The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling
Milting H, Jacob M, Kassner A, Heimann P, Mannherz HG, Becker G, Meyer HE, Bothig D, Arusoglu L, Morshuis M, Korfer R, et al. (2004)
JOURNAL OF HEART AND LUNG TRANSPLANTATION 23(4): 396-404.
Zeitschriftenaufsatz
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Autor*in
Milting, H;
Jacob, M;
Kassner, A;
Heimann, PeterUniBi;
Mannherz, HG;
Becker, G;
Meyer, HE;
Bothig, D;
Arusoglu, L;
Morshuis, M;
Korfer, R;
El Banayosy, A
Einrichtung
Abstract / Bemerkung
Background: Chronic heart failure is a multifactorial, progressive disease of many causes and is associated with complex ventricular remodeling. Deposition of extracellular matrix proteins and sarcomeric disarray of the myocytes occur in end-stage heart failure. Ventricular assist devices (VAD), implanted as bridge to transplantation, may reverse ventricular remodeling. Although successfully weaning patients from VAD support has been reported, it is not clear to what degree reversal of remodeling,occurs in unloaded failing hearts. Because collagen deposition, and ultrastructural disarray are hallmarks of myocardial remodeling, we analyzed the myocardial ultrastructure and collagen content of VAD-supported hearts before and after mechanical unloading. Methods: We used amino acid analysis to measure collagen content (4-hydroxyproline content) in 24 transplant candidates receiving VAD support. We used transmission electron microscopy to examine the ultrastructure in 6 patients receiving VAD support. Results: The 4-hydroxyprohne content increased significantly at VAD implantation and was not altered by mechanical unloading. The ultrastructure showed signs of persisting. cardiomyopathy. Conclusion: Mechanical unloading does not alter the total collagen content of the supported, failing heart. Thus, structural reversal of the remodeling process associated with heart failure is not a general phenomenon in mechanically unloaded hearts.
Erscheinungsjahr
2004
Zeitschriftentitel
JOURNAL OF HEART AND LUNG TRANSPLANTATION
Band
23
Ausgabe
4
Seite(n)
396-404
ISSN
1053-2498
Page URI
https://pub.uni-bielefeld.de/record/1608114
Zitieren
Milting H, Jacob M, Kassner A, et al. The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling. JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2004;23(4):396-404.
Milting, H., Jacob, M., Kassner, A., Heimann, P., Mannherz, H. G., Becker, G., Meyer, H. E., et al. (2004). The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 23(4), 396-404. https://doi.org/10.1016/S1053-2498(03)00205-5
Milting, H, Jacob, M, Kassner, A, Heimann, Peter, Mannherz, HG, Becker, G, Meyer, HE, et al. 2004. “The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling”. JOURNAL OF HEART AND LUNG TRANSPLANTATION 23 (4): 396-404.
Milting, H., Jacob, M., Kassner, A., Heimann, P., Mannherz, H. G., Becker, G., Meyer, H. E., Bothig, D., Arusoglu, L., Morshuis, M., et al. (2004). The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling. JOURNAL OF HEART AND LUNG TRANSPLANTATION 23, 396-404.
Milting, H., et al., 2004. The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 23(4), p 396-404.
H. Milting, et al., “The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling”, JOURNAL OF HEART AND LUNG TRANSPLANTATION, vol. 23, 2004, pp. 396-404.
Milting, H., Jacob, M., Kassner, A., Heimann, P., Mannherz, H.G., Becker, G., Meyer, H.E., Bothig, D., Arusoglu, L., Morshuis, M., Korfer, R., El Banayosy, A.: The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling. JOURNAL OF HEART AND LUNG TRANSPLANTATION. 23, 396-404 (2004).
Milting, H, Jacob, M, Kassner, A, Heimann, Peter, Mannherz, HG, Becker, G, Meyer, HE, Bothig, D, Arusoglu, L, Morshuis, M, Korfer, R, and El Banayosy, A. “The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron-microscopy and amino acid analysis reveals low degree of reverse remodeling”. JOURNAL OF HEART AND LUNG TRANSPLANTATION 23.4 (2004): 396-404.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
14 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Left ventricular reverse remodeling is not related to biopsy-detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR.
