Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro
Hegele-Hartung C, Kuhnke J, Lessl M, Grondahl C, Ottesen J, Beier HM, Eisner S, Eichenlaub-Ritter U (1999)
BIOLOGY OF REPRODUCTION 61(5): 1362-1372.
Zeitschriftenaufsatz
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Autor*in
Hegele-Hartung, C;
Kuhnke, J;
Lessl, M;
Grondahl, C;
Ottesen, J;
Beier, HM;
Eisner, S;
Eichenlaub-Ritter, UrsulaUniBi
Abstract / Bemerkung
Synthetically produced meiosis-activating sterol, a sterol originally derived from follicular fluid (FF-MAS), induces meiotic maturation of mouse oocytes in vitro. We therefore compared FF-MAS-induced maturation of naked mouse oocytes arrested in prophase I by either hypoxanthine (Hx) or forskolin (Fo) with spontaneous maturation of naked oocytes. FF-MAS-treated oocytes overcame the meiotic block by Hx or Fo, although germinal vesicle breakdown was delayed by 11 h and 7 h, respectively. We also investigated the influence of FF-MAS on chromosome, microtubule, and ultrastructural dynamics in Hx-cultured oocytes by immunocytochemistry and electron microscopy. Similarly to spontaneously matured oocytes, chromosomes became aligned, a barrel-shaped spindle formed, and overall organelle distribution was normal in FF-MAS-matured oocytes. The number of small cytoplasmic asters was elevated in FF-MAS-treated oocytes. Although the number of cortical granules (CGs) was similar to that in spontaneously matured oocytes, the overall distance between CGs and oolemma was increased in the FF-MAS group. These observations suggest that the initiation of meiotic maturation in FF-MAS-treated oocytes in the presence of high cAMP levels leads to a delayed but otherwise normal nuclear maturation. FF-MAS appears to improve oocyte quality by supporting microtubule assembly and by delaying CG release, which is known to contribute to reduced fertilization.
Erscheinungsjahr
1999
Zeitschriftentitel
BIOLOGY OF REPRODUCTION
Band
61
Ausgabe
5
Seite(n)
1362-1372
ISSN
0006-3363
eISSN
1529-7268
Page URI
https://pub.uni-bielefeld.de/record/1621578
Zitieren
Hegele-Hartung C, Kuhnke J, Lessl M, et al. Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro. BIOLOGY OF REPRODUCTION. 1999;61(5):1362-1372.
Hegele-Hartung, C., Kuhnke, J., Lessl, M., Grondahl, C., Ottesen, J., Beier, H. M., Eisner, S., et al. (1999). Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro. BIOLOGY OF REPRODUCTION, 61(5), 1362-1372. https://doi.org/10.1095/biolreprod61.5.1362
Hegele-Hartung, C, Kuhnke, J, Lessl, M, Grondahl, C, Ottesen, J, Beier, HM, Eisner, S, and Eichenlaub-Ritter, Ursula. 1999. “Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro”. BIOLOGY OF REPRODUCTION 61 (5): 1362-1372.
Hegele-Hartung, C., Kuhnke, J., Lessl, M., Grondahl, C., Ottesen, J., Beier, H. M., Eisner, S., and Eichenlaub-Ritter, U. (1999). Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro. BIOLOGY OF REPRODUCTION 61, 1362-1372.
Hegele-Hartung, C., et al., 1999. Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro. BIOLOGY OF REPRODUCTION, 61(5), p 1362-1372.
C. Hegele-Hartung, et al., “Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro”, BIOLOGY OF REPRODUCTION, vol. 61, 1999, pp. 1362-1372.
Hegele-Hartung, C., Kuhnke, J., Lessl, M., Grondahl, C., Ottesen, J., Beier, H.M., Eisner, S., Eichenlaub-Ritter, U.: Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro. BIOLOGY OF REPRODUCTION. 61, 1362-1372 (1999).
Hegele-Hartung, C, Kuhnke, J, Lessl, M, Grondahl, C, Ottesen, J, Beier, HM, Eisner, S, and Eichenlaub-Ritter, Ursula. “Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro”. BIOLOGY OF REPRODUCTION 61.5 (1999): 1362-1372.
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Maro B, Howlett SK, Webb M., J. Cell Biol. 101(5 Pt 1), 1985
PMID: 2865266
Maro B, Howlett SK, Webb M., J. Cell Biol. 101(5 Pt 1), 1985
PMID: 2865266
Centrosome and microtubule dynamics during meiotic progression in the mouse oocyte.
AUTHOR UNKNOWN, J Cell Sci 100(), 1991
AUTHOR UNKNOWN, J Cell Sci 100(), 1991
Animal cell cycles and their control.
