Engineering antibiotic producers to overcome the limitations of classical strain improvement programs

Lal R, Khanna R, Kaur H, Khanna M, Dhingra N, Lal S, Gartemann K-H, Eichenlaub R, Ghosh PK (1996)
CRITICAL REVIEWS IN MICROBIOLOGY 22(4): 201-255.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Lal, R; Khanna, R; Kaur, H; Khanna, M; Dhingra, N; Lal, S; Gartemann, Karl-HeinzUniBi ; Eichenlaub, RudolfUniBi; Ghosh, PK
Einrichtung
Fakultät für Biologie > Gentechnologie/Mikrobiologie
Abstract / Bemerkung
Improvement of the antibiotic yield of industrial strains is invariably the main target of industry-oriented research. The approaches used in the past were rational selection, extensive mutagenesis, and biochemical screening. These approaches have their limitations, which are likely to be overcome by the judicious application of recombinant DNA techniques. Efficient cloning Vectors and transformation systems have now become available even for antibiotic producers that were previously difficult to manipulate genetically. The genes responsible for antibiotic biosynthesis can now be easily isolated and manipulated. In the first half of this review article, the limitations of classical strain improvement programs and the development of recombinant DNA techniques for cloning and analyzing genes responsible for antibiotic biosynthesis are discussed. The second half of this article addresses some of the major achievements, including the development of genetically engineered microbes, especially with reference to p-lactams, anthracyclines, and rifamycins.
Stichworte
shikimate; DAOCS/DAOCH; Streptomyces violaceoruber; anthracycline; pcbC; rifamycins; Streptomyces lincolnensis; isopenicillin-N-synthase; Ampcolatopsis mediterranei
Erscheinungsjahr
1996
Zeitschriftentitel
CRITICAL REVIEWS IN MICROBIOLOGY
Band
22
Ausgabe
4
Seite(n)
201-255
ISSN
1040-841X
eISSN
1549-7828
Page URI
https://pub.uni-bielefeld.de/record/1628302

Zitieren

Lal R, Khanna R, Kaur H, et al. Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY. 1996;22(4):201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K. - H., et al. (1996). Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY, 22(4), 201-255. https://doi.org/10.3109/10408419609105481
Lal, R, Khanna, R, Kaur, H, Khanna, M, Dhingra, N, Lal, S, Gartemann, Karl-Heinz, Eichenlaub, Rudolf, and Ghosh, PK. 1996. “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”. CRITICAL REVIEWS IN MICROBIOLOGY 22 (4): 201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K. - H., Eichenlaub, R., and Ghosh, P. K. (1996). Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY 22, 201-255.
Lal, R., et al., 1996. Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY, 22(4), p 201-255.
R. Lal, et al., “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”, CRITICAL REVIEWS IN MICROBIOLOGY, vol. 22, 1996, pp. 201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K.-H., Eichenlaub, R., Ghosh, P.K.: Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY. 22, 201-255 (1996).
Lal, R, Khanna, R, Kaur, H, Khanna, M, Dhingra, N, Lal, S, Gartemann, Karl-Heinz, Eichenlaub, Rudolf, and Ghosh, PK. “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”. CRITICAL REVIEWS IN MICROBIOLOGY 22.4 (1996): 201-255.

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