Rubiś P, Wiśniowska-Śmiałek S, Biernacka-Fijałkowska B, Rudnicka-Sosin L, Wypasek E, Kozanecki A, Dziewięcka E, Faltyn P, Karabinowska A, Khachatryan L, Hlawaty M, Leśniak-Sobelga A, Kostkiewicz M, Płazak W, Podolec P., Heart Vessels 32(6), 2017
PMID: 28004175
Rubiś P, Wiśniowska-Śmiałek S, Biernacka-Fijałkowska B, Rudnicka-Sosin L, Wypasek E, Kozanecki A, Dziewięcka E, Faltyn P, Karabinowska A, Khachatryan L, Hlawaty M, Leśniak-Sobelga A, Kostkiewicz M, Płazak W, Podolec P., Heart Vessels 32(6), 2017
PMID: 28004175
The fibrosis-cell death axis in heart failure.
Piek A, de Boer RA, Silljé HH., Heart Fail Rev 21(2), 2016
PMID: 26883434
Piek A, de Boer RA, Silljé HH., Heart Fail Rev 21(2), 2016
PMID: 26883434
The paradox of left ventricular assist device unloading and myocardial recovery in end-stage dilated cardiomyopathy: implications for heart failure in the elderly.
Butler CR, Jugdutt BI., Heart Fail Rev 17(4-5), 2012
PMID: 22258830
Butler CR, Jugdutt BI., Heart Fail Rev 17(4-5), 2012
PMID: 22258830
Cardiac extracellular matrix tenascin-C deposition during fibronectin degradation.
Ma S, Yang D, Li D, Tang B, Sun M, Yang Y., Biochem Biophys Res Commun 409(2), 2011
PMID: 21586275
Ma S, Yang D, Li D, Tang B, Sun M, Yang Y., Biochem Biophys Res Commun 409(2), 2011
PMID: 21586275
G-CSF therapy reduces myocardial repolarization reserve in the presence of increased arteriogenesis, angiogenesis and connexin 43 expression in an experimental model of pacing-induced heart failure.
Milberg P, Klocke R, Frommeyer G, Quang TH, Dieks K, Stypmann J, Osada N, Kuhlmann M, Fehr M, Milting H, Nikol S, Waltenberger J, Breithardt G, Eckardt L., Basic Res Cardiol 106(6), 2011
PMID: 22072114
Milberg P, Klocke R, Frommeyer G, Quang TH, Dieks K, Stypmann J, Osada N, Kuhlmann M, Fehr M, Milting H, Nikol S, Waltenberger J, Breithardt G, Eckardt L., Basic Res Cardiol 106(6), 2011
PMID: 22072114
Mechanical ventricular assistance in heart failure: pathology of the cardiac apex removed during device implantation.
Cazes A, Duong Van Huyen JP, Fornes P, Amrein C, Guillemain R, Grinda JM, Bruneval P., Cardiovasc Pathol 19(2), 2010
PMID: 19144550
Cazes A, Duong Van Huyen JP, Fornes P, Amrein C, Guillemain R, Grinda JM, Bruneval P., Cardiovasc Pathol 19(2), 2010
PMID: 19144550
Global gene expression analysis in nonfailing and failing myocardium pre- and postpulsatile and nonpulsatile ventricular assist device support.
Schwientek P, Ellinghaus P, Steppan S, D'Urso D, Seewald M, Kassner A, Cebulla R, Schulte-Eistrup S, Morshuis M, Röfe D, El Banayosy A, Körfer R, Milting H., Physiol Genomics 42(3), 2010
PMID: 20460602
Schwientek P, Ellinghaus P, Steppan S, D'Urso D, Seewald M, Kassner A, Cebulla R, Schulte-Eistrup S, Morshuis M, Röfe D, El Banayosy A, Körfer R, Milting H., Physiol Genomics 42(3), 2010
PMID: 20460602
Plasma biomarkers of myocardial fibrosis and remodeling in terminal heart failure patients supported by mechanical circulatory support devices.
Milting H, Ellinghaus P, Seewald M, Cakar H, Bohms B, Kassner A, Körfer R, Klein M, Krahn T, Kruska L, El Banayosy A, Kramer F., J Heart Lung Transplant 27(6), 2008
PMID: 18503956
Milting H, Ellinghaus P, Seewald M, Cakar H, Bohms B, Kassner A, Körfer R, Klein M, Krahn T, Kruska L, El Banayosy A, Kramer F., J Heart Lung Transplant 27(6), 2008
PMID: 18503956
Reversal of ventricular remodeling: important to establish and difficult to define.
