Gender effects on the incidence of aneuploidy in mammalian germ cells

Pacchierotti F, Adler I-D, Eichenlaub-Ritter U, Mailhes JB (2007)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Pacchierotti, F.; Adler, I.-D.; Eichenlaub-Ritter, UrsulaUniBi; Mailhes, J. B.
Abstract / Bemerkung
Aneuploidy occurs in 0.3% of newborns, 4% of stillbirths, and more than 35% of all human spontaneous abortions. Human gametogenesis is uniquely and gender-specific susceptible to errors in chromosome segregation. Overall, between 1% and 4% of sperm and as many as 20% of human oocytes have been estimated by molecular cytogenctic analysis to be aneuploid. Maternal age remains the paramount aetiological factor associated with human aneuploidy. The majority of extra chromosomes in trisomic offspring appears to be of maternal origin resulting from nondisjunction of homologous chromosomes during the first meiotic division. Differences in the recombination patterns between male and female meiosis may partly account for the striking gender- and chromosome-specific differences in the genesis of human aneuploidy, especially in aged oocytes. Nondisjunction of entire chromosomes during meiosis I as well as premature separation of sister chromatids or homologues prior to meiotic anaphase can contribute to aneuploidy. During meiosis, checkpoints at meiotic prophase and the spindle checkpoint at M-phase can induce meiotic arrest and/or cell death in case of disturbances in pairing/recombination or spindle attachment of chromosomes. It has been suggested that gender differences in aneuploidy may result from more permissive checkpoints in females than males. Furthermore, age-related loss of chromosome cohesion in oocytes as a cause of aneuploidy may be female-specific. Comparative data about the susceptibility of human male and female germ cells to aneuploidy-causing chemicals is lacking. Increases of aneuploidy frequency in sperm have been shown after exposure to therapeutic drugs, occupational agents and lifestyle factors. Conversely, data on oocyte aneuploidy caused by exogenous agents is limited because of the small numbers of oocytes available for analysis combined with potential maternal age effects. The vast majority of animal studies on aneuploidy induction in germ cells represent cause and effect data. Specific studies designed to evaluate possible gender differences in induction of germ cell aneuploidy have not been found. However, the comparison of rodent data available from different laboratories suggests that oocytes are more sensitive than male germ cells when exposed to chemicals that effect the meiotic spindle. Only recently, in vitro experiments, analyses of transgenic animals and knockdown of expression of meiotic genes have started to address the molecular mechanisms underlying chromosome missegregation in mammalian germ cells whereby striking differences between genders could be shown. Such information is needed to clarify the extent and the mechanisms of gender effects, including possible differential susceptibility to environmental agents. (c) 2007 Elsevier Inc. All rights reserved.
gender; human gametes; mouse germ cells; aneugenic agents; aneuploidy
Page URI


Pacchierotti F, Adler I-D, Eichenlaub-Ritter U, Mailhes JB. Gender effects on the incidence of aneuploidy in mammalian germ cells. ENVIRONMENTAL RESEARCH. 2007;104(1):46-69.
Pacchierotti, F., Adler, I. - D., Eichenlaub-Ritter, U., & Mailhes, J. B. (2007). Gender effects on the incidence of aneuploidy in mammalian germ cells. ENVIRONMENTAL RESEARCH, 104(1), 46-69.
Pacchierotti, F., Adler, I.-D., Eichenlaub-Ritter, Ursula, and Mailhes, J. B. 2007. “Gender effects on the incidence of aneuploidy in mammalian germ cells”. ENVIRONMENTAL RESEARCH 104 (1): 46-69.
Pacchierotti, F., Adler, I. - D., Eichenlaub-Ritter, U., and Mailhes, J. B. (2007). Gender effects on the incidence of aneuploidy in mammalian germ cells. ENVIRONMENTAL RESEARCH 104, 46-69.
Pacchierotti, F., et al., 2007. Gender effects on the incidence of aneuploidy in mammalian germ cells. ENVIRONMENTAL RESEARCH, 104(1), p 46-69.
F. Pacchierotti, et al., “Gender effects on the incidence of aneuploidy in mammalian germ cells”, ENVIRONMENTAL RESEARCH, vol. 104, 2007, pp. 46-69.
Pacchierotti, F., Adler, I.-D., Eichenlaub-Ritter, U., Mailhes, J.B.: Gender effects on the incidence of aneuploidy in mammalian germ cells. ENVIRONMENTAL RESEARCH. 104, 46-69 (2007).
Pacchierotti, F., Adler, I.-D., Eichenlaub-Ritter, Ursula, and Mailhes, J. B. “Gender effects on the incidence of aneuploidy in mammalian germ cells”. ENVIRONMENTAL RESEARCH 104.1 (2007): 46-69.

35 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

G2/M inhibitors as pharmacotherapeutic opportunities for glioblastoma: the old, the new, and the future.
Castro-Gamero AM, Pezuk JA, Brassesco MS, Tone LG., Cancer Biol Med 15(4), 2018
PMID: 30766748
Mechanisms of Aneuploidy in Human Eggs.
Webster A, Schuh M., Trends Cell Biol 27(1), 2017
PMID: 27773484
Aurora kinases: novel therapy targets in cancers.
Tang A, Gao K, Chu L, Zhang R, Yang J, Zheng J., Oncotarget 8(14), 2017
PMID: 28147341
Systematic literature review of reproductive outcome associated with residential proximity to polluted sites.
Kihal-Talantikite W, Zmirou-Navier D, Padilla C, Deguen S., Int J Health Geogr 16(1), 2017
PMID: 28558782
Induced Aneugenic Effects in Mouse Oocytes In Vivo.
Pligina KL, Zhanataev AK, Kulakova AV, Daugel-Dauge NO, Durnev AD., Bull Exp Biol Med 163(4), 2017
PMID: 28853096
Association of Parental Age and the Type of Down Syndrome on the Territory of Bosnia and Herzegovina.
Sotonica M, Mackic-Djurovic M, Hasic S, Kiseljakovic E, Jadric R, Ibrulj S., Med Arch 70(2), 2016
PMID: 27147778
Can IVF influence human evolution?
Hanevik HI, Hessen DO, Sunde A, Breivik J., Hum Reprod 31(7), 2016
PMID: 27094480
Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells.
Inoue H, Ogonuki N, Hirose M, Hatanaka Y, Matoba S, Chuma S, Kobayashi K, Wakana S, Noguchi J, Inoue K, Tanemura K, Ogura A., Biochem Biophys Res Commun 478(2), 2016
PMID: 27473657
Sperm aneuploidy in infertile male patients: a systematic review of the literature.
Chatziparasidou A, Christoforidis N, Samolada G, Nijs M., Andrologia 47(8), 2015
PMID: 25352353
Expression and characterization of three Aurora kinase C splice variants found in human oocytes.
Fellmeth JE, Gordon D, Robins CE, Scott RT, Treff NR, Schindler K., Mol Hum Reprod 21(8), 2015
PMID: 25995441
Short- and long-term effects of chromosome mis-segregation and aneuploidy.
Santaguida S, Amon A., Nat Rev Mol Cell Biol 16(8), 2015
PMID: 26204159
Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect.
Zielinska AP, Holubcova Z, Blayney M, Elder K, Schuh M., Elife 4(), 2015
PMID: 26670547
Identification of chromosomal errors in human preimplantation embryos with oligonucleotide DNA microarray.
Liang L, Wang CT, Sun X, Liu L, Li M, Witz C, Williams D, Griffith J, Skorupski J, Haddad G, Gill J, Wang WH., PLoS One 8(4), 2013
PMID: 23613950
Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France.
Geoffroy-Siraudin C, Loundou AD, Romain F, Achard V, Courbière B, Perrard MH, Durand P, Guichaoua MR., Asian J Androl 14(4), 2012
PMID: 22522503
Human aneuploidy: mechanisms and new insights into an age-old problem.
Nagaoka SI, Hassold TJ, Hunt PA., Nat Rev Genet 13(7), 2012
PMID: 22705668
Meiotic chromosome abnormalities in fertile men: are they increasing?
Uroz L, Rajmil O, Templado C., Fertil Steril 95(1), 2011
PMID: 20674909
Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.
Xu J, Wang M, Gao X, Hu B, Du Y, Zhou J, Tian X, Huang X., PLoS One 6(4), 2011
PMID: 21494564
Frequency of aneuploidy related to age in porcine oocytes.
Hornak M, Jeseta M, Musilova P, Pavlok A, Kubelka M, Motlik J, Rubes J, Anger M., PLoS One 6(4), 2011
PMID: 21556143
Constitutional and acquired autosomal aneuploidy.
