Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system

Rathke-Hartlieb S, Budde P, Ewert S, Schlomann U, Staege MS, Jockusch H, Bartsch JW, Frey J (2000)
FEBS LETTERS 481(3): 227-234.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Reactive astrocytes occurring in response to neurodegeneration are thought to play an important role in neuronal regeneration by upregulating the expression of extracellular matrix (ECM) components as well as the ECM degrading metalloproteinases (MMPs). We examined the mRNA levels and cellular distribution of membrane type matrix metalloproteinase 1 (MT1-MMP) and tissue inhibitors 1-4 of MMPs (TIMPs) in brain stem and spinal cord of wobbler (WR) mutant mice affected by progressive neurodegeneration and astrogliosis. MT1-MMP, TIMP-1 and TIMP-3 mRNA levels were elevated, whereas TIMP-2 and TIMP-4 expression was not affected. MT1-MMP was expressed in reactive astrocytes of WR. In primary astrocyte cultures, MT1-MMP mRNA was upregulated by exogeneous tumor necrosis factor alpha. Increased plasma membrane and secreted MMP activities were found in primary WR astrocytes. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Stichworte
necrosis factor alpha; tumor; tissue inhibitor of metalloproteinase; metalloproteinase 1; membrane type matrix; astrocyte; wobbler mouse; neurodegeneration
Erscheinungsjahr
2000
Zeitschriftentitel
FEBS LETTERS
Band
481
Ausgabe
3
Seite(n)
227-234
ISSN
0014-5793
Page URI
https://pub.uni-bielefeld.de/record/1618965

Zitieren

Rathke-Hartlieb S, Budde P, Ewert S, et al. Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS. 2000;481(3):227-234.
Rathke-Hartlieb, S., Budde, P., Ewert, S., Schlomann, U., Staege, M. S., Jockusch, H., Bartsch, J. W., et al. (2000). Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS, 481(3), 227-234. doi:10.1016/S0014-5793(00)02011-1
Rathke-Hartlieb, S., Budde, P., Ewert, S., Schlomann, U., Staege, M. S., Jockusch, H., Bartsch, J. W., and Frey, J. (2000). Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS 481, 227-234.
Rathke-Hartlieb, S., et al., 2000. Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS, 481(3), p 227-234.
S. Rathke-Hartlieb, et al., “Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system”, FEBS LETTERS, vol. 481, 2000, pp. 227-234.
Rathke-Hartlieb, S., Budde, P., Ewert, S., Schlomann, U., Staege, M.S., Jockusch, H., Bartsch, J.W., Frey, J.: Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS. 481, 227-234 (2000).
Rathke-Hartlieb, S, Budde, P, Ewert, S, Schlomann, U, Staege, MS, Jockusch, Harald, Bartsch, JW, and Frey, Jürgen. “Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system”. FEBS LETTERS 481.3 (2000): 227-234.

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