Fundamentals of electroporative delivery of drugs and genes

Neumann E, Kakorin S, Tönsing K (1999)
BIOELECTROCHEMISTRY AND BIOENERGETICS 48(1): 3-16.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Electrooptical and conductometrical relaxation methods have given a new insight in the molecular mechanisms of the electroporative delivery of drug-like dyes and genes (DNA) to cells and tissues. Key findings are: (1) Membrane electroporation (ME) and hence the electroporative transmembrane transport of macromolecules are facilitated by a higher curvature of the membrane as well as by a gradient of the ionic strength across charged membranes, affecting the spontaneous curvature. (2) The degree of pore formation as the primary field response increases continuously without a threshold field strength, whereas secondary phenomena, such as a dramatic increase in the membrane permeability to drug-like dyes and DNA (also called electropermeabilization), indicate threshold field strength ranges. (3) The transfer of DNA by ME requires surface adsorption and surface insertion of the permeant molecule or part of it. The diffusion coefficient for the translocation of DNA (M-r approximate to 3.5 x 10(6)) through the electroporated membrane is D-m = 6.7 x 10(-13) cm(2) s(-1) and D-m for the drug-like dye Serva Blue G (M-r approximate to 854) is D-m = 2.0 x 10(-12) cm(2) s(-1). The slow electroporative transport of both DNA and drugs across the electroporated membrane reflects highly interactive (electro-) diffusion, involving many small pores coalesced into large, but transiently occluded pores (DNA). The data on mouse B-cells and yeast cells provide directly the flow and permeability coefficients of Serva blue G and plasmid DNA at different electroporation protocols. The physico-chemical theory of ME and electroporative transport in terms of time-dependent flow coefficients has been developed to such a degree that analytical expressions are available to handle curvature and ionic strength effects on ME and transport. The theory presents further useful tools for the optimization of the ME techniques in biotechnology and medicine, in particular in the new field of electroporative delivery of drugs (electrochemotherapy) and of DNA transfer and gene therapy. (C) 1999 Elsevier Science S.A. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
BIOELECTROCHEMISTRY AND BIOENERGETICS
Band
48
Ausgabe
1
Seite(n)
3-16
ISSN
PUB-ID

Zitieren

Neumann E, Kakorin S, Tönsing K. Fundamentals of electroporative delivery of drugs and genes. BIOELECTROCHEMISTRY AND BIOENERGETICS. 1999;48(1):3-16.
Neumann, E., Kakorin, S., & Tönsing, K. (1999). Fundamentals of electroporative delivery of drugs and genes. BIOELECTROCHEMISTRY AND BIOENERGETICS, 48(1), 3-16. doi:10.1016/S0302-4598(99)00008-2
Neumann, E., Kakorin, S., and Tönsing, K. (1999). Fundamentals of electroporative delivery of drugs and genes. BIOELECTROCHEMISTRY AND BIOENERGETICS 48, 3-16.
Neumann, E., Kakorin, S., & Tönsing, K., 1999. Fundamentals of electroporative delivery of drugs and genes. BIOELECTROCHEMISTRY AND BIOENERGETICS, 48(1), p 3-16.
E. Neumann, S. Kakorin, and K. Tönsing, “Fundamentals of electroporative delivery of drugs and genes”, BIOELECTROCHEMISTRY AND BIOENERGETICS, vol. 48, 1999, pp. 3-16.
Neumann, E., Kakorin, S., Tönsing, K.: Fundamentals of electroporative delivery of drugs and genes. BIOELECTROCHEMISTRY AND BIOENERGETICS. 48, 3-16 (1999).
Neumann, Eberhard, Kakorin, Sergej, and Tönsing, Katja. “Fundamentals of electroporative delivery of drugs and genes”. BIOELECTROCHEMISTRY AND BIOENERGETICS 48.1 (1999): 3-16.