Jackson-Cook C., Clin Lab Med 31(4), 2011
PMID: 22118733
Frequency of aneuploidy in in vitro-matured MII oocytes and corresponding first polar bodies in two dairy cattle (Bos taurus) breeds as determined by dual-color fluorescent in situ hybridization.
Nicodemo D, Pauciullo A, Cosenza G, Peretti V, Perucatti A, Di Meo GP, Ramunno L, Iannuzzi L, Rubes J, Di Berardino D., Theriogenology 73(4), 2010
PMID: 20022097
MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.
Vogt E, Sanhaji M, Klein W, Seidel T, Wordeman L, Eichenlaub-Ritter U., Mol Hum Reprod 16(9), 2010
PMID: 20406800
Aurora kinase B modulates chromosome alignment in mouse oocytes.
Shuda K, Schindler K, Ma J, Schultz RM, Donovan PJ., Mol Reprod Dev 76(11), 2009
PMID: 19565641
Inheritance of a terminal 7.1 Mb 18p deletion flanked by a 2.3 Mb duplication from a physically normal mother.
Misceo D, Orstavik KH, Lybaek H, Sandvig I, Ormerod E, Houge G, Frengen E., Am J Med Genet A 149A(12), 2009
PMID: 19938092
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U., Mutat Res 651(1-2), 2008
PMID: 18096427
Down syndrome in births near landfill sites.
Jarup L, Morris S, Richardson S, Briggs D, Cobley N, de Hoogh C, Gorog K, Elliott P., Prenat Diagn 27(13), 2007
PMID: 17987614

358 References

Daten bereitgestellt von Europe PubMed Central.

Etiology of nondisjunction in humans.
Abruzzo MA, Hassold TJ., Environ. Mol. Mutagen. 25 Suppl 26(), 1995
PMID: 7789361
Development of screening tests for aneuploidy induction by environmental pollutants.
Adler ID, Parry JM., Environ. Health Perspect. 101 Suppl 3(), 1993
PMID: 8143646
Sequential multiple probe fluorescence in-situ hybridization analysis of human oocytes and polar bodies by combining centromeric labelling and whole chromosome painting.
Anahory T, Andreo B, Regnier-Vigouroux G, Soulie JP, Baudouin M, Demaille J, Pellestor F., Mol. Hum. Reprod. 9(10), 2003
PMID: 12970395
Mechanism of chromosome nondisjunction in human oocytes.
Angell R., Prog. Clin. Biol. Res. 393(), 1995
PMID: 8545446
First-meiotic-division nondisjunction in human oocytes.
Angell R., Am. J. Hum. Genet. 61(1), 1997
PMID: 9245981
Cytogenetic analysis of unfertilized human oocytes.
Angell RR, Ledger W, Yong EL, Harkness L, Baird DT., Hum. Reprod. 6(4), 1991
PMID: 1918309
Chromosome anomalies in human oocytes in relation to age.
Angell RR, Xian J, Keith J., Hum. Reprod. 8(7), 1993
PMID: 8408485
A novel method for chromosome analysis of human sperm using enucleated mouse oocytes.
Araki Y, Yoshizawa M, Araki Y., Hum. Reprod. 20(5), 2005
PMID: 15665020
Molecular cytogenetic analysis in mouse sperm of chemically induced aneuploidy: studies with topoisomerase II inhibitors.
Attia SM, Schmid TE, Badary OA, Hamada FM, Adler ID., Mutat. Res. 520(1-2), 2002
PMID: 12297139
Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF.
Baart EB, Martini E, van den Berg I, Macklon NS, Galjaard RJ, Fauser BC, Van Opstal D., Hum. Reprod. 21(1), 2005
PMID: 16155075
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.
Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM., Nat. Genet. 13(3), 1996
PMID: 8673133
Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women.
Battaglia DE, Goodwin P, Klein NA, Soules MR., Hum. Reprod. 11(10), 1996
PMID: 8943533
Detection of aneuploidy in rodent and human sperm by multicolor FISH after chronic exposure to diazepam.
Baumgartner A, Schmid TE, Schuetz CG, Adler ID., Mutat. Res. 490(1), 2001
PMID: 11152967
Aneuploidy 16 in human embryos increases significantly with maternal age.
Benadiva CA, Kligman I, Munne S., Fertil. Steril. 66(2), 1996
PMID: 8690111
Morphological and cytogenetic analysis of intact oocytes and blocked zygotes.
Benkhalifa M, Kahraman S, Caserta D, Domez E, Qumsiyeh MB., Prenat. Diagn. 23(5), 2003
PMID: 12749038
Chromosome 21 detection in human oocyte fluorescence in situ hybridization: possible effect of maternal age.
Benzacken B, Martin-Pont B, Bergere M, Hugues JN, Wolf JP, Selva J., J. Assist. Reprod. Genet. 15(3), 1998
PMID: 9547685

Bond, 1983
Chromosome anomalies in human oocytes failing to fertilize after insemination in vitro.
Bongso A, Chye NS, Ratnam S, Sathananthan H, Wong PC., Hum. Reprod. 3(5), 1988
PMID: 3139703
Chromosomal abnormalities in human sperm: comparisons among four healthy men.
Brandriff B, Gordon L, Ashworth L, Watchmaker G, Carrano A, Wyrobek A., Hum. Genet. 66(2-3), 1984
PMID: 6714980
Preimplantation genetic diagnosis.
Braude P, Pickering S, Flinter F, Ogilvie CM., Nat. Rev. Genet. 3(12), 2002
PMID: 12459724
Effect of age on testicular germ cell apoptosis and sperm aneuploidy in MF-1 mice.
Brinkworth MH, Schmid TE., Teratog., Carcinog. Mutagen. Suppl 2(), 2003
PMID: 14691984
Testing of 3 chemical compounds for aneuploidy induction in the female mouse.
Brook JD, Chandley AC., Mutat. Res. 157(2-3), 1985
PMID: 4040608
Testing for the chemical induction of aneuploidy in the male mouse.
Brook JD, Chandley AC., Mutat. Res. 164(2), 1986
PMID: 3960041
Functionality of the spindle checkpoint during the first meiotic division of mammalian oocytes.
Brunet S, Pahlavan G, Taylor S, Maro B., Reproduction 126(4), 2003
PMID: 14525526
Non-disjunction of chromosome 18.
Bugge M, Collins A, Petersen MB, Fisher J, Brandt C, Hertz JM, Tranebjaerg L, de Lozier-Blanchet C, Nicolaides P, Brondum-Nielsen K, Morton N, Mikkelsen M., Hum. Mol. Genet. 7(4), 1998
PMID: 9499419
Culture of mammalian oocytes
Chandley, J. Reprod. Fertil. (Suppl. 14), 1971
Cytogenetics and infertility in man. II. Testicular histology and meiosis.
Chandley AC, Maclean N, Edmond P, Fletcher J, Watson GS., Ann. Hum. Genet. 40(2), 1976
PMID: 1015811
Maternal smoking and Down syndrome: the confounding effect of maternal age.
Chen CL, Gilbert TJ, Daling JR., Am. J. Epidemiol. 149(5), 1999
PMID: 10067903
Demonstration of a mechanism of aneuploidy in human oocytes using Multifluor fluorescence in situ hybridization.
Clyde JM, Gosden RG, Rutherford AJ, Picton HM., Fertil. Steril. 76(4), 2001
PMID: 11591425
Karyotyping of human metaphase II oocytes by multifluor fluorescence in situ hybridization.
Clyde JM, Hogg JE, Rutherford AJ, Picton HM., Fertil. Steril. 80(4), 2003
PMID: 14556824
Presence of chromosomal mosaicism in abnormal preimplantation embryos detected by fluorescence in situ hybridisation.
Coonen E, Harper JC, Ramaekers FC, Delhanty JD, Hopman AH, Geraedts JP, Handyside AH., Hum. Genet. 94(6), 1994
PMID: 7989035
Trichlorfon predisposes to aneuploidy and interferes with spindle formation in in vitro maturing mouse oocytes.
Cukurcam S, Sun F, Betzendahl I, Adler ID, Eichenlaub-Ritter U., Mutat. Res. 564(2), 2004
PMID: 15507381
Influence of follicular fluid meiosis-activating sterol on aneuploidy rate and precocious chromatid segregation in aged mouse oocytes.
Cukurcam S, Betzendahl I, Michel G, Vogt E, Hegele-Hartung C, Lindenthal B, Eichenlaub-Ritter U., Hum. Reprod. 22(3), 2006
PMID: 17114196
Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms.
