Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline

Hanemaaijer R, Sorsa T, Konttinen YT, Ding YL, Sutinen M, Visser H, vanHinsbergh VWM, Helaakoski T, Kainulainen T, Ronka H, Tschesche H, et al. (1997)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Hanemaaijer, R; Sorsa, T; Konttinen, YT; Ding, YL; Sutinen, M; Visser, H; vanHinsbergh, VWM; Helaakoski, T; Kainulainen, T; Ronka, H; Tschesche, HaraldUniBi; Salo, T
Abstract / Bemerkung
Neutrophil collagenase (matrix metalloproteinase-8 or MMP-8) is regarded as being synthesized exclusively by polymorphonuclear neutrophils (PMN). However, in vivo MMP-8 expression was observed in mononuclear fibroblast-like cells in the rheumatoid synovial membrane. In addition, we detected MMP-8 mRNA expression in cultured rheumatoid synovial fibroblasts and human endothelial cells. Up-regulation of MMP-8 was observed after treatment of the cells with either tumor necrosis factor-alpha (10 ng/ml) or phorbol 12-myristate 13-acetate (10 nM). Western analysis showed a similar regulation at the protein level. The size of secreted MMP-8 was 50 kDa, which is about 30 kDa smaller than MMP-8 from PMN. Conditioned media from rheumatoid synovial fibroblasts contained both type I and II collagen degrading activity. However, degradation of type II collagen, but not that of type I collagen, was completely inhibited by 50 mu M doxycycline, suggesting specific MMP-8 activity. In addition, doxycycline down-regulated MMP-8 induction, at both the mRNA and protein levels. Thus MMP-8 exerts markedly wider expression in human cells than had been thought previously, implying that PMN are not the only source of cartilage degrading activity at arthritic sites. The inhibition of both MMP-8 activity and synthesis by doxycycline provides an incentive for further studies on the clinical effects of doxycycline in the treatment of rheumatoid arthritis.
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Hanemaaijer R, Sorsa T, Konttinen YT, et al. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline. JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(50):31504-31509.
Hanemaaijer, R., Sorsa, T., Konttinen, Y. T., Ding, Y. L., Sutinen, M., Visser, H., vanHinsbergh, V. W. M., et al. (1997). Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(50), 31504-31509.
Hanemaaijer, R, Sorsa, T, Konttinen, YT, Ding, YL, Sutinen, M, Visser, H, vanHinsbergh, VWM, et al. 1997. “Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline”. JOURNAL OF BIOLOGICAL CHEMISTRY 272 (50): 31504-31509.
Hanemaaijer, R., Sorsa, T., Konttinen, Y. T., Ding, Y. L., Sutinen, M., Visser, H., vanHinsbergh, V. W. M., Helaakoski, T., Kainulainen, T., Ronka, H., et al. (1997). Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline. JOURNAL OF BIOLOGICAL CHEMISTRY 272, 31504-31509.
Hanemaaijer, R., et al., 1997. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(50), p 31504-31509.
R. Hanemaaijer, et al., “Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline”, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, 1997, pp. 31504-31509.
Hanemaaijer, R., Sorsa, T., Konttinen, Y.T., Ding, Y.L., Sutinen, M., Visser, H., vanHinsbergh, V.W.M., Helaakoski, T., Kainulainen, T., Ronka, H., Tschesche, H., Salo, T.: Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline. JOURNAL OF BIOLOGICAL CHEMISTRY. 272, 31504-31509 (1997).
Hanemaaijer, R, Sorsa, T, Konttinen, YT, Ding, YL, Sutinen, M, Visser, H, vanHinsbergh, VWM, Helaakoski, T, Kainulainen, T, Ronka, H, Tschesche, Harald, and Salo, T. “Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline”. JOURNAL OF BIOLOGICAL CHEMISTRY 272.50 (1997): 31504-31509.

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Tear fluid concentration of mmp-8 is elevated in non-allergic eosinophilic conjunctivitis and correlates with conjunctival inflammatory cell infiltration.
Kari O, Määttä M, Tervahartiala T, Peltonen S, Kari M, Hagström J, Sorsa T, Saari M, Haahtela T., Graefes Arch Clin Exp Ophthalmol 247(5), 2009
PMID: 19184080
Doxycycline inhibits the adhesion and migration of melanoma cells by inhibiting the expression and phosphorylation of focal adhesion kinase (FAK).
Sun T, Zhao N, Ni CS, Zhao XL, Zhang WZ, Su X, Zhang DF, Gu Q, Sun BC., Cancer Lett 285(2), 2009
PMID: 19482420
Role of tumor necrosis factor-alpha and matrix metalloproteinase-9 in blood-brain barrier disruption after peripheral thermal injury in rats.
