Genetics of oocyte ageing

Eichenlaub-Ritter U (1998)
MATURITAS 30(2): 143-169.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Objectives: Correlations between parental age, aneuploidy in germ cells and recent findings on aetiological factors in mammalian trisomy formation are reviewed. Methods: Data from observations in human oocytes: molecular studies on the origin of extra chromosomes in trisomies, experiments in a mouse model system, and transgenic approaches are shown. Results: Errors in chromosome segregation are most frequent in meiosis I of oogenesis in mammals and predominantly predispose specific chromosomes and susceptible chiasmate configurations to maternal age-related nondisjunction. Studies on spindle structure, cell cycle and chromosome behaviour in oocytes of the CBA/Ca mouse used as a model for the maternal age-effect suggest that hormonal homeostasis and size of the follicle pool influence the quality, maturation competence and spindle size of the mammalian oocyte. Predisposition to errors in chromosome segregation are critically dependent on altered cell cycles. Compromized protein synthesis and mitochondrial function affect maturation kinetics and spindle formation, and cause untimely segregation of chromosomes (predivision), mimicking an aged phenotype. Conclusions: Altered cell cycles and untimely resolution of chiasmata but also nondisjunction of late segregating homologues caused by asynchrony in cytoplasmic and nuclear maturation appear to be causal to errors in chromosome segregation with advanced maternal age. Oocytes appear to lack checkpoints guarding against untimely chromosome segregation. Genes and exposures affecting pool size. hormonal homeostasis and interactions between oocytes and their somatic compartment and thus quality of follicles and oocytes have the potential to critically influence chromosome distribution in female meiosis and affect fertility in humans and other mammals. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Stichworte
aneuploidy; aging; germ cells; oocyte; trisomy
Erscheinungsjahr
1998
Zeitschriftentitel
MATURITAS
Band
30
Ausgabe
2
Seite(n)
143-169
ISSN
0378-5122
Page URI
https://pub.uni-bielefeld.de/record/1623899

Zitieren

Eichenlaub-Ritter U. Genetics of oocyte ageing. MATURITAS. 1998;30(2):143-169.
Eichenlaub-Ritter, U. (1998). Genetics of oocyte ageing. MATURITAS, 30(2), 143-169. https://doi.org/10.1016/S0378-5122(98)00070-X
Eichenlaub-Ritter, Ursula. 1998. “Genetics of oocyte ageing”. MATURITAS 30 (2): 143-169.
Eichenlaub-Ritter, U. (1998). Genetics of oocyte ageing. MATURITAS 30, 143-169.
Eichenlaub-Ritter, U., 1998. Genetics of oocyte ageing. MATURITAS, 30(2), p 143-169.
U. Eichenlaub-Ritter, “Genetics of oocyte ageing”, MATURITAS, vol. 30, 1998, pp. 143-169.
Eichenlaub-Ritter, U.: Genetics of oocyte ageing. MATURITAS. 30, 143-169 (1998).
Eichenlaub-Ritter, Ursula. “Genetics of oocyte ageing”. MATURITAS 30.2 (1998): 143-169.