Cupisti S, Conn CM, Fragouli E, Whalley K, Mills JA, Faed MJ, Delhanty JD., Prenat. Diagn. 23(8), 2003
PMID: 12913873
Environmental trichlorfon and cluster of congenital abnormalities.
Czeizel AE, Elek C, Gundy S, Metneki J, Nemes E, Reis A, Sperling K, Timar L, Tusnady G, Viragh Z., Lancet 341(8844), 1993
PMID: 8094783
Association between nondisjunction and maternal age in meiosis-II human oocytes.
Dailey T, Dale B, Cohen J, Munne S., Am. J. Hum. Genet. 59(1), 1996
PMID: 8659524
Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin.
De Mas P, Daudin M, Vincent MC, Bourrouillou G, Calvas P, Mieusset R, Bujan L., Hum. Reprod. 16(6), 2001
PMID: 11387293
Specific arrests of spermatogenesis in genetically modified and mutant mice.
de Rooij DG, de Boer P., Cytogenet. Genome Res. 103(3-4), 2003
PMID: 15051947
Chromosome analysis in human oocytes unfertilized in vitro: a mathematical model for the estimation of the first meiotic non-disjunction frequency.
De Sutter P, Dhont M, Verschraegen-Spae MR, Steyaert H, Corijn W, Leroy J, Vandekerckhove D., Hum. Reprod. 6(4), 1991
PMID: 1918306
Mechanisms of aneuploidy induction in human oogenesis and early embryogenesis.
Delhanty JD., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192699
Cytogenetics of unfertilized human oocytes.
Djalali M, Rosenbusch B, Wolf M, Sterzik K., J. Reprod. Fertil. 84(2), 1988
PMID: 3199384
Detection of aneuploidy in human oocytes and corresponding first polar bodies by fluorescent in situ hybridization.
Dyban A, Freidine M, Severova E, Cieslak J, Ivakhnenko V, Verlinsky Y., J. Assist. Reprod. Genet. 13(1), 1996
PMID: 8825172
Multi-locus (ML)-FISH is a reliable tool for nondisjunction studies in human oocytes.
Eckel H, Kleinstein J, Wieacker P, Stumm M., Cytogenet. Genome Res. 103(1-2), 2003
PMID: 15004463
Cytogenetic analysis of human oocytes and embryos in an in-vitro fertilization programme.
Edirisinghe WR, Murch AR, Yovich JL., Hum. Reprod. 7(2), 1992
PMID: 1577937
Chromosome studies in human sperm nuclei using fluorescence in-situ hybridization (FISH).
Egozcue J, Blanco J, Vidal F., Hum. Reprod. Update 3(5), 1997
PMID: 9528909
Human male infertility: chromosome anomalies, meiotic disorders, abnormal spermatozoa and recurrent abortion.
Egozcue S, Blanco J, Vendrell JM, Garcia F, Veiga A, Aran B, Barri PN, Vidal F, Egozcue J., Hum. Reprod. Update 6(1), 2000
PMID: 10711834
Genetics of oocyte ageing.
Eichenlaub-Ritter U., Maturitas 30(2), 1998
PMID: 9871909
The determinants of nondisjunction and their possible relationship with oocyte ageing
Eichenlaub-Ritter, 2000
Aneuploidy in ageing oocytes and after toxic insult
Eichenlaub-Ritter, 2003
Mouse genetic models for aneuploidy induction in germ cells.
Eichenlaub-Ritter U., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192722
Spindles, mitochondria and redox potential in ageing oocytes.
Eichenlaub-Ritter U, Vogt E, Yin H, Gosden R., Reprod. Biomed. Online 8(1), 2004
PMID: 14759287
Model for aging: knockdown of Mad2 expression predisposes to non-disjunction in mammalian oocytes possessing aberrant spindles
Eichenlaub-Ritter, Hum. Reprod. 20(Suppl. 1), 2005
Genomic imprinting--insights from studies in mice.
Ferguson-Smith A, Lin SP, Tsai CE, Youngson N, Tevendale M., Semin. Cell Dev. Biol. 14(1), 2003
PMID: 12524006
The influence of paternal age on down syndrome.
Fisch H, Hyun G, Golden R, Hensle TW, Olsson CA, Liberson GL., J. Urol. 169(6), 2003
PMID: 12771769
Comparative genomic hybridization analysis of human oocytes and polar bodies.
Fragouli E, Wells D, Thornhill A, Serhal P, Faed MJ, Harper JC, Delhanty JD., Hum. Reprod. 21(9), 2006
PMID: 16704993
Women with a reduced ovarian complement may have an increased risk for a child with Down syndrome.
Freeman SB, Yang Q, Allran K, Taft LF, Sherman SL., Am. J. Hum. Genet. 66(5), 2000
PMID: 10733467
NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21.
Frias S, Van Hummelen P, Meistrich ML, Lowe XR, Hagemeister FB, Shelby MD, Bishop JB, Wyrobek AJ., Cancer Res. 63(1), 2003
PMID: 12517776
Cytogenetic analyses of culture failures by comparative genomic hybridisation (CGH)-Re-evaluation of chromosome aberration rates in early spontaneous abortions.
Fritz B, Hallermann C, Olert J, Fuchs B, Bruns M, Aslan M, Schmidt S, Coerdt W, Muntefering H, Rehder H., Eur. J. Hum. Genet. 9(7), 2001
PMID: 11464246
Male mouse recombination maps for each autosome identified by chromosome painting.
Froenicke L, Anderson LK, Wienberg J, Ashley T., Am. J. Hum. Genet. 71(6), 2002
PMID: 12432495
Non-disjunction in human sperm: evidence for an effect of increasing paternal age.
Griffin DK, Abruzzo MA, Millie EA, Sheean LA, Feingold E, Sherman SL, Hassold TJ., Hum. Mol. Genet. 4(12), 1995
PMID: 8634691
Systematic approach to the study of trisomy in the mouse. II.
Gropp A, Kolbus U, Giers D., Cytogenet. Cell Genet. 14(1), 1975
PMID: 1132247
Murine trisomy: developmental profiles of the embryo, and isolation of trisomic cellular systems.
Gropp A, Winking H, Herbst EW, Claussen CP., J. Exp. Zool. 228(2), 1983
PMID: 6141213
Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.
Gutierrez-Mateo C, Wells D, Benet J, Sanchez-Garcia JF, Bermudez MG, Belil I, Egozcue J, Munne S, Navarro J., Hum. Reprod. 19(9), 2004
PMID: 15271867
Karyotyping of human oocytes by cenM-FISH, a new 24-colour centromere-specific technique.
Gutierrez-Mateo C, Benet J, Starke H, Oliver-Bonet M, Munne S, Liehr T, Navarro J., Hum. Reprod. 20(12), 2005
PMID: 16126755
Age-associated alteration of gene expression patterns in mouse oocytes.
Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, Dudekula DB, VanBuren V, Ko MS., Hum. Mol. Genet. 13(19), 2004
PMID: 15317747
Nondisjunction in the human male.
Hassold TJ., Curr. Top. Dev. Biol. 37(), 1998
PMID: 9352193
To err (meiotically) is human: the genesis of human aneuploidy.
Hassold T, Hunt P., Nat. Rev. Genet. 2(4), 2001
PMID: 11283700
A cytogenetic study of 1000 spontaneous abortions.
Hassold T, Chen N, Funkhouser J, Jooss T, Manuel B, Matsuura J, Matsuyama A, Wilson C, Yamane JA, Jacobs PA., Ann. Hum. Genet. 44(2), 1980
PMID: 7316468
XY chromosome nondisjunction in man is associated with diminished recombination in the pseudoautosomal region.
Hassold TJ, Sherman SL, Pettay D, Page DC, Jacobs PA., Am. J. Hum. Genet. 49(2), 1991
PMID: 1867189
Recombination and maternal age-dependent nondisjunction: molecular studies of trisomy 16.
Hassold T, Merrill M, Adkins K, Freeman S, Sherman S., Am. J. Hum. Genet. 57(4), 1995
PMID: 7573048
Human aneuploidy: incidence, origin, and etiology.
Hassold T, Abruzzo M, Adkins K, Griffin D, Merrill M, Millie E, Saker D, Shen J, Zaragoza M., Environ. Mol. Mutagen. 28(3), 1996
PMID: 8908177
Multiple displacement amplification on single cell and possible PGD applications.
Hellani A, Coskun S, Benkhalifa M, Tbakhi A, Sakati N, Al-Odaib A, Ozand P., Mol. Hum. Reprod. 10(11), 2004
PMID: 15465849
Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation.
Hodges CA, Ilagan A, Jennings D, Keri R, Nilson J, Hunt PA., Hum. Reprod. 17(5), 2002
PMID: 11980735
SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction.
