Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors
Guthke R, Zeilinger K, Sickinger S, Schmidt-Heck W, Büntemeyer H, Iding K, Lehmann J, Pfaff M, Pless G, Gerlach JC (2006)
BIOPROCESS AND BIOSYSTEMS ENGINEERING 28(5): 331-340.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Guthke, R;
Zeilinger, K;
Sickinger, S;
Schmidt-Heck, W;
Büntemeyer, HeinoUniBi;
Iding, K;
Lehmann, J;
Pfaff, M;
Pless, G;
Gerlach, JC
Einrichtung
Abstract / Bemerkung
The kinetics of 18 amino acids, ammonia (NH3) and urea (UREA) in 18 liver cell bioreactor runs were analyzed and simulated by a two-compartment model consisting of a system of 42 differential equations. The model parameters, most of them representing enzymatic activities, were identified and their values discussed with respect to the different liver cell bioreactor performance levels. The nitrogen balance based model was used as a tool to quantify the variability of runs and to describe different kinetic patterns of the amino acid metabolism, in particular with respect to glutamate (GLU) and aspartate (ASP).
Stichworte
systems biology;
liver support;
bioreactor;
metabolic network
Erscheinungsjahr
2006
Zeitschriftentitel
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Band
28
Ausgabe
5
Seite(n)
331-340
ISSN
1615-7591
eISSN
1615-7605
Page URI
https://pub.uni-bielefeld.de/record/1599830
Zitieren
Guthke R, Zeilinger K, Sickinger S, et al. Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING. 2006;28(5):331-340.
Guthke, R., Zeilinger, K., Sickinger, S., Schmidt-Heck, W., Büntemeyer, H., Iding, K., Lehmann, J., et al. (2006). Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 28(5), 331-340. https://doi.org/10.1007/s00449-005-0040-1
Guthke, R, Zeilinger, K, Sickinger, S, Schmidt-Heck, W, Büntemeyer, Heino, Iding, K, Lehmann, J, Pfaff, M, Pless, G, and Gerlach, JC. 2006. “Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors”. BIOPROCESS AND BIOSYSTEMS ENGINEERING 28 (5): 331-340.
Guthke, R., Zeilinger, K., Sickinger, S., Schmidt-Heck, W., Büntemeyer, H., Iding, K., Lehmann, J., Pfaff, M., Pless, G., and Gerlach, J. C. (2006). Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING 28, 331-340.
Guthke, R., et al., 2006. Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 28(5), p 331-340.
R. Guthke, et al., “Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors”, BIOPROCESS AND BIOSYSTEMS ENGINEERING, vol. 28, 2006, pp. 331-340.
Guthke, R., Zeilinger, K., Sickinger, S., Schmidt-Heck, W., Büntemeyer, H., Iding, K., Lehmann, J., Pfaff, M., Pless, G., Gerlach, J.C.: Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING. 28, 331-340 (2006).
Guthke, R, Zeilinger, K, Sickinger, S, Schmidt-Heck, W, Büntemeyer, Heino, Iding, K, Lehmann, J, Pfaff, M, Pless, G, and Gerlach, JC. “Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors”. BIOPROCESS AND BIOSYSTEMS ENGINEERING 28.5 (2006): 331-340.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
5 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system.
Yang Y, Li J, Pan X, Zhou P, Yu X, Cao H, Wang Y, Li L., Biotechnol Bioeng 110(3), 2013
PMID: 23055347
Yang Y, Li J, Pan X, Zhou P, Yu X, Cao H, Wang Y, Li L., Biotechnol Bioeng 110(3), 2013
PMID: 23055347
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ., Nat Cell Biol 14(8), 2012
PMID: 22820375
van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ., Nat Cell Biol 14(8), 2012
PMID: 22820375
Metabolic Consequences of TGFb Stimulation in CulturedPrimary Mouse Hepatocytes Screened from Transcript Data with ModeScore .
Hoppe A, Ilkavets I, Dooley S, Holzhütter HG., Metabolites 2(4), 2012
PMID: 24957771
Hoppe A, Ilkavets I, Dooley S, Holzhütter HG., Metabolites 2(4), 2012
PMID: 24957771
A review of three-dimensional in vitro tissue models for drug discovery and transport studies.
Elliott NT, Yuan F., J Pharm Sci 100(1), 2011
PMID: 20533556
Elliott NT, Yuan F., J Pharm Sci 100(1), 2011
PMID: 20533556
High-throughput nuclear magnetic resonance metabolomic footprinting for tissue engineering.
Seagle C, Christie MA, Winnike JH, McClelland RE, Ludlow JW, O'Connell TM, Gamcsik MP, MacDonald JM., Tissue Eng Part C Methods 14(2), 2008
PMID: 18544027
Seagle C, Christie MA, Winnike JH, McClelland RE, Ludlow JW, O'Connell TM, Gamcsik MP, MacDonald JM., Tissue Eng Part C Methods 14(2), 2008
PMID: 18544027
15 References
Daten bereitgestellt von Europe PubMed Central.
Experimental evaluation of a cell module for hybrid liver support.