Hauptman PJ, Sabbah HN., Eur J Heart Fail 9(4), 2007
PMID: 17070104
Hauptman PJ, Sabbah HN., Eur J Heart Fail 9(4), 2007
PMID: 17070104
Assist devices fail to reverse patterns of fetal gene expression despite beta-blockers.
Lowes BD, Zolty R, Shakar SF, Brieke A, Gray N, Reed M, Calalb M, Minobe W, Lindenfeld J, Wolfel EE, Geraci M, Bristow MR, Cleveland J., J Heart Lung Transplant 26(11), 2007
PMID: 18022084
Lowes BD, Zolty R, Shakar SF, Brieke A, Gray N, Reed M, Calalb M, Minobe W, Lindenfeld J, Wolfel EE, Geraci M, Bristow MR, Cleveland J., J Heart Lung Transplant 26(11), 2007
PMID: 18022084
Influence of ACE-inhibition and mechanical unloading on the regulation of extracellular matrix proteins in the myocardium of heart transplantation candidates bridged by ventricular assist devices.
Milting H, Kassner A, Arusoglu L, Meyer HE, Morshuis M, Brendel R, Klauke B, El Banayosy A, Körfer R., Eur J Heart Fail 8(3), 2006
PMID: 16309954
Milting H, Kassner A, Arusoglu L, Meyer HE, Morshuis M, Brendel R, Klauke B, El Banayosy A, Körfer R., Eur J Heart Fail 8(3), 2006
PMID: 16309954
Selective upregulation of beta1-adrenergic receptors and dephosphorylation of troponin I in end-stage heart failure patients supported by ventricular assist devices.
Milting H, Scholz C, Arusoglu L, Freitag M, Cebulla R, Jaquet K, Körfer R, V Lewinski D, Kassner A, Brodde OE, Kögler H, El Banayosy A, Pieske B., J Mol Cell Cardiol 41(3), 2006
PMID: 16765375
Milting H, Scholz C, Arusoglu L, Freitag M, Cebulla R, Jaquet K, Körfer R, V Lewinski D, Kassner A, Brodde OE, Kögler H, El Banayosy A, Pieske B., J Mol Cell Cardiol 41(3), 2006
PMID: 16765375
Biventricular assist device-induced right ventricular reverse structural and functional remodeling.
Klotz S, Naka Y, Oz MC, Burkhoff D., J Heart Lung Transplant 24(9), 2005
PMID: 16143233
Klotz S, Naka Y, Oz MC, Burkhoff D., J Heart Lung Transplant 24(9), 2005
PMID: 16143233
Who would be a candidate for bridge to recovery during prolonged mechanical left ventricular support in idiopathic dilated cardiomyopathy?
Matsumiya G, Monta O, Fukushima N, Sawa Y, Funatsu T, Toda K, Matsuda H., J Thorac Cardiovasc Surg 130(3), 2005
PMID: 16153916
Matsumiya G, Monta O, Fukushima N, Sawa Y, Funatsu T, Toda K, Matsuda H., J Thorac Cardiovasc Surg 130(3), 2005
PMID: 16153916
28 References
Daten bereitgestellt von Europe PubMed Central.
The internal and external protein scaffold of the T-tubular system in cardiomyocytes.
Kostin S, Scholz D, Shimada T, Maeno Y, Mollnau H, Hein S, Schaper J., Cell Tissue Res. 294(3), 1998
PMID: 9799462
Kostin S, Scholz D, Shimada T, Maeno Y, Mollnau H, Hein S, Schaper J., Cell Tissue Res. 294(3), 1998
PMID: 9799462
The oxidative pentose phosphate pathway in the heart: regulation, physiological significance, and clinical implications.
Zimmer HG., Basic Res. Cardiol. 87(4), 1992
PMID: 1384463
Zimmer HG., Basic Res. Cardiol. 87(4), 1992
PMID: 1384463
Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling.
Li YY, McTiernan CF, Feldman AM., Cardiovasc. Res. 46(2), 2000
PMID: 10773225
Li YY, McTiernan CF, Feldman AM., Cardiovasc. Res. 46(2), 2000
PMID: 10773225
The time course of natriuretic hormones as plasma markers of myocardial recovery in heart transplant candidates during ventricular assist device support reveals differences among device types.
