Carbohydrate mimics promote functional recovery after peripheral nerve repair
Simova O, Irintchev A, Mehanna A, Liu J, Dihne M, Baechle D, Sewald N, Loers G, Schachner M (2006)
ANNALS OF NEUROLOGY 60(4): 430-437.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Simova, Olga;
Irintchev, Andrey;
Mehanna, Ali;
Liu, Jiankun;
Dihne, Marcel;
Baechle, Dirk;
Sewald, NorbertUniBi
;
Loers, Gabriele;
Schachner, Melitta
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Einrichtung
Abstract / Bemerkung
Objective: The outcome of peripheral nerve repair is often unsatisfactory, and efficient therapies are not available. We tested the therapeutic potential of functional mimics of the human natural killer cell glycan (3-sulfoglucuronyl beta 1-3 galactoside) (HNK-1) epitope, a carbohydrate indicated to favor specificity of motor reinnervation in mice. Methods: We applied a linear HNK-1 mimic peptide, scrambled peptide, or vehicle substances in polyethylene cuffs used to reconstruct the severed femoral nerves of adult mice. We used video-based motion analysis and morphological and tracing techniques to monitor the outcome of nerve repair. Results: After glycomimetic application, quadriceps muscle function recovered to 93% of normal within 3 months. Restoration of function was less complete (71-76%) in control groups. Better functional recovery was associated with larger motoneuron somata, better axonal myelination in the quadriceps nerve, and enhanced precision of target reinnervation. Lesion-induced death of motoneurons was reduced by 20 to 25%. The glycomimetic enhanced survival and neurite outgrowth of both mouse and human motoneurons in vitro by 30 to 75%. Application of a novel cyclic glycomimetic also enhanced functional recovery in vivo. Interpretation: The improved outcome of nerve repair after glycomimetic application may be attributed to neurotrophic effects. Our results hold promise for therapeutic use in humans.
Erscheinungsjahr
2006
Zeitschriftentitel
ANNALS OF NEUROLOGY
Band
60
Ausgabe
4
Seite(n)
430-437
ISSN
0364-5134
Page URI
https://pub.uni-bielefeld.de/record/1597131
Zitieren
Simova O, Irintchev A, Mehanna A, et al. Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY. 2006;60(4):430-437.
Simova, O., Irintchev, A., Mehanna, A., Liu, J., Dihne, M., Baechle, D., Sewald, N., et al. (2006). Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY, 60(4), 430-437. https://doi.org/10.1002/ana.20948
Simova, Olga, Irintchev, Andrey, Mehanna, Ali, Liu, Jiankun, Dihne, Marcel, Baechle, Dirk, Sewald, Norbert, Loers, Gabriele, and Schachner, Melitta. 2006. “Carbohydrate mimics promote functional recovery after peripheral nerve repair”. ANNALS OF NEUROLOGY 60 (4): 430-437.
Simova, O., Irintchev, A., Mehanna, A., Liu, J., Dihne, M., Baechle, D., Sewald, N., Loers, G., and Schachner, M. (2006). Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY 60, 430-437.
Simova, O., et al., 2006. Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY, 60(4), p 430-437.
O. Simova, et al., “Carbohydrate mimics promote functional recovery after peripheral nerve repair”, ANNALS OF NEUROLOGY, vol. 60, 2006, pp. 430-437.
Simova, O., Irintchev, A., Mehanna, A., Liu, J., Dihne, M., Baechle, D., Sewald, N., Loers, G., Schachner, M.: Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY. 60, 430-437 (2006).
Simova, Olga, Irintchev, Andrey, Mehanna, Ali, Liu, Jiankun, Dihne, Marcel, Baechle, Dirk, Sewald, Norbert, Loers, Gabriele, and Schachner, Melitta. “Carbohydrate mimics promote functional recovery after peripheral nerve repair”. ANNALS OF NEUROLOGY 60.4 (2006): 430-437.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
44 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Confocal Synaptology: Synaptic Rearrangements in Neurodegenerative Disorders and upon Nervous System Injury.
Vulovic M, Divac N, Jakovcevski I., Front Neuroanat 12(), 2018
PMID: 29497366
Vulovic M, Divac N, Jakovcevski I., Front Neuroanat 12(), 2018
PMID: 29497366
Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair.
Farrugia BL, Lord MS, Whitelock JM, Melrose J., Biomater Sci 6(5), 2018
PMID: 29560990
Farrugia BL, Lord MS, Whitelock JM, Melrose J., Biomater Sci 6(5), 2018
PMID: 29560990
Cell Adhesion Molecule Close Homolog of L1 (CHL1) Guides the Regrowth of Regenerating Motor Axons and Regulates Synaptic Coverage of Motor Neurons.
