Genetics of oocyte ageing

Eichenlaub-Ritter U (1998)
MATURITAS 30(2): 143-169.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Objectives: Correlations between parental age, aneuploidy in germ cells and recent findings on aetiological factors in mammalian trisomy formation are reviewed. Methods: Data from observations in human oocytes: molecular studies on the origin of extra chromosomes in trisomies, experiments in a mouse model system, and transgenic approaches are shown. Results: Errors in chromosome segregation are most frequent in meiosis I of oogenesis in mammals and predominantly predispose specific chromosomes and susceptible chiasmate configurations to maternal age-related nondisjunction. Studies on spindle structure, cell cycle and chromosome behaviour in oocytes of the CBA/Ca mouse used as a model for the maternal age-effect suggest that hormonal homeostasis and size of the follicle pool influence the quality, maturation competence and spindle size of the mammalian oocyte. Predisposition to errors in chromosome segregation are critically dependent on altered cell cycles. Compromized protein synthesis and mitochondrial function affect maturation kinetics and spindle formation, and cause untimely segregation of chromosomes (predivision), mimicking an aged phenotype. Conclusions: Altered cell cycles and untimely resolution of chiasmata but also nondisjunction of late segregating homologues caused by asynchrony in cytoplasmic and nuclear maturation appear to be causal to errors in chromosome segregation with advanced maternal age. Oocytes appear to lack checkpoints guarding against untimely chromosome segregation. Genes and exposures affecting pool size. hormonal homeostasis and interactions between oocytes and their somatic compartment and thus quality of follicles and oocytes have the potential to critically influence chromosome distribution in female meiosis and affect fertility in humans and other mammals. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Stichworte
aneuploidy; aging; germ cells; oocyte; trisomy
Erscheinungsjahr
1998
Zeitschriftentitel
MATURITAS
Band
30
Ausgabe
2
Seite(n)
143-169
ISSN
0378-5122
Page URI
https://pub.uni-bielefeld.de/record/1623899

Zitieren

Eichenlaub-Ritter U. Genetics of oocyte ageing. MATURITAS. 1998;30(2):143-169.
Eichenlaub-Ritter, U. (1998). Genetics of oocyte ageing. MATURITAS, 30(2), 143-169. doi:10.1016/S0378-5122(98)00070-X
Eichenlaub-Ritter, U. (1998). Genetics of oocyte ageing. MATURITAS 30, 143-169.
Eichenlaub-Ritter, U., 1998. Genetics of oocyte ageing. MATURITAS, 30(2), p 143-169.
U. Eichenlaub-Ritter, “Genetics of oocyte ageing”, MATURITAS, vol. 30, 1998, pp. 143-169.
Eichenlaub-Ritter, U.: Genetics of oocyte ageing. MATURITAS. 30, 143-169 (1998).
Eichenlaub-Ritter, Ursula. “Genetics of oocyte ageing”. MATURITAS 30.2 (1998): 143-169.

