The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2

Lyden TW, Robinson JM, Tridandapani S, Teillaud JL, Garber SA, Osborne JM, Frey J, Budde P, Anderson CL (2001)
JOURNAL OF IMMUNOLOGY 166(6): 3882-3889.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
To evaluate the potential role of human placental endothelial cells in the transport of IgG from maternal to fetal circulation, we studied Fc gamma receptor (Fc gammaR) expression by immunohistology and immunoblotting. Several pan-Fc gamma RII Abs that label the placental endothelium displayed a distribution pattern that correlated well with transport functions, being: intense in the terminal villus and nil in the cord, In contrast, the MHC class 1-like IgG transporter, FcRn, and the classical Fc gamma RIIa were not expressed in transport-related endothelium of the placenta. Our inference, that Fc gamma RIIb was the likely receptor, we confirmed by analyzing purified placental villi, enriched in endothelium, by immunoblotting with a new Ab specific for the cytoplasmic tail of Fc gamma RIIb, These experiments showed that the Fc gamma RII expressed in villus endothelium was the b2 isoform whose cytoplasmic tail is known to include a phosphotyrosyl-based motif that inhibits a variety of immune responses. We suggest that this receptor is perfectly positioned to transport IgG although as well it may scavenge immune complexes.
Erscheinungsjahr
Zeitschriftentitel
JOURNAL OF IMMUNOLOGY
Band
166
Ausgabe
6
Seite(n)
3882-3889
ISSN
PUB-ID

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Lyden TW, Robinson JM, Tridandapani S, et al. The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2. JOURNAL OF IMMUNOLOGY. 2001;166(6):3882-3889.
Lyden, T. W., Robinson, J. M., Tridandapani, S., Teillaud, J. L., Garber, S. A., Osborne, J. M., Frey, J., et al. (2001). The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2. JOURNAL OF IMMUNOLOGY, 166(6), 3882-3889. doi:10.4049/jimmunol.166.6.3882
Lyden, T. W., Robinson, J. M., Tridandapani, S., Teillaud, J. L., Garber, S. A., Osborne, J. M., Frey, J., Budde, P., and Anderson, C. L. (2001). The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2. JOURNAL OF IMMUNOLOGY 166, 3882-3889.
Lyden, T.W., et al., 2001. The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2. JOURNAL OF IMMUNOLOGY, 166(6), p 3882-3889.
T.W. Lyden, et al., “The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2”, JOURNAL OF IMMUNOLOGY, vol. 166, 2001, pp. 3882-3889.
Lyden, T.W., Robinson, J.M., Tridandapani, S., Teillaud, J.L., Garber, S.A., Osborne, J.M., Frey, J., Budde, P., Anderson, C.L.: The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2. JOURNAL OF IMMUNOLOGY. 166, 3882-3889 (2001).
Lyden, TW, Robinson, JM, Tridandapani, S, Teillaud, JL, Garber, SA, Osborne, JM, Frey, Jürgen, Budde, P, and Anderson, CL. “The Fc receptor for IgG expressed in the villus endothelium of human placenta ts Fc gamma RIIb2”. JOURNAL OF IMMUNOLOGY 166.6 (2001): 3882-3889.

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