Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study

Naib-Majani W, Eltohami I, Wernert N, Watts W, Tschesche H, Pleyer U, Breipohl W (2004)
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 242(4): 332-338.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ;
Abstract / Bemerkung
Purpose: This study was carried out to monitor the expression of extracellular matrix proteins (ECMs) and metalloproteinases (MMPs) in pterygial tissue. Methods: Twenty primary nasal pterygia were studied by indirect routine immunohistochemistry using 13 different primary antibodies against 8 ECMs (five collagens, fibronectin, heparan sulfate, and laminin) fibroblast growth factor (bFGF), von Willebrand factor (vWF), and 3 MMPs (8, 9, and 13). Secondary antibodies were fluoresceinated. Intensity of reaction on individual sections was graded semi-quantitatively. Results: No expression of collagens I, II, and VII was found. Antibodies against collagen III reacted strongly positively (+++) with the entire pterygial stroma. Collagen IV expression was strongly positive in the wall of pterygial blood vessels, moderately positive (++) in the epithelial basement membrane, and only weakly positive (+) all over the stroma. Antibodies against fibronectin reacted moderately positively with stroma, blood vessel walls and epithelial basement membrane. Heparan sulfate was strongly expressed in the blood vessel walls and epithelial basement membrane. Antibodies against bFGF reacted only with pterygial epithelium. Laminin was strongly expressed in blood vessel wall, moderately (++) in the epithelial basement membrane and weakly over the entire stroma. vWF was strongly positive (+++) with pterygial blood vessel walls. Antibody reactions for MMPs differed. It was strong with pterygial epithelium (MMPs 8, 9 and 13), strong to moderate with pterygial stroma (MMPs 8 and 13 versus 9), and absent to weak with pterygial vascular walls (MMPs 8 and 13 versus 9). Conclusions: This study documents the presence of several ECMs but excludes the expression of others in pterygial tissues. The results especially indicate an active involvement of MMPs 8, 9 and 13 in the pathogenesis of pterygia.
Erscheinungsjahr
Zeitschriftentitel
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Band
242
Ausgabe
4
Seite(n)
332-338
ISSN
eISSN
PUB-ID

Zitieren

Naib-Majani W, Eltohami I, Wernert N, et al. Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2004;242(4):332-338.
Naib-Majani, W., Eltohami, I., Wernert, N., Watts, W., Tschesche, H., Pleyer, U., & Breipohl, W. (2004). Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 242(4), 332-338. doi:10.1007/s00417-003-0846-y
Naib-Majani, W., Eltohami, I., Wernert, N., Watts, W., Tschesche, H., Pleyer, U., and Breipohl, W. (2004). Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 242, 332-338.
Naib-Majani, W., et al., 2004. Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 242(4), p 332-338.
W. Naib-Majani, et al., “Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study”, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 242, 2004, pp. 332-338.
Naib-Majani, W., Eltohami, I., Wernert, N., Watts, W., Tschesche, H., Pleyer, U., Breipohl, W.: Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 242, 332-338 (2004).
Naib-Majani, W, Eltohami, I, Wernert, N, Watts, W, Tschesche, Harald, Pleyer, U, and Breipohl, W. “Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study”. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 242.4 (2004): 332-338.

10 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Pyroptosis in pterygium pathogenesis.
Sun N, Zhang H., Biosci Rep 38(3), 2018
PMID: 29724886
Molecular Basis of Pterygium Development.
Cárdenas-Cantú E, Zavala J, Valenzuela J, Valdez-García JE., Semin Ophthalmol 31(6), 2016
PMID: 25415268
The role of ultraviolet radiation in the pathogenesis of pterygia (Review).
Zhou WP, Zhu YF, Zhang B, Qiu WY, Yao YF., Mol Med Rep 14(1), 2016
PMID: 27176595
Cyclosporine A Downregulates MMP-3 and MMP-13 Expression in Cultured Pterygium Fibroblasts.
Kim YH, Jung JC, Jung SY, Kim YI, Lee KW, Park YJ., Cornea 34(9), 2015
PMID: 26057330
Ophthalmic pterygium: a stem cell disorder with premalignant features.
Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D, Di Girolamo N., Am J Pathol 178(2), 2011
PMID: 21281814
The Ets-1 transcription factor is involved in pterygial angiogenesis.
Naib-Majani W, Breipohl W, Shazli EE, Theuerkauf I, Pleyer U, Hahne JC, Wernert N., Anat Histol Embryol 36(2), 2007
PMID: 17371382
Pterygium.
Solomon AS., Br J Ophthalmol 90(6), 2006
PMID: 16714259

32 References

Daten bereitgestellt von Europe PubMed Central.

Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula.
Austin P, Jakobiec FA, Iwamoto T., Ophthalmology 90(1), 1983
PMID: 6828309
Collagen can modulate cell interactions with fibronectin.
Nagata K, Humphries MJ, Olden K, Yamada KM., J. Cell Biol. 101(2), 1985
PMID: 3160713
Cell cycle kinetics in pterygium at three latitudes.
Karukonda SR, Thompson HW, Beuerman RW, Lam DS, Wilson R, Chew SJ, Steinemann TL., Br J Ophthalmol 79(4), 1995
PMID: 7742273
Collagen abnormalities in conjunctiva of patients with cicatricial pemphigoid.
Dutt JE, Ledoux D, Baer H, Foster CS., Cornea 15(6), 1996
PMID: 8899273
von Willebrand factor binds to native collagen VI primarily via its A1 domain.
Hoylaerts MF, Yamamoto H, Nuyts K, Vreys I, Deckmyn H, Vermylen J., Biochem. J. 324 ( Pt 1)(), 1997
PMID: 9164855
Identification of a cell surface-binding protein for the core protein of the basement membrane proteoglycan.
Clement B, Segui-Real B, Hassell JR, Martin GR, Yamada Y., J. Biol. Chem. 264(21), 1989
PMID: 2526126
Laminin--a glycoprotein from basement membranes.
Timpl R, Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR., J. Biol. Chem. 254(19), 1979
PMID: 114518
Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells.
Di Girolamo N, McCluskey P, Lloyd A, Coroneo MT, Wakefield D., Invest. Ophthalmol. Vis. Sci. 41(3), 2000
PMID: 10711680
Substrate adhesion of rat hepatocytes: a comparison of laminin and fibronectin as attachment proteins.
Johansson S, Kjellen L, Hook M, Timpl R., J. Cell Biol. 90(1), 1981
PMID: 6265475
Distribution of collagen IV in human ocular tissues.
Ishizaki M, Westerhausen-Larson A, Kino J, Hayashi T, Kao WW., Invest. Ophthalmol. Vis. Sci. 34(9), 1993
PMID: 7688359
The histochemical examination of the fibers of pterygium by elastase.
Vass Z, Tapaszto I., Acta Ophthalmol (Copenh) 42(4), 1964
PMID: 5899961
The pterygium: its etiology and treatment.
KAMEL S., Am. J. Ophthalmol. 38(5), 1954
PMID: 13207277
Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart.
Soini Y, Satta J, Maatta M, Autio-Harmainen H., J. Pathol. 194(2), 2001
PMID: 11400152
Proteoglycans as modulators of growth factor activities.
Ruoslahti E, Yamaguchi Y., Cell 64(5), 1991
PMID: 2001586
Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts.
Li DQ, Lee SB, Gunja-Smith Z, Liu Y, Solomon A, Meller D, Tseng SC., Arch. Ophthalmol. 119(1), 2001
PMID: 11146729
Immunohistochemical localization of collagen types I, II, III, and IV in pterygium tissues.
Dake Y, Mukae R, Soda Y, Kaneko M, Amemiya T., Acta Histochem. 87(1), 1989
PMID: 2513700
Role of laminin receptor in tumor cell migration.
Wewer UM, Taraboletti G, Sobel ME, Albrechtsen R, Liotta LA., Cancer Res. 47(21), 1987
PMID: 2959357
Immunolocalization of bFGF in pterygia: association with mast cells.
Powers MR, Qu Z, O'Brien B, Wilson DJ, Thompson JE, Rosenbaum JT., Cornea 16(5), 1997
PMID: 9294687
Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms.
Ljubimov AV, Burgeson RE, Butkowski RJ, Michael AF, Sun TT, Kenney MC., Lab. Invest. 72(4), 1995
PMID: 7723285
Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development.
Lee PP, Hwang JJ, Mead L, Ip MM., J. Cell. Physiol. 188(1), 2001
PMID: 11382924
Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis.
Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS., Circ. Res. 88(11), 2001
PMID: 11397779
Angiogenic factors.
Folkman J, Klagsbrun M., Science 235(4787), 1987
PMID: 2432664

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 14749931
PubMed | Europe PMC

Suchen in

Google Scholar