Spindles, mitochondria and redox potential in ageing oocytes

Eichenlaub-Ritter U, Vogt E, Yin H, Gosden R (2004)
REPRODUCTIVE BIOMEDICINE ONLINE 8(1): 45-58.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor/in
; ; ;
Abstract / Bemerkung
Studies of human oocytes obtained from women of advanced reproductive age revealed that spindles are frequently aberrant, with chromosomes sometimes failing to align properly at the equator during meiosis I and II. Chromosomal analyses of donated and spare human oocytes and cytogenetic and molecular studies on the origin of trisomies collectively suggest that errors in chromosome segregation during oogenesis increase with advancing maternal age and as the menopause approaches. Disturbances in the fidelity of chromosome segregation, especially at anaphase I, leading to aneuploidy are prime causes of reduced developmental competence of embryos in assisted reproduction, as well as being responsible for the genesis of genetic disease. This review provides an overview of spindle formation and chromosome behaviour in mammalian oocytes. Evidence of a link between abnormal mitochondrial function in oocytes and somatic follicular cells, and finally disturbances in chromosome cohesion and segregation, and cell cycle control in aged mammalian oocytes, are also discussed.
Stichworte
ageing oocytes; chromosome segregation; mitochondria; potential; redox; aneuploidy
Erscheinungsjahr
2004
Zeitschriftentitel
REPRODUCTIVE BIOMEDICINE ONLINE
Band
8
Ausgabe
1
Seite(n)
45-58
ISSN
1472-6483
Page URI
https://pub.uni-bielefeld.de/record/1605404

Zitieren

Eichenlaub-Ritter U, Vogt E, Yin H, Gosden R. Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE. 2004;8(1):45-58.
Eichenlaub-Ritter, U., Vogt, E., Yin, H., & Gosden, R. (2004). Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE, 8(1), 45-58. doi:10.1016/S1472-6483(10)60497-X
Eichenlaub-Ritter, U., Vogt, E., Yin, H., and Gosden, R. (2004). Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE 8, 45-58.
Eichenlaub-Ritter, U., et al., 2004. Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE, 8(1), p 45-58.
U. Eichenlaub-Ritter, et al., “Spindles, mitochondria and redox potential in ageing oocytes”, REPRODUCTIVE BIOMEDICINE ONLINE, vol. 8, 2004, pp. 45-58.
Eichenlaub-Ritter, U., Vogt, E., Yin, H., Gosden, R.: Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE. 8, 45-58 (2004).
Eichenlaub-Ritter, Ursula, Vogt, E, Yin, H, and Gosden, R. “Spindles, mitochondria and redox potential in ageing oocytes”. REPRODUCTIVE BIOMEDICINE ONLINE 8.1 (2004): 45-58.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 14759287
PubMed | Europe PMC

Suchen in

Google Scholar