Reyes R, Guo M, Swann K, Shetgeri SU, Sprague SM, Jimenez DF, Barone CM, Ding Y., J Neurosurg 110(6), 2009
PMID: 19199470
Healing of extraction sockets in collagenase-2 (matrix metalloproteinase-8)-deficient mice.
Korpi JT, Aström P, Lehtonen N, Tjäderhane L, Kallio-Pulkkinen S, Siponen M, Sorsa T, Pirilä E, Salo T., Eur J Oral Sci 117(3), 2009
PMID: 19583751
Placenta-derived fetal specific mRNA is more readily detectable in maternal plasma than in whole blood.
Heung MM, Jin S, Tsui NB, Ding C, Leung TY, Lau TK, Chiu RW, Lo YM., PLoS One 4(6), 2009
PMID: 19516908
Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.
Sabeh F, Li XY, Saunders TL, Rowe RG, Weiss SJ., J Biol Chem 284(34), 2009
PMID: 19542530
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Biyikoğlu B, Buduneli N, Kardeşler L, Aksu K, Pitkala M, Sorsa T., J Periodontol 80(8), 2009
PMID: 19656031
Factors affecting matrix metalloproteinase-8 levels in the vaginal and cervical fluids in the first and second trimester of pregnancy.
Rahkonen L, Rutanen EM, Unkila-Kallio L, Nuutila M, Nieminen P, Sorsa T, Paavonen J., Hum Reprod 24(11), 2009
PMID: 19654111
Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome.
Xiong W, Knispel RA, Dietz HC, Ramirez F, Baxter BT., J Vasc Surg 47(1), 2008
PMID: 18178469
Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy.
Lauhio A, Sorsa T, Srinivas R, Stenman M, Tervahartiala T, Stenman UH, Grönhagen-Riska C, Honkanen E., Ann Med 40(4), 2008
PMID: 18428024
Matrix metalloproteinase control of capillary morphogenesis.
Ghajar CM, George SC, Putnam AJ., Crit Rev Eukaryot Gene Expr 18(3), 2008
PMID: 18540825
Experimental tooth pain elevates substance P and matrix metalloproteinase-8 levels in human gingival crevice fluid.
Avellán NL, Sorsa T, Tervahartiala T, Forster C, Kemppainen P., Acta Odontol Scand 66(1), 2008
PMID: 18320414
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Korpi JT, Kervinen V, Mäklin H, Väänänen A, Lahtinen M, Läärä E, Ristimäki A, Thomas G, Ylipalosaari M, Aström P, Lopez-Otin C, Sorsa T, Kantola S, Pirilä E, Salo T., Br J Cancer 98(4), 2008
PMID: 18253113
Relaxation of the mouse pubic symphysis during late pregnancy is not accompanied by the influx of granulocytes.
Rosa RG, Tarsitano CA, Hyslop S, Yamada AT, Toledo OM, Joazeiro PP., Microsc Res Tech 71(3), 2008
PMID: 18044701
Elevated expression and activation of matrix metalloproteinase 8 in tear fluid in atopic blepharoconjunctivitis.
Määttä M, Kari O, Tervahartiala T, Wahlgren J, Peltonen S, Kari M, Rytilä P, Saari M, Sorsa T., Cornea 27(3), 2008
PMID: 18362656
Matrix metalloproteinases and bone.
Krane SM, Inada M., Bone 43(1), 2008
PMID: 18486584
Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma.
Vihinen P, Koskivuo I, Syrjänen K, Tervahartiala T, Sorsa T, Pyrhönen S., Melanoma Res 18(4), 2008
PMID: 18626311
The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts.
Laragione T, Brenner M, Mello A, Symons M, Gulko PS., Arthritis Rheum 58(8), 2008
PMID: 18668563
Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature.
Laragione T, Brenner M, Li W, Gulko PS., Arthritis Res Ther 10(4), 2008
PMID: 18706093
The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis.
Vardar-Sengul S, Buduneli E, Turkoglu O, Buduneli N, Atilla G, Wahlgren J, Sorsa T, Baylas H., J Periodontol 79(10), 2008
PMID: 18834249
Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin.
Sulkala M, Tervahartiala T, Sorsa T, Larmas M, Salo T, Tjäderhane L., Arch Oral Biol 52(2), 2007
PMID: 17045563
Matrix metalloproteinases in inflammatory bowel disease: boon or a bane?
Ravi A, Garg P, Sitaraman SV., Inflamm Bowel Dis 13(1), 2007
PMID: 17206645
Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies.
