The heparanome - The enigma of encoding and decoding heparan sulfate sulfation

Lamanna WC, Kalus I, Padva M, Baldwin RJ, Merry CLR, Dierks T (2007)
JOURNAL OF BIOTECHNOLOGY 129(2): 290-307.

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Konferenzbeitrag | Veröffentlicht | Englisch
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Abstract / Bemerkung
Heparan sulfate (HS) is a cell surface carbohydrate polymer modified with sulfate moieties whose highly ordered composition is central to directing specific cell signaling events. The ability of the cell to generate these information rich glycans with such specificity has opened up a new field of "heparanomics" which seeks to understand the systems involved in generating these cell type and developmental stage specific HS sulfation patterns. Unlike other instances where biological information is encrypted as linear sequences in molecules such as DNA, HS sulfation patterns are generated through a non-template driven process. Thus, deciphering the sulfation code and the dynamic nature of its generation has posed a new challenge to system biologists. The recent discovery of two sulfatases, Sulf1 and Sulf2, with the unique ability to edit sulfation patterns at the cell surface, has opened up a new dimension as to how we understand the regulation of HS sulfation patterning and pattern-dependent cell signaling events. This review will focus on the functional relationship between HS sulfation patterning and biological processes. Special attention will be given to Sulf1 and Sulf2 and how these key editing enzymes might act in concert with the HS biosynthetic enzymes to generate and regulate specific HS sulfation patterns in vivo. We will further explore the use of knock out mice as biological models for understanding the dynamic systems involved in generating HS sulfation patterns and their biological relevance. A brief overview of new technologies and innovations summarizes advances in the systems biology field for understanding non-template molecular networks and their influence on the "heparanome". Published by Elsevier B.V.
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129
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2
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290-307
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Lamanna WC, Kalus I, Padva M, Baldwin RJ, Merry CLR, Dierks T. The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. JOURNAL OF BIOTECHNOLOGY. 2007;129(2):290-307.
Lamanna, W. C., Kalus, I., Padva, M., Baldwin, R. J., Merry, C. L. R., & Dierks, T. (2007). The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. JOURNAL OF BIOTECHNOLOGY, 129(2), 290-307. doi:10.1016/j.jbiotec.2007.01.022
Lamanna, W. C., Kalus, I., Padva, M., Baldwin, R. J., Merry, C. L. R., and Dierks, T. (2007). The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. JOURNAL OF BIOTECHNOLOGY 129, 290-307.
Lamanna, W.C., et al., 2007. The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. JOURNAL OF BIOTECHNOLOGY, 129(2), p 290-307.
W.C. Lamanna, et al., “The heparanome - The enigma of encoding and decoding heparan sulfate sulfation”, JOURNAL OF BIOTECHNOLOGY, vol. 129, 2007, pp. 290-307.
Lamanna, W.C., Kalus, I., Padva, M., Baldwin, R.J., Merry, C.L.R., Dierks, T.: The heparanome - The enigma of encoding and decoding heparan sulfate sulfation. JOURNAL OF BIOTECHNOLOGY. 129, 290-307 (2007).
Lamanna, William C., Kalus, Ina, Padva, Michael, Baldwin, Rebecca J., Merry, Catherine L. R., and Dierks, Thomas. “The heparanome - The enigma of encoding and decoding heparan sulfate sulfation”. JOURNAL OF BIOTECHNOLOGY 129.2 (2007): 290-307.

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Harmer NJ, Ilag LL, Mulloy B, Pellegrini L, Robinson CV, Blundell TL., J. Mol. Biol. 339(4), 2004
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Irie A, Yates EA, Turnbull JE, Holt CE., Development 129(1), 2002
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Keiser N, Venkataraman G, Shriver Z, Sasisekharan R., Nat. Med. 7(1), 2001
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When sugars guide axons: insights from heparan sulphate proteoglycan mutants.
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Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants.
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The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse.
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Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer.
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A new model for the domain structure of heparan sulfate based on the novel specificity of K5 lyase.
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Modular synthesis of heparin oligosaccharides.
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Structural insights into biological roles of protein-glycosaminoglycan interactions.
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Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.
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Glycomics approach to structure-function relationships of glycosaminoglycans.
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Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
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Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
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Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes.
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Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces.
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Mice deficient in Ext2 lack heparan sulfate and develop exostoses.
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Effects of sulfate position on heparin octasaccharide binding to CCL2 examined by tandem mass spectrometry.
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Heparan sulfate: decoding a dynamic multifunctional cell regulator.
Turnbull J, Powell A, Guimond S., Trends Cell Biol. 11(2), 2001
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HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.
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Heparan sulfate proteoglycans and the emergence of neuronal connectivity.
Van Vactor D, Wall DP, Johnson KG., Curr. Opin. Neurobiol. 16(1), 2006
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Sequencing complex polysaccharides.
Venkataraman G, Shriver Z, Raman R, Sasisekharan R., Science 286(5439), 1999
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Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin.
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A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease.
von Figura K, Schmidt B, Selmer T, Dierks T., Bioessays 20(6), 1998
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QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis.
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Heparan sulfate: a complex polymer charged with biological activity.
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Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes.
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Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6.
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