Gerlach JC, Botsch M, Kardassis D, Lemmens P, Schon M, Janke J, Puhl G, Unger J, Kraemer M, Busse B, Bohmer C, Belal R, Ingenlath M, Kosan M, Kosan B, Sultmann J, Patzold A, Tietze S, Rossaint R, Muller C, Monch E, Sauer IM, Neuhaus P., Int J Artif Organs 24(11), 2001
PMID: 11797849
Gerlach JC, Botsch M, Kardassis D, Lemmens P, Schon M, Janke J, Puhl G, Unger J, Kraemer M, Busse B, Bohmer C, Belal R, Ingenlath M, Kosan M, Kosan B, Sultmann J, Patzold A, Tietze S, Rossaint R, Muller C, Monch E, Sauer IM, Neuhaus P., Int J Artif Organs 24(11), 2001
PMID: 11797849
Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study.
Gerlach JC, Mutig K, Sauer IM, Schrade P, Efimova E, Mieder T, Naumann G, Grunwald A, Pless G, Mas A, Bachmann S, Neuhaus P, Zeilinger K., Transplantation 76(5), 2003
PMID: 14501853
Gerlach JC, Mutig K, Sauer IM, Schrade P, Efimova E, Mieder T, Naumann G, Grunwald A, Pless G, Mas A, Bachmann S, Neuhaus P, Zeilinger K., Transplantation 76(5), 2003
PMID: 14501853
Time course of primary liver cell reorganization in three-dimensional high-density bioreactors for extracorporeal liver support: an immunohistochemical and ultrastructural study.
Zeilinger K, Holland G, Sauer IM, Efimova E, Kardassis D, Obermayer N, Liu M, Neuhaus P, Gerlach JC., Tissue Eng. 10(7-8), 2004
PMID: 15363168
Zeilinger K, Holland G, Sauer IM, Efimova E, Kardassis D, Obermayer N, Liu M, Neuhaus P, Gerlach JC., Tissue Eng. 10(7-8), 2004
PMID: 15363168
AUTHOR UNKNOWN, 0
Network analysis of the kinetics of amino acid metabolism in a liver cell bioreactor
Schmidt-Heck W, Zeilinger K, Pfaff M, Toepfer S, Driesch D, Pless G, Neuhaus P, Gerlach JC, Guthke R., 2004
Schmidt-Heck W, Zeilinger K, Pfaff M, Toepfer S, Driesch D, Pless G, Neuhaus P, Gerlach JC, Guthke R., 2004
Prediction of the performance of human liver cell bioreactors by donor organ data
Schmidt-Heck W, Zeilinger K, Pless G, Gerlach JC, Pfaff M, Guthke R., 2005
Schmidt-Heck W, Zeilinger K, Pless G, Gerlach JC, Pfaff M, Guthke R., 2005
Is a clinical application of hybrid liver support systems limited by an initial disorder in cellular amino acid and alpha-keto acid metabolism, rather than by later gradual loss of primary hepatocyte function?
Gerlach JC, Fuchs M, Smith MD, Bornemann R, Encke J, Neuhaus P, Riedel E., Transplantation 62(2), 1996
PMID: 8755820
Gerlach JC, Fuchs M, Smith MD, Bornemann R, Encke J, Neuhaus P, Riedel E., Transplantation 62(2), 1996
PMID: 8755820
Comparison of four methods for mass hepatocyte isolation from pig and human livers.
Gerlach JC, Brombacher J, Kloppel K, Schnoy N, Neuhaus P., Transplantation 57(9), 1994
PMID: 8184468
Gerlach JC, Brombacher J, Kloppel K, Schnoy N, Neuhaus P., Transplantation 57(9), 1994
PMID: 8184468
Methods for off-line analysis in animal cell culture
Buentemeyer H., 2000
Buentemeyer H., 2000
Characterization of the distribution of matter in hybrid liver support devices where cells are cultured in a 3-D membrane network or on flat substrata.
Catapano G, Euler M, Gaylor JDS , Gerlach J., Int J Artif Organs 24(2), 2001
PMID: 11256506
Catapano G, Euler M, Gaylor JDS , Gerlach J., Int J Artif Organs 24(2), 2001
PMID: 11256506
Systems analysis of the dynamic input/output behaviour of a multi-compartment capillary membrane bioreactor for high-density liver cell culture
Pfaff M, Toepfer S, Zeilinger K, Roth S, Driesch D, Woetzel D, Schmidt-Heck W, Guthke R, Witaschek T, Gerlach JC., 2005
Pfaff M, Toepfer S, Zeilinger K, Roth S, Driesch D, Woetzel D, Schmidt-Heck W, Guthke R, Witaschek T, Gerlach JC., 2005
The biplot graphical display of matrices with applications to principal component analysis
Gabriel KR., 1971
Gabriel KR., 1971
Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs.
Kilberg MS, Handlogten ME, Christensen HN., J. Biol. Chem. 255(9), 1980
PMID: 7372663
Kilberg MS, Handlogten ME, Christensen HN., J. Biol. Chem. 255(9), 1980
PMID: 7372663
Metabolic zonation of the liver: regulation and implications for liver function.
Gebhardt R., Pharmacol. Ther. 53(3), 1992
PMID: 1409850
Gebhardt R., Pharmacol. Ther. 53(3), 1992
PMID: 1409850
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 16550345
PubMed | Europe PMC
Suchen in
Google Scholar