Pirilä E, Korpi JT, Korkiamäki T, Jahkola T, Gutierrez-Fernandez A, Lopez-Otin C, Saarialho-Kere U, Salo T, Sorsa T., Wound Repair Regen 15(1), 2007
PMID: 17244319
Matrix metalloproteinases -8, -9 and -12 in smokers and patients with stage 0 COPD.
Ilumets H, Rytilä P, Demedts I, Brusselle GG, Sovijärvi A, Myllärniemi M, Sorsa T, Kinnula VL., Int J Chron Obstruct Pulmon Dis 2(3), 2007
PMID: 18229576
Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases.
Vidal A, Sabatini M, Rolland-Valognes G, Renard P, Madelmont JC, Mounetou E., Bioorg Med Chem 15(6), 2007
PMID: 17267227
Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis.
Hästbacka J, Hynninen M, Kolho E, Pettilä V, Tervahartiala T, Sorsa T, Lauhio A., Shock 27(2), 2007
PMID: 17224788
Evaluation of immunoassay-based MMP-8 detection in gingival crevicular fluid on a point-of-care platform.
Munjal SK, Prescher N, Struck F, Sorsa T, Maier K, Netuschil L., Ann N Y Acad Sci 1098(), 2007
PMID: 17435156
Influence of early neutrophil depletion on MMPs/TIMP-1 balance in bleomycin-induced lung fibrosis.
Manoury B, Manoury B, Nénan S, Guénon I, Lagente V, Boichot E., Int Immunopharmacol 7(7), 2007
PMID: 17499192
MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis.
Beklen A, Ainola M, Hukkanen M, Gürgan C, Sorsa T, Konttinen YT., J Dent Res 86(4), 2007
PMID: 17384030
Metalloproteinase function in chronic rhinosinusitis with nasal polyposis.
Kostamo K, Tervahartiala T, Sorsa T, Richardson M, Toskala E., Laryngoscope 117(4), 2007
PMID: 17429873
Pathogenesis of endometriosis: the role of defective 'immunosurveillance'.
Christodoulakos G, Augoulea A, Lambrinoudaki I, Sioulas V, Creatsas G., Eur J Contracept Reprod Health Care 12(3), 2007
PMID: 17763257
Gingival tissue and crevicular fluid co-operation in adult periodontitis.
Beklen A, Tüter G, Sorsa T, Hanemaaijer R, Virtanen I, Tervahartiala T, Konttinen YT., J Dent Res 85(1), 2006
PMID: 16373682
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.
Sorsa T, Tjäderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mäntylä P., Ann Med 38(5), 2006
PMID: 16938801
Tear fluid levels of MMP-8 are elevated in ocular rosacea--treatment effect of oral doxycycline.
Määttä M, Kari O, Tervahartiala T, Peltonen S, Kari M, Saari M, Sorsa T., Graefes Arch Clin Exp Ophthalmol 244(8), 2006
PMID: 16411105
Capsaicin-induced local elevations in collagenase-2 (matrix metalloproteinase-8) levels in human gingival crevice fluid.
Avellan NL, Kemppainen P, Tervahartiala T, Vilppola P, Forster C, Sorsa T., J Periodontal Res 41(1), 2006
PMID: 16409253
Tetracyclines: nonantibiotic properties and their clinical implications.
Sapadin AN, Fleischmajer R., J Am Acad Dermatol 54(2), 2006
PMID: 16443056
Gingival crevicular fluid matrix metalloproteinase-25 and -26 levels in periodontal disease.
Emingil G, Kuula H, Sorsa T, Atilla G., J Periodontol 77(4), 2006
PMID: 16584348
EMMPRIN and MMP-1 in keratoconus.
Seppälä HP, Määttä M, Rautia M, Mackiewicz Z, Tuisku I, Tervo T, Konttinen YT., Cornea 25(3), 2006
PMID: 16633034
Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides.
Heikkilä P, Suojanen J, Pirilä E, Väänänen A, Koivunen E, Sorsa T, Salo T., Int J Cancer 118(9), 2006
PMID: 16331606
Characterization of the protease activity that cleaves the extracellular domain of beta-dystroglycan.
Zhong D, Saito F, Saito Y, Nakamura A, Shimizu T, Matsumura K., Biochem Biophys Res Commun 345(2), 2006
PMID: 16701552
Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children.
Lindberg RL, Sorsa T, Tervahartiala T, Hoffmann F, Mellanen L, Kappos L, Schaad UB, Leib SL, Leppert D., Neuropathol Appl Neurobiol 32(3), 2006
PMID: 16640649
Collagenolytic proteinases in keratoconus.
Mackiewicz Z, Määttä M, Stenman M, Konttinen L, Tervo T, Konttinen YT., Cornea 25(5), 2006
PMID: 16783151
Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma.
