Dynamic force spectroscopy: Optimized data analysis

Evstigneev M, Reimann P (2003)
PHYSICAL REVIEW E 68(4).

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
The forced rupture of single chemical bonds in biomolecular compounds (e.g., ligand-receptor systems) as observed in dynamic force spectroscopy experiments is addressed. An optimized method of data analysis is proposed. This method significantly outperforms the current standard one when applied to data from an idealized numerical computer simulation of an experiment with realistic parameter values. In particular, the force-free dissociation rate can be inferred with a considerably smaller statistical uncertainty and without the systematic overestimation of about 30%, which is shown to be inherent in the standard method.
Erscheinungsjahr
2003
Zeitschriftentitel
PHYSICAL REVIEW E
Band
68
Ausgabe
4
ISSN
1063-651X
eISSN
1095-3787
Page URI
https://pub.uni-bielefeld.de/record/1609633

Zitieren

Evstigneev M, Reimann P. Dynamic force spectroscopy: Optimized data analysis. PHYSICAL REVIEW E. 2003;68(4).
Evstigneev, M., & Reimann, P. (2003). Dynamic force spectroscopy: Optimized data analysis. PHYSICAL REVIEW E, 68(4). doi:10.1103/PhysRevE.68.045103
Evstigneev, M., and Reimann, P. (2003). Dynamic force spectroscopy: Optimized data analysis. PHYSICAL REVIEW E 68.
Evstigneev, M., & Reimann, P., 2003. Dynamic force spectroscopy: Optimized data analysis. PHYSICAL REVIEW E, 68(4).
M. Evstigneev and P. Reimann, “Dynamic force spectroscopy: Optimized data analysis”, PHYSICAL REVIEW E, vol. 68, 2003.
Evstigneev, M., Reimann, P.: Dynamic force spectroscopy: Optimized data analysis. PHYSICAL REVIEW E. 68, (2003).
Evstigneev, Mykhaylo, and Reimann, Peter. “Dynamic force spectroscopy: Optimized data analysis”. PHYSICAL REVIEW E 68.4 (2003).

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