Hodges CA, Revenkova E, Jessberger R, Hassold TJ, Hunt PA., Nat. Genet. 37(12), 2005
PMID: 16258540
RNA interference in meiosis I human oocytes: towards an understanding of human aneuploidy.
Homer HA, McDougall A, Levasseur M, Murdoch AP, Herbert M., Mol. Hum. Reprod. 11(6), 2005
PMID: 15908454
Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes.
Homer HA, McDougall A, Levasseur M, Yallop K, Murdoch AP, Herbert M., Genes Dev. 19(2), 2005
PMID: 15655110
Chromosomal FISH analysis of unfertilized human oocytes and polar bodies.
Honda N, Miharu N, Hara T, Samura O, Honda H, Ohama K., J. Hum. Genet. 47(9), 2002
PMID: 12202989
Effects of low O2 and ageing on spindles and chromosomes in mouse oocytes from pre-antral follicle culture.
Hu Y, Betzendahl I, Cortvrindt R, Smitz J, Eichenlaub-Ritter U., Hum. Reprod. 16(4), 2001
PMID: 11278227
Sex matters in meiosis.
Hunt PA, Hassold TJ., Science 296(5576), 2002
PMID: 12077403
A high degree of aneuploidy in frozen-thawed human preimplantation embryos.
Iwarsson E, Lundqvist M, Inzunza J, Ahrlund-Richter L, Sjoblom P, Lundkvist O, Simberg N, Nordenskjold M, Blennow E., Hum. Genet. 104(5), 1999
PMID: 10394928
The chromosome complement of human gametes.
Jacobs PA., Oxf Rev Reprod Biol 14(), 1992
PMID: 1437215
The chromosome constitution of human preimplantation embryos fertilized in vitro
Jamieson, Mol. Hum. Reprod. 9(), 1994
Determinants of the rate of nicotine metabolism and effects on smoking behavior.
Johnstone E, Benowitz N, Cargill A, Jacob R, Hinks L, Day I, Murphy M, Walton R., Clin. Pharmacol. Ther. 80(4), 2006
PMID: 17015050
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
Jordan A, Hadfield JA, Lawrence NJ, McGown AT., Med Res Rev 18(4), 1998
PMID: 9664292
Chromosomal analysis of unfertilized human oocytes prepared by a gradual fixation-air drying method.
Kamiguchi Y, Rosenbusch B, Sterzik K, Mikamo K., Hum. Genet. 90(5), 1993
PMID: 8428752
A second-generation linkage map of the bovine genome.
Kappes SM, Keele JW, Stone RT, McGraw RA, Sonstegard TS, Smith TP, Lopez-Corrales NL, Beattie CW., Genome Res. 7(3), 1997
PMID: 9074927
Mitotic errors in chromosome 21 of human preimplantation embryos are associated with non-viability.
Katz-Jaffe MG, Trounson AO, Cram DS., Mol. Hum. Reprod. 10(2), 2004
PMID: 14742700
Generating oocytes and sperm from embryonic stem cells.
Kehler J, Hubner K, Garrett S, Scholer HR., Semin. Reprod. Med. 23(3), 2005
PMID: 16059828
Trisomic pregnancy and earlier age at menopause.
Kline J, Kinney A, Levin B, Warburton D., Am. J. Hum. Genet. 67(2), 2000
PMID: 10873791
Trisomic pregnancy and the oocyte pool.
Kline J, Kinney A, Reuss ML, Kelly A, Levin B, Ferin M, Warburton D., Hum. Reprod. 19(7), 2004
PMID: 15166127
Chromosomal analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space.
Kola I, Lacham O, Jansen RP, Turner M, Trounson A., Hum. Reprod. 5(5), 1990
PMID: 2394787
A high-resolution recombination map of the human genome.
Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K., Nat. Genet. 31(3), 2002
PMID: 12053178
Recombination rate and reproductive success in humans.
Kong A, Barnard J, Gudbjartsson DF, Thorleifsson G, Jonsdottir G, Sigurdardottir S, Richardsson B, Jonsdottir J, Thorgeirsson T, Frigge ML, Lamb NE, Sherman S, Gulcher JR, Stefansson K., Nat. Genet. 36(11), 2004
PMID: 15467721
Reproductive functions of the ageing male.
Kuhnert B, Nieschlag E., Hum. Reprod. Update 10(4), 2004
PMID: 15192059
Meiotic and mitotic nondisjunction: lessons from preimplantation genetic diagnosis.
Kuliev A, Verlinsky Y., Hum. Reprod. Update 10(5), 2004
PMID: 15319376
Chromosomal abnormalities in a series of 6,733 human oocytes in preimplantation diagnosis for age-related aneuploidies.
Kuliev A, Cieslak J, Ilkevitch Y, Verlinsky Y., Reprod. Biomed. Online 6(1), 2003
PMID: 12626143
Semen quality of male smokers and nonsmokers in infertile couples.
Kunzle R, Mueller MD, Hanggi W, Birkhauser MH, Drescher H, Bersinger NA., Fertil. Steril. 79(2), 2003
PMID: 12568836
Chromosomal mosaicism in cleavage-stage human embryos and the accuracy of single-cell genetic analysis.
Kuo HC, Ogilvie CM, Handyside AH., J. Assist. Reprod. Genet. 15(5), 1998
PMID: 9604759
Susceptible chiasmate configurations of chromosome 21 predispose to non-disjunction in both maternal meiosis I and meiosis II.
Lamb NE, Freeman SB, Savage-Austin A, Pettay D, Taft L, Hersey J, Gu Y, Shen J, Saker D, May KM, Avramopoulos D, Petersen MB, Hallberg A, Mikkelsen M, Hassold TJ, Sherman SL., Nat. Genet. 14(4), 1996
PMID: 8944019
Effect of meiotic recombination on the production of aneuploid gametes in humans.
Lamb NE, Sherman SL, Hassold TJ., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192701
Association between maternal age and meiotic recombination for trisomy 21.
Lamb NE, Yu K, Shaffer J, Feingold E, Sherman SL., Am. J. Hum. Genet. 76(1), 2004
PMID: 15551222
Single-cell chromosomal imbalances detection by array CGH.
Le Caignec C, Spits C, Sermon K, De Rycke M, Thienpont B, Debrock S, Staessen C, Moreau Y, Fryns JP, Van Steirteghem A, Liebaers I, Vermeesch JR., Nucleic Acids Res. 34(9), 2006
PMID: 16698960
The molecular basis of sister-chromatid cohesion.
Lee JY, Orr-Weaver TL., Annu. Rev. Cell Dev. Biol. 17(), 2001
PMID: 11687503
Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes.
Lenzi ML, Smith J, Snowden T, Kim M, Fishel R, Poulos BK, Cohen PE., Am. J. Hum. Genet. 76(1), 2004
PMID: 15558497
In vivo studies on chemically induced aneuploidy in mouse somatic and germinal cells.
Leopardi P, Zijno A, Bassani B, Pacchierotti F., Mutat. Res. 287(1), 1993
PMID: 7683378
Relationship between frequencies of univalents and meiotic segregation in different mouse strains and their hybrids.
Leotard D, Kirsch-Volders M, Alexandre H, Poma K, Susanne C., Genetica 75(3), 1987
PMID: 3505225
Cytogenetic investigation of chemically-induced aneuploidy in mouse spermatocytes.
Liang JC, Pacchierotti F., Mutat. Res. 201(2), 1988
PMID: 3173381
The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression.
Libby BJ, De La Fuente R, O'Brien MJ, Wigglesworth K, Cobb J, Inselman A, Eaker S, Handel MA, Eppig JJ, Schimenti JC., Dev. Biol. 242(2), 2002
PMID: 11820814
Age-related decline in fertility: a link to degenerative oocytes?
Lim AS, Tsakok MF., Fertil. Steril. 68(2), 1997
PMID: 9240254
Chromosomes of oocytes failing in-vitro fertilization.
Lim AS, Ho AT, Tsakok MF., Hum. Reprod. 10(10), 1995
PMID: 8567772
Sperm aneuploidy rates in younger and older men.
Luetjens CM, Rolf C, Gassner P, Werny JE, Nieschlag E., Hum. Reprod. 17(7), 2002
PMID: 12093846
Variation in human meiotic recombination.
Lynn A, Ashley T, Hassold T., Annu Rev Genomics Hum Genet 5(), 2004
PMID: 15485352
Chromosome analysis of human oocytes failing to fertilize in vitro.