Määttä M, Tervahartiala T, Vesti E, Airaksinen J, Sorsa T., J Glaucoma 15(3), 2006
PMID: 16778646
Vaginal matrix metalloproteinase levels in pregnant women with bacterial vaginosis.
Diaz-Cueto L, Cuica-Flores A, Ziga-Cordero F, Ayala-Mendez JA, Tena-Alavez G, Dominguez-Lopez P, Cuevas-Antonio R, Arechavaleta-Velasco F., J Soc Gynecol Investig 13(6), 2006
PMID: 16872847
Up-regulation of trypsin and mesenchymal MMP-8 during development of hyperoxic lung injury in the rat.
Cederqvist K, Janer J, Tervahartiala T, Sorsa T, Haglund C, Salmenkivi K, Stenman UH, Andersson S., Pediatr Res 60(4), 2006
PMID: 16940237
Increased collagen degradation around loosened total hip replacement implants.
Ma GF, Ali A, Verzijl N, Hanemaaijer R, TeKoppele J, Konttinen YT, Salo J., Arthritis Rheum 54(9), 2006
PMID: 16948130
Salivary matrix metalloproteinase-8 in patients with and without coronary heart disease may indicate an increased susceptibility to periodontal disease.
Furuholm J, Sorsa T, Qvarnström M, Janket SJ, Tervahartiala T, Nuutinen P, Meurman JH., J Periodontal Res 41(5), 2006
PMID: 16953826
Matrix metalloproteinase-7, -8, -9, -25, and -26 and CD43, -45, and -68 cell-markers in HIV-infected patients' saliva and gingival tissue.
Mellanen L, Lähdevirta J, Tervahartiala T, Meurman JH, Sorsa T., J Oral Pathol Med 35(9), 2006
PMID: 16968233
Collagenase and surgical disease.
Donahue TR, Hiatt JR, Busuttil RW., Hernia 10(6), 2006
PMID: 16977344
Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test.
Mäntylä P, Stenman M, Kinane D, Salo T, Suomalainen K, Tikanoja S, Sorsa T., J Periodontal Res 41(6), 2006
PMID: 17076774
MMP-3 and -8 expression is found in the condylar surface of temporomandibular joints with internal derangement.
Tiilikainen P, Pirttiniemi P, Kainulainen T, Pernu H, Raustia A., J Oral Pathol Med 34(1), 2005
PMID: 15610405
Human neutrophil collagenase expression is C/EBP-dependent during myeloid development.
Khanna-Gupta A, Zibello T, Idone V, Sun H, Lekstrom-Himes J, Berliner N., Exp Hematol 33(1), 2005
PMID: 15661397
Collagenases in cancer.
Ala-aho R, Kähäri VM., Biochimie 87(3-4), 2005
PMID: 15781314
Painful tooth stimulation elevates matrix metalloproteinase-8 levels locally in human gingival crevicular fluid.
Avellan NL, Sorsa T, Tervahartiala T, Mäntylä P, Forster C, Kemppainen P., J Dent Res 84(4), 2005
PMID: 15790739
Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases.
Heljasvaara R, Nyberg P, Luostarinen J, Parikka M, Heikkilä P, Rehn M, Sorsa T, Salo T, Pihlajaniemi T., Exp Cell Res 307(2), 2005
PMID: 15950618
Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity.
Harty MW, Huddleston HM, Papa EF, Puthawala T, Tracy AP, Ramm GA, Gehring S, Gregory SH, Tracy TF., Surgery 138(2), 2005
PMID: 16153442
A review of biological factors implicated in abdominal aortic aneurysm rupture.
Choke E, Cockerill G, Wilson WR, Sayed S, Dawson J, Loftus I, Thompson MM., Eur J Vasc Endovasc Surg 30(3), 2005
PMID: 15893484
Effect of E. faecalis on the release of serine proteases elastase and cathepsin G, and collagenase-2 (MMP-8) by human polymorphonuclear leukocytes (PMNs).
Reynaud af Geijersstam A, Sorsa T, Stackelberg S, Tervahartiala T, Haapasalo M., Int Endod J 38(9), 2005
PMID: 16104981
Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases.
Parikka V, Väänänen A, Risteli J, Salo T, Sorsa T, Väänänen HK, Lehenkari P., Matrix Biol 24(6), 2005
PMID: 16098718
In vivo relationship between collagenase-2 and interleukin-8 but not tumour necrosis factor-alpha in chronic rhinosinusitis with nasal polyposis.
Kostamo K, Sorsa T, Leino M, Tervahartiala T, Alenius H, Richardson M, Toskala E., Allergy 60(10), 2005
PMID: 16134994
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue.