177 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Effect of electroporation medium conductivity on exogenous molecule transfer to cells in vitro.
Ruzgys P, Jakutavičiūtė M, Šatkauskienė I, Čepurnienė K, Šatkauskas S., Sci Rep 9(1), 2019
PMID: 30723286
Ionomycin-Induced Changes in Membrane Potential Alter Electroporation Outcomes in HL-60 Cells.
Aiken EJ, Kilberg BG, Yu S, Hagness SC, Booske JH., Biophys J 114(12), 2018
PMID: 29925024
Geometrical Characterization of an Electropore from Water Positional Fluctuations.
Marracino P, Castellani F, Vernier PT, Liberti M, Apollonio F., J Membr Biol 250(1), 2017
PMID: 27435217
Effective treatment of intractable cutaneous metastases of breast cancer with electrochemotherapy: Ten-year audit of single centre experience.
Bourke MG, Salwa SP, Sadadcharam M, Whelan MC, Forde PF, Larkin JO, Collins CG, O'Reilly S, O'Sullivan GC, Clover AJ, Soden DM., Breast Cancer Res Treat 161(2), 2017
PMID: 27878392
Nuclear transformation and functional gene expression in the oleaginous microalga Monoraphidium neglectum.
Jaeger D, Hübner W, Huser T, Mussgnug JH, Kruse O., J Biotechnol 249(), 2017
PMID: 28302588
Gene Electrotransfer: A Mechanistic Perspective.
Rosazza C, Meglic SH, Zumbusch A, Rols MP, Miklavcic D., Curr Gene Ther 16(2), 2016
PMID: 27029943
Electrochemotherapy in pancreatic adenocarcinoma treatment: pre-clinical and clinical studies.
Bimonte S, Leongito M, Granata V, Barbieri A, Del Vecchio V, Falco M, Nasto A, Albino V, Piccirillo M, Palaia R, Amore A, Giacomo Rd, Lastoria S, Setola SV, Fusco R, Petrillo A, Izzo F., Radiol Oncol 50(1), 2016
PMID: 27069445
Electrochemotherapy by pulsed electromagnetic field treatment (PEMF) in mouse melanoma B16F10 in vivo.
Kranjc S, Kranjc M, Scancar J, Jelenc J, Sersa G, Miklavcic D., Radiol Oncol 50(1), 2016
PMID: 27069448
Comparison between direct and reverse electroporation of cells in situ: a simulation study.
Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M, Krams R., Physiol Rep 4(6), 2016
PMID: 27009275
Micro-/nanoscale electroporation.
Chang L, Li L, Shi J, Sheng Y, Lu W, Gallego-Perez D, Lee LJ., Lab Chip 16(21), 2016
PMID: 27713986
The conductance of cellular membranes at supra-physiological voltages.
Wegner LH., Bioelectrochemistry 103(), 2015
PMID: 25246349
Biophysical effects in off-resonant gold nanoparticle mediated (GNOME) laser transfection of cell lines, primary- and stem cells using fs laser pulses.
Schomaker M, Killian D, Willenbrock S, Heinemann D, Kalies S, Ngezahayo A, Nolte I, Ripken T, Junghanß C, Meyer H, Murua Escobar H, Heisterkamp A., J Biophotonics 8(8), 2015
PMID: 25302483
Feasibility and safety of electrochemotherapy (ECT) in the pancreas: a pre-clinical investigation.
Girelli R, Prejanò S, Cataldo I, Corbo V, Martini L, Scarpa A, Claudio B., Radiol Oncol 49(2), 2015
PMID: 26029026
Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation.
Venslauskas MS, Šatkauskas S., Eur Biophys J 44(5), 2015
PMID: 25939984
Silver nanoparticles and electroporation: Their combinational effect on Leishmania major.
Dolat E, Rajabi O, Salarabadi SS, Yadegari-Dehkordi S, Sazgarnia A., Bioelectromagnetics 36(8), 2015
PMID: 26769083
Transmedulla Neurons in the Sky Compass Network of the Honeybee (Apis mellifera) Are a Possible Site of Circadian Input.
Zeller M, Held M, Bender J, Berz A, Heinloth T, Hellfritz T, Pfeiffer K., PLoS One 10(12), 2015
PMID: 26630286
Juxtasomal biocytin labeling to study the structure-function relationship of individual cortical neurons.
Narayanan RT, Mohan H, Broersen R, de Haan R, Pieneman AW, de Kock CP., J Vis Exp (84), 2014
PMID: 24638127
Flow-through comb electroporation device for delivery of macromolecules.
Adamo A, Arione A, Sharei A, Jensen KF., Anal Chem 85(3), 2013
PMID: 23259401
Suppression of epileptiform activity by a single short-duration electric field in rat hippocampus in vitro.
