DIALIGN: finding local similarities by multiple sequence alignment

Morgenstern B, Frech K, Dress A, Werner T (1998)
Bioinformatics 14(3): 290-294.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Morgenstern, Burkhard; Frech, Kornelie; Dress, AndreasUniBi; Werner, Thomas
Abstract / Bemerkung
Motivation: DIALIGN is a new method for pairwise as Well as multiple alignment oSlzucleic acid and protein sequences. While standard alignment programs rely on comparing single residues and imposing gap penalties, DIALIGN constructs alignments by comparing whole segments of the sequences. No gap penalty is employed. This point of view is especially adequate if sequences ai-e not globally related, bur share only local similarities, as is the case in genomic DNA sequences and in many protein families. Results: Using four different data sers, we show that DIALICN is able correctly to align conserved motifs in protein sequences. Alignments produced by DIALIGN are compared systematically to the results of five other alignment programs.
Erscheinungsjahr
1998
Zeitschriftentitel
Bioinformatics
Band
14
Ausgabe
3
Seite(n)
290-294
ISSN
1367-4803
Page URI
https://pub.uni-bielefeld.de/record/1625411

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Morgenstern B, Frech K, Dress A, Werner T. DIALIGN: finding local similarities by multiple sequence alignment. Bioinformatics. 1998;14(3):290-294.
Morgenstern, B., Frech, K., Dress, A., & Werner, T. (1998). DIALIGN: finding local similarities by multiple sequence alignment. Bioinformatics, 14(3), 290-294. https://doi.org/10.1093/bioinformatics/14.3.290
Morgenstern, B., Frech, K., Dress, A., and Werner, T. (1998). DIALIGN: finding local similarities by multiple sequence alignment. Bioinformatics 14, 290-294.
Morgenstern, B., et al., 1998. DIALIGN: finding local similarities by multiple sequence alignment. Bioinformatics, 14(3), p 290-294.
B. Morgenstern, et al., “DIALIGN: finding local similarities by multiple sequence alignment”, Bioinformatics, vol. 14, 1998, pp. 290-294.
Morgenstern, B., Frech, K., Dress, A., Werner, T.: DIALIGN: finding local similarities by multiple sequence alignment. Bioinformatics. 14, 290-294 (1998).
Morgenstern, Burkhard, Frech, Kornelie, Dress, Andreas, and Werner, Thomas. “DIALIGN: finding local similarities by multiple sequence alignment”. Bioinformatics 14.3 (1998): 290-294.

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