Guseva D, Jakovcevski I, Irintchev A, Leshchyns'ka I, Sytnyk V, Ponimaskin E, Schachner M., Front Mol Neurosci 11(), 2018
PMID: 29881335
Guseva D, Jakovcevski I, Irintchev A, Leshchyns'ka I, Sytnyk V, Ponimaskin E, Schachner M., Front Mol Neurosci 11(), 2018
PMID: 29881335
Botulinum Neurotoxin Application to the Severed Femoral Nerve Modulates Spinal Synaptic Responses to Axotomy and Enhances Motor Recovery in Rats.
Irintchev M, Guntinas-Lichius O, Irintchev A., Neural Plast 2018(), 2018
PMID: 30254669
Irintchev M, Guntinas-Lichius O, Irintchev A., Neural Plast 2018(), 2018
PMID: 30254669
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
García-Ayllón MS, Botella-López A, Cuchillo-Ibañez I, Rábano A, Andreasen N, Blennow K, Ávila J, Sáez-Valero J., Mol Neurobiol 54(1), 2017
PMID: 26738850
García-Ayllón MS, Botella-López A, Cuchillo-Ibañez I, Rábano A, Andreasen N, Blennow K, Ávila J, Sáez-Valero J., Mol Neurobiol 54(1), 2017
PMID: 26738850
The Adhesion Molecule-Characteristic HNK-1 Carbohydrate Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish.
Ma L, Shen HF, Shen YQ, Schachner M., Mol Neurobiol 54(5), 2017
PMID: 27086029
Ma L, Shen HF, Shen YQ, Schachner M., Mol Neurobiol 54(5), 2017
PMID: 27086029
Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury.
Lutz D, Kataria H, Kleene R, Loers G, Chaudhary H, Guseva D, Wu B, Jakovcevski I, Schachner M., Mol Neurobiol 53(5), 2016
PMID: 26081148
Lutz D, Kataria H, Kleene R, Loers G, Chaudhary H, Guseva D, Wu B, Jakovcevski I, Schachner M., Mol Neurobiol 53(5), 2016
PMID: 26081148
Small Molecule Agonists of Cell Adhesion Molecule L1 Mimic L1 Functions In Vivo.
Kataria H, Lutz D, Chaudhary H, Schachner M, Loers G., Mol Neurobiol 53(7), 2016
PMID: 26253722
Kataria H, Lutz D, Chaudhary H, Schachner M, Loers G., Mol Neurobiol 53(7), 2016
PMID: 26253722
Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions.
Loers G, Saini V, Mishra B, Gul S, Chaudhury S, Wallqvist A, Kaur G, Schachner M., J Neurochem 136(1), 2016
PMID: 26443186
Loers G, Saini V, Mishra B, Gul S, Chaudhury S, Wallqvist A, Kaur G, Schachner M., J Neurochem 136(1), 2016
PMID: 26443186
Porous and Nonporous Nerve Conduits: The Effects of a Hydrogel Luminal Filler With and Without a Neurite-Promoting Moiety.
Ezra M, Bushman J, Shreiber D, Schachner M, Kohn J., Tissue Eng Part A 22(9-10), 2016
PMID: 27102571
Ezra M, Bushman J, Shreiber D, Schachner M, Kohn J., Tissue Eng Part A 22(9-10), 2016
PMID: 27102571
Glycosaminoglycans and glycomimetics in the central nervous system.
Rowlands D, Sugahara K, Kwok JC., Molecules 20(3), 2015
PMID: 25706756
Rowlands D, Sugahara K, Kwok JC., Molecules 20(3), 2015
PMID: 25706756
Tegaserod mimics the neurostimulatory glycan polysialic acid and promotes nervous system repair.
Bushman J, Mishra B, Ezra M, Gul S, Schulze C, Chaudhury S, Ripoll D, Wallqvist A, Kohn J, Schachner M, Loers G., Neuropharmacology 79(), 2014
PMID: 24067923
Bushman J, Mishra B, Ezra M, Gul S, Schulze C, Chaudhury S, Ripoll D, Wallqvist A, Kohn J, Schachner M, Loers G., Neuropharmacology 79(), 2014
PMID: 24067923
Enhanced femoral nerve regeneration after tubulization with a tyrosine-derived polycarbonate terpolymer: effects of protein adsorption and independence of conduit porosity.
Ezra M, Bushman J, Shreiber D, Schachner M, Kohn J., Tissue Eng Part A 20(3-4), 2014
PMID: 24011026
Ezra M, Bushman J, Shreiber D, Schachner M, Kohn J., Tissue Eng Part A 20(3-4), 2014
PMID: 24011026
Improved regeneration after femoral nerve injury in mice lacking functional T- and B-lymphocytes.
Mehanna A, Szpotowicz E, Schachner M, Jakovcevski I., Exp Neurol 261(), 2014
PMID: 24967682
Mehanna A, Szpotowicz E, Schachner M, Jakovcevski I., Exp Neurol 261(), 2014
PMID: 24967682
Motoneuron regeneration accuracy and recovery of gait after femoral nerve injuries in rats.
