Engineering antibiotic producers to overcome the limitations of classical strain improvement programs

Lal R, Khanna R, Kaur H, Khanna M, Dhingra N, Lal S, Gartemann K-H, Eichenlaub R, Ghosh PK (1996)
CRITICAL REVIEWS IN MICROBIOLOGY 22(4): 201-255.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Lal, R; Khanna, R; Kaur, H; Khanna, M; Dhingra, N; Lal, S; Gartemann, Karl-HeinzUniBi ; Eichenlaub, RudolfUniBi; Ghosh, PK
Abstract / Bemerkung
Improvement of the antibiotic yield of industrial strains is invariably the main target of industry-oriented research. The approaches used in the past were rational selection, extensive mutagenesis, and biochemical screening. These approaches have their limitations, which are likely to be overcome by the judicious application of recombinant DNA techniques. Efficient cloning Vectors and transformation systems have now become available even for antibiotic producers that were previously difficult to manipulate genetically. The genes responsible for antibiotic biosynthesis can now be easily isolated and manipulated. In the first half of this review article, the limitations of classical strain improvement programs and the development of recombinant DNA techniques for cloning and analyzing genes responsible for antibiotic biosynthesis are discussed. The second half of this article addresses some of the major achievements, including the development of genetically engineered microbes, especially with reference to p-lactams, anthracyclines, and rifamycins.
Stichworte
shikimate; DAOCS/DAOCH; Streptomyces violaceoruber; anthracycline; pcbC; rifamycins; Streptomyces lincolnensis; isopenicillin-N-synthase; Ampcolatopsis mediterranei
Erscheinungsjahr
1996
Zeitschriftentitel
CRITICAL REVIEWS IN MICROBIOLOGY
Band
22
Ausgabe
4
Seite(n)
201-255
ISSN
1040-841X
eISSN
1549-7828
Page URI
https://pub.uni-bielefeld.de/record/1628302

Zitieren

Lal R, Khanna R, Kaur H, et al. Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY. 1996;22(4):201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K. - H., et al. (1996). Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY, 22(4), 201-255. https://doi.org/10.3109/10408419609105481
Lal, R, Khanna, R, Kaur, H, Khanna, M, Dhingra, N, Lal, S, Gartemann, Karl-Heinz, Eichenlaub, Rudolf, and Ghosh, PK. 1996. “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”. CRITICAL REVIEWS IN MICROBIOLOGY 22 (4): 201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K. - H., Eichenlaub, R., and Ghosh, P. K. (1996). Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY 22, 201-255.
Lal, R., et al., 1996. Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY, 22(4), p 201-255.
R. Lal, et al., “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”, CRITICAL REVIEWS IN MICROBIOLOGY, vol. 22, 1996, pp. 201-255.
Lal, R., Khanna, R., Kaur, H., Khanna, M., Dhingra, N., Lal, S., Gartemann, K.-H., Eichenlaub, R., Ghosh, P.K.: Engineering antibiotic producers to overcome the limitations of classical strain improvement programs. CRITICAL REVIEWS IN MICROBIOLOGY. 22, 201-255 (1996).
Lal, R, Khanna, R, Kaur, H, Khanna, M, Dhingra, N, Lal, S, Gartemann, Karl-Heinz, Eichenlaub, Rudolf, and Ghosh, PK. “Engineering antibiotic producers to overcome the limitations of classical strain improvement programs”. CRITICAL REVIEWS IN MICROBIOLOGY 22.4 (1996): 201-255.

12 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Bioprocess intensification of antibiotic production by Streptomyces coelicolor A3(2) in micro-porous culture.
Ndlovu TM, Ward AC, Glassey J, Eskildsen J, Akay G., Mater Sci Eng C Mater Biol Appl 49(), 2015
PMID: 25687011
Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis.
Nigam A, Almabruk KH, Saxena A, Yang J, Mukherjee U, Kaur H, Kohli P, Kumari R, Singh P, Zakharov LN, Singh Y, Mahmud T, Lal R., J Biol Chem 289(30), 2014
PMID: 24923585
A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea.
Chng C, Lum AM, Vroom JA, Kao CM., Proc Natl Acad Sci U S A 105(32), 2008
PMID: 18685110
Streptomyces genetics: a genomic perspective.
Paradkar A, Trefzer A, Chakraburtty R, Stassi D., Crit Rev Biotechnol 23(1), 2003
PMID: 12693442
Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.
Tamehiro N, Hosaka T, Xu J, Hu H, Otake N, Ochi K., Appl Environ Microbiol 69(11), 2003
PMID: 14602594
Regulation and manipulation of the gene clusters encoding type-I PKSs.
Lal R, Kumari R, Kaur H, Khanna R, Dhingra N, Tuteja D., Trends Biotechnol 18(6), 2000
PMID: 10802562

218 References

Daten bereitgestellt von Europe PubMed Central.


AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Transformation of rifamycin S into rifamycins B and L. A revision of the current biosynthetic hypothesis.
Ghisalba O, Roos R, Schupp T, Nuesch J., J. Antibiot. 35(1), 1982
PMID: 7200089

Schupp, FEMS Microbiol. Lett. 6(), 1979
New rifamycins produced by a recombinant strain of Nocardia mediterranei.
Schupp T, Traxler P, Auden JA., J. Antibiot. 34(8), 1981
PMID: 7319929

Alvarez, Biotechnol. Lett. 12(), 1990

Wovcha, 1990
The selection, improvement, and preservation of micro-organisms.
Calam CT., Prog Ind Microbiol 5(), 1964
PMID: 4860386
Applied aspects of microbial genetics.
Alikhanian S., Curr. Top. Microbiol. Immunol. 53(), 1970
PMID: 4920484

Elander, Industrial Microbiology 192(), 1976

Sermonti, Ann. N.Y. Acad. Sci. 81(), 1959

Simpson, Aspergillus nidulans, J. Gen. Microbiol. 126(), 1981
Genetics of antibiotic production.
Hopwood DA, Merrick MJ., Bacteriol Rev 41(3), 1977
PMID: 334152

Schupp, Nocardia mediterranei, FEMS Microbiol. Lett. 36(), 1986

Elander, 1973

McDonald, J. Microbiol. Serol. 32(), 1966

McDonald, Antonie VanLeeuwenhoek, J. Microbiol. Serol. 30(), 1964

Wesseling, Nocardia lactamdurans and Streptomyces griseus (), 1978

Hopwood, Streptomyces coelicolor, Mol. Gen. Genet. 162(), 1978

Cohen, Streptomyces, Nature (London) 268(), 1977
Genome rearrangement and genetic instability in Streptomyces spp.
Birch A, Hausler A, Hutter R., J. Bacteriol. 172(8), 1990
PMID: 2198246

Chen, TIBTECH 13(), 1995

Kieser, Biotechnology 7(), 1992

Martin, TIBTECH 5(), 1987
Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.
Baldwin JE, Adlington RM, Coates JB, Crabbe MJ, Crouch NP, Keeping JW, Knight GC, Schofield CJ, Ting HH, Vallejo CA., Biochem. J. 245(3), 1987
PMID: 3663194

Hopwood, John Innes Foundation (), 1985

Arrowsmith, Streptomyces cinnamonensis, Mol. Gen. Genet. 234(), 1992

Lal, Amycolatopsis mediterranei, Appl. Environ. Microbiol. 57(), 1991

Lal, Bioassays 16(), 1994
Rifamycins: strain improvement program.
Lal R, Khanna M, Kaur H, Srivastava N, Tripathi KK, Lal S., Crit. Rev. Microbiol. 21(1), 1995
PMID: 7576149

Malpartida, Nature (London) 309(), 1984
Genetics of actinorhodin biosynthesis by Streptomyces coelicolor A3(2).
Rudd BA, Hopwood DA., J. Gen. Microbiol. 114(1), 1979
PMID: 521794
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.
Sherman DH, Malpartida F, Bibb MJ, Kieser HM, Bibb MJ, Hopwood DA., EMBO J. 8(9), 1989
PMID: 2583128

Hallam, Streptomyces coelicolor, Gene 74(), 1988

Stutzman-Engwall, Streptomyces peucetius, Proc. Natl. Acad. Sci. U.S.A. 86(), 1989

Stutzman-Engwall, Streptomyces peucetius, J. Bacteriol. 174(), 1992

Otten, S. peucetius caesius, J. Bacteriol. 172(), 1990

Hopwood, 1992
Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase.
Shen B, Summers RG, Gramajo H, Bibb MJ, Hutchinson CR., J. Bacteriol. 174(11), 1992
PMID: 1592832