Mikkelsen R, Andreasen M, Nedergaard S., J Neurophysiol 109(11), 2013
PMID: 23486200
Molecular dynamic simulation of transmembrane pore growth.
Deminsky M, Eletskii A, Kniznik A, Odinokov A, Pentkovskii V, Potapkin B., J Membr Biol 246(11), 2013
PMID: 23660813
Localized, macromolecular transport for thin, adherent, single cells via an automated, single cell electroporation biomanipulator.
Sakaki K, Esmaeilsabzali H, Massah S, Prefontaine GG, Dechev N, Burke RD, Park EJ., IEEE Trans Biomed Eng 60(11), 2013
PMID: 23771309
Long-lasting single-neuron labeling by in vivo electroporation without microscopic guidance.
Oyama K, Ohara S, Sato S, Karube F, Fujiyama F, Isomura Y, Mushiake H, Iijima T, Tsutsui K., J Neurosci Methods 218(2), 2013
PMID: 23769867
Voltage-Gated Lipid Ion Channels.
Blicher A, Heimburg T., PLoS One 8(6), 2013
PMID: 23823188
Cancer vaccination by electro-gene-transfer.
Aurisicchio L, Mancini R, Ciliberto G., Expert Rev Vaccines 12(10), 2013
PMID: 24066796
BNNT-mediated irreversible electroporation: its potential on cancer cells.
Raffa V, Riggio C, Smith MW, Jordan KC, Cao W, Cuschieri A., Technol Cancer Res Treat 11(5), 2012
PMID: 22475064
Size-controlled nanopores in lipid membranes with stabilizing electric fields.
Fernández ML, Risk M, Reigada R, Vernier PT., Biochem Biophys Res Commun 423(2), 2012
PMID: 22659739
Electric field orientation for gene delivery using high-voltage and low-voltage pulses.
Orio J, Coustets M, Mauroy C, Teissie J., J Membr Biol 245(10), 2012
PMID: 22836668
Encapsulation of biomacromolecules within polymersomes by electroporation.
Wang L, Chierico L, Little D, Patikarnmonthon N, Yang Z, Azzouz M, Madsen J, Armes SP, Battaglia G., Angew Chem Int Ed Engl 51(44), 2012
PMID: 23023772
Equivalent pulse parameters for electroporation.
Pucihar G, Krmelj J, Reberšek M, Napotnik TB, Miklavčič D., IEEE Trans Biomed Eng 58(11), 2011
PMID: 21900067
Carbon nanotube-mediated wireless cell permeabilization: drug and gene uptake.
Raffa V, Gherardini L, Vittorio O, Bardi G, Ziaei A, Pizzorusso T, Riggio C, Nitodas S, Karachalios T, Al-Jamal KT, Kostarelos K, Costa M, Cuschieri A., Nanomedicine (Lond) 6(10), 2011
PMID: 22122583
Carbon nanotube-enhanced cell electropermeabilisation.
Raffa V, Ciofani G, Vittorio O, Pensabene V, Cuschieri A., Bioelectrochemistry 79(1), 2010
PMID: 19926536
Moderate electric fields can inactivate Escherichia coli at room temperature
Machado LuísF, Pereira RicardoN, Martins RuiC, Teixeira JoséA, Vicente AntónioA., Journal of food engineering. 96(4), 2010
PMID: IND44280344
Transmembrane potential induced on the internal organelle by a time-varying magnetic field: a model study.
Ye H, Cotic M, Kang EE, Fehlings MG, Carlen PL., J Neuroeng Rehabil 7(), 2010
PMID: 20170538
Lipid ion channels.
Heimburg T., Biophys Chem 150(1-3), 2010
PMID: 20385440
Electroporation for DNA immunization: clinical application.
van Drunen Littel-van den Hurk S, Hannaman D., Expert Rev Vaccines 9(5), 2010
PMID: 20450325
Bioelectric applications for treatment of melanoma.
Beebe SJ, Schoenbach KH, Heller R., Cancers (Basel) 2(3), 2010
PMID: 24281185
Single neuron electroporation in manipulating and measuring the central nervous system.
Yuan TF, Menéndez-González M, Arias-Carrión O., Int Arch Med 3(), 2010
PMID: 21054865
Enhanced low voltage cell electropermeabilization by boron nitride nanotubes.
Raffa V, Ciofani G, Cuschieri A., Nanotechnology 20(7), 2009
PMID: 19417408
Tolerability of two sequential electroporation treatments using MedPulser DNA delivery system (DDS) in healthy adults.
Wallace M, Evans B, Woods S, Mogg R, Zhang L, Finnefrock AC, Rabussay D, Fons M, Mallee J, Mehrotra D, Schödel F, Musey L., Mol Ther 17(5), 2009
PMID: 19277016
A system for the determination of planar lipid bilayer breakdown voltage and its applications.
Kramar P, Miklavcic D, Lebar AM., IEEE Trans Nanobioscience 8(2), 2009