Stenman M, Ainola M, Valmu L, Bjartell A, Ma G, Stenman UH, Sorsa T, Luukkainen R, Konttinen YT., Am J Pathol 167(4), 2005
PMID: 16192646
Levels of matrix metalloproteinase-2, -9 and -8 in the skin, serum and saliva of smokers and non-smokers.
Raitio A, Tuomas H, Kokkonen N, Salo T, Sorsa T, Hanemaaijer R, Oikarinen A., Arch Dermatol Res 297(6), 2005
PMID: 16215764
Role of TNF-alpha and its receptors in pericoronitis.
Beklen A, Laine M, Ventä I, Hyrkäs T, Konttinen YT., J Dent Res 84(12), 2005
PMID: 16304450
Antiinflammatory therapy for dry eye.
Pflugfelder SC., Am J Ophthalmol 137(2), 2004
PMID: 14962426
Matrix metalloproteinase-8 is expressed in human chorion during labor.
Arechavaleta-Velasco F, Marciano D, Díaz-Cueto L, Parry S., Am J Obstet Gynecol 190(3), 2004
PMID: 15042023
Doxycycline-a role in ocular surface repair.
Smith VA, Cook SD., Br J Ophthalmol 88(5), 2004
PMID: 15090411
Advances in periodontal disease markers.
Ozmeric N., Clin Chim Acta 343(1-2), 2004
PMID: 15115674
Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM).
Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF., Hum Mol Genet 13(21), 2004
PMID: 15367487
Matrix metalloproteinases (MMPs) in oral diseases.
Sorsa T, Tjäderhane L, Salo T., Oral Dis 10(6), 2004
PMID: 15533204
Expression of matrix metalloproteinases in patients with Wegener's granulomatosis.
Bjerkeli V, Halvorsen B, Damås JK, Nordøy I, Yndestad A, Aukrust P, Frøland SS., Ann Rheum Dis 63(12), 2004
PMID: 15547092
Alterations of gene expression in human neutrophils induced by smoking cessation.
Morozumi T, Kubota T, Sugita N, Itagaki M, Yoshie H., J Clin Periodontol 31(12), 2004
PMID: 15560814
Implications for matrix metalloproteinases as modulators of pediatric lung disease.
Winkler MK, Foldes JK, Bunn RC, Fowlkes JL., Am J Physiol Lung Cell Mol Physiol 284(4), 2003
PMID: 12456387
Metalloproteinases: their role in arthritis and potential as therapeutic targets.
Clark IM, Parker AE., Expert Opin Ther Targets 7(1), 2003
PMID: 12556200
Laminin-5 gamma2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid.
Kivelä-Rajamäki MJ, Teronen OP, Maisi P, Husa V, Tervahartiala TI, Pirilä EM, Salo TA, Mellanen L, Sorsa TA., Clin Oral Implants Res 14(2), 2003
PMID: 12656874
Matrix metalloproteinases process the laminin-5 gamma 2-chain and regulate epithelial cell migration.
Pirilä E, Sharabi A, Salo T, Quaranta V, Tu H, Heljasvaara R, Koshikawa N, Sorsa T, Maisi P., Biochem Biophys Res Commun 303(4), 2003
PMID: 12684035
Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium.
Goffin F, Munaut C, Frankenne F, Perrier D'Hauterive S, Béliard A, Fridman V, Nervo P, Colige A, Foidart JM., Biol Reprod 69(3), 2003
PMID: 12773401
Vascular expression of matrix metalloproteinase-13 (collagenase-3) in basal cell carcinoma.
Hattori Y, Nerusu KC, Bhagavathula N, Brennan M, Hattori N, Murphy HS, Su LD, Wang TS, Johnson TM, Varani J., Exp Mol Pathol 74(3), 2003
PMID: 12782009
Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance.
Kinane DF, Darby IB, Said S, Luoto H, Sorsa T, Tikanoja S, Mäntylä P., J Periodontal Res 38(4), 2003
PMID: 12828657
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis.
Mäntylä P, Stenman M, Kinane DF, Tikanoja S, Luoto H, Salo T, Sorsa T., J Periodontal Res 38(4), 2003
PMID: 12828663
A nonantibiotic chemically modified tetracycline (CMT-3) inhibits intimal thickening.
Islam MM, Franco CD, Courtman DW, Bendeck MP., Am J Pathol 163(4), 2003
PMID: 14507662
Cytokine-regulated expression of collagenase-2 (MMP-8) is involved in the progression of ovarian cancer.