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In vitro fertilization and oocyte donation in women 45 years of age and older.
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Chiasma function
Carpenter, Cell 77(), 1994
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Lamb NE, Freeman SB, Savage-Austin A, Pettay D, Taft L, Hersey J, Gu Y, Shen J, Saker D, May KM, Avramopoulos D, Petersen MB, Hallberg A, Mikkelsen M, Hassold TJ, Sherman SL., Nat. Genet. 14(4), 1996
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Mitotic errors in somatic cells cause trisomy 21 in about 4.5% of cases and are not associated with advanced maternal age.
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Recombination and maternal age-dependent nondisjunction: molecular studies of trisomy 16.
Hassold T, Merrill M, Adkins K, Freeman S, Sherman S., Am. J. Hum. Genet. 57(4), 1995
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Retrospective study of the parental origin of the extra chromosome in trisomy 18 (Edwards syndrome).
Nothen MM, Eggermann T, Erdmann J, Eiben B, Hofmann D, Propping P, Schwanitz G., Hum. Genet. 92(4), 1993
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Ramesh KH, Verma RS., Ann. Genet. 39(2), 1996
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The origin of 47,XXY and 47,XXX aneuploidy: heterogeneous mechanisms and role of aberrant recombination.
MacDonald M, Hassold T, Harvey J, Wang LH, Morton NE, Jacobs P., Hum. Mol. Genet. 3(8), 1994
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Reduced recombination and paternal age effect in Klinefelter syndrome.
Lorda-Sanchez I, Binkert F, Maechler M, Robinson WP, Schinzel AA., Hum. Genet. 89(5), 1992
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Separation anxiety: the etiology of nondisjunction in flies and people.
Hawley RS, Frazier JA, Rasooly R., Hum. Mol. Genet. 3(9), 1994
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Prader-Willi and Angelman syndromes. Disorders of genomic imprinting.
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Increased parental ages and uniparental disomy 15: a paternal age effect?
Robinson WP, Lorda-Sanchez I, Malcolm S, Langlois S, Schuffenhauer S, Knoblauch H, Horsthemke B, Schinzel AA., Eur. J. Hum. Genet. 1(4), 1993
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Maternal meiosis I non-disjunction of chromosome 15: dependence of the maternal age effect on level of recombination.
Robinson WP, Kuchinka BD, Bernasconi F, Petersen MB, Schulze A, Brondum-Nielsen K, Christian SL, Ledbetter DH, Schinzel AA, Horsthemke B, Schuffenhauer S, Michaelis RC, Langlois S, Hassold TJ., Hum. Mol. Genet. 7(6), 1998
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Cytogenetic and age-dependent risk factors associated with uniparental disomy 15.
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Studies on the genetic and immunologic components of the maternal age effect
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Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause.
Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF., Hum. Reprod. 7(10), 1992
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Follicular status at the menopause.
Gosden RG., Hum. Reprod. 2(7), 1987
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The oxidizing agent tertiary butyl hydroperoxide induces disturbances in spindle organization, c-meiosis, and aneuploidy in mouse oocytes
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Activation of p34cdc2 protein kinase activity in meiotic and mitotic cell cycles in mouse oocytes and embryos.
Choi T, Aoki F, Mori M, Yamashita M, Nagahama Y, Kohmoto K., Development 113(3), 1991
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Hashimoto N, Watanabe N, Furuta Y, Tamemoto H, Sagata N, Yokoyama M, Okazaki K, Nagayoshi M, Takeda N, Ikawa Y., Nature 370(6484), 1994
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Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos.
Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE., Hum. Reprod. 10(3), 1995
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Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse.
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Roles of ubiquitin-mediated proteolysis in cell cycle control.
Hershko A., Curr. Opin. Cell Biol. 9(6), 1997
PMID: 9425343
Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control.
Lew DJ, Kornbluth S., Curr. Opin. Cell Biol. 8(6), 1996
PMID: 8939679

AUTHOR UNKNOWN, 0
Predivision and altered maturation are implicated in maternal age-related errors in chromosome segregation in mammalian oogenesis
Eichenlaub-Ritter, Eur J Hum Genet 6(Suppl 1), 1998
Checkpoints: controls that ensure the order of cell cycle events.
Hartwell LH, Weinert TA., Science 246(4930), 1989
PMID: 2683079
Cell cycle checkpoints: preventing an identity crisis.
Elledge SJ., Science 274(5293), 1996
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Cell cycle: checkpoint proteins and kinetochores.
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Kinetochores, microtubules and the metaphase checkpoint.
Gorbsky GJ., Trends Cell Biol. 5(4), 1995
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How cells get the right chromosomes.
Nicklas RB., Science 275(5300), 1997
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Cell division gatekeepers identified.
Pennisi E., Science 279(5350), 1998
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Coupling cell division and cell death to microtubule dynamics
Sorger, Curr Opin Cell Biol 6(), 1997
What does Mos do in oocytes and somatic cells?
Sagata N., Bioessays 19(1), 1997
PMID: 9008413
CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II.
Duesbery NS, Choi T, Brown KD, Wood KW, Resau J, Fukasawa K, Cleveland DW, Vande Woude GF., Proc. Natl. Acad. Sci. U.S.A. 94(17), 1997
PMID: 9256453
Meiotic abnormalities of c-mos knockout mouse oocytes: activation after first meiosis or entrance into third meiotic metaphase.
Araki K, Naito K, Haraguchi S, Suzuki R, Yokoyama M, Inoue M, Aizawa S, Toyoda Y, Sato E., Biol. Reprod. 55(6), 1996
PMID: 8949889
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs.
Colledge WH, Carlton MB, Udy GB, Evans MJ., Nature 370(6484), 1994
PMID: 8015609
Damaged chromatin does not prevent the exit from metaphase I in fused mouse oocytes.
Fulka J Jr, Kalab P, First NL, Moor RM., Hum. Reprod. 12(11), 1997
PMID: 9436688
Replicating DNA does not block germinal vesicle breakdown in mouse oocytes.
Fulka J Jr, Moor RM, Fulka J., J. Exp. Zool. 272(3), 1995
PMID: 7790845
Mouse oocyte maturation: meiotic checkpoints.
Fulka J Jr, Moor RM, Fulka J., Exp. Cell Res. 219(2), 1995
PMID: 7641792
Significant increase in trisomy 21 in Berlin nine months after Chernobyl reactor accident: temporal correlation or causal relation?
Sperling, Br Med J 309(), 1994
Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes.
Eichenlaub-Ritter U, Betzendahl I., Mutagenesis 10(6), 1995
PMID: 8596466
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis.
Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K., Steroids 62(1), 1997
PMID: 9029710
Benzodiazepines that bind at peripheral sites inhibit cell proliferation.
Wang JK, Morgan JI, Spector S., Proc. Natl. Acad. Sci. U.S.A. 81(3), 1984
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Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA.
de la Asuncion JG, Millan A, Pla R, Bruseghini L, Esteras A, Pallardo FV, Sastre J, Vina J., FASEB J. 10(2), 1996
PMID: 8641567
Morphological-cytochemical and molecular genetic analyses of mitochondria in isolated human oocytes in the reproductive age.
Muller-Hocker J, Schafer S, Weis S, Munscher C, Strowitzki T., Mol. Hum. Reprod. 2(12), 1996
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Ooplasmic transfer in mature human oocytes.
Cohen J, Scott R, Alikani M, Schimmel T, Munne S, Levron J, Wu L, Brenner C, Warner C, Willadsen S., Mol. Hum. Reprod. 4(3), 1998
PMID: 9570273
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.
Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M., Nat. Genet. 12(4), 1996
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Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene.
Whitney MA, Royle G, Low MJ, Kelly MA, Axthelm MK, Reifsteck C, Olson S, Braun RE, Heinrich MC, Rathbun RK, Bagby GC, Grompe M., Blood 88(1), 1996
PMID: 8704201

