Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer

Devkota KP, Choudhary MI, Nawaz SA, Lannang AM, Lenta BN, Fokou PA, Sewald N (2007)
Chemical & Pharmaceutical Bulletin 55(4): 682-684.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Devkota, Krishna Prasad; Choudhary, Muhammad Iqbal; Nawaz, Sarfaraz Ahmed; Lannang, Alain Meli; Lenta, Bruno Ndjakou; Fokou, Patrice Aime; Sewald, NorbertUniBi
Einrichtung
Centrum für Biotechnologie > Arbeitsgruppe N. Sewald
Centrum für Biotechnologie > Institut für Biochemie und Biotechnik
Fakultät für Chemie > Organische Chemie III
Abstract / Bemerkung
The microbial transformation of a steroidal alkaloid, dictyophlebine (1) with Rhizopus stolonifer (ATCC 10404) afforded three oxidized metabolites 2-4. Compound 2 was found to be a new product. These metabolites were structurally characterized on the basis of modern spectroscopic techniques. Their inhibitory activity towards acetyl- and butyrylcholinesterase has been evaluated and the new product 2 has been found to be more potent than the parent compound and other metabolites.
Stichworte
cholinesterase inhibition; Rhizopus stolonifer; dictyophlebine; oxidized metabolite
Erscheinungsjahr
2007
Zeitschriftentitel
Chemical & Pharmaceutical Bulletin
Band
55
Ausgabe
4
Seite(n)
682-684
ISSN
0009-2363
eISSN
1347-5223
Page URI
https://pub.uni-bielefeld.de/record/1593944

Zitieren

Devkota KP, Choudhary MI, Nawaz SA, et al. Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer. Chemical & Pharmaceutical Bulletin. 2007;55(4):682-684.
Devkota, K. P., Choudhary, M. I., Nawaz, S. A., Lannang, A. M., Lenta, B. N., Fokou, P. A., & Sewald, N. (2007). Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer. Chemical & Pharmaceutical Bulletin, 55(4), 682-684. https://doi.org/10.1248/cpb.55.682
Devkota, Krishna Prasad, Choudhary, Muhammad Iqbal, Nawaz, Sarfaraz Ahmed, Lannang, Alain Meli, Lenta, Bruno Ndjakou, Fokou, Patrice Aime, and Sewald, Norbert. 2007. “Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer”. Chemical & Pharmaceutical Bulletin 55 (4): 682-684.
Devkota, K. P., Choudhary, M. I., Nawaz, S. A., Lannang, A. M., Lenta, B. N., Fokou, P. A., and Sewald, N. (2007). Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer. Chemical & Pharmaceutical Bulletin 55, 682-684.
Devkota, K.P., et al., 2007. Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer. Chemical & Pharmaceutical Bulletin, 55(4), p 682-684.
K.P. Devkota, et al., “Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer”, Chemical & Pharmaceutical Bulletin, vol. 55, 2007, pp. 682-684.
Devkota, K.P., Choudhary, M.I., Nawaz, S.A., Lannang, A.M., Lenta, B.N., Fokou, P.A., Sewald, N.: Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer. Chemical & Pharmaceutical Bulletin. 55, 682-684 (2007).
Devkota, Krishna Prasad, Choudhary, Muhammad Iqbal, Nawaz, Sarfaraz Ahmed, Lannang, Alain Meli, Lenta, Bruno Ndjakou, Fokou, Patrice Aime, and Sewald, Norbert. “Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer”. Chemical & Pharmaceutical Bulletin 55.4 (2007): 682-684.

13 Zitationen in Europe PMC

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