PMID: 19457754
The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics.
Blicher A, Wodzinska K, Fidorra M, Winterhalter M, Heimburg T., Biophys J 96(11), 2009
PMID: 19486680
Blumlein configuration for high-repetition-rate pulse generation of variable duration and polarity using synchronized switch control.
Rebersek M, Kranjc M, Pavliha D, Batista-Napotnik T, Vrtacnik D, Amon S, Miklavcic D., IEEE Trans Biomed Eng 56(11), 2009
PMID: 19635688
Electroporation advances in large animals.
Reed SD, Li S., Curr Gene Ther 9(4), 2009
PMID: 19545229
Electrically initiated upstream coalescence cascade of droplets in a microfluidic flow.
Zagnoni M, Baroud CN, Cooper JM., Phys Rev E Stat Nonlin Soft Matter Phys 80(4 pt 2), 2009
PMID: 19905432
Gene electrotransfer: from biophysical mechanisms to in vivo applications : Part 1- Biophysical mechanisms.
Escoffre JM, Mauroy C, Portet T, Wasungu L, Rosazza C, Gilbart Y, Mallet L, Bellard E, Golzio M, Rols MP, Teissié J., Biophys Rev 1(4), 2009
PMID: 28510029
Mechanistic analysis of electroporation-induced cellular uptake of macromolecules.
Zaharoff DA, Henshaw JW, Mossop B, Yuan F., Exp Biol Med (Maywood) 233(1), 2008
PMID: 18156311
Variability of the minimal transmembrane voltage resulting in detectable membrane electroporation.
Towhidi L, Kotnik T, Pucihar G, Firoozabadi SM, Mozdarani H, Miklavcic D., Electromagn Biol Med 27(4), 2008
PMID: 19037786
Single-cell electroporation of adult sensory neurons for gene screening with RNA interference mechanism.
Boudes M, Pieraut S, Valmier J, Carroll P, Scamps F., J Neurosci Methods 170(2), 2008
PMID: 18314198
Vaccine submission with muscle electroporation.
Yuan TF., Vaccine 26(15), 2008
PMID: 18313811
Simulation studies of ultrashort, high-intensity electric pulse induced action potential block in whole-animal nerves.
Joshi RP, Mishra A, Song J, Pakhomov AG, Schoenbach KH., IEEE Trans Biomed Eng 55(4), 2008
PMID: 18390330
Space and time-resolved gene expression experiments on cultured mammalian cells by a single-cell electroporation microarray.
Vassanelli S, Bandiera L, Borgo M, Cellere G, Santoni L, Bersani C, Salamon M, Zaccolo M, Lorenzelli L, Girardi S, Maschietto M, Dal Maschio M, Paccagnella A., N Biotechnol 25(1), 2008
PMID: 18504020
The remarkable mechanism of prostaglandin E2 on synaptic plasticity.
Akaneya Y., Gene Regul Syst Bio 1(), 2008
PMID: 19936099
A numerical model of permeabilized skin with local transport regions.
Pavselj N, Miklavcic D., IEEE Trans Biomed Eng 55(7), 2008
PMID: 18595814
Efficiency of high- and low-voltage pulse combinations for gene electrotransfer in muscle, liver, tumor, and skin.
André FM, Gehl J, Sersa G, Préat V, Hojman P, Eriksen J, Golzio M, Cemazar M, Pavselj N, Rols MP, Miklavcic D, Neumann E, Teissié J, Mir LM., Hum Gene Ther 19(11), 2008
PMID: 19866490
Determination of the lipid bilayer breakdown voltage by means of linear rising signal.
Kramar P, Miklavcic D, Lebar AM., Bioelectrochemistry 70(1), 2007
PMID: 16713748
Simulation of electroporated cell by chronopotentiometry.
Kalinowski S, Koronkiewicz S, Kotulska M, Kubica K., Bioelectrochemistry 70(1), 2007
PMID: 16720110
Real time electroporation control for accurate and safe in vivo non-viral gene therapy.
Cukjati D, Batiuskaite D, André F, Miklavcic D, Mir LM., Bioelectrochemistry 70(2), 2007
PMID: 17258942
Efficacy of Farabloc as an analgesic in primary fibromyalgia.
Bach GL, Clement DB., Clin Rheumatol 26(3), 2007
PMID: 17216399
Electropermeabilization of dense cell suspensions.
Pucihar G, Kotnik T, Teissié J, Miklavcic D., Eur Biophys J 36(3), 2007
PMID: 17294179
Electrically assisted ocular gene therapy.
Bejjani RA, Andrieu C, Bloquel C, Berdugo M, BenEzra D, Behar-Cohen F., Surv Ophthalmol 52(2), 2007
PMID: 17355857
Nanosecond pulsed electric fields have differential effects on cells in the S-phase.