Kruspe M, Thieme H, Guntinas-Lichius O, Irintchev A., Neuroscience 280(), 2014
PMID: 25220899
Kruspe M, Thieme H, Guntinas-Lichius O, Irintchev A., Neuroscience 280(), 2014
PMID: 25220899
Function-triggering antibodies to the adhesion molecule L1 enhance recovery after injury of the adult mouse femoral nerve.
Guseva D, Loers G, Schachner M., PLoS One 9(11), 2014
PMID: 25393007
Guseva D, Loers G, Schachner M., PLoS One 9(11), 2014
PMID: 25393007
Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration.
Akyüz N, Rost S, Mehanna A, Bian S, Loers G, Oezen I, Mishra B, Hoffmann K, Guseva D, Laczynska E, Irintchev A, Jakovcevski I, Schachner M., Exp Neurol 247(), 2013
PMID: 23360803
Akyüz N, Rost S, Mehanna A, Bian S, Loers G, Oezen I, Mishra B, Hoffmann K, Guseva D, Laczynska E, Irintchev A, Jakovcevski I, Schachner M., Exp Neurol 247(), 2013
PMID: 23360803
Deficient functional recovery after facial nerve crush in rats is associated with restricted rearrangements of synaptic terminals in the facial nucleus.
Hundeshagen G, Szameit K, Thieme H, Finkensieper M, Angelov DN, Guntinas-Lichius O, Irintchev A., Neuroscience 248(), 2013
PMID: 23806716
Hundeshagen G, Szameit K, Thieme H, Finkensieper M, Angelov DN, Guntinas-Lichius O, Irintchev A., Neuroscience 248(), 2013
PMID: 23806716
Gold nanoparticles functionalized with a fragment of the neural cell adhesion molecule L1 stimulate L1-mediated functions.
Schulz F, Lutz D, Rusche N, Bastús NG, Stieben M, Höltig M, Grüner F, Weller H, Schachner M, Vossmeyer T, Loers G., Nanoscale 5(21), 2013
PMID: 24056775
Schulz F, Lutz D, Rusche N, Bastús NG, Stieben M, Höltig M, Grüner F, Weller H, Schachner M, Vossmeyer T, Loers G., Nanoscale 5(21), 2013
PMID: 24056775
Inhibition of the bacterial lectins of Pseudomonas aeruginosa with monosaccharides and peptides.
Gustke H, Kleene R, Loers G, Nehmann N, Jaehne M, Bartels KM, Jaeger KE, Schachner M, Schumacher U., Eur J Clin Microbiol Infect Dis 31(2), 2012
PMID: 21604096
Gustke H, Kleene R, Loers G, Nehmann N, Jaehne M, Bartels KM, Jaeger KE, Schachner M, Schumacher U., Eur J Clin Microbiol Infect Dis 31(2), 2012
PMID: 21604096
The injured and regenerating nervous system: immunoglobulin superfamily members as key players.
Irintchev A, Schachner M., Neuroscientist 18(5), 2012
PMID: 21903634
Irintchev A, Schachner M., Neuroscientist 18(5), 2012
PMID: 21903634
Neural cell type-specific responses to glycomimetic functionalized collagen.
Masand SN, Perron IJ, Schachner M, Shreiber DI., Biomaterials 33(3), 2012
PMID: 22027596
Masand SN, Perron IJ, Schachner M, Shreiber DI., Biomaterials 33(3), 2012
PMID: 22027596
Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate.
Kizuka Y, Oka S., Cell Mol Life Sci 69(24), 2012
PMID: 22669261
Kizuka Y, Oka S., Cell Mol Life Sci 69(24), 2012
PMID: 22669261
The effect of glycomimetic functionalized collagen on peripheral nerve repair.
Masand SN, Chen J, Perron IJ, Hammerling BC, Loers G, Schachner M, Shreiber DI., Biomaterials 33(33), 2012
PMID: 22917737
Masand SN, Chen J, Perron IJ, Hammerling BC, Loers G, Schachner M, Shreiber DI., Biomaterials 33(33), 2012
PMID: 22917737
Positively and negatively modulating cell adhesion to type I collagen via peptide grafting.
Monteiro GA, Fernandes AV, Sundararaghavan HG, Shreiber DI., Tissue Eng Part A 17(13-14), 2011
PMID: 19196133
Monteiro GA, Fernandes AV, Sundararaghavan HG, Shreiber DI., Tissue Eng Part A 17(13-14), 2011
PMID: 19196133
Adhesion molecule L1 overexpressed under the control of the neuronal Thy-1 promoter improves myelination after peripheral nerve injury in adult mice.
