Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor

Winkler M, Oberpichler A, Tschesche H, Ruck P, Fischer DC, Rath W (1999)
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 181(1): 153-158.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Winkler, M; Oberpichler, A; Tschesche, HaraldUniBi; Ruck, P; Fischer, DC; Rath, W
Einrichtung
Fakultät für Chemie > Biochemie I
Abstract / Bemerkung
OBJECTIVE: The objective of this study was to quantify the extent of neutrophil infiltration and the concentrations of enzymes involved in collagenolysis in the lower uterine segment in relation to the degree of cervical dilatation and the duration of labor. STUDY DESIGN: Biopsy specimens of the lower uterine segment were obtained from 62 women undergoing cesarean section at term. The number of extravascular neutrophils was assessed with enzyme histochemical evaluation, and the concentrations of matrix metalloproteinase-8, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinases-1 by were assessed by enzyme-linked immunosorbent assay. RESULTS: The neutrophil count and the concentrations of matrix metalloproteinase-8, matrix metalloproteinase-9, and tissue inhibitor of metalloproieinases-1 increased with increasing cervical dilatation. At >6 cm the neutrophil count and the concentrations of matrix metalloproteinase-8, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinases-1 were significantly higher than at <2 cm. An association with the duration of labor was found for the neutrophil count and the concentrations of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1. Multiple linear regression analysis showed that the degree of cervical dilatation is more closely related to the 4 laboratory parameters investigated than to the duration of labor. CONCLUSION: The findings support the hypothesis that local changes (ie, collagenolysis) in the lower uterine segment unrelated to uterine activity play a crucial role in cervical dilatation at term.
Stichworte
parturition; metalloproteinases; collagenolysis; uterine cervix; inhibitor of metalloproteinases; tissue
Erscheinungsjahr
1999
Zeitschriftentitel
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Band
181
Ausgabe
1
Seite(n)
153-158
ISSN
0002-9378
Page URI
https://pub.uni-bielefeld.de/record/1622495

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Winkler M, Oberpichler A, Tschesche H, Ruck P, Fischer DC, Rath W. Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 1999;181(1):153-158.
Winkler, M., Oberpichler, A., Tschesche, H., Ruck, P., Fischer, D. C., & Rath, W. (1999). Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 181(1), 153-158. https://doi.org/10.1016/S0002-9378(99)70452-7
Winkler, M, Oberpichler, A, Tschesche, Harald, Ruck, P, Fischer, DC, and Rath, W. 1999. “Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor”. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 181 (1): 153-158.
Winkler, M., Oberpichler, A., Tschesche, H., Ruck, P., Fischer, D. C., and Rath, W. (1999). Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 181, 153-158.
Winkler, M., et al., 1999. Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 181(1), p 153-158.
M. Winkler, et al., “Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor”, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 181, 1999, pp. 153-158.
Winkler, M., Oberpichler, A., Tschesche, H., Ruck, P., Fischer, D.C., Rath, W.: Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 181, 153-158 (1999).
Winkler, M, Oberpichler, A, Tschesche, Harald, Ruck, P, Fischer, DC, and Rath, W. “Collagenolysis in the lower uterine segment during parturition at term: Correlations with stage of cervical dilatation and duration of labor”. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 181.1 (1999): 153-158.

31 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Urinary phthalate metabolite concentrations in relation to levels of circulating matrix metalloproteinases in pregnant women.
Bedrosian LD, Ferguson KK, Cantonwine DE, McElrath TF, Meeker JD., Sci Total Environ 613-614(), 2018
PMID: 28968947
Roles and regulation of the matrix metalloproteinase system in parturition.
Geng J, Huang C, Jiang S., Mol Reprod Dev 83(4), 2016
PMID: 26888468
Previous prelabor or intrapartum cesarean delivery and risk of placenta previa.
Downes KL, Hinkle SN, Sjaarda LA, Albert PS, Grantz KL., Am J Obstet Gynecol 212(5), 2015
PMID: 25576818
Maternal circulating leukocytes display early chemotactic responsiveness during late gestation.