Hall EH, Schoenbach KH, Beebe SJ., DNA Cell Biol 26(3), 2007
PMID: 17417944
Gene transfer strategies in tissue engineering.
Bleiziffer O, Eriksson E, Yao F, Horch RE, Kneser U., J Cell Mol Med 11(2), 2007
PMID: 17488473
Numerical calculations of single-cell electroporation with an electrolyte-filled capillary.
Zudans I, Agarwal A, Orwar O, Weber SG., Biophys J 92(10), 2007
PMID: 17351001
Ion transport across transmembrane pores.
Leontiadou H, Mark AE, Marrink SJ., Biophys J 92(12), 2007
PMID: 17384063
Feasibility study for cell electroporation detection and separation by means of dielectrophoresis.
Oblak J, Krizaj D, Amon S, Macek-Lebar A, Miklavcic D., Bioelectrochemistry 71(2), 2007
PMID: 17509948
Effect of cell size and shape on single-cell electroporation.
Agarwal A, Zudans I, Weber EA, Olofsson J, Orwar O, Weber SG., Anal Chem 79(10), 2007
PMID: 17444611
Gene expression profiles in skeletal muscle after gene electrotransfer.
Hojman P, Zibert JR, Gissel H, Eriksen J, Gehl J., BMC Mol Biol 8(), 2007
PMID: 17598924
Electroporator with automatic change of electric field direction improves gene electrotransfer in-vitro.
Rebersek M, Faurie C, Kanduser M, Corović S, Teissié J, Rols MP, Miklavcic D., Biomed Eng Online 6(), 2007
PMID: 17601347
Electroporation-based DNA immunisation: translation to the clinic.
Luxembourg A, Evans CF, Hannaman D., Expert Opin Biol Ther 7(11), 2007
PMID: 17961089
Ultrastructural modifications of cell membranes induced by "electroporation" on melanoma xenografts.
Spugnini EP, Arancia G, Porrello A, Colone M, Formisano G, Stringaro A, Citro G, Molinari A., Microsc Res Tech 70(12), 2007
PMID: 17722056
Electroporation of neurons and growth cones in Aplysia californica.
Lovell P, Jezzini SH, Moroz LL., J Neurosci Methods 151(2), 2006
PMID: 16174534
Cell membrane fluidity related to electroporation and resealing.
Kanduser M, Sentjurc M, Miklavcic D., Eur Biophys J 35(3), 2006
PMID: 16215750
Electroporation therapy in soft tissue sarcoma: a potentially effective novel treatment.
de Bree R, Tijink BM, van Groeningen CJ, Leemans CR., Sarcoma 2006(), 2006
PMID: 17251660
Mechanism of in vivo DNA transport into cells by electroporation: electrophoresis across the plasma membrane may not be involved.
Liu F, Heston S, Shollenberger LM, Sun B, Mickle M, Lovell M, Huang L., J Gene Med 8(3), 2006
PMID: 16353289
Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons.
Terreno E, Geninatti Crich S, Belfiore S, Biancone L, Cabella C, Esposito G, Manazza AD, Aime S., Magn Reson Med 55(3), 2006
PMID: 16450336
Membrane electroporation theories: a review.
Chen C, Smye SW, Robinson MP, Evans JA., Med Biol Eng Comput 44(1-2), 2006
PMID: 16929916
Plasma membrane voltage changes during nanosecond pulsed electric field exposure.
Frey W, White JA, Price RO, Blackmore PF, Joshi RP, Nuccitelli R, Beebe SJ, Schoenbach KH, Kolb JF., Biophys J 90(10), 2006
PMID: 16513782
Numerical determination of transmembrane voltage induced on irregularly shaped cells.
Pucihar G, Kotnik T, Valic B, Miklavcic D., Ann Biomed Eng 34(4), 2006
PMID: 16547608
Nanosecond pulsed electric field generators for the study of subcellular effects.
Kolb JF, Kono S, Schoenbach KH., Bioelectromagnetics 27(3), 2006
PMID: 16304697
Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery.
Mossop BJ, Barr RC, Henshaw JW, Zaharoff DA, Yuan F., Ann Biomed Eng 34(10), 2006
PMID: 16917743
In vivo electroporation for gene therapy.
Heller LC, Heller R., Hum Gene Ther 17(9), 2006
PMID: 16972757
Non-viral ocular gene therapy: potential ocular therapeutic avenues.
Bloquel C, Bourges JL, Touchard E, Berdugo M, BenEzra D, Behar-Cohen F., Adv Drug Deliv Rev 58(11), 2006
PMID: 17095114
Avian superior olivary nucleus provides divergent inhibitory input to parallel auditory pathways.
Burger RM, Cramer KS, Pfeiffer JD, Rubel EW., J Comp Neurol 481(1), 2005