Stadlmann S, Pollheimer J, Moser PL, Raggi A, Amberger A, Margreiter R, Offner FA, Mikuz G, Dirnhofer S, Moch H., Eur J Cancer 39(17), 2003
PMID: 14602136
Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives.
Grenier D, Plamondon P, Sorsa T, Lee HM, McNamara T, Ramamurthy NS, Golub LM, Teronen O, Mayrand D., J Periodontol 73(1), 2002
PMID: 11846203
Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 gamma2-chain.
Pirilä E, Parikka M, Ramamurthy NS, Maisi P, McClain S, Kucine A, Tervahartiala T, Prikk K, Golub LM, Salo T, Sorsa T., Wound Repair Regen 10(1), 2002
PMID: 11983005
Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy.
Moon JB, Kim JC, Yoon BH, Romero R, Kim G, Oh SY, Kim M, Shim SS., J Perinat Med 30(4), 2002
PMID: 12235718
Abdominal aortic aneurysms: basic mechanisms and clinical implications.
Thompson RW, Geraghty PJ, Lee JK., Curr Probl Surg 39(2), 2002
PMID: 11884965
Gene expression of MMP8 and MMP13 during embryonic development of bone and cartilage in the rat mandible and hind limb.
Sasano Y, Zhu JX, Tsubota M, Takahashi I, Onodera K, Mizoguchi I, Kagayama M., J Histochem Cytochem 50(3), 2002
PMID: 11850435
Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury.
Bendeck MP, Conte M, Zhang M, Nili N, Strauss BH, Farwell SM., Am J Pathol 160(3), 2002
PMID: 11891205
Smoking affects collagen synthesis and extracellular matrix turnover in human skin.
Knuutinen A, Kokkonen N, Risteli J, Vähäkangas K, Kallioinen M, Salo T, Sorsa T, Oikarinen A., Br J Dermatol 146(4), 2002
PMID: 11966688
Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas.
Moilanen M, Pirilä E, Grénman R, Sorsa T, Salo T., J Pathol 197(1), 2002
PMID: 12081207
Matrix metalloproteinases in arthritic disease.
Murphy G, Knäuper V, Atkinson S, Butler G, English W, Hutton M, Stracke J, Clark I., Arthritis Res 4 Suppl 3(), 2002
PMID: 12110122
Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines.
Ramamurthy NS, Rifkin BR, Greenwald RA, Xu JW, Liu Y, Turner G, Golub LM, Vernillo AT., J Periodontol 73(7), 2002
PMID: 12146531
Expression of MMP-8 and MMP-13 mRNAs in rat periodontium during tooth eruption.
Tsubota M, Sasano Y, Takahashi I, Kagayama M, Shimauchi H., J Dent Res 81(10), 2002
PMID: 12351664
MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?
Müller-Ladner U, Gay S., Ann Rheum Dis 61(11), 2002
PMID: 12379515
Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10.
Tolboom TC, Pieterman E, van der Laan WH, Toes RE, Huidekoper AL, Nelissen RG, Breedveld FC, Huizinga TW., Ann Rheum Dis 61(11), 2002
PMID: 12379519
Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates.
Wahlgren J, Salo T, Teronen O, Luoto H, Sorsa T, Tjäderhane L., Int Endod J 35(11), 2002
PMID: 12453017
The role of matrix metalloproteinases in rheumatoid tendon disease.
Jain A, Brennan F, Troeberg L, Nanchahal J., J Hand Surg Am 27(6), 2002
PMID: 12457358
Collagenolytic activity in bronchoalveolar lavage fluid in canine pulmonary eosinophilia.
Rajamäki MM, Järvinen AK, Sorsa T, Maisi P., J Vet Intern Med 16(6), 2002
PMID: 12465761
Matrix metalloproteinases and TIMP-1 production by peripheral blood granulocytes from COPD patients and asthmatics.
Cataldo D, Munaut C, Noël A, Frankenne F, Bartsch P, Foidart JM, Louis R., Allergy 56(2), 2001
PMID: 11167375
Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease.
Sweet DG, McMahon KJ, Curley AE, O'Connor CM, Halliday HL., Arch Dis Child Fetal Neonatal Ed 84(3), 2001
PMID: 11320042
Matrix metalloproteinases in mild and severe temporomandibular joint internal derangement synovial fluid.
Srinivas R, Sorsa T, Tjäderhane L, Niemi E, Raustia A, Pernu H, Teronen O, Salo T., Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91(5), 2001
PMID: 11346728
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
Wahlgren J, Maisi P, Sorsa T, Sutinen M, Tervahartiala T, Pirilä E, Teronen O, Hietanen J, Tjäderhane L, Salo T., J Pathol 194(2), 2001
PMID: 11400151
In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis.