AUTHOR UNKNOWN, 0
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE, Flaggs G, Bentley NJ, Taylor EM, Meyn MS, Moss SB, Carr AM, Ashley T, Hoekstra MF., Genes Dev. 10(19), 1996
PMID: 8843195
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D., Genes Dev. 10(19), 1996
PMID: 8843194
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.
Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM., Nat. Genet. 13(3), 1996
PMID: 8673133
Zfx mutation results in small animal size and reduced germ cell number in male and female mice.
Luoh SW, Bain PA, Polakiewicz RD, Goodheart ML, Gardner H, Jaenisch R, Page DC., Development 124(11), 1997
PMID: 9187153
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O., Proc. Natl. Acad. Sci. U.S.A. 90(23), 1993
PMID: 8248223
Growth differentiation factor-9 is required during early ovarian folliculogenesis.
Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM., Nature 383(6600), 1996
PMID: 8849725
Reduced fecundity in insulin-like growth factor-binding protein-1 transgenic mice.
Huang H, Rajkumar K, Murphy LJ., Biol. Reprod. 56(1), 1997
PMID: 9002662
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis.
Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA., Nature 384(6608), 1996
PMID: 8945475
Female infertility in mice lacking connexin 37.
Simon AM, Goodenough DA, Li E, Paul DL., Nature 385(6616), 1997
PMID: 9020357
Possible direct action of leptin on the human ovary
Billig, Hum Reprod 12(), 1997
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM., Cell 85(5), 1996
PMID: 8646781
An essential role for C/EBPbeta in female reproduction.
Sterneck E, Tessarollo L, Johnson PF., Genes Dev. 11(17), 1997
PMID: 9303532
Premature centromere division in three unrelated families.
Keser I, Luleci G, Gunduz G., Ann. Genet. 39(2), 1996
PMID: 8766139
Triple autosomal trisomy in a pregnancy at risk for Bloom's syndrome.
Petrella R, Hirschhorn K, German J., Am. J. Med. Genet. 40(3), 1991
PMID: 1951436
Environmental trichlorfon and cluster of congenital abnormalities.
Czeizel AE, Elek C, Gundy S, Metneki J, Nemes E, Reis A, Sperling K, Timar L, Tusnady G, Viragh Z., Lancet 341(8844), 1993
PMID: 8094783
The detection and evaluation of aneugenic chemicals.
Parry JM, Parry EM, Bourner R, Doherty A, Ellard S, O'Donovan J, Hoebee B, de Stoppelaar JM, Mohn GR, Onfelt A, Renglin A, Schultz N, Soderpalm-Berndes C, Jensen KG, Kirsch-Volders M, Elhajouji A, Van Hummelen P, Degrassi F, Antoccia A, Cimini D, Izzo M, Tanzarella C, Adler ID, Kliesch U, Hess P., Mutat. Res. 353(1-2), 1996
PMID: 8692188
Cytogenetic analysis of human spermatozoa and oocytes
Okada, JPN J Fertil Steril 36(), 1991
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