Milting H, EL Banayosy A, Kassner A, Fey O, Sarnowski P, Arusoglu L, Thieleczek R, Brinkmann T, Kleesiek K, Korfer R., J. Heart Lung Transplant. 20(9), 2001
PMID: 11557189
Milting H, EL Banayosy A, Kassner A, Fey O, Sarnowski P, Arusoglu L, Thieleczek R, Brinkmann T, Kleesiek K, Korfer R., J. Heart Lung Transplant. 20(9), 2001
PMID: 11557189
Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading.
Levin HR, Oz MC, Chen JM, Packer M, Rose EA, Burkhoff D., Circulation 91(11), 1995
PMID: 7758175
Levin HR, Oz MC, Chen JM, Packer M, Rose EA, Burkhoff D., Circulation 91(11), 1995
PMID: 7758175
Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts.
Takeishi Y, Jalili T, Hoit BD, Kirkpatrick DL, Wagoner LE, Abraham WT, Walsh RA., Cardiovasc. Res. 45(4), 2000
PMID: 10728414
Takeishi Y, Jalili T, Hoit BD, Kirkpatrick DL, Wagoner LE, Abraham WT, Walsh RA., Cardiovasc. Res. 45(4), 2000
PMID: 10728414
Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading.
Flesch M, Margulies KB, Mochmann HC, Engel D, Sivasubramanian N, Mann DL., Circulation 104(19), 2001
PMID: 11696464
Flesch M, Margulies KB, Mochmann HC, Engel D, Sivasubramanian N, Mann DL., Circulation 104(19), 2001
PMID: 11696464
Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart.
Ogletree-Hughes ML, Stull LB, Sweet WE, Smedira NG, McCarthy PM, Moravec CS., Circulation 104(8), 2001
PMID: 11514373
Ogletree-Hughes ML, Stull LB, Sweet WE, Smedira NG, McCarthy PM, Moravec CS., Circulation 104(8), 2001
PMID: 11514373
Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure.
Bartling B, Milting H, Schumann H, Darmer D, Arusoglu L, Koerner MM, El-Banayosy A, Koerfer R, Holtz J, Zerkowski HR., Circulation 100(19 Suppl), 1999
PMID: 10567307
Bartling B, Milting H, Schumann H, Darmer D, Arusoglu L, Koerner MM, El-Banayosy A, Koerfer R, Holtz J, Zerkowski HR., Circulation 100(19 Suppl), 1999
PMID: 10567307
Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure.
Heerdt PM, Holmes JW, Cai B, Barbone A, Madigan JD, Reiken S, Lee DL, Oz MC, Marks AR, Burkhoff D., Circulation 102(22), 2000
PMID: 11094037
Heerdt PM, Holmes JW, Cai B, Barbone A, Madigan JD, Reiken S, Lee DL, Oz MC, Marks AR, Burkhoff D., Circulation 102(22), 2000
PMID: 11094037
Decreased expression of tumor necrosis factor-alpha in failing human myocardium after mechanical circulatory support : A potential mechanism for cardiac recovery.
Torre-Amione G, Stetson SJ, Youker KA, Durand JB, Radovancevic B, Delgado RM, Frazier OH, Entman ML, Noon GP., Circulation 100(11), 1999
PMID: 10484539
Torre-Amione G, Stetson SJ, Youker KA, Durand JB, Radovancevic B, Delgado RM, Frazier OH, Entman ML, Noon GP., Circulation 100(11), 1999
PMID: 10484539
Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure.
Dipla K, Mattiello JA, Jeevanandam V, Houser SR, Margulies KB., Circulation 97(23), 1998
PMID: 9639375
Dipla K, Mattiello JA, Jeevanandam V, Houser SR, Margulies KB., Circulation 97(23), 1998
PMID: 9639375
Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support.
Bruckner BA, Stetson SJ, Perez-Verdia A, Youker KA, Radovancevic B, Connelly JH, Koerner MM, Entman ME, Frazier OH, Noon GP, Torre-Amione G., J. Heart Lung Transplant. 20(4), 2001
PMID: 11295584
Bruckner BA, Stetson SJ, Perez-Verdia A, Youker KA, Radovancevic B, Connelly JH, Koerner MM, Entman ME, Frazier OH, Noon GP, Torre-Amione G., J. Heart Lung Transplant. 20(4), 2001
PMID: 11295584
Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure.
Mancini DM, Beniaminovitz A, Levin H, Catanese K, Flannery M, DiTullio M, Savin S, Cordisco ME, Rose E, Oz M., Circulation 98(22), 1998
PMID: 9832482
Mancini DM, Beniaminovitz A, Levin H, Catanese K, Flannery M, DiTullio M, Savin S, Cordisco ME, Rose E, Oz M., Circulation 98(22), 1998
PMID: 9832482
Determination and location of phosphoserine in proteins and peptides by conversion to S-ethylcysteine.
