Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56
Perlova O, Gerth K, Kaiser O, Hans A, Muller R (2006)
JOURNAL OF BIOTECHNOLOGY 121(2): 174-191.
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Autor*in
Perlova, O;
Gerth, K;
Kaiser, O;
Hans, A;
Muller, R
Abstract / Bemerkung
Myxobacteria belonging to the genus Sorangium are known to produce a variety of biologically active secondary metabolites. Chivosazol is a macrocyclic antibiotic active against yeast, filamentous fungi and especially against mammalian cells. The compound specifically destroys the actin skeleton of eucaryotic cells and does not show activity against bacteria. Chivosazol contains an oxazole ring and a glycosidically bound 6-deoxyglucose (except for chivosazol F). In this paper we describe the biosynthetic gene cluster that directs chivosazol biosynthesis in the model strain Sorangium cellulosum So ce56. This biosynthetic gene cluster spans 92 kbp on the chromosome and contains four polyketide synthase genes and one hybrid polyketide synthase/nonribosomal peptide synthetase gene. An additional gene encoding a protein with similarity to different methyltransferases and presumably involved in post-polyketide modification was identified downstream of the core biosynthetic gene cluster. The chivosazol biosynthetic gene locus belongs to the recently identified and rapidly growing class of trans-acyltransferase polyketide synthases, which do not contain acyltransferase domains integrated into the multimodular megasynthetases. (c) 2005 Elsevier B.V. All rights reserved.
Stichworte
PKS;
chivosazol;
secondary metabolism;
NRPS;
biosynthetic gene cluster;
Sorangium cellulosum;
myxobacteria
Erscheinungsjahr
2006
Zeitschriftentitel
JOURNAL OF BIOTECHNOLOGY
Band
121
Ausgabe
2
Seite(n)
174-191
ISSN
0168-1656
Page URI
https://pub.uni-bielefeld.de/record/1600813
Zitieren
Perlova O, Gerth K, Kaiser O, Hans A, Muller R. Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY. 2006;121(2):174-191.
Perlova, O., Gerth, K., Kaiser, O., Hans, A., & Muller, R. (2006). Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY, 121(2), 174-191. https://doi.org/10.1016/j.jbiotec.2005.10.011
Perlova, O, Gerth, K, Kaiser, O, Hans, A, and Muller, R. 2006. “Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56”. JOURNAL OF BIOTECHNOLOGY 121 (2): 174-191.
Perlova, O., Gerth, K., Kaiser, O., Hans, A., and Muller, R. (2006). Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY 121, 174-191.
Perlova, O., et al., 2006. Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY, 121(2), p 174-191.
O. Perlova, et al., “Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56”, JOURNAL OF BIOTECHNOLOGY, vol. 121, 2006, pp. 174-191.
Perlova, O., Gerth, K., Kaiser, O., Hans, A., Muller, R.: Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY. 121, 174-191 (2006).
Perlova, O, Gerth, K, Kaiser, O, Hans, A, and Muller, R. “Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56”. JOURNAL OF BIOTECHNOLOGY 121.2 (2006): 174-191.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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UNIPROT
9 Einträge gefunden, die diesen Artikel zitieren
Acyltransferase/oxidoreductase (UNIPROT: Q2N3T2)
Organism: Sorangium cellulosum
Download in FASTA format
Organism: Sorangium cellulosum
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Putative uncharacterized protein (UNIPROT: Q2N3T3)
Organism: Sorangium cellulosum
Download in FASTA format
Organism: Sorangium cellulosum
Download in FASTA format
Hybrid nonribosomal peptide synthetase/polyketide synthase (UNIPROT: Q2N3S9)
Organism: Sorangium cellulosum
Download in FASTA format
Organism: Sorangium cellulosum
Download in FASTA format
Putative uncharacterized protein (UNIPROT: Q2N3S5)
Organism: Sorangium cellulosum
Download in FASTA format
Organism: Sorangium cellulosum
Download in FASTA format
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