The heparanome - The enigma of encoding and decoding heparan sulfate sulfation

Lamanna WC, Kalus I, Padva M, Baldwin RJ, Merry CLR, Dierks T (2007)
In: Journal of Biotechnology. JOURNAL OF BIOTECHNOLOGY, 129(2). ELSEVIER SCIENCE BV: 290-307.

Konferenzbeitrag | Veröffentlicht | Englisch
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Lamanna, William C.; Kalus, InaUniBi; Padva, Michael; Baldwin, Rebecca J.; Merry, Catherine L. R.; Dierks, ThomasUniBi
Abstract / Bemerkung
Heparan sulfate (HS) is a cell surface carbohydrate polymer modified with sulfate moieties whose highly ordered composition is central to directing specific cell signaling events. The ability of the cell to generate these information rich glycans with such specificity has opened up a new field of "heparanomics" which seeks to understand the systems involved in generating these cell type and developmental stage specific HS sulfation patterns. Unlike other instances where biological information is encrypted as linear sequences in molecules such as DNA, HS sulfation patterns are generated through a non-template driven process. Thus, deciphering the sulfation code and the dynamic nature of its generation has posed a new challenge to system biologists. The recent discovery of two sulfatases, Sulf1 and Sulf2, with the unique ability to edit sulfation patterns at the cell surface, has opened up a new dimension as to how we understand the regulation of HS sulfation patterning and pattern-dependent cell signaling events. This review will focus on the functional relationship between HS sulfation patterning and biological processes. Special attention will be given to Sulf1 and Sulf2 and how these key editing enzymes might act in concert with the HS biosynthetic enzymes to generate and regulate specific HS sulfation patterns in vivo. We will further explore the use of knock out mice as biological models for understanding the dynamic systems involved in generating HS sulfation patterns and their biological relevance. A brief overview of new technologies and innovations summarizes advances in the systems biology field for understanding non-template molecular networks and their influence on the "heparanome". Published by Elsevier B.V.
sulf knock out; sulf; heparanome; heparan sulfate; glycosaminogiycans; mice; systems biololgy
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Journal of Biotechnology
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Lamanna WC, Kalus I, Padva M, Baldwin RJ, Merry CLR, Dierks T. The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. In: Journal of Biotechnology. JOURNAL OF BIOTECHNOLOGY. Vol 129. ELSEVIER SCIENCE BV; 2007: 290-307.
Lamanna, W. C., Kalus, I., Padva, M., Baldwin, R. J., Merry, C. L. R., & Dierks, T. (2007). The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. Journal of Biotechnology, JOURNAL OF BIOTECHNOLOGY, 129, 290-307. ELSEVIER SCIENCE BV.
Lamanna, William C., Kalus, Ina, Padva, Michael, Baldwin, Rebecca J., Merry, Catherine L. R., and Dierks, Thomas. 2007. “The heparanome - The enigma of encoding and decoding heparan sulfate sulfation”. In Journal of Biotechnology, 129:290-307. JOURNAL OF BIOTECHNOLOGY. ELSEVIER SCIENCE BV.
Lamanna, W. C., Kalus, I., Padva, M., Baldwin, R. J., Merry, C. L. R., and Dierks, T. (2007). “The heparanome - The enigma of encoding and decoding heparan sulfate sulfation” in Journal of Biotechnology JOURNAL OF BIOTECHNOLOGY, vol. 129, (ELSEVIER SCIENCE BV), 290-307.
Lamanna, W.C., et al., 2007. The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. In Journal of Biotechnology. JOURNAL OF BIOTECHNOLOGY. no.129 ELSEVIER SCIENCE BV, pp. 290-307.
W.C. Lamanna, et al., “The heparanome - The enigma of encoding and decoding heparan sulfate sulfation”, Journal of Biotechnology, JOURNAL OF BIOTECHNOLOGY, vol. 129, ELSEVIER SCIENCE BV, 2007, pp.290-307.
Lamanna, W.C., Kalus, I., Padva, M., Baldwin, R.J., Merry, C.L.R., Dierks, T.: The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. Journal of Biotechnology. JOURNAL OF BIOTECHNOLOGY. 129, p. 290-307. ELSEVIER SCIENCE BV (2007).
Lamanna, William C., Kalus, Ina, Padva, Michael, Baldwin, Rebecca J., Merry, Catherine L. R., and Dierks, Thomas. “The heparanome - The enigma of encoding and decoding heparan sulfate sulfation”. Journal of Biotechnology. ELSEVIER SCIENCE BV, 2007.Vol. 129. JOURNAL OF BIOTECHNOLOGY. 290-307.

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Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants.
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The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse.
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Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
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Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces.
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Heparan sulfate: decoding a dynamic multifunctional cell regulator.
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Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes.
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Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6.
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