Guseva D, Zerwas M, Xiao MF, Jakovcevski I, Irintchev A, Schachner M., Exp Neurol 229(2), 2011
PMID: 21376041
Guseva D, Zerwas M, Xiao MF, Jakovcevski I, Irintchev A, Schachner M., Exp Neurol 229(2), 2011
PMID: 21376041
Potentials and limitations of peripheral nerve injury models in rodents with particular reference to the femoral nerve.
Irintchev A., Ann Anat 193(4), 2011
PMID: 21481575
Irintchev A., Ann Anat 193(4), 2011
PMID: 21481575
Glycomimetic improves recovery after femoral injury in a non-human primate.
Irintchev A, Wu MM, Lee HJ, Zhu H, Feng YP, Liu YS, Bernreuther C, Loers G, You SW, Schachner M., J Neurotrauma 28(7), 2011
PMID: 21463132
Irintchev A, Wu MM, Lee HJ, Zhu H, Feng YP, Liu YS, Bernreuther C, Loers G, You SW, Schachner M., J Neurotrauma 28(7), 2011
PMID: 21463132
Polysialic acid glycomimetic promotes functional recovery and plasticity after spinal cord injury in mice.
Mehanna A, Jakovcevski I, Acar A, Xiao M, Loers G, Rougon G, Irintchev A, Schachner M., Mol Ther 18(1), 2010
PMID: 19826404
Mehanna A, Jakovcevski I, Acar A, Xiao M, Loers G, Rougon G, Irintchev A, Schachner M., Mol Ther 18(1), 2010
PMID: 19826404
A novel motion analysis approach reveals late recovery in C57BL/6 mice and deficits in NCAM-deficient mice after sciatic nerve crush.
Fey A, Schachner M, Irintchev A., J Neurotrauma 27(5), 2010
PMID: 20121417
Fey A, Schachner M, Irintchev A., J Neurotrauma 27(5), 2010
PMID: 20121417
[Regeneration of the facial nerve in comparison to other peripheral nerves : from bench to bedside].
Irintchev A, Angelov DN, Guntinas-Lichius O., HNO 58(5), 2010
PMID: 20454881
Irintchev A, Angelov DN, Guntinas-Lichius O., HNO 58(5), 2010
PMID: 20454881
Functional role of the interaction between polysialic acid and extracellular histone H1.
Mishra B, von der Ohe M, Schulze C, Bian S, Makhina T, Loers G, Kleene R, Schachner M., J Neurosci 30(37), 2010
PMID: 20844135
Mishra B, von der Ohe M, Schulze C, Bian S, Makhina T, Loers G, Kleene R, Schachner M., J Neurosci 30(37), 2010
PMID: 20844135
Functional effects of local thyroid hormone administration after sciatic nerve injury in rats.
Papakostas I, Mourouzis I, Mourouzis K, Macheras G, Boviatsis E, Pantos C., Microsurgery 29(1), 2009
PMID: 18942650
Papakostas I, Mourouzis I, Mourouzis K, Macheras G, Boviatsis E, Pantos C., Microsurgery 29(1), 2009
PMID: 18942650
Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.
Lieberoth A, Splittstoesser F, Katagihallimath N, Jakovcevski I, Loers G, Ranscht B, Karagogeos D, Schachner M, Kleene R., J Neurosci 29(20), 2009
PMID: 19458237
Lieberoth A, Splittstoesser F, Katagihallimath N, Jakovcevski I, Loers G, Ranscht B, Karagogeos D, Schachner M, Kleene R., J Neurosci 29(20), 2009
PMID: 19458237
Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice.
Mehanna A, Mishra B, Kurschat N, Schulze C, Bian S, Loers G, Irintchev A, Schachner M., Brain 132(pt 6), 2009
PMID: 19454531
Mehanna A, Mishra B, Kurschat N, Schulze C, Bian S, Loers G, Irintchev A, Schachner M., Brain 132(pt 6), 2009
PMID: 19454531
Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury.
Guseva D, Angelov DN, Irintchev A, Schachner M., Brain 132(pt 8), 2009
PMID: 19541848
Guseva D, Angelov DN, Irintchev A, Schachner M., Brain 132(pt 8), 2009
PMID: 19541848
Chemical communication between regenerating motor axons and Schwann cells in the growth pathway.
Vrbova G, Mehra N, Shanmuganathan H, Tyreman N, Schachner M, Gordon T., Eur J Neurosci 30(3), 2009
PMID: 19656172
Vrbova G, Mehra N, Shanmuganathan H, Tyreman N, Schachner M, Gordon T., Eur J Neurosci 30(3), 2009
PMID: 19656172
Electrical stimulation accelerates motor functional recovery in autograft-repaired 10 mm femoral nerve gap in rats.
Huang J, Hu X, Lu L, Ye Z, Wang Y, Luo Z., J Neurotrauma 26(10), 2009
PMID: 19226192
Huang J, Hu X, Lu L, Ye Z, Wang Y, Luo Z., J Neurotrauma 26(10), 2009
PMID: 19226192
Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury.
