Pregnancy-associated plasma protein-E (PAPP-E)

Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (2000)
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493(3): 356-362.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Farr, M; Strube, J; Geppert, HG; Kocourek, A; Mahne, M; Tschesche, HaraldUniBi
Einrichtung
Fakultät für Chemie > Biochemie I
Abstract / Bemerkung
A full-length cDNA encoding a novel human protein was cloned from placenta cDNA. The corresponding 1542 amino acid protein sequence was termed 'pregnancy-associated plasma protein-E' (PAPP-E) as it shows a 62% homology to the human pregnancy-associated plasma protein-A (PAPP-A) that is a diagnostic marker for trisomies, especially Down syndrome. The conserved domain structure contains five motifs related to the short consensus repeats of complement proteins and selectins, three motifs related to the lin-notch motifs of proteins regulating early tissue differentiation, and a putative zinc-binding motif and active site of the metzincin-superfamily of metalloproteases. The PAPP-E gene was localized to chromosome 1q23-25. Northern blot analysis showed that PAPP-E is predominantly expressed in placenta. (C) 2000 Elsevier Science B.V. All rights reserved.
Stichworte
pregnancy-associated plasma protein; novel human cDNA; chromosome; 1q23-25; placenta
Erscheinungsjahr
2000
Zeitschriftentitel
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Band
1493
Ausgabe
3
Seite(n)
356-362
ISSN
0167-4781
Page URI
https://pub.uni-bielefeld.de/record/1618893

Zitieren

Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 2000;1493(3):356-362.
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., & Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), 356-362. https://doi.org/10.1016/S0167-4781(00)00195-0
Farr, M, Strube, J, Geppert, HG, Kocourek, A, Mahne, M, and Tschesche, Harald. 2000. “Pregnancy-associated plasma protein-E (PAPP-E)”. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493 (3): 356-362.
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., and Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493, 356-362.
Farr, M., et al., 2000. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), p 356-362.
M. Farr, et al., “Pregnancy-associated plasma protein-E (PAPP-E)”, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, vol. 1493, 2000, pp. 356-362.
Farr, M., Strube, J., Geppert, H.G., Kocourek, A., Mahne, M., Tschesche, H.: Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 1493, 356-362 (2000).
Farr, M, Strube, J, Geppert, HG, Kocourek, A, Mahne, M, and Tschesche, Harald. “Pregnancy-associated plasma protein-E (PAPP-E)”. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493.3 (2000): 356-362.

12 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birth.
Pereyra S, Sosa C, Bertoni B, Sapiro R., BMC Med Genomics 12(1), 2019
PMID: 30935390
First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the maternal circulation are elevated in pregnancies that subsequently develop preeclampsia.
Crosley EJ, Durland U, Seethram K, MacRae S, Gruslin A, Christians JK., Reprod Sci 21(6), 2014
PMID: 24336677
A robust immunoassay for pregnancy-associated plasma protein-A2 based on analysis of circulating antigen: establishment of normal ranges in pregnancy.
Kløverpris S, Gaidamauskas E, Rasmussen LC, Overgaard MT, Kronborg C, Knudsen UB, Christiansen M, Kumar A, Oxvig C., Mol Hum Reprod 19(11), 2013
PMID: 23804707
PAPP-A levels of late pregnancy in preeclampsia and HELLP syndrome.
Atis A, Aydin Y, Basol E, Kaleli S, Turgay F, Goker N., Arch Gynecol Obstet 285(1), 2012
PMID: 21533533
Altered placental expression of PAPPA2 does not affect birth weight in mice.
Wagner PK, Christians JK., Reprod Biol Endocrinol 8(), 2010
PMID: 20642865
Altered levels of insulin-like growth factor binding protein proteases in preeclampsia and intrauterine growth restriction.
Christians JK, Gruslin A., Prenat Diagn 30(9), 2010
PMID: 20658698
Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.
Nishizawa H, Pryor-Koishi K, Suzuki M, Kato T, Kogo H, Sekiya T, Kurahashi H, Udagawa Y., Mol Hum Reprod 14(10), 2008
PMID: 18805800
Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex.
García-Castellanos R, Tallant C, Marrero A, Solà M, Baumann U, Gomis-Rüth FX., Arch Biochem Biophys 457(1), 2007
PMID: 17097044
Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease.
Tallant C, García-Castellanos R, Marrero A, Canals F, Yang Y, Reymond JL, Solà M, Baumann U, Gomis-Rüth FX., Biol Chem 388(11), 2007
PMID: 17976018
Structural aspects of the metzincin clan of metalloendopeptidases.
Gomis-Rüth FX., Mol Biotechnol 24(2), 2003
PMID: 12746556
Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.
Boldt HB, Overgaard MT, Laursen LS, Weyer K, Sottrup-Jensen L, Oxvig C., Biochem J 358(pt 2), 2001
PMID: 11513734
The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant.
Page NM, Butlin DJ, Lomthaisong K, Lowry PJ., Placenta 22(8-9), 2001
PMID: 11597188

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