Meyer HE, Hoffmann-Posorske E, Heilmeyer LM Jr., Meth. Enzymol. 201(), 1991
PMID: 1943763
Meyer HE, Hoffmann-Posorske E, Heilmeyer LM Jr., Meth. Enzymol. 201(), 1991
PMID: 1943763
Sequence analysis of phosphotyrosine-containing peptides.
Meyer HE, Hoffmann-Posorske E, Donella-Deana A, Korte H., Meth. Enzymol. 201(), 1991
PMID: 1719340
Meyer HE, Hoffmann-Posorske E, Donella-Deana A, Korte H., Meth. Enzymol. 201(), 1991
PMID: 1719340
Remodeling of human myocardial collagen in idiopathic dilated cardiomyopathy. Role of metalloproteinases and pyridinoline cross-links.
Gunja-Smith Z, Morales AR, Romanelli R, Woessner JF Jr., Am. J. Pathol. 148(5), 1996
PMID: 8623931
Gunja-Smith Z, Morales AR, Romanelli R, Woessner JF Jr., Am. J. Pathol. 148(5), 1996
PMID: 8623931
Images in cardiovascular medicine. Connective tissue skeleton of the human heart: a demonstration by cell-maceration scanning electron microscope method.
Rossi MA, Abreu MA, Santoro LB., Circulation 97(9), 1998
PMID: 9521343
Rossi MA, Abreu MA, Santoro LB., Circulation 97(9), 1998
PMID: 9521343
A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure.
Spinale FG, Coker ML, Heung LJ, Bond BR, Gunasinghe HR, Etoh T, Goldberg AT, Zellner JL, Crumbley AJ., Circulation 102(16), 2000
PMID: 11034943
Spinale FG, Coker ML, Heung LJ, Bond BR, Gunasinghe HR, Etoh T, Goldberg AT, Zellner JL, Crumbley AJ., Circulation 102(16), 2000
PMID: 11034943
Differential gene expression of extracellular matrix components in dilated cardiomyopathy.
Tyagi SC, Kumar S, Voelker DJ, Reddy HK, Janicki JS, Curtis JJ., J. Cell. Biochem. 63(2), 1996
PMID: 8913870
Tyagi SC, Kumar S, Voelker DJ, Reddy HK, Janicki JS, Curtis JJ., J. Cell. Biochem. 63(2), 1996
PMID: 8913870
Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy.
Thomas CV, Coker ML, Zellner JL, Handy JR, Crumbley AJ 3rd, Spinale FG., Circulation 97(17), 1998
PMID: 9591765
Thomas CV, Coker ML, Zellner JL, Handy JR, Crumbley AJ 3rd, Spinale FG., Circulation 97(17), 1998
PMID: 9591765
Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devices.
Li YY, Feng Y, McTiernan CF, Pei W, Moravec CS, Wang P, Rosenblum W, Kormos RL, Feldman AM., Circulation 104(10), 2001
PMID: 11535571
Li YY, Feng Y, McTiernan CF, Pei W, Moravec CS, Wang P, Rosenblum W, Kormos RL, Feldman AM., Circulation 104(10), 2001
PMID: 11535571
AUTHOR UNKNOWN, 0
Left ventricular assist device in end-stage heart failure: persistence of structural myocyte damage after unloading. An immunohistochemical analysis of the contractile myofilaments.
de Jonge N, van Wichen DF, Schipper ME, Lahpor JR, Gmelig-Meyling FH, Robles de Medina EO, de Weger RA., J. Am. Coll. Cardiol. 39(6), 2002
PMID: 11897437
de Jonge N, van Wichen DF, Schipper ME, Lahpor JR, Gmelig-Meyling FH, Robles de Medina EO, de Weger RA., J. Am. Coll. Cardiol. 39(6), 2002
PMID: 11897437
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin.
Barral JM, Hutagalung AH, Brinker A, Hartl FU, Epstein HF., Science 295(5555), 2002
PMID: 11809970
Barral JM, Hutagalung AH, Brinker A, Hartl FU, Epstein HF., Science 295(5555), 2002
PMID: 11809970
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.
Knoll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR., Cell 111(7), 2002
PMID: 12507422
Knoll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR., Cell 111(7), 2002
PMID: 12507422
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