Gordon T, Chan KM, Sulaiman OA, Udina E, Amirjani N, Brushart TM., Neurosurgery 65(4 suppl), 2009
PMID: 19927058
Gordon T, Chan KM, Sulaiman OA, Udina E, Amirjani N, Brushart TM., Neurosurgery 65(4 suppl), 2009
PMID: 19927058
The impact of motor and sensory nerve architecture on nerve regeneration.
Moradzadeh A, Borschel GH, Luciano JP, Whitlock EL, Hayashi A, Hunter DA, Mackinnon SE., Exp Neurol 212(2), 2008
PMID: 18550053
Moradzadeh A, Borschel GH, Luciano JP, Whitlock EL, Hayashi A, Hunter DA, Mackinnon SE., Exp Neurol 212(2), 2008
PMID: 18550053
Manual stimulation of the suprahyoid-sublingual region diminishes polynnervation of the motor endplates and improves recovery of function after hypoglossal nerve injury in rats.
Evgenieva E, Schweigert P, Guntinas-Lichius O, Pavlov S, Grosheva M, Angelova S, Streppel M, Irintchev A, Skouras E, Kuerten S, Sinis N, Dunlop S, Radeva V, Angelov DN., Neurorehabil Neural Repair 22(6), 2008
PMID: 18612142
Evgenieva E, Schweigert P, Guntinas-Lichius O, Pavlov S, Grosheva M, Angelova S, Streppel M, Irintchev A, Skouras E, Kuerten S, Sinis N, Dunlop S, Radeva V, Angelov DN., Neurorehabil Neural Repair 22(6), 2008
PMID: 18612142
Recognition molecules and neural repair.
Loers G, Schachner M., J Neurochem 101(4), 2007
PMID: 17254012
Loers G, Schachner M., J Neurochem 101(4), 2007
PMID: 17254012
One hour electrical stimulation accelerates functional recovery after femoral nerve repair.
Ahlborn P, Schachner M, Irintchev A., Exp Neurol 208(1), 2007
PMID: 17919580
Ahlborn P, Schachner M, Irintchev A., Exp Neurol 208(1), 2007
PMID: 17919580
Differential expression of HNK-1 and p75(NTR) in adult canine Schwann cells and olfactory ensheathing cells in situ but not in vitro.
Bock P, Beineke A, Techangamsuwan S, Baumgärtner W, Wewetzer K., J Comp Neurol 505(5), 2007
PMID: 17924534
Bock P, Beineke A, Techangamsuwan S, Baumgärtner W, Wewetzer K., J Comp Neurol 505(5), 2007
PMID: 17924534
50 References
Daten bereitgestellt von Europe PubMed Central.
Peripheral nerve injury and repair.
Lee SK, Wolfe SW., J Am Acad Orthop Surg 8(4), 2000
PMID: 10951113
Lee SK, Wolfe SW., J Am Acad Orthop Surg 8(4), 2000
PMID: 10951113
Richard P. Bunge memorial lecture. Nerve injury and repair--a challenge to the plastic brain.
Lundborg G., J. Peripher. Nerv. Syst. 8(4), 2003
PMID: 14641646
Lundborg G., J. Peripher. Nerv. Syst. 8(4), 2003
PMID: 14641646
Alteration in connections between muscle and anterior horn motoneurons after peripheral nerve repair.
Brushart TM, Mesulam MM., Science 208(4444), 1980
PMID: 7367884
Brushart TM, Mesulam MM., Science 208(4444), 1980
PMID: 7367884
Preferential reinnervation of motor nerves by regenerating motor axons.
Brushart TM., J. Neurosci. 8(3), 1988
PMID: 3346713
Brushart TM., J. Neurosci. 8(3), 1988
PMID: 3346713
Motor axons preferentially reinnervate motor pathways.
Brushart TM., J. Neurosci. 13(6), 1993
PMID: 8501535
Brushart TM., J. Neurosci. 13(6), 1993
PMID: 8501535
Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons.
Madison RD, Archibald SJ, Brushart TM., J. Neurosci. 16(18), 1996
PMID: 8795625
Madison RD, Archibald SJ, Brushart TM., J. Neurosci. 16(18), 1996
PMID: 8795625
Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve.
Martini R, Schachner M., J. Cell Biol. 103(6 Pt 1), 1986
PMID: 2430983
Martini R, Schachner M., J. Cell Biol. 103(6 Pt 1), 1986
PMID: 2430983
The L2/HNK-1 Carbohydrate Epitope is Involved in the Preferential Outgrowth of Motor Neurons on Ventral Roots and Motor Nerves.
Martini R, Xin Y, Schmitz B, Schachner M., Eur. J. Neurosci. 4(7), 1992
PMID: 12106326
Martini R, Xin Y, Schmitz B, Schachner M., Eur. J. Neurosci. 4(7), 1992
PMID: 12106326
The L2/HNK-1 carbohydrate is preferentially expressed by previously motor axon-associated Schwann cells in reinnervated peripheral nerves.