Caballero, Streptomyces coelicolor, Mol. Gen. Genet. 230(), 1991

Bergh, Streptomyces curacoi, Gene 117(), 1992

Bergh, Streptomyces curacoi, Biotechnol. Appl. Biochem. 15(), 1992

Yu, Streptomyces griseus, J. Bacteriol. 176(), 1994

Butler, Streptomyces rimosus, Mol. Gen. Genet. 215(), 1989
Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.
Hopwood DA, Sherman DH., Annu. Rev. Genet. 24(), 1990
PMID: 2088174

Wohllenben, Streptomyces viridochromogenes, Gene 115(), 1992

Wovcha, 1986
Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.
Peschke U, Schmidt H, Zhang HZ, Piepersberg W., Mol. Microbiol. 16(6), 1995
PMID: 8577249

Cortes, Saccharopolyspora erythraea, Nature (London) 348(), 1990
An erythromycin analog produced by reprogramming of polyketide synthesis.
Donadio S, McAlpine JB, Sheldon PJ, Jackson M, Katz L., Proc. Natl. Acad. Sci. U.S.A. 90(15), 1993
PMID: 8346223
Biosynthesis of the erythromycin macrolactone and a rational approach for producing hybrid macrolides.
Donadio S, Staver MJ, McAlpine JB, Swanson SJ, Katz L., Gene 115(1-2), 1992
PMID: 1612455

Weber, Saccharopolyspora erythraea, Science 252(), 1991

Bibb, Streptomyces erythraeus, Gene 38(), 1985

Donadio, Saccharopolyspora erythraea, Gene 111(), 1992

Distler, FEMS Microbiol. Lett. 28(), 1985

Piepersberg, 1994

Coque, Acremonium chrysogenumPenicillium chrysogenum, Mol. Microbiol. 5(), 1991

Coque, Nocardia lactamdurans, J. Bacteriol. 173(), 1991

Diez, J. Biol. Chem. 265(), 1990

Samson, Cephalosporium acremonium, Nature (London) 318(), 1985

Samson, Biotechnology 5(), 1987

Carr, Penicillium chrysogenum, Gene 48(), 1986

Tsukamoto, Streptomyces galilaeus, J. Bacteriol. 176(), 1994

Tsukamoto, Streptomyces galilaeus, J. Antibiot. 45(), 1992

Niemi, Streptomyces galilaeus, Microbiology 140(), 1994

Guilfoile, J. Bacteriol. 174(), 1991

Hutchinson, Am. Soc. Microbiol. (), 1993

Hutchinson, Streptomyces, Antonie VanLeeuwenhoek, J. Microbiol. Serol. 20(), 1994

Motamedi, Streptomyces glaucescens, Proc. Natl. Acad. Sci. U.S.A. 84(), 1987

Barredo, Penicillium chrysogenum, Gene 83(), 1989

Malshman, EP 0437 378(), 1991

Malpartida, Nature, (London) 325(), 1987

Cortes, Saccharopolyspora erythraea, Nature (London) 348(), 1990
Modular organization of genes required for complex polyketide biosynthesis.
Donadio S, Staver MJ, McAlpine JB, Swanson SJ, Katz L., Science 252(5006), 1991
PMID: 2024119

Stockmann, FEMS Microbiol. Lett. 90(), 1992

Hara, Streptomyces mycarofaciens, J. Bacteriol. 174(), 1992

Madduri, Escherichia coli, J. Bacteriol. 175(), 1993

Cane, J. Am. Chem. Soc. 103(), 1981
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.
Sherman DH, Malpartida F, Bibb MJ, Kieser HM, Bibb MJ, Hopwood DA., EMBO J. 8(9), 1989
PMID: 2583128
Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.
Kim ES, Bibb MJ, Butler MJ, Hopwood DA, Sherman DH., Gene 141(1), 1994
PMID: 8163168
The genetics of chemical diversity.
Cerda-Olmedo E., Crit. Rev. Microbiol. 20(2), 1994
PMID: 8080627
Engineered biosynthesis of novel polyketides: properties of the whiE aromatase/cyclase.
Alvarez MA, Fu H, Khosla C, Hopwood DA, Bailey JE., Nat. Biotechnol. 14(3), 1996
PMID: 9630896
Distribution of oxoacyl synthase homology sequences within Streptomyces DNA.
Kuczek K, Mordarski M, Goodfellow M., FEMS Microbiol. Lett. 118(3), 1994
PMID: 8020754
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
Schwecke T, Aparicio JF, Molnar I, Konig A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB., Proc. Natl. Acad. Sci. U.S.A. 92(17), 1995
PMID: 7644502