Gomez-Lopez N, Tanaka S, Zaeem Z, Metz GA, Olson DM., BMC Pregnancy Childbirth 13 Suppl 1(), 2013
PMID: 23445935
Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid in late pregnancy and labor.
Heng YJ, Di Quinzio MK, Liong S, Permezel M, Rice GE, Georgiou HM., Reprod Sci 19(1), 2012
PMID: 22051851
Distribution of estrogen receptor alpha and progesterone receptor, and leukocyte infiltration in the cervix of cyclic bitches and those with pyometra.
Kunkitti P, Srisuwatanasagul S, Chatdarong K., Theriogenology 75(6), 2011
PMID: 21196032
Cervical ripening and parturition in cows are driven by a cascade of pro-inflammatory cytokines.
van Engelen E, de Groot MW, Breeveld-Dwarkasing VN, Everts ME, van der Weyden GC, Taverne MA, Rutten VP., Reprod Domest Anim 44(5), 2009
PMID: 19769639
MMP-2 expression precedes the final ripening process of the bovine cervix.
van Engelen E, Breeveld-Dwarkasing VN, Taverne MA, Everts ME, van der Weijden GC, Rutten VP., Mol Reprod Dev 75(11), 2008
PMID: 18361420
Use of hyaluronidase for cervical ripening: a randomized trial.
Spallicci MD, Chiea MA, Singer JM, Albuquerque PB, Bittar RE, Zugaib M., Eur J Obstet Gynecol Reprod Biol 130(1), 2007
PMID: 16324780
Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function.
Yan T, Liu B, Du D, Eisenach JC, Tong C., Anesth Analg 104(5), 2007
PMID: 17456681
The value of cervical length and plasma proMMP-9 levels for the prediction of preterm delivery in pregnant women presenting with threatened preterm labor.
Botsis D, Makrakis E, Papagianni V, Kouskouni E, Grigoriou O, Dendrinos S, Creatsas G., Eur J Obstet Gynecol Reprod Biol 128(1-2), 2006
PMID: 16314025
Chronic estrogen sensitizes a subset of mechanosensitive afferents innervating the uterine cervix.
Liu B, Eisenach JC, Tong C., J Neurophysiol 93(4), 2005
PMID: 15774714
Gene expression signatures in neutrophils exposed to glucocorticoids: a new paradigm to help explain "neutrophil dysfunction" in parturient dairy cows.
Burton JL, Madsen SA, Chang LC, Weber PS, Buckham KR, van Dorp R, Hickey MC, Earley B., Vet Immunol Immunopathol 105(3-4), 2005
PMID: 15808301
Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection.
Esplin MS, Romero R, Chaiworapongsa T, Kim YM, Edwin S, Gomez R, Mazor M, Adashi EY., J Matern Fetal Neonatal Med 17(6), 2005
PMID: 16009638
Macrophages and not granulocytes are involved in cervical ripening.
Sakamoto Y, Moran P, Bulmer JN, Searle RF, Robson SC., J Reprod Immunol 66(2), 2005
PMID: 16045998
The role of nuclear factor kappa B in human labour.
Lindström TM, Bennett PR., Reproduction 130(5), 2005
PMID: 16264088
Thrombospondin 2 deficiency in pregnant mice results in premature softening of the uterine cervix.
Kokenyesi R, Armstrong LC, Agah A, Artal R, Bornstein P., Biol Reprod 70(2), 2004
PMID: 14561659
Amniotic fluid concentrations of collagenase-1 and collagenase-3 are increased in polyhydramnios.
Fortunato SJ, Menon R, Ahmed NU, Bourgeois M, Dildy GA., J Perinat Med 32(2), 2004
PMID: 15085886
Prostaglandins and the myometrium and cervix.
Hertelendy F, Zakár T., Prostaglandins Leukot Essent Fatty Acids 70(2), 2004
PMID: 14683694
Decidualisation of cervical stromal cells.
Cowan S, Calder AA, Kelly RW., Eur J Obstet Gynecol Reprod Biol 114(2), 2004
PMID: 15140514
Interleukin-8 is involved in cervical dilatation but not in prelabour cervical ripening.
