MMP-TIMP interaction depends on residue 2 in TIMP-4

Stratmann B, Farr M, Tschesche H (2001)
FEBS LETTERS 507(3): 285-287.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Stratmann, B; Farr, M; Tschesche, HaraldUniBi
Einrichtung
Fakultät für Chemie > Biochemie I
Abstract / Bemerkung
Extracellular matrix remodeling and degradation are of great importance in both physiological and pathological: situations. Matrix metalloproteinases (MMPs) and their, natural occurring inhibitors - tissue inhibitors of metalloproteinases (TIMPs) - are involved in matrix turnover. Among the TIMP's there is only little specificity for inhibiting individual MMPs. In this report we describe the mutational analysis of the interaction of human TIMP-4 with several MMPs. The effects of different substitutions of residue 2 (Ser(2)) in the inhibitory domain of TIMP-4 were determined by kinetic measurements. Size, charge and polarity of residue 2 in the TIMP structure are key factors in MMP inhibition. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Stichworte
metalloproteinase-tissue inhibitor of metalloproteinase interaction; matrix metalloproteinase; tissue inhibitor of metalloproteinase; matrix; tissue inhibitor of metalloproteinase specifity
Erscheinungsjahr
2001
Zeitschriftentitel
FEBS LETTERS
Band
507
Ausgabe
3
Seite(n)
285-287
ISSN
0014-5793
Page URI
https://pub.uni-bielefeld.de/record/1615871

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Stratmann B, Farr M, Tschesche H. MMP-TIMP interaction depends on residue 2 in TIMP-4. FEBS LETTERS. 2001;507(3):285-287.
Stratmann, B., Farr, M., & Tschesche, H. (2001). MMP-TIMP interaction depends on residue 2 in TIMP-4. FEBS LETTERS, 507(3), 285-287. https://doi.org/10.1016/S0014-5793(01)02987-8
Stratmann, B, Farr, M, and Tschesche, Harald. 2001. “MMP-TIMP interaction depends on residue 2 in TIMP-4”. FEBS LETTERS 507 (3): 285-287.
Stratmann, B., Farr, M., and Tschesche, H. (2001). MMP-TIMP interaction depends on residue 2 in TIMP-4. FEBS LETTERS 507, 285-287.
Stratmann, B., Farr, M., & Tschesche, H., 2001. MMP-TIMP interaction depends on residue 2 in TIMP-4. FEBS LETTERS, 507(3), p 285-287.
B. Stratmann, M. Farr, and H. Tschesche, “MMP-TIMP interaction depends on residue 2 in TIMP-4”, FEBS LETTERS, vol. 507, 2001, pp. 285-287.
Stratmann, B., Farr, M., Tschesche, H.: MMP-TIMP interaction depends on residue 2 in TIMP-4. FEBS LETTERS. 507, 285-287 (2001).
Stratmann, B, Farr, M, and Tschesche, Harald. “MMP-TIMP interaction depends on residue 2 in TIMP-4”. FEBS LETTERS 507.3 (2001): 285-287.

10 Zitationen in Europe PMC

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