PMID: 15558730
RNAi-induced gene silencing by local electroporation in targeting brain region.
Akaneya Y, Jiang B, Tsumoto T., J Neurophysiol 93(1), 2005
PMID: 15604463
Skin targeted DNA vaccine delivery using electroporation in rabbits. I: efficacy.
Medi BM, Hoselton S, Marepalli RB, Singh J., Int J Pharm 294(1-2), 2005
PMID: 15814230
FVIII gene delivery by muscle electroporation corrects murine hemophilia A.
Long YC, Jaichandran S, Ho LP, Tien SL, Tan SY, Kon OL., J Gene Med 7(4), 2005
PMID: 15521095
Sequential finite element model of tissue electropermeabilization.
Sel D, Cukjati D, Batiuskaite D, Slivnik T, Mir LM, Miklavcic D., IEEE Trans Biomed Eng 52(5), 2005
PMID: 15887531
Electroporative adjustment of pH in living yeast cells: ratiometric fluorescence pH imaging.
Herman P, Drapalova H, Muzikova R, Vecer J., J Fluoresc 15(5), 2005
PMID: 16341795
Schistosoma japonicum: a method for transformation by electroporation.
Yuan XS, Shen JL, Wang XL, Wu XS, Liu DP, Dong HF, Jiang MS., Exp Parasitol 111(4), 2005
PMID: 16212956
Highly efficient constant-current electroporation increases in vivo plasmid expression.
Khan AS, Pope MA, Draghia-Akli R., DNA Cell Biol 24(12), 2005
PMID: 16332178
The effect of resting transmembrane voltage on cell electropermeabilization: a numerical analysis.
Valic B, Pavlin M, Miklavcic D., Bioelectrochemistry 63(1-2), 2004
PMID: 15110294
Techniques of signal generation required for electropermeabilization. Survey of electropermeabilization devices.
Puc M, Corović S, Flisar K, Petkovsek M, Nastran J, Miklavcic D., Bioelectrochemistry 64(2), 2004
PMID: 15296784
Electric fields within cells as a function of membrane resistivity--a model study.
Mossop BJ, Barr RC, Zaharoff DA, Yuan F., IEEE Trans Nanobioscience 3(3), 2004
PMID: 15473075
Tumor regression by combination antisense therapy against Plk1 and Bcl-2.
Elez R, Piiper A, Kronenberger B, Kock M, Brendel M, Hermann E, Pliquett U, Neumann E, Zeuzem S., Oncogene 22(1), 2003
PMID: 12527909
Cell membrane electropermeabilization with arbitrary pulse waveforms.
Flisar K, Puc M, Kotnik T, Miklavcic D., IEEE Eng Med Biol Mag 22(1), 2003
PMID: 12683066
High-efficiency transfection of individual neurons using modified electrophysiology techniques.
Rathenberg J, Nevian T, Witzemann V., J Neurosci Methods 126(1), 2003
PMID: 12788505
Electrotransfer at MR imaging: tool for optimization of gene transfer protocols--feasibility study in mice.
Paturneau-Jouas M, Parzy E, Vidal G, Carlier PG, Wary C, Vilquin JT, de Kerviler E, Schwartz K, Leroy-Willig A., Radiology 228(3), 2003
PMID: 12881580
Quantitative model of small molecules uptake after in vitro cell electropermeabilization.
Puc M, Kotnik T, Mir LM, Miklavcic D., Bioelectrochemistry 60(1-2), 2003
PMID: 12893304
Electroporation: a novel approach to enhance the radioiodine uptake in a human thyroid cancer cell line.
Gopal R, Narkar AA, Mishra KP, Samuel AM, Nair N., Appl Radiat Isot 59(5-6), 2003
PMID: 14622927
Cell and animal imaging of electrically mediated gene transfer.
Faurie C, Golzio M, Moller P, Teissié J, Rols MP., DNA Cell Biol 22(12), 2003
PMID: 14683588
Diverse effects of nanosecond pulsed electric fields on cells and tissues.
Beebe SJ, White J, Blackmore PF, Deng Y, Somers K, Schoenbach KH., DNA Cell Biol 22(12), 2003
PMID: 14683589
Modeling the electromobility of ions in a target tissue.
Hickey JD, Gilbert R., DNA Cell Biol 22(12), 2003
PMID: 14683593
Gene therapy in plastic surgery.
Tepper OM, Mehrara BJ., Plast Reconstr Surg 109(2), 2002
PMID: 11818860
Mechanisms of in vivo DNA electrotransfer: respective contributions of cell electropermeabilization and DNA electrophoresis.
Satkauskas S, Bureau MF, Puc M, Mahfoudi A, Scherman D, Miklavcic D, Mir LM., Mol Ther 5(2), 2002
PMID: 11829520
Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery.