Ma S, Kalousek DK, Zouves C, Yuen BH, Gomel V, Moon YS., Fertil. Steril. 51(6), 1989
PMID: 2721734
Chromosome investigation in in vitro fertilization failure.
Ma S, Kalousek DK, Yuen BH, Gomel V, Katagiri S, Moon YS., J. Assist. Reprod. Genet. 11(9), 1994
PMID: 7633164
Abnormal chromosomal arrangements in human oocytes.
Macas E, Floersheim Y, Hotz E, Imthurn B, Keller PJ, Walt H., Hum. Reprod. 5(6), 1990
PMID: 2254403
The origin of 47,XXY and 47,XXX aneuploidy: heterogeneous mechanisms and role of aberrant recombination.
MacDonald M, Hassold T, Harvey J, Wang LH, Morton NE, Jacobs P., Hum. Mol. Genet. 3(8), 1994
PMID: 7987316
An enhanced linkage map of the sheep genome comprising more than 1000 loci.
Maddox JF, Davies KP, Crawford AM, Hulme DJ, Vaiman D, Cribiu EP, Freking BA, Beh KJ, Cockett NE, Kang N, Riffkin CD, Drinkwater R, Moore SS, Dodds KG, Lumsden JM, van Stijn TC, Phua SH, Adelson DL, Burkin HR, Broom JE, Buitkamp J, Cambridge L, Cushwa WT, Gerard E, Galloway SM, Harrison B, Hawken RJ, Hiendleder S, Henry HM, Medrano JF, Paterson KA, Schibler L, Stone RT, van Hest B., Genome Res. 11(7), 2001
PMID: 11435411
First meiosis errors in immature oocytes generated by stimulated cycles.
Magli MC, Ferraretti AP, Crippa A, Lappi M, Feliciani E, Gianaroli L., Fertil. Steril. 86(3), 2006
PMID: 16793041
Embryo morphology and development are dependent on the chromosomal complement
Magli, Fertil. Steril. 12(), 2006
Mechanisms of maternal aneuploidy: FISH analysis of oocytes and polar bodies in patients undergoing assisted conception.
Mahmood R, Brierley CH, Faed MJ, Mills JA, Delhanty JD., Hum. Genet. 106(6), 2000
PMID: 10942110
Benomyl-induced aneuploidy in mouse oocytes.
Mailhes JB, Aardema MJ., Mutagenesis 7(4), 1992
PMID: 1518415
Mechanisms and chemical induction of aneuploidy in rodent germ cells.
Mailhes JB, Marchetti F., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192721
Cytogenetic technique for mouse metaphase II oocytes.
Mailhes JB, Yuan ZP., Gamete Res 18(1), 1987
PMID: 3507364
Analysis of mouse metaphase II oocytes as an assay for chemically induced aneuploidy.
Mailhes JB, Preston RJ, Yuan ZP, Payne HS., Mutat. Res. 198(1), 1988
PMID: 3352624
Griseofulvin-induced aneuploidy and meiotic delay in mouse oocytes: effect of dose and harvest time.
Mailhes JB, Marchetti F, Aardema MJ., Mutat. Res. 300(3-4), 1993
PMID: 7687015
Preferential pericentric lesions and aneuploidy induced in mouse oocytes by the topoisomerase II inhibitor etoposide.
Mailhes JB, Marchetti F, Phillips GL Jr, Barnhill DR., Teratog., Carcinog. Mutagen. 14(1), 1994
PMID: 7910418
Thiabendazole-induced cytogenetic abnormalities in mouse oocytes.
Mailhes JB, Young D, Aardema MJ, London SN., Environ. Mol. Mutagen. 29(4), 1997
PMID: 9212787
Taxol-induced meiotic maturation delay, spindle defects, and aneuploidy in mouse oocytes and zygotes.
Mailhes JB, Carabatsos MJ, Young D, London SN, Bell M, Albertini DF., Mutat. Res. 423(1-2), 1999
PMID: 10029682
Comparison of the aneugenic activity of diazepam in mouse oocytes and other mammalian cells.
Marchetti F, Mailhes JB, Aardema MJ., Mutat. Res. 322(1), 1994
PMID: 7517506
Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse.
Marchetti F, Bishop JB, Lowe X, Generoso WM, Hozier J, Wyrobek AJ., Proc. Natl. Acad. Sci. U.S.A. 98(7), 2001
PMID: 11274416
Chromosome identification in human oocytes and polar bodies by spectral karyotyping.
Marquez C, Cohen J, Munne S., Cytogenet. Cell Genet. 81(3-4), 1998
PMID: 9730613
Detection of genetic damage in human sperm.
Martin RH., Reprod. Toxicol. 7 Suppl 1(), 1993
PMID: 8400640
Mechanisms of nondisjunction in human spermatogenesis.
Martin RH., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192700
Chromosomal analysis of unfertilized human oocytes.
Martin RH, Mahadevan MM, Taylor PJ, Hildebrand K, Long-Simpson L, Peterson D, Yamamoto J, Fleetham J., J. Reprod. Fertil. 78(2), 1986
PMID: 3806521
Distribution of aneuploidy in human gametes: comparison between human sperm and oocytes.
Martin RH, Ko E, Rademaker A., Am. J. Med. Genet. 39(3), 1991
PMID: 1867285
Chromosomal abnormalities in sperm from testicular cancer patients before and after chemotherapy.
Martin RH, Ernst S, Rademaker A, Barclay L, Ko E, Summers N., Hum. Genet. 99(2), 1997
PMID: 9048924
Analysis of human sperm karyotypes in testicular cancer patients before and after chemotherapy.
Martin RH, Ernst S, Rademaker A, Barclay L, Ko E, Summers N., Cytogenet. Cell Genet. 78(2), 1997
PMID: 9371403
Analysis of sperm chromosome complements before, during, and after chemotherapy.
Martin RH, Ernst S, Rademaker A, Barclay L, Ko E, Summers N., Cancer Genet. Cytogenet. 108(2), 1999
PMID: 9973940
FISH analysis of six chromosomes in unfertilized human oocytes after polar body removal.
Martini E, Flaherty SP, Swann NJ, Matthews CD, Ramaekers FC, Geraedts JP., J. Assist. Reprod. Genet. 17(5), 2000
PMID: 10976415
Paternal age and the risk of birth defects in offspring.
McIntosh GC, Olshan AF, Baird PA., Epidemiology 6(3), 1995
PMID: 7619937
Chromosomal analysis of unfertilized oocytes and morphologically abnormal preimplantation embryos from an in vitro fertilization program.
Michaeli G, Fejgin M, Ghetler Y, Ben Nun I, Beyth Y, Amiel A., J In Vitro Fert Embryo Transf 7(6), 1990
PMID: 2077088
Cytogenetic investigations on human oocytes and early human embryonic stages.
Michelmann HW, Mettler L., Fertil. Steril. 43(2), 1985
PMID: 3967790
A linkage map of 243 DNA markers in an intercross of Gottingen miniature and Meishan pigs.
Mikawa S, Akita T, Hisamatsu N, Inage Y, Ito Y, Kobayashi E, Kusumoto H, Matsumoto T, Mikami H, Minezawa M, Miyake M, Shimanuki S, Sugiyama C, Uchida Y, Wada Y, Yanai S, Yasue H., Anim. Genet. 30(6), 1999
PMID: 10612229
Aneuploidy induction in mouse spermatocytes.
Miller BM, Adler ID., Mutagenesis 7(1), 1992
PMID: 1635458
Azoospermia in patients heterozygous for a mutation in SYCP3.
Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ., Lancet 362(9397), 2003
PMID: 14643120
Polar body biopsy and aneuploidy testing by simultaneous detection of six chromosomes.
Montag M, Limbach N, Sabarstinski M, van der Ven K, Dorn C, van der Ven H., Prenat. Diagn. 25(10), 2005
PMID: 16193457
Increased aneuploid frequency in spermatozoa from a Hodgkin's disease patient after chemotherapy and radiotherapy.
Monteil M, Rousseaux S, Chevret E, Pelletier R, Cozzi J, Sele B., Cytogenet. Cell Genet. 76(3-4), 1997
PMID: 9186506
Chromosome mosaicism in human embryos.
Munne S, Weier HU, Grifo J, Cohen J., Biol. Reprod. 51(3), 1994
PMID: 7803609
Chromosome mosaicism in cleavage-stage human embryos: evidence of a maternal age effect.
Munne S, Sandalinas M, Escudero T, Marquez C, Cohen J., Reprod. Biomed. Online 4(3), 2002
PMID: 12709271
Differences in chromosome susceptibility to aneuploidy and survival to first trimester.
