttinen YT, Golub LM., J. Periodontol. 64(2), 1993
PMID: 8433257
Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients.
Ingman T, Sorsa T, Lindy O, Koski H, Konttinen YT., J. Clin. Periodontol. 21(1), 1994
PMID: 8126240
Immunohistochemical study of neutrophil- and fibroblast-type collagenases and stromelysin-1 in adult periodontitis.
Ingman T, Sorsa T, Michaelis J, Konttinen YT., Scand J Dent Res 102(6), 1994
PMID: 7871357
Preparation of active recombinant TIMP-1 from Escherichia coli inclusion bodies and complex formation with the recombinant catalytic domain of PMNL-collagenase.
Kleine T, Bartsch S, Blaser J, Schnierer S, Triebel S, Valentin M, Gote T, Tschesche H., Biochemistry 32(51), 1993
PMID: 8260495

Kubota, Journal of Dental Research 74(), 1995

Lauhio, Clinical Experimental Immunology 98(), 1994
Tetracyclines in treatment of rheumatoid arthritis.
Lauhio A, Salo T, Tjaderhane L, Lahdevirta J, Golub LM, Sorsa T., Lancet 346(8975), 1995
PMID: 7651040
Immunolocalization of matrix metalloproteinases and TIMP-1 (tissue inhibitor of metalloproteinases) in human gingival tissues from periodontitis patients.
Meikle MC, Hembry RM, Holley J, Horton C, McFarlane CG, Reynolds JJ., J. Periodont. Res. 29(2), 1994
PMID: 8158500
Evidence for polymorphonuclear leukocyte collagenase and 92-kilodalton gelatinase in gingival crevicular fluid.
Overall CM, Sodek J, McCulloch CA, Birek P., Infect. Immun. 59(12), 1991
PMID: 1657787

Salo, Journal of Denial Research 4(), 1995
Comparison of interstitial collagenases from human gingiva, sulcular fluid and polymorphonuclear leukocytes.
Sorsa T, Uitto VJ, Suomalainen K, Vauhkonen M, Lindy S., J. Periodont. Res. 23(6), 1988
PMID: 2851042
Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases.
Sorsa T, Ingman T, Suomalainen K, Haapasalo M, Konttinen YT, Lindy O, Saari H, Uitto VJ., Infect. Immun. 60(11), 1992
PMID: 1398963
Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases.
Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Takeha S, Konttinen YT., Ann. N. Y. Acad. Sci. 732(), 1994
PMID: 7978785
Cellular source, activation and inhibition of dental plaque collagenase.
Sorsa T, Ding YL, Ingman T, Salo T, Westerlund U, Haapasalo M, Tschesche H, Konttinen YT., J. Clin. Periodontol. 22(9), 1995
PMID: 7593702

Sorsa, 1996
Collagenase activity in gingival crevicular fluid of patients with juvenile periodontitis.
Suomalainen K, Sorsa T, Saxen L, Vauhkonen M, Uitto VJ., Oral Microbiol. Immunol. 6(1), 1991
PMID: 1658711
Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo.
Suomalainen K, Sorsa T, Ingman T, Lindy O, Golub LM., Oral Microbiol. Immunol. 7(2), 1992
PMID: 1326740
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Tervahartiala T, Konttinen YT, INgman T, Hayrinen-Immonen R, Ding Y, Sorsa T., J. Clin. Periodontol. 23(2), 1996
PMID: 8849841

Tijssen, 1985
Detection of interleukin-8 and matrix metalloproteinases transcripts in healthy and diseased gingival biopsies by RNA/PCR.
Tonetti MS, Freiburghaus K, Lang NP, Bickel M., J. Periodont. Res. 28(6 Pt 2), 1993
PMID: 8263721
Evidence for the tissue inhibitor of metalloproteinases-1 (TIMP-1) in human polymorphonuclear leukocytes.
Triebel S, Blaser J, Gote T, Pelz G, Schuren E, Schmitt M, Tschesche H., Eur. J. Biochem. 231(3), 1995
PMID: 7649172
Salivary collagenase. Origin, characteristics and relationship to periodontal health.
Uitto VJ, Suomalainen K, Sorsa T., J. Periodont. Res. 25(3), 1990
PMID: 2163444

Uitto, Infection and Immunity 57(), 1988
Human neutrophil gelatinase and associated lipocalin in adult and localized juvenile periodontitis.
Westerlund U, Ingman T, Lukinmaa PL, Salo T, Kjeldsen L, Borregaard N, Tjaderhane L, Konttinen YT, Sorsa T., J. Dent. Res. 75(8), 1996
PMID: 8906123

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 8997658
PubMed | Europe PMC

Suchen in

Google Scholar