Prikk K, Maisi P, Pirilä E, Sepper R, Salo T, Wahlgren J, Sorsa T., J Pathol 194(2), 2001
PMID: 11400153
Host metalloproteinases in Lyme arthritis.
Hu LT, Eskildsen MA, Masgala C, Steere AC, Arner EC, Pratta MA, Grodzinsky AJ, Loening A, Perides G., Arthritis Rheum 44(6), 2001
PMID: 11407701
Tumor necrosis factor-alpha and its receptors, p55 and p75, in gingiva of adult periodontitis.
Tervahartiala T, Koski H, Xu JW, Häyrinen-Immonen R, Hietanen J, Sorsa T, Konttinen YT., J Dent Res 80(6), 2001
PMID: 11499508
Vascular smooth muscle cells and pericytes express MMP-1, MMP-9, TIMP-1 and type I procollagen in inflammatory bowel disease.
Arihiro S, Ohtani H, Hiwatashi N, Torii A, Sorsa T, Nagura H., Histopathology 39(1), 2001
PMID: 11454044
Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo.
Fisher GJ, Choi HC, Bata-Csorgo Z, Shao Y, Datta S, Wang ZQ, Kang S, Voorhees JJ., J Invest Dermatol 117(2), 2001
PMID: 11511297
Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling.
Herman MP, Sukhova GK, Libby P, Gerdes N, Tang N, Horton DB, Kilbride M, Breitbart RE, Chun M, Schönbeck U., Circulation 104(16), 2001
PMID: 11602491
Expression and regulation of MMP-20 in human tongue carcinoma cells.
Väänänen A, Srinivas R, Parikka M, Palosaari H, Bartlett JD, Iwata K, Grenman R, Stenman UH, Sorsa T, Salo T., J Dent Res 80(10), 2001
PMID: 11706946
The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis.
Park JS, Romero R, Yoon BH, Moon JB, Oh SY, Han SY, Ko EM., Am J Obstet Gynecol 185(5), 2001
PMID: 11717650
Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor alpha transgenic mice.
Schett G, Hayer S, Tohidast-Akrad M, Schmid BJ, Lang S, Türk B, Kainberger F, Haralambous S, Kollias G, Newby AC, Xu Q, Steiner G, Smolen J., Arthritis Rheum 44(12), 2001
PMID: 11762950
The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1.
Palosaari H, Wahlgren J, Larmas M, Rönkä H, Sorsa T, Salo T, Tjäderhane L., J Dent Res 79(1), 2000
PMID: 10690664
Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms.
Curci JA, Mao D, Bohner DG, Allen BT, Rubin BG, Reilly JM, Sicard GA, Thompson RW., J Vasc Surg 31(2), 2000
PMID: 10664501
Collagenolytic and gelatinolytic matrix metalloproteinases and their inhibitors in basal cell carcinoma of skin: comparison with normal skin.
Varani J, Hattori Y, Chi Y, Schmidt T, Perone P, Zeigler ME, Fader DJ, Johnson TM., Br J Cancer 82(3), 2000
PMID: 10682680
Inhibition of human gingival gelatinases (MMP-2 and MMP-9) by metal salts.
de Souza AP, Gerlach RF, Line SR., Dent Mater 16(2), 2000
PMID: 11203530
Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration.
Lukkonen A, Sorsa T, Salo T, Tervahartiala T, Koivunen E, Golub L, Simon S, Stenman UH., Int J Cancer 86(4), 2000
PMID: 10797274
Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and -13 and of TIMP-1.
Bachmeier BE, Nerlich AG, Boukamp P, Lichtinghagen R, Tschesche H, Fritz H, Fink E., Biol Chem 381(5-6), 2000
PMID: 10937883
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis.
Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K, Okada Y., Ann Rheum Dis 59(6), 2000
PMID: 10834863
Fibroblast biology. Signals targeting the synovial fibroblast in arthritis.
Konttinen YT, Li TF, Hukkanen M, Ma J, Xu JW, Virtanen I., Arthritis Res 2(5), 2000
PMID: 11094447
Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagen.
Siller-López F, García-Bañuelos J, Hasty KA, Segura J, Ramos-Márquez M, Qoronfleh MW, Aguilar-Cordova E, Armendáriz-Borunda J., J Hepatol 33(5), 2000
PMID: 11097484
Collagenases in different categories of peri-implant vertical bone loss.
Ma J, Kitti U, Teronen O, Sorsa T, Husa V, Laine P, Rönkä H, Salo T, Lindqvist C, Konttinen YT., J Dent Res 79(11), 2000
PMID: 11145357
Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints.