Sakamoto Y, Moran P, Searle RF, Bulmer JN, Robson SC., Clin Exp Immunol 138(1), 2004
PMID: 15373918
Cervical dilatation related to uterine electromyographic activity and endocrinological changes during prostaglandin F(2alpha)-induced parturition in cows.
Breeveld-Dwarkasing VN, Struijk PC, Lotgering FK, Eijskoot F, Kindahl H, van der Weijden GC, Taverne MA., Biol Reprod 68(2), 2003
PMID: 12533417
Cytokines, prostaglandins and parturition--a review.
Keelan JA, Blumenstein M, Helliwell RJ, Sato TA, Marvin KW, Mitchell MD., Placenta 24 Suppl A(), 2003
PMID: 12842412
Changes in water content, collagen degradation, collagen content, and concentration in repeated biopsies of the cervix of pregnant cows.
Breeveld-Dwarkasing VN, te Koppele JM, Bank RA, van der Weijden GC, Taverne MA, van Dissel-Emiliani FM., Biol Reprod 69(5), 2003
PMID: 12855606
The role of leukocyte traffic and activation in parturition.
Yellon SM, Mackler AM, Kirby MA., J Soc Gynecol Investig 10(6), 2003
PMID: 12969775
Chorioamnionitis: elevated interleukin-6 and interleukin-8 concentrations in the lower uterine segment.
Willi MJ, Winkler M, Fischer DC, Reineke T, Maul H, Rath W., J Perinat Med 30(4), 2002
PMID: 12235716
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes.
Rosen T, Schatz F, Kuczynski E, Lam H, Koo AB, Lockwood CJ., J Matern Fetal Neonatal Med 11(1), 2002
PMID: 12380602
Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition.
Bowen JM, Chamley L, Keelan JA, Mitchell MD., Placenta 23(4), 2002
PMID: 11969336
Estrogen receptor alpha and progesterone receptor A and B concentration and localization in the lower uterine segment in term parturition.
Winkler M, Kemp B, Classen-Linke I, Fischer DC, Zlatinsi S, Neulen J, Beier HM, Rath W., J Soc Gynecol Investig 9(4), 2002
PMID: 12113882
Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes.
Ognjanovic S, Bryant-Greenwood GD., Am J Obstet Gynecol 187(4), 2002
PMID: 12389004
Tissue concentrations of cytokines in the lower uterine segment during preterm parturition.
Winkler M, Kemp B, Fischer DC, Maul H, Hlubek M, Rath W., J Perinat Med 29(6), 2001
PMID: 11776683

27 References

Daten bereitgestellt von Europe PubMed Central.

Morphologic and histochemical evidence for the occurrence of collagenolysis and for the role of neutrophilic polymorphonuclear leukocytes during cervical dilation.
Junqueira LC, Zugaib M, Montes GS, Toledo OM, Krisztan RM, Shigihara KM., Am. J. Obstet. Gynecol. 138(3), 1980
PMID: 7416217
Interleukin-8 associated increase in the number of neutrophilic granulocytes in the cervical stroma as a basic mechanism of cervical dilatation during parturition at term
Winkler, Geburtsh Frauenheilk 57(), 1997
Elevated tissue levels of collagenase during dilation of uterine cervix in human parturition.
Rajabi MR, Dean DD, Beydoun SN, Woessner JF Jr., Am. J. Obstet. Gynecol. 159(4), 1988
PMID: 2845786
Origin of cervical collagenase during parturition.
Osmers R, Rath W, Adelmann-Grill BC, Fittkow C, Kuloczik M, Szeverenyi M, Tschesche H, Kuhn W., Am. J. Obstet. Gynecol. 166(5), 1992
PMID: 1317677
Serum collagenase levels in relation to the state of the human cervix during pregnancy and labor.
Granstrom LM, Ekman GE, Malmstrom A, Ulmsten U, Woessner JF Jr., Am. J. Obstet. Gynecol. 167(5), 1992
PMID: 1442977
Collagen changes in rat cervix in pregnancy--polarized light microscopic and electron microscopic studies.
