A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus

Butz M, Lehmann K, Dammasch IE, Teuchert-Noodt G (2006)
NEURAL NETWORKS 19(10): 1490-1505.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
We describe a strongly biologically motivated artificial neural network approach to model neurogenesis and synaptic turnover as it naturally occurs for example in the hippocampal dentate gyrus (DG) of the developing and adult mammalian and human brain. The results suggest that cell proliferation (CP) has not only a functional meaning for computational tasks and learning but is also relevant for maintaining homeostatic stability of the neural activity. Moderate rates of CP buffer disturbances in input activity more effectively than networks without or very high CR. Up to a critical mark an increase of CP enhances synaptogenesis which might be beneficial for learning. However, higher rates of CP are rather ineffective as they destabilize the network: high CP rates and a disturbing input activity effect a reduced cell survival. By these results the simulation model sheds light on the recurrent interdependence of structure and function in biological neural networks especially in hippocampal circuits and the interacting morphogenetic effects of neurogenesis and synaptogenesis. (c) 2006 Elsevier Ltd. All rights reserved.
Stichworte
network model; apoptosis; cell proliferation; synaptogenesis; neurogenesis; hippocampus; rewiring; homoestatic plasticity
Erscheinungsjahr
2006
Zeitschriftentitel
NEURAL NETWORKS
Band
19
Ausgabe
10
Seite(n)
1490-1505
ISSN
0893-6080
Page URI
https://pub.uni-bielefeld.de/record/1596265

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Butz M, Lehmann K, Dammasch IE, Teuchert-Noodt G. A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus. NEURAL NETWORKS. 2006;19(10):1490-1505.
Butz, M., Lehmann, K., Dammasch, I. E., & Teuchert-Noodt, G. (2006). A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus. NEURAL NETWORKS, 19(10), 1490-1505. doi:10.1016/j.neunet.2006.07.007
Butz, M., Lehmann, K., Dammasch, I. E., and Teuchert-Noodt, G. (2006). A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus. NEURAL NETWORKS 19, 1490-1505.
Butz, M., et al., 2006. A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus. NEURAL NETWORKS, 19(10), p 1490-1505.
M. Butz, et al., “A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus”, NEURAL NETWORKS, vol. 19, 2006, pp. 1490-1505.
Butz, M., Lehmann, K., Dammasch, I.E., Teuchert-Noodt, G.: A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus. NEURAL NETWORKS. 19, 1490-1505 (2006).
Butz, Markus, Lehmann, Konrad, Dammasch, Ingolf E., and Teuchert-Noodt, Gertraud. “A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus”. NEURAL NETWORKS 19.10 (2006): 1490-1505.

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