Goldberg EP, Hadba AR, Almond BA, Marotta JS., J Pharm Pharmacol 54(2), 2002
PMID: 11848280
Ionic conductivity of electroporated lipid bilayer membranes.
Kakorin S, Neumann E., Bioelectrochemistry 56(1-2), 2002
PMID: 12009466
Improved mRNA electroporation method for Xenopus neurula embryos.
Sasagawa S, Takabatake T, Takabatake Y, Muramatsu T, Takeshima K., Genesis 33(2), 2002
PMID: 12112876
In vivo electroporation for genetic manipulations of whole Hydra polyps.
Bosch TC, Augustin R, Gellner K, Khalturin K, Lohmann JU., Differentiation 70(4-5), 2002
PMID: 12147133
Electrochemical evaluation of rhodium dimer-DNA interactions.
Gil Ede S, Serrano SH, Ferreira EI, Kubota LT., J Pharm Biomed Anal 29(4), 2002
PMID: 12093486
Inter-pulse interval between rectangular voltage pulses affects electroporation threshold of artificial lipid bilayers.
Lebar AM, Troiano GC, Tung L, Miklavcic D., IEEE Trans Nanobioscience 1(3), 2002
PMID: 16696301
Poly-L-glutamate, an anionic polymer, enhances transgene expression for plasmids delivered by intramuscular injection with in vivo electroporation.
Nicol F, Wong M, MacLaughlin FC, Perrard J, Wilson E, Nordstrom JL, Smith LC., Gene Ther 9(20), 2002
PMID: 12365000
Digression on membrane electroporation for drug and gene delivery.
Neumann E, Kakorin S., Technol Cancer Res Treat 1(5), 2002
PMID: 12625758
Cationic lipid-DNA complexes-lipoplexes-for gene transfer and therapy.
Zhdanov RI, Podobed OV, Vlassov VV., Bioelectrochemistry 58(1), 2002
PMID: 12401571
In vivo DNA electrotransfer.
Trezise AE., DNA Cell Biol 21(12), 2002
PMID: 12573047
Topical gene transfer into rat skin using electroporation.
Dujardin N, Van Deŕ Smissen P, Préat V., Pharm Res 18(1), 2001
PMID: 11336354
Single-cell electroporation for gene transfer in vivo.
Haas K, Sin WC, Javaherian A, Li Z, Cline HT., Neuron 29(3), 2001
PMID: 11301019
Muscle-specific enhancement of gene expression by incorporation of SV40 enhancer in the expression plasmid.
Li S, MacLaughlin FC, Fewell JG, Gondo M, Wang J, Nicol F, Dean DA, Smith LC., Gene Ther 8(6), 2001
PMID: 11313829
Anticytokine gene therapy of autoimmune diseases.
Prud'homme GJ, Lawson BR, Theofilopoulos AN., Expert Opin Biol Ther 1(3), 2001
PMID: 11727511
Pulsed electric field breakage of cellular tissues: visualisation of percolative properties.
Lebovka NI, Bazhal MI, Vorobiev E., Innovative food science & emerging technologies : IFSET : the official scientific journal of the European Federation of Food Science and Technology. 2(2), 2001
PMID: IND23297796
The influence of medium conductivity on electropermeabilization and survival of cells in vitro.
Pucihar G, Kotnik T, Kanduser M, Miklavcic D., Bioelectrochemistry 54(2), 2001
PMID: 11694390
Biophysical injury mechanisms in electrical shock trauma.
Lee RC, Zhang D, Hannig J., Annu Rev Biomed Eng 2(), 2000
PMID: 11701521
Amplifiable DNA from gram-negative and gram-positive bacteria by a low strength pulsed electric field method.
Vitzthum F, Geiger G, Bisswanger H, Elkine B, Brunner H, Bernhagen J., Nucleic Acids Res 28(8), 2000
PMID: 10734214
Perspectives for microelectrode arrays for biosensing and membrane electroporation.
Neumann E, Tönsing K, Siemens P., Bioelectrochemistry 51(2), 2000
PMID: 10910160
Gerhard schwarz: scientist and colleague
Neuman E, Winterhalter M., Biophys Chem 85(2-3), 2000
PMID: 10961499
Electroporation of curved lipid membranes in ionic strength gradients
Neumann E, Kakorin S., Biophys Chem 85(2-3), 2000
PMID: 10961510
Efficient nonviral cutaneous transfection.
Glasspool-Malone J, Somiari S, Drabick JJ, Malone RW., Mol Ther 2(2), 2000
PMID: 10947941
Theory and in vivo application of electroporative gene delivery.
Somiari S, Glasspool-Malone J, Drabick JJ, Gilbert RA, Heller R, Jaroszeski MJ, Malone RW., Mol Ther 2(3), 2000
PMID: 10985947
In vivo cell electrofusion.
Mekid H, Mir LM., Biochim Biophys Acta 1524(2-3), 2000
PMID: 11113558

