Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases

Krumme D, Wenzel H, Tschesche H (1998)
FEBS LETTERS 436(2): 209-212.

Zeitschriftenaufsatz | Veröffentlicht| Englisch
 
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Abstract / Bemerkung
Novel peptides containing the sequence -Pro-Leu-Ama(NHOH)- were synthesized and characterized by spectroscopic techniques. Their inhibitory properties towards the activated form of native human gelatinase B (MMP-9) and the catalytic domain of neutrophil collagenase (cdMMP-8) were determined. The most effective inhibitor synthesized exhibits K-i values of 2 x 10(-6) Il I (cdMMP-8) and 5 x 10(-9) RI (MMP-9) thus attaining interesting discrimination between the tested metalloproteinases. A most important feature of this type of inhibitor is its peptide nature making the compounds similar to natural substrates. In spite of the peptide character of the inhibitors synthesized, the P-1-P-1'-peptide bond shows a high resistance to cleavage by the proteinases. (C) 1998 Federation of European Biochemical Societies.
Stichworte
aminomalonic acid; peptide inhibitor; matrix metalloproteinase; inhibition; hydroxamate
Erscheinungsjahr
1998
Zeitschriftentitel
FEBS LETTERS
Band
436
Ausgabe
2
Seite(n)
209-212
ISSN
0014-5793
Page URI
https://pub.uni-bielefeld.de/record/1624672

Zitieren

Krumme D, Wenzel H, Tschesche H. Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases. FEBS LETTERS. 1998;436(2):209-212.
Krumme, D., Wenzel, H., & Tschesche, H. (1998). Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases. FEBS LETTERS, 436(2), 209-212. doi:10.1016/S0014-5793(98)01128-4
Krumme, D., Wenzel, H., and Tschesche, H. (1998). Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases. FEBS LETTERS 436, 209-212.
Krumme, D., Wenzel, H., & Tschesche, H., 1998. Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases. FEBS LETTERS, 436(2), p 209-212.
D. Krumme, H. Wenzel, and H. Tschesche, “Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases”, FEBS LETTERS, vol. 436, 1998, pp. 209-212.
Krumme, D., Wenzel, H., Tschesche, H.: Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases. FEBS LETTERS. 436, 209-212 (1998).
Krumme, D, Wenzel, Herbert, and Tschesche, Harald. “Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases”. FEBS LETTERS 436.2 (1998): 209-212.

11 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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