Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse

Heimann P, Kuschel T, Jockusch H (2004)
Cell Tissue Res 315(2): 243-247.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Muscular dysgenesis (mdg) in the mouse is a loss-of-function mutation of the skeletal muscle isoform of the voltage-sensor Ca2+ channel of skeletal muscle (DHP receptor alpha1 subunit, Cchl1a3, Chr1), which is essential for excitation-contraction coupling. Affected individuals (genotype mdg/mdg, phenotype MDG) are unable to breathe and die perinatally. We introduce here extraocular muscles in the study of MDG myopathy and show that, despite their developmental origin from head placodes, they are affected like trunk and limb muscles. MDG myotubes in situ are eliminated by necrosis, not apoptosis.
Stichworte
necrosis/apoptosis; calcium channel; dysgenesis; slow T-tubular; muscular; mouse (mdg/mdg); extraocular muscles
Erscheinungsjahr
2004
Zeitschriftentitel
Cell Tissue Res
Band
315
Ausgabe
2
Seite(n)
243-247
ISSN
0302-766X
eISSN
1432-0878
Page URI
https://pub.uni-bielefeld.de/record/1608937

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Heimann P, Kuschel T, Jockusch H. Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse. Cell Tissue Res. 2004;315(2):243-247.
Heimann, P., Kuschel, T., & Jockusch, H. (2004). Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse. Cell Tissue Res, 315(2), 243-247. doi:10.1007/s00441-003-0831-0
Heimann, P., Kuschel, T., and Jockusch, H. (2004). Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse. Cell Tissue Res 315, 243-247.
Heimann, P., Kuschel, T., & Jockusch, H., 2004. Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse. Cell Tissue Res, 315(2), p 243-247.
P. Heimann, T. Kuschel, and H. Jockusch, “Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse”, Cell Tissue Res, vol. 315, 2004, pp. 243-247.
Heimann, P., Kuschel, T., Jockusch, H.: Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse. Cell Tissue Res. 315, 243-247 (2004).
Heimann, Peter, Kuschel, T, and Jockusch, Harald. “Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse”. Cell Tissue Res 315.2 (2004): 243-247.

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