Yu SY, Tozzi CA, Babiarz J, Leppert PC., Proc. Soc. Exp. Biol. Med. 209(4), 1995
PMID: 7638243
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL., J. Biol. Chem. 265(20), 1990
PMID: 2164002
The collagen substrate specificity of human neutrophil collagenase.
Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG., J. Biol. Chem. 262(21), 1987
PMID: 3038863
Matrix metalloproteinases and their inhibitors in connective tissue remodeling.
Woessner JF Jr., FASEB J. 5(8), 1991
PMID: 1850705
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI., J. Biol. Chem. 264(29), 1989
PMID: 2551898
Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.
Hibbs MS, Hasty KA, Seyer JM, Kang AH, Mainardi CL., J. Biol. Chem. 260(4), 1985
PMID: 2982822
Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages.
Hibbs MS, Hoidal JR, Kang AH., J. Clin. Invest. 80(6), 1987
PMID: 3680518
Human 92- and 72-kilodalton type IV collagenases are elastases.
Senior RM, Griffin GL, Fliszar CJ, Shapiro SD, Goldberg GI, Welgus HG., J. Biol. Chem. 266(12), 1991
PMID: 1850424
Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.
Murphy G, Reynolds JJ, Werb Z., J. Biol. Chem. 260(5), 1985
PMID: 2982848
Matrix metalloproteinases 1, 2 and 3: substrate specificities and activation mechanisms
Nagase, 1991
Collagenase, its inhibitors, and decorin in the lower uterine segment in pregnant women.
Rechberger T, Woessner JF Jr., Am. J. Obstet. Gynecol. 168(5), 1993
PMID: 8498448
Interleukin-1beta and interleukin-8 concentrations in the lower uterine segment during parturition at term.
Winkler M, Fischer DC, Hlubek M, van de Leur E, Haubeck HD, Rath W., Obstet Gynecol 91(6), 1998
PMID: 9611001
An intravaginal controlled-release prostaglandin E2 pessary for cervical ripening and initiation of labor at term.
Rayburn WF, Wapner RJ, Barss VA, Spitzberg E, Molina RD, Mandsager N, Yonekura ML., Obstet Gynecol 79(3), 1992
PMID: 1738517
Cervical dilatation as an acute inflammatory reaction: increasing concentrations of interleukin-1 are associated with an increased expression of cell adhesion molecules within the lower uterine segment during parturition
Winkler, Geburtshilfe Frauenheilkd 57(), 1997
[ON THE SELECTIVE ENZYME-CYTOCHEMICAL DEMONSTRATION OF NEUTROPHILIC MYELOID CELLS AND TISSUE MAST CELLS IN PARAFFIN SECTIONS].
LEDER LD., Klin. Wochenschr. 42(), 1964
PMID: 14233286
Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase.
Bergmann U, Michaelis J, Oberhoff R, Knauper V, Beckmann R, Tschesche H., J. Clin. Chem. Clin. Biochem. 27(6), 1989
PMID: 2547014
Collagenase activity in the cervix of non-pregnant and pregnant women.
Osmers R, Rath W, Adelmann-Grill BC, Fittkow C, Severenyi M, Kuhn W., Arch. Gynecol. Obstet. 248(2), 1990
PMID: 1964036
Interleukin-8 synthesis and the onset of labor.
Osmers RG, Blaser J, Kuhn W, Tschesche H., Obstet Gynecol 86(2), 1995
PMID: 7617353
Interleukin 1 stimulation of collagenase production by cultured fibroblasts.
Postlethwaite AE, Lachman LB, Mainardi CL, Kang AH., J. Exp. Med. 157(2), 1983
PMID: 6296266
Human recombinant interleukin-1 alpha-mediated stimulation of procollagenase production and suppression of biosynthesis of tissue inhibitor of metalloproteinases in rabbit uterine cervical fibroblasts.
Ito A, Goshowaki H, Sato T, Mori Y, Yamashita K, Hayakawa T, Nagase H., FEBS Lett. 234(2), 1988
PMID: 2839371
The existing forms of collagenase in the human uterine cervix.
Kitamura K, Ito A, Mori Y., J. Biochem. 87(3), 1980
PMID: 6248499
Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.
MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI., J. Biol. Chem. 265(28), 1990
PMID: 1698773
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