Martini R, Schachner M, Brushart TM., J. Neurosci. 14(11 Pt 2), 1994
PMID: 7525896
Martini R, Schachner M, Brushart TM., J. Neurosci. 14(11 Pt 2), 1994
PMID: 7525896
Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses.
Saghatelyan AK, Snapyan M, Gorissen S, Meigel I, Mosbacher J, Kaupmann K, Bettler B, Kornilov AV, Nifantiev NE, Sakanyan V, Schachner M, Dityatev A., Mol. Cell. Neurosci. 24(2), 2003
PMID: 14572452
Saghatelyan AK, Snapyan M, Gorissen S, Meigel I, Mosbacher J, Kaupmann K, Bettler B, Kornilov AV, Nifantiev NE, Sakanyan V, Schachner M, Dityatev A., Mol. Cell. Neurosci. 24(2), 2003
PMID: 14572452
Identification of a peptide mimic of the L2/HNK-1 carbohydrate epitope.
Simon-Haldi M, Mantei N, Franke J, Voshol H, Schachner M., J. Neurochem. 83(6), 2002
PMID: 12472892
Simon-Haldi M, Mantei N, Franke J, Voshol H, Schachner M., J. Neurochem. 83(6), 2002
PMID: 12472892
Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice.
Irintchev A, Simova O, Eberhardt KA, Morellini F, Schachner M., Eur. J. Neurosci. 22(4), 2005
PMID: 16115204
Irintchev A, Simova O, Eberhardt KA, Morellini F, Schachner M., Eur. J. Neurosci. 22(4), 2005
PMID: 16115204
Polysialylated neural cell adhesion molecule is necessary for selective targeting of regenerating motor neurons.
Franz CK, Rutishauser U, Rafuse VF., J. Neurosci. 25(8), 2005
PMID: 15728848
Franz CK, Rutishauser U, Rafuse VF., J. Neurosci. 25(8), 2005
PMID: 15728848
Antibodies to myelin-associated glycoprotein accelerate preferential motor reinnervation.
Mears S, Schachner M, Brushart TM., J. Peripher. Nerv. Syst. 8(2), 2003
PMID: 12795713
Mears S, Schachner M, Brushart TM., J. Peripher. Nerv. Syst. 8(2), 2003
PMID: 12795713
Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture.
Robinson GA, Madison RD., Muscle Nerve 28(2), 2003
PMID: 12872328
Robinson GA, Madison RD., Muscle Nerve 28(2), 2003
PMID: 12872328
Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons.
Robinson GA, Madison RD., Exp. Neurol. 192(1), 2005
PMID: 15698617
Robinson GA, Madison RD., Exp. Neurol. 192(1), 2005
PMID: 15698617
Altered expression of immune-related antigens by neuronophages does not improve neuronal survival after severe lesion of the facial nerve in rats.
Angelov DN, Krebs C, Walther M, Martinez-Portillo FJ, Gunkel A, Lay CH, Streppel M, Guntinas-Lichius O, Stennert E, Neiss WF., Glia 24(2), 1998
PMID: 9728762
Angelov DN, Krebs C, Walther M, Martinez-Portillo FJ, Gunkel A, Lay CH, Streppel M, Guntinas-Lichius O, Stennert E, Neiss WF., Glia 24(2), 1998
PMID: 9728762
Displacement of synaptic terminals from regenerating motoneurons by microglial cells.
Blinzinger K, Kreutzberg G., Z Zellforsch Mikrosk Anat 85(2), 1968
PMID: 5706753
Blinzinger K, Kreutzberg G., Z Zellforsch Mikrosk Anat 85(2), 1968
PMID: 5706753
The facial nerve axotomy model.
Moran LB, Graeber MB., Brain Res. Brain Res. Rev. 44(2-3), 2004
PMID: 15003391
Moran LB, Graeber MB., Brain Res. Brain Res. Rev. 44(2-3), 2004
PMID: 15003391
Recovery of synapses in axotomized adult cat spinal motoneurons after reinnervation into muscle.
Brannstrom T, Kellerth JO., Exp Brain Res 125(1), 1999
PMID: 10100972
Brannstrom T, Kellerth JO., Exp Brain Res 125(1), 1999
PMID: 10100972
Acetylcholinesterase activity and type C synapses in the hypoglossal, facial and spinal-cord motor nuclei of rats. An electron-microscope study.
Davidoff MS, Irintchev AP., Histochemistry 84(4-6), 1986
PMID: 3721918
Davidoff MS, Irintchev AP., Histochemistry 84(4-6), 1986
PMID: 3721918
Large cholinergic nerve terminals on subsets of motoneurons and their relation to muscarinic receptor type 2.