Norbury C, Nurse P., Annu. Rev. Biochem. 61(), 1992
PMID: 1497317
Norbury C, Nurse P., Annu. Rev. Biochem. 61(), 1992
PMID: 1497317
Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse.
Verlhac MH, Kubiak JZ, Weber M, Geraud G, Colledge WH, Evans MJ, Maro B., Development 122(3), 1996
PMID: 8631259
Verlhac MH, Kubiak JZ, Weber M, Geraud G, Colledge WH, Evans MJ, Maro B., Development 122(3), 1996
PMID: 8631259
Oocyte maturation can be induced by a synthetic meiosis activating sterol (MAS) leading to an improvement of IVF rate in mice.
AUTHOR UNKNOWN, Hum Reprod 13(), 1998
AUTHOR UNKNOWN, Hum Reprod 13(), 1998
Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes.
Eichenlaub-Ritter U, Betzendahl I., Mutagenesis 10(6), 1995
PMID: 8596466
Eichenlaub-Ritter U, Betzendahl I., Mutagenesis 10(6), 1995
PMID: 8596466
Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes.
Yin H, Cukurcam S, Betzendahl I, Adler ID, Eichenlaub-Ritter U., Chromosoma 107(6-7), 1998
PMID: 9914385
Yin H, Cukurcam S, Betzendahl I, Adler ID, Eichenlaub-Ritter U., Chromosoma 107(6-7), 1998
PMID: 9914385
AUTHOR UNKNOWN, 1974
Changes in the distribution of mouse oocyte cortical granules and ability to undergo the cortical reaction during gonadotropin-stimulated meiotic maturation and aging in vivo.
Ducibella T, Duffy P, Reindollar R, Su B., Biol. Reprod. 43(5), 1990
PMID: 2291919
Ducibella T, Duffy P, Reindollar R, Su B., Biol. Reprod. 43(5), 1990
PMID: 2291919
AUTHOR UNKNOWN, 1985
Involvement of the cytoskeleton in the movement of cortical granules during oocyte maturation, and cortical granule anchoring in mouse eggs.
AUTHOR UNKNOWN, Dev Biol 200(), 1988
AUTHOR UNKNOWN, Dev Biol 200(), 1988
Spontaneous cortical granule release and alteration of zona pellucida properties during and after meiotic maturation of mouse oocytes.
Okada A, Inomata K, Nagae T., Anat. Rec. 237(4), 1993
PMID: 8311265
Okada A, Inomata K, Nagae T., Anat. Rec. 237(4), 1993
PMID: 8311265
Spontaneous hardening of the zona pellucida of mouse oocytes during in vitro culture.
AUTHOR UNKNOWN, Gamete Res 6(), 1982
AUTHOR UNKNOWN, Gamete Res 6(), 1982
Precocious loss of cortical granules during mouse oocyte meiotic maturation and correlation with an egg-induced modification of the zona pellucida.
Ducibella T, Kurasawa S, Rangarajan S, Kopf GS, Schultz RM., Dev. Biol. 137(1), 1990
PMID: 2104813
Ducibella T, Kurasawa S, Rangarajan S, Kopf GS, Schultz RM., Dev. Biol. 137(1), 1990
PMID: 2104813
Sperm penetration in vitro of mouse oocytes at various times during maturation.
Iwamatsu T, Chang MC., J. Reprod. Fertil. 31(2), 1972
PMID: 4118050
Iwamatsu T, Chang MC., J. Reprod. Fertil. 31(2), 1972
PMID: 4118050
Microtubules and the endoplasmic reticulum are highly interdependent structures.
Terasaki M, Chen LB, Fujiwara K., J. Cell Biol. 103(4), 1986
PMID: 3533956
Terasaki M, Chen LB, Fujiwara K., J. Cell Biol. 103(4), 1986
PMID: 3533956
Microtubule mediation of cytoplasmic and nuclear maturation during the early stages of resumed meiosis in cultured mouse oocytes.
Van Blerkom J., Proc. Natl. Acad. Sci. U.S.A. 88(11), 1991
PMID: 2052585
Van Blerkom J., Proc. Natl. Acad. Sci. U.S.A. 88(11), 1991
PMID: 2052585
Effects of ketoconazole on ovulatory changes in the rat: implications on the role of a meiosis-activating sterol.
Tsafriri A, Popliker M, Nahum R, Beyth Y., Mol. Hum. Reprod. 4(5), 1998
PMID: 9665635
Tsafriri A, Popliker M, Nahum R, Beyth Y., Mol. Hum. Reprod. 4(5), 1998
PMID: 9665635
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