Takei I, Takagi M, Santavirta S, Ida H, Ishii M, Ogino T, Ainola M, Konttinen YT., J Biomed Mater Res 52(4), 2000
PMID: 11033543
Suppression of adjuvant arthritis of rats by a novel matrix metalloproteinase-inhibitor.
Hamada T, Arima N, Shindo M, Sugama K, Sasaguri Y., Br J Pharmacol 131(8), 2000
PMID: 11139426
The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis.
Tervahartiala T, Pirilä E, Ceponis A, Maisi P, Salo T, Tuter G, Kallio P, Törnwall J, Srinivas R, Konttinen YT, Sorsa T., J Dent Res 79(12), 2000
PMID: 11201047
Matrix metalloproteinases and their inhibitors in tumour growth and invasion.
Kähäri VM, Saarialho-Kere U., Ann Med 31(1), 1999
PMID: 10219712
Regulation of matrix metalloproteinase expression in tumor invasion.
Westermarck J, Kähäri VM., FASEB J 13(8), 1999
PMID: 10224222
Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine.
Gendron R, Grenier D, Sorsa T, Mayrand D., Clin Diagn Lab Immunol 6(3), 1999
PMID: 10225852
Activation of neutrophil collagenase in periodontitis.
Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA., Infect Immun 67(5), 1999
PMID: 10225890
Signaling and effector pathways.
Müller-Ladner U, Gay RE, Gay S., Curr Opin Rheumatol 11(3), 1999
PMID: 10328579
Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema.
Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Venge P, Xu S, Kawakami Y., Am J Respir Crit Care Med 159(6), 1999
PMID: 10351949
Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease.
Sorsa T, Mäntylä P, Rönkä H, Kallio P, Kallis GB, Lundqvist C, Kinane DF, Salo T, Golub LM, Teronen O, Tikanoja S., Ann N Y Acad Sci 878(), 1999
PMID: 10415725
MMP-9 activity in urine from patients with various tumors, as measured by a novel MMP activity assay using modified urokinase as a substrate.
Hanemaaijer R, Sier CF, Visser H, Scholte L, van Lent N, Toet K, Hoekman K, Verheijen JH., Ann N Y Acad Sci 878(), 1999
PMID: 10415726
MMP inhibition and downregulation by bisphosphonates.
Teronen O, Heikkilä P, Konttinen YT, Laitinen M, Salo T, Hanemaaijer R, Teronen A, Maisi P, Sorsa T., Ann N Y Acad Sci 878(), 1999
PMID: 10415748
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Westhoff CS, Freudiger D, Petrow P, Seyfert C, Zacher J, Kriegsmann J, Pap T, Gay S, Stiehl P, Gromnica-Ihle E, Wernicke D., Arthritis Rheum 42(7), 1999
PMID: 10403281
Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes.
Mäkelä M, Larjava H, Pirilä E, Maisi P, Salo T, Sorsa T, Uitto VJ., Exp Cell Res 251(1), 1999
PMID: 10438572
Expression of collagenase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture.
Mao D, Lee JK, VanVickle SJ, Thompson RW., Biochem Biophys Res Commun 261(3), 1999
PMID: 10441523
Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate.
Konttinen YT, Salo T, Hanemaaijer R, Valleala H, Sorsa T, Sutinen M, Ceponis A, Xu JW, Santavirta S, Teronen O, López-Otín C., Matrix Biol 18(4), 1999
PMID: 10517187
Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis.
Konttinen YT, Ainola M, Valleala H, Ma J, Ida H, Mandelin J, Kinne RW, Santavirta S, Sorsa T, López-Otín C, Takagi M., Ann Rheum Dis 58(11), 1999
PMID: 10531073
The association between smoking cessation and periodontal status and salivary proteinase levels.
Liede KE, Haukka JK, Hietanen JH, Mattila MH, Rönkä H, Sorsa T., J Periodontol 70(11), 1999
PMID: 10588500
The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions.
Tjäderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T., J Dent Res 77(8), 1998
PMID: 9719036
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Levin JI, DiJoseph JF, Killar LM, Sung A, Walter T, Sharr MA, Roth CE, Skotnicki JS, Albright JD., Bioorg Med Chem Lett 8(19), 1998
PMID: 9873598
Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells.
Hanemaaijer R, Visser H, Koolwijk P, Sorsa T, Salo T, Golub LM, van Hinsbergh VW., Adv Dent Res 12(2), 1998
PMID: 9972133
The effects of chemically modified tetracyclines (CMTs) on human keratinocyte proliferation and migration.
Mäkelä M, Sorsa T, Uitto VJ, Salo T, Teronen O, Larjava H., Adv Dent Res 12(2), 1998
PMID: 9972137

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