Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors

Guthke R, Zeilinger K, Sickinger S, Schmidt-Heck W, Büntemeyer H, Iding K, Lehmann J, Pfaff M, Pless G, Gerlach JC (2006)
BIOPROCESS AND BIOSYSTEMS ENGINEERING 28(5): 331-340.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Guthke, R; Zeilinger, K; Sickinger, S; Schmidt-Heck, W; Büntemeyer, HeinoUniBi; Iding, K; Lehmann, J; Pfaff, M; Pless, G; Gerlach, JC
Abstract / Bemerkung
The kinetics of 18 amino acids, ammonia (NH3) and urea (UREA) in 18 liver cell bioreactor runs were analyzed and simulated by a two-compartment model consisting of a system of 42 differential equations. The model parameters, most of them representing enzymatic activities, were identified and their values discussed with respect to the different liver cell bioreactor performance levels. The nitrogen balance based model was used as a tool to quantify the variability of runs and to describe different kinetic patterns of the amino acid metabolism, in particular with respect to glutamate (GLU) and aspartate (ASP).
Stichworte
systems biology; liver support; bioreactor; metabolic network
Erscheinungsjahr
2006
Zeitschriftentitel
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Band
28
Ausgabe
5
Seite(n)
331-340
ISSN
1615-7591
eISSN
1615-7605
Page URI
https://pub.uni-bielefeld.de/record/1599830

Zitieren

Guthke R, Zeilinger K, Sickinger S, et al. Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING. 2006;28(5):331-340.
Guthke, R., Zeilinger, K., Sickinger, S., Schmidt-Heck, W., Büntemeyer, H., Iding, K., Lehmann, J., et al. (2006). Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 28(5), 331-340. https://doi.org/10.1007/s00449-005-0040-1
Guthke, R, Zeilinger, K, Sickinger, S, Schmidt-Heck, W, Büntemeyer, Heino, Iding, K, Lehmann, J, Pfaff, M, Pless, G, and Gerlach, JC. 2006. “Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors”. BIOPROCESS AND BIOSYSTEMS ENGINEERING 28 (5): 331-340.
Guthke, R., Zeilinger, K., Sickinger, S., Schmidt-Heck, W., Büntemeyer, H., Iding, K., Lehmann, J., Pfaff, M., Pless, G., and Gerlach, J. C. (2006). Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING 28, 331-340.
Guthke, R., et al., 2006. Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 28(5), p 331-340.
R. Guthke, et al., “Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors”, BIOPROCESS AND BIOSYSTEMS ENGINEERING, vol. 28, 2006, pp. 331-340.
Guthke, R., Zeilinger, K., Sickinger, S., Schmidt-Heck, W., Büntemeyer, H., Iding, K., Lehmann, J., Pfaff, M., Pless, G., Gerlach, J.C.: Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. BIOPROCESS AND BIOSYSTEMS ENGINEERING. 28, 331-340 (2006).
Guthke, R, Zeilinger, K, Sickinger, S, Schmidt-Heck, W, Büntemeyer, Heino, Iding, K, Lehmann, J, Pfaff, M, Pless, G, and Gerlach, JC. “Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors”. BIOPROCESS AND BIOSYSTEMS ENGINEERING 28.5 (2006): 331-340.

5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system.
Yang Y, Li J, Pan X, Zhou P, Yu X, Cao H, Wang Y, Li L., Biotechnol Bioeng 110(3), 2013
PMID: 23055347
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ., Nat Cell Biol 14(8), 2012
PMID: 22820375
High-throughput nuclear magnetic resonance metabolomic footprinting for tissue engineering.
Seagle C, Christie MA, Winnike JH, McClelland RE, Ludlow JW, O'Connell TM, Gamcsik MP, MacDonald JM., Tissue Eng Part C Methods 14(2), 2008
PMID: 18544027

15 References

Daten bereitgestellt von Europe PubMed Central.

Experimental evaluation of a cell module for hybrid liver support.
Gerlach JC, Botsch M, Kardassis D, Lemmens P, Schon M, Janke J, Puhl G, Unger J, Kraemer M, Busse B, Bohmer C, Belal R, Ingenlath M, Kosan M, Kosan B, Sultmann J, Patzold A, Tietze S, Rossaint R, Muller C, Monch E, Sauer IM, Neuhaus P., Int J Artif Organs 24(11), 2001
PMID: 11797849
A comparison of ecotoxicological tests.
Botsford JL., Altern Lab Anim 30(5), 2002
PMID: 12432890
Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study.
Gerlach JC, Mutig K, Sauer IM, Schrade P, Efimova E, Mieder T, Naumann G, Grunwald A, Pless G, Mas A, Bachmann S, Neuhaus P, Zeilinger K., Transplantation 76(5), 2003
PMID: 14501853
Time course of primary liver cell reorganization in three-dimensional high-density bioreactors for extracorporeal liver support: an immunohistochemical and ultrastructural study.
Zeilinger K, Holland G, Sauer IM, Efimova E, Kardassis D, Obermayer N, Liu M, Neuhaus P, Gerlach JC., Tissue Eng. 10(7-8), 2004
PMID: 15363168

AUTHOR UNKNOWN, 0
Network analysis of the kinetics of amino acid metabolism in a liver cell bioreactor
Schmidt-Heck W, Zeilinger K, Pfaff M, Toepfer S, Driesch D, Pless G, Neuhaus P, Gerlach JC, Guthke R., 2004
Prediction of the performance of human liver cell bioreactors by donor organ data
Schmidt-Heck W, Zeilinger K, Pless G, Gerlach JC, Pfaff M, Guthke R., 2005
Comparison of four methods for mass hepatocyte isolation from pig and human livers.
Gerlach JC, Brombacher J, Kloppel K, Schnoy N, Neuhaus P., Transplantation 57(9), 1994
PMID: 8184468
Methods for off-line analysis in animal cell culture
Buentemeyer H., 2000
Systems analysis of the dynamic input/output behaviour of a multi-compartment capillary membrane bioreactor for high-density liver cell culture
Pfaff M, Toepfer S, Zeilinger K, Roth S, Driesch D, Woetzel D, Schmidt-Heck W, Guthke R, Witaschek T, Gerlach JC., 2005
The biplot graphical display of matrices with applications to principal component analysis
Gabriel KR., 1971
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 16550345
PubMed | Europe PMC

Suchen in

Google Scholar