Hellstrom J, Oliveira AL, Meister B, Cullheim S., J. Comp. Neurol. 460(4), 2003
PMID: 12717708
Hellstrom J, Oliveira AL, Meister B, Cullheim S., J. Comp. Neurol. 460(4), 2003
PMID: 12717708
Changes in synaptology of adult cat spinal alpha-motoneurons after axotomy.
Brannstrom T, Kellerth JO., Exp Brain Res 118(1), 1998
PMID: 9547066
Brannstrom T, Kellerth JO., Exp Brain Res 118(1), 1998
PMID: 9547066
Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves.
Martini R., J. Neurocytol. 23(1), 1994
PMID: 8176415
Martini R., J. Neurocytol. 23(1), 1994
PMID: 8176415
The L2/HNK-1 carbohydrate is carried by the myelin associated glycoprotein and sulphated glucuronyl glycolipids in muscle but not cutaneous nerves of adult mice.
Low K, Orberger G, Schmitz B, Martini R, Schachner M., Eur. J. Neurosci. 6(12), 1994
PMID: 7535628
Low K, Orberger G, Schmitz B, Martini R, Schachner M., Eur. J. Neurosci. 6(12), 1994
PMID: 7535628
BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair.
Eberhardt KA, Irintchev A, Al-Majed AA, Simova O, Brushart TM, Gordon T, Schachner M., Exp. Neurol. 198(2), 2006
PMID: 16460731
Eberhardt KA, Irintchev A, Al-Majed AA, Simova O, Brushart TM, Gordon T, Schachner M., Exp. Neurol. 198(2), 2006
PMID: 16460731
Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival.
Chen S, Mange A, Dong L, Lehmann S, Schachner M., Mol. Cell. Neurosci. 22(2), 2003
PMID: 12676532
Chen S, Mange A, Dong L, Lehmann S, Schachner M., Mol. Cell. Neurosci. 22(2), 2003
PMID: 12676532
Retinal ganglion cell survival in vitro maintained by a chondroitin sulfate proteoglycan from the superior colliculus carrying the HNK-1 epitope.
Nichol KA, Everett AW, Schulz M, Bennett MR., J. Neurosci. Res. 37(5), 1994
PMID: 7518009
Nichol KA, Everett AW, Schulz M, Bennett MR., J. Neurosci. Res. 37(5), 1994
PMID: 7518009
The L2/HNK-1 carbohydrate mediates adhesion of neural cells to laminin.
Hall H, Liu L, Schachner M, Schmitz B., Eur. J. Neurosci. 5(1), 1993
PMID: 8261088
Hall H, Liu L, Schachner M, Schmitz B., Eur. J. Neurosci. 5(1), 1993
PMID: 8261088
Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules.
Holm J, Hillenbrand R, Steuber V, Bartsch U, Moos M, Lubbert H, Montag D, Schachner M., Eur. J. Neurosci. 8(8), 1996
PMID: 8921253
Holm J, Hillenbrand R, Steuber V, Bartsch U, Moos M, Lubbert H, Montag D, Schachner M., Eur. J. Neurosci. 8(8), 1996
PMID: 8921253
Glycans and neural cell interactions.
Kleene R, Schachner M., Nat. Rev. Neurosci. 5(3), 2004
PMID: 14976519
Kleene R, Schachner M., Nat. Rev. Neurosci. 5(3), 2004
PMID: 14976519
Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.
Kruse J, Mailhammer R, Wernecke H, Faissner A, Sommer I, Goridis C, Schachner M., Nature 311(5982), 1984
PMID: 6206400
Kruse J, Mailhammer R, Wernecke H, Faissner A, Sommer I, Goridis C, Schachner M., Nature 311(5982), 1984
PMID: 6206400
Sulfoglycolipids bind to adhesive protein amphoterin (P30) in the nervous system.
Mohan PS, Laitinen J, Merenmies J, Rauvala H, Jungalwala FB., Biochem. Biophys. Res. Commun. 182(2), 1992
PMID: 1370890
Mohan PS, Laitinen J, Merenmies J, Rauvala H, Jungalwala FB., Biochem. Biophys. Res. Commun. 182(2), 1992
PMID: 1370890
Heat-stable antigen (mouse CD24) in the brain: dual but distinct interaction with P-selectin and L1.
Sammar M, Aigner S, Altevogt P., Biochim. Biophys. Acta 1337(2), 1997
PMID: 9048906
Sammar M, Aigner S, Altevogt P., Biochim. Biophys. Acta 1337(2), 1997
PMID: 9048906
Glycans and the modulation of neural-recognition molecule function.
Schachner M, Martini R., Trends Neurosci. 18(4), 1995
PMID: 7539963
Schachner M, Martini R., Trends Neurosci. 18(4), 1995
PMID: 7539963
The HNK-1 reactive sulfoglucuronyl glycolipids are ligands for L-selectin and P-selectin but not E-selectin.