Munne S, Bahce M, Sandalinas M, Escudero T, Marquez C, Velilla E, Colls P, Oter M, Alikani M, Cohen J., Reprod. Biomed. Online 8(1), 2004
PMID: 14759293
Increased rate of aneuploid embryos in young women with previous aneuploid conceptions.
Munne S, Sandalinas M, Magli C, Gianaroli L, Cohen J, Warburton D., Prenat. Diagn. 24(8), 2004
PMID: 15305354
Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages.
Munne S, Chen S, Fischer J, Colls P, Zheng X, Stevens J, Escudero T, Oter M, Schoolcraft B, Simpson JL, Cohen J., Fertil. Steril. 84(2), 2005
PMID: 16084873
The spindle checkpoint: structural insights into dynamic signalling.
Musacchio A, Hardwick KG., Nat. Rev. Mol. Cell Biol. 3(10), 2002
PMID: 12360190
Sperm-FISH analysis and human monitoring: a study on workers occupationally exposed to styrene.
Naccarati A, Zanello A, Landi S, Consigli R, Migliore L., Mutat. Res. 537(2), 2003
PMID: 12787818

Nagy, 2003
The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans.
Neel JV, Schull WJ, Awa AA, Satoh C, Kato H, Otake M, Yoshimoto Y., Am. J. Hum. Genet. 46(6), 1990
PMID: 2339701
A second-generation genetic linkage map of the domestic dog, Canis familiaris.
Neff MW, Broman KW, Mellersh CS, Ray K, Acland GM, Aguirre GD, Ziegle JS, Ostrander EA, Rine J., Genetics 151(2), 1999
PMID: 9927471
Ovarian senescence in the rhesus monkey (Macaca mulatta).
Nichols SM, Bavister BD, Brenner CA, Didier PJ, Harrison RM, Kubisch HM., Hum. Reprod. 20(1), 2004
PMID: 15498779
[A cytogenetic study of human oocytes unfertilized in in-vitro fertilization (IVF)].
Nishino T, Kamiguchi Y, Tateno H, Sengoku K, Ishikawa M., Nippon Sanka Fujinka Gakkai Zasshi 46(2), 1994
PMID: 8126388
Toward maintaining the genome: DNA damage and replication checkpoints.
Nyberg KA, Michelson RJ, Putnam CW, Weinert TA., Annu. Rev. Genet. 36(), 2002
PMID: 12429704
The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis.
Odorisio T, Rodriguez TA, Evans EP, Clarke AR, Burgoyne PS., Nat. Genet. 18(3), 1998
PMID: 9500548
Studying meiosis: a review of FISH and M-FISH techniques used in the analysis of meiotic processes in humans.
Oliver-Bonet M, Benet J, Martin RH., Cytogenet. Genome Res. 114(3-4), 2006
PMID: 16954672
Hepatic CYP1A, 2B, 2C, 2E and 3A regulation by methoxychlor in male and female rats.
Oropeza-Hernandez LF, Lopez-Romero R, Albores A., Toxicol. Lett. 144(1), 2003
PMID: 12919727
Aneuploidy dose-responses following radiation or chemical exposures in mammals
Pacchierotti, 1991
Mechanisms and risk of chemically induced aneuploidy in mammalian germ cells.
Pacchierotti F, Ranaldi R., Curr. Pharm. Des. 12(12), 2006
PMID: 16611130
Sperm aneuploidy among Chinese pesticide factory workers: scoring by the FISH method.
Padungtod C, Hassold TJ, Millie E, Ryan LM, Savitz DA, Christiani DC, Xu X., Am. J. Ind. Med. 36(2), 1999
PMID: 10398931
The peptide nucleic acids as probes for chromosomal analysis: application to human oocytes, polar bodies and preimplantation embryos.
Paulasova P, Andreo B, Diblik J, Macek M, Pellestor F., Mol. Hum. Reprod. 10(6), 2004
PMID: 15100384
Assessment of aneuploidy in the human female by using cytogenetics of IVF failures.
Pellestor F, Sele B., Am. J. Hum. Genet. 42(2), 1988
PMID: 3341382
Human oocyte chromosome analysis
Pellestor, Am. J. Hum. Genet. 45(Suppl.), 1989
Relationship between morphology and chromosomal constitution in human preimplantation embryo.
Pellestor F, Girardet A, Andreo B, Arnal F, Humeau C., Mol. Reprod. Dev. 39(2), 1994
PMID: 7826614
Preimplantation embryo chromosome analysis by primed in situ labeling method.
Pellestor F, Girardet A, Andreo B, Lefort G, Charlieu JP., Fertil. Steril. 66(5), 1996
PMID: 8893685
Direct detection of disomy in human sperm by the PRINS technique.
Pellestor F, Quennesson I, Coignet L, Girardet A, Andreo B, Charlieu JP., Hum. Genet. 97(1), 1996
PMID: 8557255
Rapid chromosome detection in human gametes, zygotes, and preimplantation embryos using the PRINS technique.
Pellestor F, Girardet A, Lefort G, Andreo B, Charlieu JP., J. Assist. Reprod. Genet. 13(8), 1996
PMID: 8897129
Maternal aging and chromosomal abnormalities: new data drawn from in vitro unfertilized human oocytes.
Pellestor F, Andreo B, Arnal F, Humeau C, Demaille J., Hum. Genet. 112(2), 2002
PMID: 12522562
Fast multicolor primed in situ protocol for chromosome identification in isolated cells may be used for human oocytes and polar bodies.
Pellestor F, Anahory T, Andreo B, Regnier-Vigouroux G, Soulie JP, Baudouin M, Demaille J., Fertil. Steril. 81(2), 2004
PMID: 14967382
The peptide nucleic acids: a new way for chromosomal investigation on isolated cells?
Pellestor F, Paulasova P, Macek M, Hamamah S., Hum. Reprod. 19(9), 2004
PMID: 15229198
The chromosomal analysis of human oocytes. An overview of established procedures.
Pellestor F, Anahory T, Hamamah S., Hum. Reprod. Update 11(1), 2004
PMID: 15569701
Effect of maternal age on the frequency of cytogenetic abnormalities in human oocytes.
Pellestor F, Anahory T, Hamamah S., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192696
The relative effects of paternal and maternal age in mongolism
Penrose, J. Genet. 27(), 1933
Integrating new tests of sperm genetic integrity into semen analysis: breakout group discussion.
Perreault SD, Aitken RJ, Baker HW, Evenson DP, Huszar G, Irvine DS, Morris ID, Morris RA, Robbins WA, Sakkas D, Spano M, Wyrobek AJ., Adv. Exp. Med. Biol. 518(), 2003
PMID: 12817694
Cytogenetic analysis of in vitro fertilization (IVF) failures.
Pieters MH, Geraedts JP, Dumoulin JC, Evers JL, Bras M, Kornips FH, Menheere PP., Hum. Genet. 81(4), 1989
PMID: 2703240
Immaturity and aneuploidy in human oocytes after different stimulation protocols.
Pieters MH, Dumoulin JC, Engelhart CM, Bras M, Evers JL, Geraedts JP., Fertil. Steril. 56(2), 1991
PMID: 1906409
Genetic analysis of the oocyte--a review.
Plachot M., Placenta 24 Suppl B(), 2003
PMID: 14559033
Chromosome investigations in early life. I. Human oocytes recovered in an IVF programme.
Plachot M, Junca AM, Mandelbaum J, de Grouchy J, Salat-Baroux J, Cohen J., Hum. Reprod. 1(8), 1986
PMID: 3818913
Are clinical and biological IVF parameters correlated with chromosomal disorders in early life: a multicentric study.
Plachot M, Veiga A, Montagut J, de Grouchy J, Calderon G, Lepretre S, Junca AM, Santalo J, Carles E, Mandelbaum J., Hum. Reprod. 3(5), 1988
PMID: 3170703
Smoking and infertility.
Practice Committee of the American Society for Reproductive Medicine., Fertil. Steril. 81(4), 2004
PMID: 15066502
Analysis of nine chromosome probes in first polar bodies and metaphase II oocytes for the detection of aneuploidies.
Pujol A, Boiso I, Benet J, Veiga A, Durban M, Campillo M, Egozcue J, Navarro J., Eur. J. Hum. Genet. 11(4), 2003
PMID: 12700606
Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy.
Recio R, Robbins WA, Borja-Aburto V, Moran-Martinez J, Froines JR, Hernandez RM, Cebrian ME., Environ. Health Perspect. 109(12), 2001
PMID: 11748030
Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination.
Revenkova E, Eijpe M, Heyting C, Hodges CA, Hunt PA, Liebe B, Scherthan H, Jessberger R., Nat. Cell Biol. 6(6), 2004
PMID: 15146193
Meiotic segregation of sex chromosomes in mosaic and non-mosaic XYY males: case reports and review of the literature.
