Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level

Eichenlaub-Ritter U, Peschke M (2002)
HUMAN REPRODUCTION UPDATE 8(1): 21-41.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor/in
Abstract / Bemerkung
Studies of expression in in-vivo and in-vitro maturing oocytes have the potential to elucidate signalling pathways involved in the intricate crosstalk between the oocyte and its somatic compartment during differentiation and morphogenetic processes, and the origin of disturbances in oocyte maturation possibly involved in reduced fertility. This review summarizes data on expression studies with focus on regulation of expression at the translational level in the maturing oocyte. The regulation of gene expression at the translational level as analysed in in-vitro maturing oocytes is complex and highly conserved between different species. It is characterized by differential degradation, and by storage and recruitment of distinct maternal mRNAs involving conserved consensus sequences in the 5' or 3' untranslated regions (UTRs) of mRNAs. Proteins interacting with such sequences affect the temporal 3' polyadenylation, and bring the 5' and, 3' UTRs of mRNAs into close proximity for efficient initiation of translation. Post-translational modifications of mRNA-associated proteins contribute to maturation- and developmentally controlled and to cell cycle-dependent expression. New methodologies for analysis of ovary-specific gene expression and function of genes in oogenesis,are also reviewed, e.g. RT-PCR, SAGE-PCR, real-time rapid cycle fluorescence monitored RT-PCR, differential display techniques, and microinjection of anti-sense RNA, double-stranded RNAs or mRNAs expressing green fluorescent protein-tagged proteins into maturing oocytes.
Stichworte
maturation; expression; translation; oocyte
Erscheinungsjahr
2002
Zeitschriftentitel
HUMAN REPRODUCTION UPDATE
Band
8
Ausgabe
1
Seite(n)
21-41
ISSN
1355-4786
eISSN
1460-2369
Page URI
https://pub.uni-bielefeld.de/record/1615353

Zitieren

Eichenlaub-Ritter U, Peschke M. Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level. HUMAN REPRODUCTION UPDATE. 2002;8(1):21-41.
Eichenlaub-Ritter, U., & Peschke, M. (2002). Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level. HUMAN REPRODUCTION UPDATE, 8(1), 21-41. doi:10.1093/humupd/8.1.21
Eichenlaub-Ritter, U., and Peschke, M. (2002). Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level. HUMAN REPRODUCTION UPDATE 8, 21-41.
Eichenlaub-Ritter, U., & Peschke, M., 2002. Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level. HUMAN REPRODUCTION UPDATE, 8(1), p 21-41.
U. Eichenlaub-Ritter and M. Peschke, “Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level”, HUMAN REPRODUCTION UPDATE, vol. 8, 2002, pp. 21-41.
Eichenlaub-Ritter, U., Peschke, M.: Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level. HUMAN REPRODUCTION UPDATE. 8, 21-41 (2002).
Eichenlaub-Ritter, Ursula, and Peschke, M. “Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational level”. HUMAN REPRODUCTION UPDATE 8.1 (2002): 21-41.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 11866238
PubMed | Europe PMC

Suchen in

Google Scholar