Needham LK, Schnaar RL., Proc. Natl. Acad. Sci. U.S.A. 90(4), 1993
PMID: 7679503
Needham LK, Schnaar RL., Proc. Natl. Acad. Sci. U.S.A. 90(4), 1993
PMID: 7679503
Chromatin and cell death.
Bianchi ME, Manfredi A., Biochim. Biophys. Acta 1677(1-3), 2004
PMID: 15020058
Bianchi ME, Manfredi A., Biochim. Biophys. Acta 1677(1-3), 2004
PMID: 15020058
HMGB1: guiding immunity from within.
Dumitriu IE, Baruah P, Manfredi AA, Bianchi ME, Rovere-Querini P., Trends Immunol. 26(7), 2005
PMID: 15978523
Dumitriu IE, Baruah P, Manfredi AA, Bianchi ME, Rovere-Querini P., Trends Immunol. 26(7), 2005
PMID: 15978523
Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation.
Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H., J. Biol. Chem. 275(51), 2000
PMID: 11007787
Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H., J. Biol. Chem. 275(51), 2000
PMID: 11007787
Receptor for advanced glycation end products plays a more important role in cellular survival than in neurite outgrowth during retinoic acid-induced differentiation of neuroblastoma cells.
Sajithlal G, Huttunen H, Rauvala H, Munch G., J. Biol. Chem. 277(9), 2001
PMID: 11739380
Sajithlal G, Huttunen H, Rauvala H, Munch G., J. Biol. Chem. 277(9), 2001
PMID: 11739380
Regulation of expression of sulfoglucuronyl carbohydrate (HNK-1), Amphoterin and RAGE in retinoic acid-differentiated P19 embryonal carcinoma cells.
Chou DK, Henion TR, Jungalwala FB., J. Neurochem. 86(4), 2003
PMID: 12887690
Chou DK, Henion TR, Jungalwala FB., J. Neurochem. 86(4), 2003
PMID: 12887690
Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration.
Chou DK, Zhang J, Smith FI, McCaffery P, Jungalwala FB., J. Neurochem. 90(6), 2004
PMID: 15341523
Chou DK, Zhang J, Smith FI, McCaffery P, Jungalwala FB., J. Neurochem. 90(6), 2004
PMID: 15341523
Expression of P30, a protein with adhesive properties, in Schwann cells and neurons of the developing and regenerating peripheral nerve.
Daston MM, Ratner N., J. Cell Biol. 112(6), 1991
PMID: 1999471
Daston MM, Ratner N., J. Cell Biol. 112(6), 1991
PMID: 1999471
Antagonism of RAGE suppresses peripheral nerve regeneration.
Rong LL, Trojaborg W, Qu W, Kostov K, Yan SD, Gooch C, Szabolcs M, Hays AP, Schmidt AM., FASEB J. 18(15), 2004
PMID: 15576484
Rong LL, Trojaborg W, Qu W, Kostov K, Yan SD, Gooch C, Szabolcs M, Hays AP, Schmidt AM., FASEB J. 18(15), 2004
PMID: 15576484
RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways.
Rong LL, Yan SF, Wendt T, Hans D, Pachydaki S, Bucciarelli LG, Adebayo A, Qu W, Lu Y, Kostov K, Lalla E, Yan SD, Gooch C, Szabolcs M, Trojaborg W, Hays AP, Schmidt AM., FASEB J. 18(15), 2004
PMID: 15576485
Rong LL, Yan SF, Wendt T, Hans D, Pachydaki S, Bucciarelli LG, Adebayo A, Qu W, Lu Y, Kostov K, Lalla E, Yan SD, Gooch C, Szabolcs M, Trojaborg W, Hays AP, Schmidt AM., FASEB J. 18(15), 2004
PMID: 15576485
Specific expression of an HNK-1 carbohydrate epitope and NCAM on femoral nerve Schwann cells in mice.
Saito H, Nakao Y, Takayama S, Toyama Y, Asou H., Neurosci. Res. 53(3), 2005
PMID: 16171882
Saito H, Nakao Y, Takayama S, Toyama Y, Asou H., Neurosci. Res. 53(3), 2005
PMID: 16171882
Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron.
Brushart TM, Hoffman PN, Royall RM, Murinson BB, Witzel C, Gordon T., J. Neurosci. 22(15), 2002
PMID: 12151542
Brushart TM, Hoffman PN, Royall RM, Murinson BB, Witzel C, Gordon T., J. Neurosci. 22(15), 2002
PMID: 12151542
Pathway sampling by regenerating peripheral axons.
Witzel C, Rohde C, Brushart TM., J. Comp. Neurol. 485(3), 2005
PMID: 15791642
Witzel C, Rohde C, Brushart TM., J. Comp. Neurol. 485(3), 2005
PMID: 15791642
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 16958115
PubMed | Europe PMC
Suchen in