A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives

Schmoldt P, Mattay J (2003)
SYNTHESIS-STUTTGART (7): 1071-1078.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
A novel sequence for the synthesis of substituted bicyclo[2.2.2]oct-5-en-2-one derivatives starting from substituted cyclohex-2-en-1-ones is presented. The Michael addition of malonic esters to an alpha,beta-unsaturated ketone and an intramolecular aldol reaction are the key steps. A generally applicable synthetic strategy for the construction of 5-substituted cyclohex-2-en-1-ones is presented as well.
Stichworte
bicyclo[2.2.2]octan-2-ones; bicyclic compounds; intramolecular aldol reactions; Michael additions; substituted cyclohex-2-en-1-ones
Erscheinungsjahr
2003
Zeitschriftentitel
SYNTHESIS-STUTTGART
Ausgabe
7
Seite(n)
1071-1078
ISSN
0039-7881
Page URI
https://pub.uni-bielefeld.de/record/1611474

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Schmoldt P, Mattay J. A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives. SYNTHESIS-STUTTGART. 2003;(7):1071-1078.
Schmoldt, P., & Mattay, J. (2003). A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives. SYNTHESIS-STUTTGART(7), 1071-1078.
Schmoldt, P., and Mattay, J. (2003). A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives. SYNTHESIS-STUTTGART, 1071-1078.
Schmoldt, P., & Mattay, J., 2003. A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives. SYNTHESIS-STUTTGART, (7), p 1071-1078.
P. Schmoldt and J. Mattay, “A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives”, SYNTHESIS-STUTTGART, 2003, pp. 1071-1078.
Schmoldt, P., Mattay, J.: A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives. SYNTHESIS-STUTTGART. 1071-1078 (2003).
Schmoldt, P, and Mattay, Jochen. “A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives”. SYNTHESIS-STUTTGART 7 (2003): 1071-1078.