46 References

Daten bereitgestellt von Europe PubMed Central.

Permeability changes induced by electric impulses in vesicular membranes.
Neumann E, Rosenheck K., J. Membr. Biol. 10(3), 1972
PMID: 4667921
Electric field mediated gene transfer
Wong, Biophys. Biochem. Res. Commun. 107(), 1982
Gene transfer into mouse lyoma cells by electroporation in high electric fields.
Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH., EMBO J. 1(7), 1982
PMID: 6329708
Digression on membrane electroporation and electroporative delivery of drugs and genes
Neumann, Radiol. Oncol. 32(), 1998
Cell fusion induced by electric impulses applied to dictyostelium
Neumann, Naturwissenschaften 67(), 1980
Electro-insertion of xenoglycophorin into the red blood cell membrane
Mouneimne, Biophys. Biochem. Res. Commun. 159(), 1989
Biomedical applications of electric pulses with special emphasis on antitumor electrochemotherapy
Mir, Bioelectrochem. Bioenerg. 38(), 1995
Mechanism of electroporative dye uptake by mouse B cells.
Neumann E, Toensing K, Kakorin S, Budde P, Frey J., Biophys. J. 74(1), 1998
PMID: 9449314
Calcium-mediated DNA adsorption to yeast cells and kinetics of cell transformation by electroporation.
Neumann E, Kakorin S, Tsoneva I, Nikolova B, Tomov T., Biophys. J. 71(2), 1996
PMID: 8842225
Electroporative deformation of salt filled lipid vesicles
Kakorin, Eur. Biophys. J. 27(), 1998
Kinetics of electroporative deformation of lipid vesicles and biological cells in an electric field
Kakorin, Ber. Bunsenges, Phys. Chem. 102(), 1998
On the dynamics of the electric field induced breakdown in lipid membranes
Winterhalter, IEEE Trans. Ind. Appl. 32(), 1996

AUTHOR UNKNOWN, 0
Molecular-basis for cell-membrane electroporation
Weaver, Ann. New York Acad. Sci. 720(), 1994
Theory of electroporation: a review
Weaver, Biolectrochem. Bioenerg. 41(), 1996
Electrooptics of membrane electroporation and vesicle shape deformation
Neumann, Curr. Opin. Colloid. Interface Sci. 1(), 1996
Electro-optics of membrane electroporation in diphenylhexatriene-doped lipid bilayer vesicles.
Kakorin S, Stoylov SP, Neumann E., Biophys. Chem. 58(1-2), 1996
PMID: 8679914

AUTHOR UNKNOWN, 0
Annexin V and vesicle membrane electroporation.
Tonsing K, Kakorin S, Neumann E, Liemann S, Huber R., Eur. Biophys. J. 26(4), 1997
PMID: 9378099

AUTHOR UNKNOWN, 0
Membrane electrostatics
Cevc, Biochim. Biophys. Acta 1031–3(), 1990

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Membrane electroporation and direct gene transfer
Neumann, Biochem. Bioenerg. 28(), 1992
Electroporation of cell membrane visualized under a pulsed-laser fluorescence microscope.
Kinosita K Jr, Ashikawa I, Saita N, Yoshimura H, Itoh H, Nagayama K, Ikegami A., Biophys. J. 53(6), 1988
PMID: 3395657

AUTHOR UNKNOWN, 0
Chemical electric field effects in biological macromolecules.
Neumann E., Prog. Biophys. Mol. Biol. 47(3), 1986
PMID: 3544052

AUTHOR UNKNOWN, 0
Vesicles and Biomembranes
Lipowsky, Encyclopedia Appl. Phys. 23(), 1998
Effect of surface charge on the curvature elasticity of membranes
Winterhalter, J. Phys. Chem. 92(), 1988
Undulations of charged membranes
Fogden, Langmuir 6(), 1990
Electric breakdown of bilayer lipid membrane: I. The main experimental facts and their theoretical discussion
Abidor, Bioelectrochem. Bioenerg. 6(), 1979

AUTHOR UNKNOWN, 0
Dip patch clamp currents suggest electrodiffusive transport of the polyelectrolyte DNA through lipid bilayers.
Spassova M, Tsoneva I, Petrov AG, Petkova JI, Neumann E., Biophys. Chem. 52(3), 1994
PMID: 7999976
Sphingosine-mediated electroporative DNA transfer through lipid bilayers.
Hristova NI, Tsoneva I, Neumann E., FEBS Lett. 415(1), 1997
PMID: 9326374
Measurement of the hydrophobic interaction between two hydrophobic surfaces in aqueous electrolyte solutions
Israelachvili, J. Coll. Int. Sci. 98(), 1984
Electroporation and electrophoretic DNA transfer into cells. The effect of DNA interaction with electropores.
Sukharev SI, Klenchin VA, Serov SM, Chernomordik LV, Chizmadzhev YuA ., Biophys. J. 63(5), 1992
PMID: 1282374
Light scattering of DNA plasmids containing repeated curved insertions: anomalous compaction
Chirico, Biophys. Chem. 45(), 1992
Bleomycin: revival of an old drug.
Mir LM, Tounekti O, Orlowski S., Gen. Pharmacol. 27(5), 1996
PMID: 8842674
Enhancement of cytotoxicity by electropermeabilization: an improved method for screening drugs.
Gehl J, Skovsgaard T, Mir LM., Anticancer Drugs 9(4), 1998
PMID: 9635922
Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy.
Heller R, Jaroszeski MJ, Glass LF, Messina JL, Rapaport DP, DeConti RC, Fenske NA, Gilbert RA, Mir LM, Reintgen DS., Cancer 77(5), 1996
PMID: 8608491

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 10228565
PubMed | Europe PMC

Suchen in

Google Scholar