Tuan, Gene 111(), 1990

Weber, Streptomyces erythraeus, J. Bacteriol. 164(), 1985

Weber, Saccharopolyspora erythraea, Gene 75(), 1989

Weber, Saccharopolyspora erythraea (Streptomyces erythraeus), Gene 68(), 1988

Weber, Saccharopolyspora erythraea, J. Bacteriol. 172(), 1990

Thompson, Gene 20(), 1992
ATP:streptomycin 3"=phosphotransferase.
Walker JB, Walker MS., Meth. Enzymol. 43(), 1975
PMID: 49000

Heinzel, Arch. Microbiol. 15(), 1988

Chung, Enzyme Microbiol. Technol. 9(), 1987

Rodriguez, Streptomyces antibioticus, FEMS Microbiol. Lett. 127(), 1995

Vara, Saccharopolyspora erythraea (Streptomyces erythreus), J. Bacteriol. 171(), 1989

Cane, J. Am. Chem. Soc. 108(), 1986

Cane, J. Am. Chem. Soc. 109(), 1987

Muth, Streptomyces, Mol. Gene Genet. 219(), 1989

Streicher, Genetics and Molecular Biology of Industrial Microorganisms 44(), 1989

Richardson, Genetics and Molecular Biology of Industrial Microorganisms (), 1989

Tang, Streptomyces fradiae, J. Bacteriol. 176(), 1994

Shen, J. Bacteriol. 174(), 1993

Shen, Science 262(), 1992

Hopwood, Nature (London) 314(), 1986
Drug synthesis by genetically engineered microorganisms.
Hutchinson CR., Biotechnology (N.Y.) 12(4), 1994
PMID: 7764683
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions.
Bartel PL, Zhu CB, Lampel JS, Dosch DC, Connors NC, Strohl WR, Beale JM Jr, Floss HG., J. Bacteriol. 172(9), 1990
PMID: 2394677
Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins.
Khosla C, McDaniel R, Ebert-Khosla S, Torres R, Sherman DH, Bibb MJ, Hopwood DA., J. Bacteriol. 175(8), 1993
PMID: 8468280

Krupa, Ann. Chem. 7(), 1989

McDaniel, J. Am. Chem. Soc. 115(), 1993
Engineered biosynthesis of a complete macrolactone in a heterologous host.
Kao CM, Katz L, Khosla C., Science 265(5171), 1994
PMID: 8036492
Beta-lactam biosynthetic genes.
Ingolia TD, Queener SW., Med Res Rev 9(2), 1989
PMID: 2654524

Coque, Nocardia lactamdurans, EMBO J. 12(), 1993

Coque, Streptomyces clavuligerus, Mol. Genet. 236(), 1993

Ghosh, Int. Symp. Recent Adv. in Bioindustry. Seoul Korea 25(), 1996

Vanliempt, Aspergillus nidulans, J. Biol Chem. 265(), 1989

Kovacevic, Streptomyces clavuligerus, J. Bacteriol. 172(), 1990

Skatrud, Cephalosporium acremonium, Biotechnology 7(), 1989

Skatrud, Cephalosporium acremonium, Gene 78(), 1989
Cloning, characterization, and use in strain improvement of the Cephalosporium acremonium gene cefG encoding acetyl transferase.
Mathison L, Soliday C, Stepan T, Aldrich T, Rambosek J., Curr. Genet. 23(1), 1993
PMID: 8428381

Baldwin, Tetrahedron 43(), 1987
The functional role of cysteines in isopenicillin N synthase. Correlation of cysteine reactivities toward sulfhydryl reagents with kinetic properties of cysteine mutants.
Kriauciunas A, Frolik CA, Hassell TC, Skatrud PL, Johnson MG, Holbrook NL, Chen VJ., J. Biol. Chem. 266(18), 1991
PMID: 2050677

Cantwell, Penicillium chrysogenum, Curr. Genet. 17(), 1990
Microbial penicillin acylases.
Vandamme EJ, Voets JP., Adv. Appl. Microbiol. 17(0), 1974
PMID: 4371337
Stereoselective synthesis of ectocarpene and its antipode via microbilogical asymmetric hydrolysis.
Kajiwara T, Sasaki Y, Kimura F, Hatanaka A., Agric. Biol. Chem. 45(6), 1981
PMID: IND81081535