Rives N, Simeon N, Milazzo JP, Barthelemy C, Mace B., Int. J. Androl. 26(4), 2003
PMID: 12846800
Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm.
Robbins WA, Meistrich ML, Moore D, Hagemeister FB, Weier HU, Cassel MJ, Wilson G, Eskenazi B, Wyrobek AJ., Nat. Genet. 16(1), 1997
PMID: 9140398
Effect of lifestyle exposures on sperm aneuploidy.
Robbins WA, Elashoff DA, Xun L, Jia J, Li N, Wu G, Wei F., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192719
Increase in the rate of diploidy with maternal age in unfertilized in-vitro fertilization oocytes
Roberts, Hum. Reprod. 8(), 1995
Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro.
Roberts R, Iatropoulou A, Ciantar D, Stark J, Becker DL, Franks S, Hardy K., Biol. Reprod. 72(1), 2004
PMID: 15371272
Maternal meiosis I non-disjunction of chromosome 15: dependence of the maternal age effect on level of recombination.
Robinson WP, Kuchinka BD, Bernasconi F, Petersen MB, Schulze A, Brondum-Nielsen K, Christian SL, Ledbetter DH, Schinzel AA, Horsthemke B, Schuffenhauer S, Michaelis RC, Langlois S, Hassold TJ., Hum. Mol. Genet. 7(6), 1998
PMID: 9580665
The pachytene checkpoint.
Roeder GS, Bailis JM., Trends Genet. 16(9), 2000
PMID: 10973068
Convential cytogenetics of human oocytes
Rosenbusch, 2006
Smoking cigarettes is associated with increased sperm disomy in teenage men.
Rubes J, Lowe X, Moore D 2nd, Perreault S, Slott V, Evenson D, Selevan SG, Wyrobek AJ., Fertil. Steril. 70(4), 1998
PMID: 9797104
Individual variation in the frequency of sperm aneuploidy in humans.
Rubes J, Vozdova M, Oracova E, Perreault SD., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192698
Chromosomal abnormalities and embryo development in recurrent miscarriage couples.
Rubio C, Simon C, Vidal F, Rodrigo L, Pehlivan T, Remohi J, Pellicer A., Hum. Reprod. 18(1), 2003
PMID: 12525464
Direct analysis of the chromosome constitution of human spermatozoa.
Rudak E, Jacobs PA, Yanagimachi R., Nature 274(5674), 1978
PMID: 683334
Meiotic arrest and aneuploidy induced by vinblastine in mouse oocytes.
Russo A, Pacchierotti F., Mutat. Res. 202(1), 1988
PMID: 3185591
Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage.
Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J, Munne S., Hum. Reprod. 16(9), 2001
PMID: 11527904
Spectral karyotyping of fresh, non-inseminated oocytes.
Sandalinas M, Marquez C, Munne S., Mol. Hum. Reprod. 8(6), 2002
PMID: 12029077

Sankaranarayanan, 1982
Evaluation of inter-scorer and inter-laboratory reliability of the mouse epididymal sperm aneuploidy (m-ESA) assay.
Schmid TE, Lowe X, Marchetti F, Bishop J, Haseman J, Wyrobek AJ., Mutagenesis 16(3), 2001
PMID: 11320142
Multicolor spectral karyotyping of human chromosomes.
Schrock E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA, Ning Y, Ledbetter DH, Bar-Am I, Soenksen D, Garini Y, Ried T., Science 273(5274), 1996
PMID: 8662537
Cytogenetic study of human oocytes uncleaved after in-vitro fertilization.
Selva J, Martin-Pont B, Hugues JN, Rince P, Fillion C, Herve F, Tamboise A, Tamboise E., Hum. Reprod. 6(5), 1991
PMID: 1939554
The chromosomal normality of unfertilized oocytes from patients with polycystic ovarian syndrome.
Sengoku K, Tamate K, Takuma N, Yoshida T, Goishi K, Ishikawa M., Hum. Reprod. 12(3), 1997
PMID: 9130743
Environment, lifestyle and infertility--an inter-generational issue.
Sharpe RM, Franks S., Nat. Cell Biol. 4 Suppl(), 2002
PMID: 12479613
Risk factors for nondisjunction of trisomy 21.
Sherman SL, Freeman SB, Allen EG, Lamb NE., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192705
Cigarette smoking and aneuploidy in human sperm.
Shi Q, Ko E, Barclay L, Hoang T, Rademaker A, Martin R., Mol. Reprod. Dev. 59(4), 2001
PMID: 11468778
Oocyte-based screening system for anti-microtubule agents.
Shin DY, Choi TS., J. Reprod. Dev. 50(6), 2004
PMID: 15647616
Increased chromosome abnormalities in human preimplantation embryos after in-vitro fertilization in patients with recurrent miscarriage.
Simon C, Rubio C, Vidal F, Gimenez C, Moreno C, Parrilla JJ, Pellicer A., Reprod. Fertil. Dev. 10(1), 1998
PMID: 9727597
Sex-specific recombination rates in zebrafish (Danio rerio).
Singer A, Perlman H, Yan Y, Walker C, Corley-Smith G, Brandhorst B, Postlethwait J., Genetics 160(2), 2002
PMID: 11861568
Griseofulvin: association with tubulin and inhibition of in vitro microtubule assembly.
Sloboda RD, Van Blaricom G, Creasey WA, Rosenbaum JL, Malawista SE., Biochem. Biophys. Res. Commun. 105(3), 1982
PMID: 7092906
Human sperm aneuploidy after exposure to pesticides.
Smith JL, Garry VF, Rademaker AW, Martin RH., Mol. Reprod. Dev. 67(3), 2004
PMID: 14735496
Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells.
Sonoda E, Matsusaka T, Morrison C, Vagnarelli P, Hoshi O, Ushiki T, Nojima K, Fukagawa T, Waizenegger IC, Peters JM, Earnshaw WC, Takeda S., Dev. Cell 1(6), 2001
PMID: 11740938
Karyotyping human chromosomes by combinatorial multi-fluor FISH.
Speicher MR, Gwyn Ballard S, Ward DC., Nat. Genet. 12(4), 1996
PMID: 8630489
Significant increase in trisomy 21 in Berlin nine months after the Chernobyl reactor accident: temporal correlation or causal relation?
Sperling K, Pelz J, Wegner RD, Dorries A, Gruters A, Mikkelsen M., BMJ 309(6948), 1994
PMID: 8044094
Abnormal chromosome behavior in human oocytes which remained unfertilized during human in vitro fertilization.
Spielmann H, Kruger C, Stauber M, Vogel R., J In Vitro Fert Embryo Transf 2(3), 1985
PMID: 4056560
Meiotic spindle checkpoints for assessment of aneuploid oocytes.
Steuerwald N., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192702
Association between spindle assembly checkpoint expression and maternal age in human oocytes.
Steuerwald N, Cohen J, Herrera RJ, Sandalinas M, Brenner CA., Mol. Hum. Reprod. 7(1), 2001
PMID: 11134360
Trichlorfon induces spindle disturbances in V79 cells and aneuploidy in male mouse germ cells.
Sun FY, Schmid TE, Schmid E, Baumgartner A, Adler ID., Mutagenesis 15(1), 2000
PMID: 10640526
Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes.
Sun F, Betzendahl I, Shen Y, Cortvrindt R, Smitz J, Eichenlaub-Ritter U., Mutagenesis 19(1), 2004
PMID: 14681309
Human male recombination maps for individual chromosomes.
Sun F, Oliver-Bonet M, Liehr T, Starke H, Ko E, Rademaker A, Navarro J, Benet J, Martin RH., Am. J. Hum. Genet. 74(3), 2004
PMID: 14973780
Aneuploidy in mouse metaphase II oocytes exposed in vivo and in vitro in preantral follicle culture to nocodazole.
Sun F, Betzendahl I, Pacchierotti F, Ranaldi R, Smitz J, Cortvrindt R, Eichenlaub-Ritter U., Mutagenesis 20(1), 2005
PMID: 15701686
Immunofluorescent synaptonemal complex analysis in azoospermic men.
Sun F, Greene C, Turek PJ, Ko E, Rademaker A, Martin RH., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192718
Gender difference in serum bisphenol A levels may be caused by liver UDP-glucuronosyltransferase activity in rats.
Takeuchi T, Tsutsumi O, Nakamura N, Ikezuki Y, Takai Y, Yano T, Taketani Y., Biochem. Biophys. Res. Commun. 325(2), 2004
PMID: 15530427
Failed in vitro fertilization of human oocytes: a cytogenetic analysis.
