Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge

Neddens J, Bagorda F, Busche A, Horstmann S, Moll GH, Dawirs RR, Teuchert-Noodt G (2003)
DEVELOPMENTAL BRAIN RESEARCH 146(1-2): 119-130.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Neddens, J; Bagorda, FrancescoUniBi; Busche, A; Horstmann, S; Moll, GH; Dawirs, RR; Teuchert-Noodt, GertraudUniBi
Abstract / Bemerkung
The effects of disjunctive environmental deprivation combined with a single methamphetamine (MA) challenge on postnatal maturation of the serotonin (5-HT) innervation pattern in cerebral cortex of gerbils were studied. Gerbils were assigned to either enriched (ER) or impoverished (M) environmental rearing conditions. On postnatal day I 10, 5-HT was immunostained. The 5-HT innervation pattern of the brain was qualitatively evaluated and provided in graphic form. The densities of 5-HT fibres were quantified in areas of prefrontal, insular, frontal, parietal, and entorhinal cortices of the right hemisphere using digital image analysis. The early MA challenge led to an overshoot of the fibre density in medial and orbital prefrontal cortex and entorhinal cortex of ER animals. IR animals mostly resisted MA effects except of a restraint of the innervation of the insular cortex. In comparison to enriched rearing, restricted rearing caused overshoot maturation of 5-HT innervation in insular and entorhinal cortices. The present data provide evidence for a region-specific postnatal vulnerability of the maturing 5-HT innervation, namely in association cortices. In contrast, both sensory and motor cortices showed no significant changes at all. The results are discussed in context with previously presented findings of alterations of the cortical dopamine innervation depending on both epigenetic factors. In conclusion, both experimental variables together give new insight into raphe-cortical plasticity that may contribute to a better understanding of the role of 5-HT fibre systems in structural maturation of the cortex. Postnatal environment may be involved in individual vulnerability of a variety of mental disorders during adolescence and aging. (C) 2003 Elsevier B.V. All rights reserved.
Stichworte
immunohistochemistry; epigenetics; environment; development; serotonin; and receptors; transporters; neurotransmitters; modulators; neuroplasticity; monoamines
Erscheinungsjahr
2003
Zeitschriftentitel
DEVELOPMENTAL BRAIN RESEARCH
Band
146
Ausgabe
1-2
Seite(n)
119-130
ISSN
0165-3806
Page URI
https://pub.uni-bielefeld.de/record/1609423

Zitieren

Neddens J, Bagorda F, Busche A, et al. Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge. DEVELOPMENTAL BRAIN RESEARCH. 2003;146(1-2):119-130.
Neddens, J., Bagorda, F., Busche, A., Horstmann, S., Moll, G. H., Dawirs, R. R., & Teuchert-Noodt, G. (2003). Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge. DEVELOPMENTAL BRAIN RESEARCH, 146(1-2), 119-130. https://doi.org/10.1016/j.devbrainres.2003.09.016
Neddens, J, Bagorda, Francesco, Busche, A, Horstmann, S, Moll, GH, Dawirs, RR, and Teuchert-Noodt, Gertraud. 2003. “Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge”. DEVELOPMENTAL BRAIN RESEARCH 146 (1-2): 119-130.
Neddens, J., Bagorda, F., Busche, A., Horstmann, S., Moll, G. H., Dawirs, R. R., and Teuchert-Noodt, G. (2003). Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge. DEVELOPMENTAL BRAIN RESEARCH 146, 119-130.
Neddens, J., et al., 2003. Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge. DEVELOPMENTAL BRAIN RESEARCH, 146(1-2), p 119-130.
J. Neddens, et al., “Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge”, DEVELOPMENTAL BRAIN RESEARCH, vol. 146, 2003, pp. 119-130.
Neddens, J., Bagorda, F., Busche, A., Horstmann, S., Moll, G.H., Dawirs, R.R., Teuchert-Noodt, G.: Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge. DEVELOPMENTAL BRAIN RESEARCH. 146, 119-130 (2003).
Neddens, J, Bagorda, Francesco, Busche, A, Horstmann, S, Moll, GH, Dawirs, RR, and Teuchert-Noodt, Gertraud. “Epigenetic factors differentially influence postnatal maturation of serotonin (5-HT) innervation in cerebral cortex of gerbils: interaction of rearing conditions and early methamphetamine challenge”. DEVELOPMENTAL BRAIN RESEARCH 146.1-2 (2003): 119-130.

21 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Decreased white matter FA values in the left inferior frontal gyrus is a possible intermediate phenotype of schizophrenia: evidences from a novel group strategy.
Ou J, Lyu H, Hu M, Li J, Guo W, Guo X, Li L, Zheng J, Wei Q, Liu F, He Z, Wang J, Liu F, Wu R, Chen J, Li L, Hu B, Chen H, Zhao J., Eur Arch Psychiatry Clin Neurosci 268(1), 2018
PMID: 27942861
Assessment of Topographic Memory in Mice in a Complex Environment Using the Hamlet Test.
Crouzier L, Maurice T., Curr Protoc Mouse Biol 8(2), 2018
PMID: 29927555
Developmental neuroplasticity and the origin of neurodegenerative diseases.
Schaefers AT, Teuchert-Noodt G., World J Biol Psychiatry 17(8), 2016
PMID: 23705632
Social experience modulates ocular dominance plasticity differentially in adult male and female mice.
Balog J, Matthies U, Naumann L, Voget M, Winter C, Lehmann K., Neuroimage 103(), 2014
PMID: 25173416
Activity-dependent structural plasticity.
Butz M, Wörgötter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur J Pharmacol 616(1-3), 2009
PMID: 19540225
Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents.
Lukkes JL, Watt MJ, Lowry CA, Forster GL., Front Behav Neurosci 3(), 2009
PMID: 19738931
Developmental pattern changes of prefrontal efferents in the juvenile gerbil (Meriones unguiculatus).
Witte AV, Brummelte S, Teuchert-Noodt G., J Neural Transm (Vienna) 114(11), 2007
PMID: 17557126
Association between body weight of newborn rats and density of serotonin transporters in the frontal cortex at adulthood.
Himpel S, Bartels J, Zimdars K, Huether G, Adler L, Dawirs RR, Moll GH., J Neural Transm (Vienna) 113(3), 2006
PMID: 15997417
Influence of methylphenidate on brain development--an update of recent animal experiments.
Grund T, Lehmann K, Bock N, Rothenberger A, Teuchert-Noodt G., Behav Brain Funct 2(), 2006
PMID: 16403217
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
Postnatal maturation of cortical serotonin lateral asymmetry in gerbils is vulnerable to both environmental and pharmacological epigenetic challenges.
Neddens J, Dawirs RR, Bagorda F, Busche A, Horstmann S, Teuchert-Noodt G., Brain Res 1021(2), 2004
PMID: 15342268

References

Daten bereitgestellt von Europe PubMed Central.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 14643018
PubMed | Europe PMC

Suchen in

Google Scholar