Ichikawa, Pseudomonas, Agric. Biol. Chem. 45(), 1981
Penicillin acylase from E. coli: unique gene-protein relation.
Schumacher G, Sizmann D, Haug H, Buckel P, Bock A., Nucleic Acids Res. 14(14), 1986
PMID: 3016663

Isogai, Acremonium chrysogenium, Biotechnology 9(), 1991
Cloning and characterization of the genes for two distinct cephalosporin acylases from a Pseudomonas strain.
Matsuda A, Matsuyama K, Yamamoto K, Ichikawa S, Komatsu K., J. Bacteriol. 169(12), 1987
PMID: 2824449

Matsuda, J. Bacteriol. 169(), 1989

Aramori, J. Ferment. Bioeng. 4(), 1991

Tsuzuki, Nippon Nogrikagaku Kaishi 63(), 1989

Matsumoto, Industrial Application of Immobilized Biocatalysts (), 1993

Kupka, Cephalosporium acremonium, FEMS Microbiol. Lett. 16(), 1983

Yeh, 1994

Cantwell, Proc. R. Soc. London 248(), 1992
Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity.
Crawford L, Stepan AM, McAda PC, Rambosek JA, Conder MJ, Vinci VA, Reeves CD., Biotechnology (N.Y.) 13(1), 1995
PMID: 9634750
Biosynthesis of aklavinone and aclacinomycins.
Kitamura I, Tobe H, Yoshimoto A, Oki T, Naganawa H, Takeuchi T, Umezawa H., J. Antibiot. 34(11), 1981
PMID: 7319911
[Studies on the metabolism of aclacinomycin A (author's transl)].
Oki T, Shibamoto N, Iguchi H, Shirai M., Jpn J Antibiot 33(2), 1980
PMID: 6768910

Ollis, Proc. Chem. Soc. (London) 347(), 1960

Casey, J. Org. Chem. 43(), 1978

Shen, J. Bacteriol. 171(), 1992

Cassinelli, J. Microbiol. 11(), 1963

D'bost, C.R. Acad. Sci. Agric. Belg. 257(), 1963

White, 1984

Acramone, caesius, Biotechnol. Bioeng. 11(), 1969
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.
Ye J, Dickens ML, Plater R, Li Y, Lawrence J, Strohl WR., J. Bacteriol. 176(20), 1994
PMID: 7928998

Niemi, Streptomyces galilaeus, J. Bacteriol. 77(), 1995

Colombo, Streptomyces peucetius, J. Bacteriol. 174(), 1992
Streptomyces peucetius daunorubicin biosynthesis gene, dnrF: sequence and heterologous expression.
Filippini S, Solinas MM, Breme U, Schluter MB, Gabellini D, Biamonti G, Colombo AL, Garofano L., Microbiology (Reading, Engl.) 141 ( Pt 4)(), 1995
PMID: 7773378

Blumaulerova, Streptomyces galilaeus, Folia Microbiol. 24(), 1979

Yoshimoto, Streptomyces coeruleorubidus, J. Antibiot. 33(), 1980

Mandell, 1980
CGP 4832, a new semisynthetic rifamycin derivative highly active against some gram-negative bacteria.
Wehrli W, Zimmermann W, Kump W, Tosch W, Vischer W, Zak O., J. Antibiot. 40(12), 1987
PMID: 2448280

Lancini, J. Antibiot. 12(), 1969

Kuzmina, Anti Khimioter 35(), 1990

Lysko, Antibiot. Med. Biotechnol. 31(), 1986

Chio, Biology of Actinomycetes (reprint) (), 1983

Chung, 1995
Microbial transformation of rifamycin B: a new synthetic approach to rifamycin derivatives.
Seong BL, Son HJ, Mheen TI, Han MH., J. Antibiot. 36(10), 1983
PMID: 6685721

Taguchi, Chem. Pharm. Bull. 33(), 1985
Genetic recombination in Nocardia mediterranei.
Schupp T, Hutter R, Hopwood DA., J. Bacteriol. 121(1), 1975
PMID: 1116983

Madon, Nocardia mediterranei, Mol. Gen. Genet. 209(), 1987

Moretii, Nocardia mediterranei, Plasmid 14(), 1985

Vrijbloed, J. Bacteriol. 76(), 1994

Kumar, TIBTECH 9(), 1991

Birch, Streptomyces glaucescens, Mol. Gen. Genet. 217(), 1989

Hütter, 1988

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