Tarin JJ, Ruiz A, Miro F, Bonilla-Musoles F, Pellicer A., Fertil. Steril. 56(2), 1991
PMID: 2070859
Cytogenetic analysis of human oocytes from fertile women.
Tarin JJ, Gomez E, Sampaio M, Ruiz M, Remohi J, Pellicer A., Hum. Reprod. 6(8), 1991
PMID: 1806569
An air-drying method for chromosome preparation from mouse eggs
Tarkowski, Cytogenetics 5(), 1966
Radiation-induced aneuploidy in germ cells of female mammals
Tease, 1988
Oocytes from young and old female mice respond differently to colchicine.
Tease C, Fisher G., Mutat. Res. 173(1), 1986
PMID: 3941676
Patterns of meiotic recombination in human fetal oocytes.
Tease C, Hartshorne GM, Hulten MA., Am. J. Hum. Genet. 70(6), 2002
PMID: 11992253
The relationship between male infertility and increased levels of sperm disomy.
Tempest HG, Griffin DK., Cytogenet. Genome Res. 107(1-2), 2004
PMID: 15305060
Frequency and distribution of chromosome abnormalities in human spermatozoa.
Templado C, Bosch M, Benet J., Cytogenet. Genome Res. 111(3-4), 2005
PMID: 16192695
Aberrant recombination and the origin of Klinefelter syndrome.
Thomas NS, Hassold TJ., Hum. Reprod. Update 9(4), 2003
PMID: 12926525
A reinvestigation of non-disjunction resulting in 47, XXY males of paternal origin.
Thomas NS, Collins AR, Hassold TJ, Jacobs PA., Eur. J. Hum. Genet. 8(10), 2000
PMID: 11039584
Investigation of chromosomal imbalance in human embryos using comparative genomic hybridization.
Trussler JL, Pickering SJ, Ogilvie CM., Reprod. Biomed. Online 8(6), 2004
PMID: 15169589
A possible association between maternal radiation and mongolism.
UCHIDA IA, CURTIS EJ., Lancet 2(7207), 1961
PMID: 13923410
Chromosome cohesion and separation: from men and molecules.
Uhlmann F., Curr. Biol. 13(3), 2003
PMID: 12573239
Chromosome studies in oocytes and zygotes from an IVF programme.
Veiga A, Calderon G, Santalo J, Barri PN, Egozcue J., Hum. Reprod. 2(5), 1987
PMID: 3654932
Down syndrome and ionizing radiation.
Verger P., Health Phys 73(6), 1997
PMID: 9373065
Polar body diagnosis of common aneuploidies by FISH.
Verlinsky Y, Cieslak J, Freidine M, Ivakhnenko V, Wolf G, Kovalinskaya L, White M, Lifchez A, Kaplan B, Moise J, Valle J, Ginsberg N, Strom C, Kuliev A., J. Assist. Reprod. Genet. 13(2), 1996
PMID: 8688589
Prepregnancy genetic testing for age-related aneuploidies by polar body analysis.
Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wolf G, White M, Lifchez A, Kaplan B, Moise J, Valle J, Ginsberg N, Strom C, Kuliev A., Genet. Test. 1(4), 1997
PMID: 10464651
Prevention of age-related aneuploidies by polar body testing of oocytes.
Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wolf G, White M, Lifchez A, Kaplan B, Moise J, Valle J, Ginsberg N, Strom C, Kuliev A., J. Assist. Reprod. Genet. 16(4), 1999
PMID: 10224558
Chromosomal abnormalities in the first and second polar body.
Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wolf G, White M, Lifchez A, Kaplan B, Moise J, Valle J, Ginsberg N, Strom C, Kuliev A., Mol. Cell. Endocrinol. 183 Suppl 1(), 2001
PMID: 11576732
The radiosensitivity of the human oocyte.
Wallace WH, Thomson AB, Kelsey TW., Hum. Reprod. 18(1), 2003
PMID: 12525451
Chromosomal differences in susceptibility to meiotic aneuploidy.
Warburton D, Kinney A., Environ. Mol. Mutagen. 28(3), 1996
PMID: 8908182
Fluorescence in situ hybridization and spectral imaging analysis of human oocytes and first polar bodies.
Weier HU, Weier JF, Renom MO, Zheng X, Colls P, Nureddin A, Pham CD, Chu LW, Racowsky C, Munne S., J. Histochem. Cytochem. 53(3), 2005
PMID: 15749999
First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
Wells D, Escudero T, Levy B, Hirschhorn K, Delhanty JD, Munne S., Fertil. Steril. 78(3), 2002
PMID: 12215331
Incidence of early loss of pregnancy.
Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, Canfield RE, Armstrong EG, Nisula BC., N. Engl. J. Med. 319(4), 1988
PMID: 3393170
Maternal age and trisomy--a unifying mechanism of formation.
Wolstenholme J, Angell RR., Chromosoma 109(7), 2000
PMID: 11151672
A gradual fixation method for chromosomal preparations of human oocytes.
Wramsby H, Liedholm P., Fertil. Steril. 41(5), 1984
PMID: 6714451
Chromosome analysis of human oocytes recovered from preovulatory follicles in stimulated cycles.
Wramsby H, Fredga K, Liedholm P., N. Engl. J. Med. 316(3), 1987
PMID: 3796682
Fluorescence in situ hybridization to Y chromosomes in decondensed human sperm nuclei.
Wyrobek AJ, Alhborn T, Balhorn R, Stanker L, Pinkel D., Mol. Reprod. Dev. 27(3), 1990
PMID: 2078335
Smokers produce more aneuploid sperm than non-smokers
Wyrobek, Am. J. Hum. Genet. 57(Suppl.), 1995
Mechanisms and targets involved in maternal and paternal age effects on numerical aneuploidy.
Wyrobek AJ, Aardema M, Eichenlaub-Ritter U, Ferguson L, Marchetti F., Environ. Mol. Mutagen. 28(3), 1996
PMID: 8908184
Genotoxic effects on human spermatozoa among pesticide factory workers exposed to fenvalerate.
Xia Y, Bian Q, Xu L, Cheng S, Song L, Liu J, Wu W, Wang S, Wang X., Toxicology 203(1-3), 2004
PMID: 15363581
Exposure to acrylonitrile induced DNA strand breakage and sex chromosome aneuploidy in human spermatozoa.
Xu DX, Zhu QX, Zheng LK, Wang QN, Shen HM, Deng LX, Ong CN., Mutat. Res. 537(1), 2003
PMID: 12742510
Risk factors for trisomy 21: maternal cigarette smoking and oral contraceptive use in a population-based case-control study.
Yang Q, Sherman SL, Hassold TJ, Allran K, Taft L, Pettay D, Khoury MJ, Erickson JD, Freeman SB., Genet. Med. 1(3), 1999
PMID: 11336457
Diazepam induces meiotic delay, aneuploidy and predivision of homologues and chromatids in mammalian oocytes.
Yin H, Baart E, Betzendahl I, Eichenlaub-Ritter U., Mutagenesis 13(6), 1998
PMID: 9862187
Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3.
Yuan L, Liu JG, Hoja MR, Wilbertz J, Nordqvist K, Hoog C., Science 296(5570), 2002
PMID: 12004129
Smoking and reproduction: gene damage to human gametes and embryos.
Zenzes MT., Hum. Reprod. Update 6(2), 2000
PMID: 10782570
Cigarette smoking may affect meiotic maturation of human oocytes.
Zenzes MT, Wang P, Casper RF., Hum. Reprod. 10(12), 1995
PMID: 8822447
Effects of cigarette smoking and age on the maturation of human oocytes.
Zenzes MT, Reed TE, Casper RF., Hum. Reprod. 12(8), 1997
PMID: 9308804
Analysis of human unfertilized oocytes and pronuclear zygotes-Correlation between chromosome/chromatin status and patient-related factors
Zhivkova, Eur. J. Obstet. Gynecol. Reprod. Biol. (), 2006
Embryo quality and developmental potential is compromised by age.
Ziebe S, Loft A, Petersen JH, Andersen AG, Lindenberg S, Petersen K, Andersen AN., Acta Obstet Gynecol Scand 80(2), 2001
PMID: 11167214
Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection.
Zitzmann M, Rolf C, Nordhoff V, Schrader G, Rickert-Fohring M, Gassner P, Behre HM, Greb RR, Kiesel L, Nieschlag E., Fertil. Steril. 79 Suppl 3(), 2003
PMID: 12801558

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 17292877
PubMed | Europe PMC

Suchen in

Google Scholar