Modeling microarray data using a threshold mixture model
Kauermann G, Eilers P (2004)
BIOMETRICS 60(2): 376-387.
Zeitschriftenaufsatz
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Autor*in
Kauermann, GöranUniBi;
Eilers, P
Einrichtung
Abstract / Bemerkung
An important goal of microarray studies is the detection of genes that show significant changes in expression when two classes of biological samples are being compared. We present an ANOVA-style mixed model with parameters for array normalization, overall level of gene expression, and change of expression between the classes. For the latter we assume a mixing distribution with a probability mass concentrated at zero, representing genes with no changes, and a normal distribution representing the level of change for the other genes. We estimate the parameters by optimizing the marginal likelihood. To make this practical, Laplace approximations and a backfitting algorithm are used. The performance of the model is studied by simulation and by application to publicly available data sets.
Stichworte
marginal likelihood;
microarray;
mixed model;
laplace approximation;
backfitting;
data
Erscheinungsjahr
2004
Zeitschriftentitel
BIOMETRICS
Band
60
Ausgabe
2
Seite(n)
376-387
ISSN
0006-341X
Page URI
https://pub.uni-bielefeld.de/record/1607637
Zitieren
Kauermann G, Eilers P. Modeling microarray data using a threshold mixture model. BIOMETRICS. 2004;60(2):376-387.
Kauermann, G., & Eilers, P. (2004). Modeling microarray data using a threshold mixture model. BIOMETRICS, 60(2), 376-387. https://doi.org/10.1111/j.0006-341X.2004.00182.x
Kauermann, Göran, and Eilers, P. 2004. “Modeling microarray data using a threshold mixture model”. BIOMETRICS 60 (2): 376-387.
Kauermann, G., and Eilers, P. (2004). Modeling microarray data using a threshold mixture model. BIOMETRICS 60, 376-387.
Kauermann, G., & Eilers, P., 2004. Modeling microarray data using a threshold mixture model. BIOMETRICS, 60(2), p 376-387.
G. Kauermann and P. Eilers, “Modeling microarray data using a threshold mixture model”, BIOMETRICS, vol. 60, 2004, pp. 376-387.
Kauermann, G., Eilers, P.: Modeling microarray data using a threshold mixture model. BIOMETRICS. 60, 376-387 (2004).
Kauermann, Göran, and Eilers, P. “Modeling microarray data using a threshold mixture model”. BIOMETRICS 60.2 (2004): 376-387.
8 Zitationen in Europe PMC
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