Misfolded plant virus proteins: elicitors and targets of ubiquitylation

Jockusch H, Wiegand C (2003)
FEBS LETTERS 545(2-3): 229-232.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Mutant tobacco mosaic virus (TMV) coat proteins (CPs) with known amino acid replacements provide well defined examples of destabilized tertiary structures. Here we show that misfolded TMV CPs, but not functional wild-type CPs, induce massive ubiquitylation in tobacco cells and that denatured, insoluble CP subunits are the main substrates of ubiquitin conjugation. As TMV CPs can be easily manipulated they are unique tools to study the molecular basis of the plant cell's response to aberrant protein structures and the associated intracellular stress reactions. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
temperature-sensitive; mutation; insoluble protein; denaturation; coat protein; ubiquitin; tobacco mosaic virus
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Jockusch H, Wiegand C. Misfolded plant virus proteins: elicitors and targets of ubiquitylation. FEBS LETTERS. 2003;545(2-3):229-232.
Jockusch, H., & Wiegand, C. (2003). Misfolded plant virus proteins: elicitors and targets of ubiquitylation. FEBS LETTERS, 545(2-3), 229-232. https://doi.org/10.1016/S0014-5793(03)00549-0
Jockusch, H., and Wiegand, C. (2003). Misfolded plant virus proteins: elicitors and targets of ubiquitylation. FEBS LETTERS 545, 229-232.
Jockusch, H., & Wiegand, C., 2003. Misfolded plant virus proteins: elicitors and targets of ubiquitylation. FEBS LETTERS, 545(2-3), p 229-232.
H. Jockusch and C. Wiegand, “Misfolded plant virus proteins: elicitors and targets of ubiquitylation”, FEBS LETTERS, vol. 545, 2003, pp. 229-232.
Jockusch, H., Wiegand, C.: Misfolded plant virus proteins: elicitors and targets of ubiquitylation. FEBS LETTERS. 545, 229-232 (2003).
Jockusch, Harald, and Wiegand, C. “Misfolded plant virus proteins: elicitors and targets of ubiquitylation”. FEBS LETTERS 545.2-3 (2003): 229-232.

8 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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The ubiquitin/26S proteasome system in plant-pathogen interactions: a never-ending hide-and-seek game.
Dielen AS, Badaoui S, Candresse T, German-Retana S., Mol Plant Pathol 11(2), 2010
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The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis.
Sugio A, Dreos R, Aparicio F, Maule AJ., Plant Cell 21(2), 2009
PMID: 19244141
Proteasomal degradation in plant-pathogen interactions.
Citovsky V, Zaltsman A, Kozlovsky SV, Gafni Y, Krichevsky A., Semin Cell Dev Biol 20(9), 2009
PMID: 19505586
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Jin Y, Ma D, Dong J, Jin J, Li D, Deng C, Wang T., J Virol 81(23), 2007
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Tobacco mosaic virus: a model system for plant biology.
Scholthof KB., Annu Rev Phytopathol 42(), 2004
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20 References

Daten bereitgestellt von Europe PubMed Central.

The ubiquitin system.
Hershko A, Ciechanover A., Annu. Rev. Biochem. 67(), 1998
PMID: 9759494
Ubiquitylation in plants: a post-genomic look at a post-translational modification.
Bachmair A, Novatchkova M, Potuschak T, Eisenhaber F., Trends Plant Sci. 6(10), 2001
PMID: 11590065
Plant development: regulation by protein degradation.
Hellmann H, Estelle M., Science 297(5582), 2002
PMID: 12161644
Ubiquitin-mediated proteolysis in plant hormone signal transduction.
Frugis G, Chua NH., Trends Cell Biol. 12(7), 2002
PMID: 12185846
Tobacco mosaic virus particles contain ubiquitinated coat protein subunits.
Dunigan DD, Dietzgen RG, Schoelz JE, Zaitlin M., Virology 165(1), 1988
PMID: 2838968
Ubiquitinated conjugates are found in preparations of several plant viruses.
Hazelwood D, Zaitlin M., Virology 177(1), 1990
PMID: 2162109

Jockusch, Z. Vererbungsl. 98(), 1966
Stability and genetic variation of a structural protein.
Jockusch H., Naturwissenschaften 55(11), 1968
PMID: 5727497
Mutants of tobacco mosaic virus with temperature-sensitive coat proteins induce heat shock response in tobacco leaves.
Jockusch H, Wiegand C, Mersch B, Rajes D., Mol. Plant Microbe Interact. 14(7), 2001
PMID: 11437266

Wittmann, Z. Vererbungsl. 93(), 1962
Protein chemical studies of two RNA viruses and their mutants.
Wittmann HG, Wittmann-Liebold B., Cold Spring Harb. Symp. Quant. Biol. 31(), 1966
PMID: 5237188
High resolution two-dimensional electrophoresis of proteins.
O'Farrell PH., J. Biol. Chem. 250(10), 1975
PMID: 236308
Properties of the coat protein of a new tobacco mosaic virus coat protein ts-mutant.
Dobrov EN, Abu-Eid MM, Solovyev AG, Kust SV, Novikov VK., J. Protein Chem. 16(1), 1997
PMID: 9055205
Early cell death caused by TMV mutants with defective coat proteins.
Jockusch H, Jockusch B., Mol. Gen. Genet. 102(3), 1968
PMID: 5711443


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