Pregnancy-associated plasma protein-E (PAPP-E)

Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (2000)
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493(3): 356-362.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
A full-length cDNA encoding a novel human protein was cloned from placenta cDNA. The corresponding 1542 amino acid protein sequence was termed 'pregnancy-associated plasma protein-E' (PAPP-E) as it shows a 62% homology to the human pregnancy-associated plasma protein-A (PAPP-A) that is a diagnostic marker for trisomies, especially Down syndrome. The conserved domain structure contains five motifs related to the short consensus repeats of complement proteins and selectins, three motifs related to the lin-notch motifs of proteins regulating early tissue differentiation, and a putative zinc-binding motif and active site of the metzincin-superfamily of metalloproteases. The PAPP-E gene was localized to chromosome 1q23-25. Northern blot analysis showed that PAPP-E is predominantly expressed in placenta. (C) 2000 Elsevier Science B.V. All rights reserved.
Stichworte
pregnancy-associated plasma protein; novel human cDNA; chromosome; 1q23-25; placenta
Erscheinungsjahr
2000
Zeitschriftentitel
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Band
1493
Ausgabe
3
Seite(n)
356-362
ISSN
0167-4781
Page URI
https://pub.uni-bielefeld.de/record/1618893

Zitieren

Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 2000;1493(3):356-362.
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., & Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), 356-362. doi:10.1016/S0167-4781(00)00195-0
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., and Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493, 356-362.
Farr, M., et al., 2000. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), p 356-362.
M. Farr, et al., “Pregnancy-associated plasma protein-E (PAPP-E)”, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, vol. 1493, 2000, pp. 356-362.
Farr, M., Strube, J., Geppert, H.G., Kocourek, A., Mahne, M., Tschesche, H.: Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 1493, 356-362 (2000).
Farr, M, Strube, J, Geppert, HG, Kocourek, A, Mahne, M, and Tschesche, Harald. “Pregnancy-associated plasma protein-E (PAPP-E)”. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493.3 (2000): 356-362.

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