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Retrospective study of the parental origin of the extra chromosome in trisomy 18 (Edwards syndrome).
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The origin of 47,XXY and 47,XXX aneuploidy: heterogeneous mechanisms and role of aberrant recombination.
MacDonald M, Hassold T, Harvey J, Wang LH, Morton NE, Jacobs P., Hum. Mol. Genet. 3(8), 1994
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Reduced recombination and paternal age effect in Klinefelter syndrome.
Lorda-Sanchez I, Binkert F, Maechler M, Robinson WP, Schinzel AA., Hum. Genet. 89(5), 1992
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Separation anxiety: the etiology of nondisjunction in flies and people.
Hawley RS, Frazier JA, Rasooly R., Hum. Mol. Genet. 3(9), 1994
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Prader-Willi and Angelman syndromes. Disorders of genomic imprinting.
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Increased parental ages and uniparental disomy 15: a paternal age effect?
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Maternal meiosis I non-disjunction of chromosome 15: dependence of the maternal age effect on level of recombination.
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Studies on the genetic and immunologic components of the maternal age effect
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Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause.
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Activation of p34cdc2 protein kinase activity in meiotic and mitotic cell cycles in mouse oocytes and embryos.
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Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse.
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Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control.
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AUTHOR UNKNOWN, 0
Predivision and altered maturation are implicated in maternal age-related errors in chromosome segregation in mammalian oogenesis
Eichenlaub-Ritter, Eur J Hum Genet 6(Suppl 1), 1998
Checkpoints: controls that ensure the order of cell cycle events.
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Cell cycle checkpoints: preventing an identity crisis.
Elledge SJ., Science 274(5293), 1996
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Cell cycle: checkpoint proteins and kinetochores.
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Kinetochores, microtubules and the metaphase checkpoint.
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How cells get the right chromosomes.
Nicklas RB., Science 275(5300), 1997
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What does Mos do in oocytes and somatic cells?
Sagata N., Bioessays 19(1), 1997
PMID: 9008413
CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II.
Duesbery NS, Choi T, Brown KD, Wood KW, Resau J, Fukasawa K, Cleveland DW, Vande Woude GF., Proc. Natl. Acad. Sci. U.S.A. 94(17), 1997
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Meiotic abnormalities of c-mos knockout mouse oocytes: activation after first meiosis or entrance into third meiotic metaphase.
Araki K, Naito K, Haraguchi S, Suzuki R, Yokoyama M, Inoue M, Aizawa S, Toyoda Y, Sato E., Biol. Reprod. 55(6), 1996
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Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs.
Colledge WH, Carlton MB, Udy GB, Evans MJ., Nature 370(6484), 1994
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Damaged chromatin does not prevent the exit from metaphase I in fused mouse oocytes.
Fulka J Jr, Kalab P, First NL, Moor RM., Hum. Reprod. 12(11), 1997
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Replicating DNA does not block germinal vesicle breakdown in mouse oocytes.
Fulka J Jr, Moor RM, Fulka J., J. Exp. Zool. 272(3), 1995
PMID: 7790845
Mouse oocyte maturation: meiotic checkpoints.
Fulka J Jr, Moor RM, Fulka J., Exp. Cell Res. 219(2), 1995
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Significant increase in trisomy 21 in Berlin nine months after Chernobyl reactor accident: temporal correlation or causal relation?
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Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes.
Eichenlaub-Ritter U, Betzendahl I., Mutagenesis 10(6), 1995
PMID: 8596466
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis.
Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K., Steroids 62(1), 1997
PMID: 9029710
Benzodiazepines that bind at peripheral sites inhibit cell proliferation.
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Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA.
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Morphological-cytochemical and molecular genetic analyses of mitochondria in isolated human oocytes in the reproductive age.
Muller-Hocker J, Schafer S, Weis S, Munscher C, Strowitzki T., Mol. Hum. Reprod. 2(12), 1996
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Cohen J, Scott R, Alikani M, Schimmel T, Munne S, Levron J, Wu L, Brenner C, Warner C, Willadsen S., Mol. Hum. Reprod. 4(3), 1998
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Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.
Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M., Nat. Genet. 12(4), 1996
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Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene.
Whitney MA, Royle G, Low MJ, Kelly MA, Axthelm MK, Reifsteck C, Olson S, Braun RE, Heinrich MC, Rathbun RK, Bagby GC, Grompe M., Blood 88(1), 1996
PMID: 8704201

AUTHOR UNKNOWN, 0
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE, Flaggs G, Bentley NJ, Taylor EM, Meyn MS, Moss SB, Carr AM, Ashley T, Hoekstra MF., Genes Dev. 10(19), 1996
PMID: 8843195
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D., Genes Dev. 10(19), 1996
PMID: 8843194
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.
Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM., Nat. Genet. 13(3), 1996
PMID: 8673133
Zfx mutation results in small animal size and reduced germ cell number in male and female mice.
Luoh SW, Bain PA, Polakiewicz RD, Goodheart ML, Gardner H, Jaenisch R, Page DC., Development 124(11), 1997
PMID: 9187153
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O., Proc. Natl. Acad. Sci. U.S.A. 90(23), 1993
PMID: 8248223
Growth differentiation factor-9 is required during early ovarian folliculogenesis.
Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM., Nature 383(6600), 1996
PMID: 8849725
Reduced fecundity in insulin-like growth factor-binding protein-1 transgenic mice.
Huang H, Rajkumar K, Murphy LJ., Biol. Reprod. 56(1), 1997
PMID: 9002662
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis.
Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA., Nature 384(6608), 1996
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Female infertility in mice lacking connexin 37.
Simon AM, Goodenough DA, Li E, Paul DL., Nature 385(6616), 1997
PMID: 9020357
Possible direct action of leptin on the human ovary
Billig, Hum Reprod 12(), 1997
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM., Cell 85(5), 1996
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An essential role for C/EBPbeta in female reproduction.
Sterneck E, Tessarollo L, Johnson PF., Genes Dev. 11(17), 1997
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Premature centromere division in three unrelated families.
Keser I, Luleci G, Gunduz G., Ann. Genet. 39(2), 1996
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Triple autosomal trisomy in a pregnancy at risk for Bloom's syndrome.
Petrella R, Hirschhorn K, German J., Am. J. Med. Genet. 40(3), 1991
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Environmental trichlorfon and cluster of congenital abnormalities.
Czeizel AE, Elek C, Gundy S, Metneki J, Nemes E, Reis A, Sperling K, Timar L, Tusnady G, Viragh Z., Lancet 341(8844), 1993
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The detection and evaluation of aneugenic chemicals.
Parry JM, Parry EM, Bourner R, Doherty A, Ellard S, O'Donovan J, Hoebee B, de Stoppelaar JM, Mohn GR, Onfelt A, Renglin A, Schultz N, Soderpalm-Berndes C, Jensen KG, Kirsch-Volders M, Elhajouji A, Van Hummelen P, Degrassi F, Antoccia A, Cimini D, Izzo M, Tanzarella C, Adler ID, Kliesch U, Hess P., Mutat. Res. 353(1-2), 1996
PMID: 8692188
Cytogenetic analysis of human spermatozoa and oocytes
Okada, JPN J Fertil Steril 36(), 1991

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