Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells

Adler I-D, Carere A, Eichenlaub-Ritter U, Pacchierotti F (2007)
ENVIRONMENTAL RESEARCH 104(1): 37-45.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Adler, Ilse-Dore; Carere, Angelo; Eichenlaub-Ritter, UrsulaUniBi; Pacchierotti, Francesca
Abstract / Bemerkung
Germ cell mutagenicity testing provides experimental data to quantify genetic risk for exposed human populations. The majority of tests are performed with exposure of males, and female data are relatively rare. The reason for this paucity lies in the differences between male and female germ cell biology. Male germ cells are produced throughout reproductive life and all developmental stages can be ascertained by appropriate breeding schemes. In contrast, the female germ cell pool is limited, meiosis begins during embryogenesis and oocytes are arrested over long periods of time until maturation processes start for small numbers of oocytes during the oestrus cycle in mature females. The literature data are reviewed to point out possible gender differences of germ cells to exogenous agents such as chemicals or ionizing radiation. From the limited information, it can be concluded that male germ cells are more sensitive than female germ cells to the induction of chromosomal aberrations and gene mutations. However, exceptions are described which shed doubt on the extrapolation of experimental data from male rodents to the genetic risk of the human population. Furthermore, the female genome may be more sensitive to mutation induction during peri-conceptional stages compared to the male genome of the zygote. With few exceptions, germ cell experiments have been carried out under high acute exposure to optimize the effects and to compensate for the limited sample size in animal experiments. Human exposure to environmental agents, on the other hand, is usually chronic and involves low doses. Under these conditions, gender differences may become apparent that have not been studied so far. Additionally, data are reviewed that suggest a false impression of safety when responses are negative under high acute exposure of male rodents while a mutational response is induced by low chronic exposure. The classical (morphological) germ cell mutation tests are not performed anymore because they are animal and time consuming. Nevertheless, information is needed to place genetic risk extrapolations on more solid grounds and thereby to prevent an increased genetic burden to future generations. It is pointed out that modern molecular methodologies are available now to experimentally address the open questions. (c) 2006 Elsevier Inc. All rights reserved.
Stichworte
germ cell mutagenesis; progeny testing; rodents; stage specificity; gender differences
Erscheinungsjahr
2007
Zeitschriftentitel
ENVIRONMENTAL RESEARCH
Band
104
Ausgabe
1
Seite(n)
37-45
ISSN
0013-9351
Page URI
https://pub.uni-bielefeld.de/record/1593932

Zitieren

Adler I-D, Carere A, Eichenlaub-Ritter U, Pacchierotti F. Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells. ENVIRONMENTAL RESEARCH. 2007;104(1):37-45.
Adler, I. - D., Carere, A., Eichenlaub-Ritter, U., & Pacchierotti, F. (2007). Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells. ENVIRONMENTAL RESEARCH, 104(1), 37-45. https://doi.org/10.1016/j.envres.2006.08.010
Adler, Ilse-Dore, Carere, Angelo, Eichenlaub-Ritter, Ursula, and Pacchierotti, Francesca. 2007. “Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells”. ENVIRONMENTAL RESEARCH 104 (1): 37-45.
Adler, I. - D., Carere, A., Eichenlaub-Ritter, U., and Pacchierotti, F. (2007). Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells. ENVIRONMENTAL RESEARCH 104, 37-45.
Adler, I.-D., et al., 2007. Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells. ENVIRONMENTAL RESEARCH, 104(1), p 37-45.
I.-D. Adler, et al., “Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells”, ENVIRONMENTAL RESEARCH, vol. 104, 2007, pp. 37-45.
Adler, I.-D., Carere, A., Eichenlaub-Ritter, U., Pacchierotti, F.: Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells. ENVIRONMENTAL RESEARCH. 104, 37-45 (2007).
Adler, Ilse-Dore, Carere, Angelo, Eichenlaub-Ritter, Ursula, and Pacchierotti, Francesca. “Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells”. ENVIRONMENTAL RESEARCH 104.1 (2007): 37-45.

9 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

A perspective on the developmental toxicity of inhaled nanoparticles.
Hougaard KS, Campagnolo L, Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D, Valentino S, Park MV, de Jong WH, Wolterink G, Piersma AH, Ross BL, Hutchison GR, Hansen JS, Vogel U, Jackson P, Slama R, Pietroiusti A, Cassee FR., Reprod Toxicol 56(), 2015
PMID: 26050605
In utero exposure to nanosized carbon black (Printex90) does not induce tandem repeat mutations in female murine germ cells.
Boisen AM, Shipley T, Jackson P, Wallin H, Nellemann C, Vogel U, Yauk CL, Hougaard KS., Reprod Toxicol 41(), 2013
PMID: 23871697
NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice.
Boisen AM, Shipley T, Jackson P, Hougaard KS, Wallin H, Yauk CL, Vogel U., Part Fibre Toxicol 9(), 2012
PMID: 22656316
Radiobiology and reproduction-what can we learn from Mammalian females?
Ruiz-Herrera A, Garcia F, Garcia-Caldés M., Genes (Basel) 3(3), 2012
PMID: 24704983
Sex-gender research sensitivity and healthcare disparities.
Gochfeld M., J Womens Health (Larchmt) 19(2), 2010
PMID: 20113150
MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.
Vogt E, Sanhaji M, Klein W, Seidel T, Wordeman L, Eichenlaub-Ritter U., Mol Hum Reprod 16(9), 2010
PMID: 20406800
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U., Mutat Res 651(1-2), 2008
PMID: 18096427

106 References

Daten bereitgestellt von Europe PubMed Central.

Male germ cell cytogenetics
Adler, 1982
Transmission of mutations in the lacI transgene to the offspring of ENU-treated Big Blue male mice.
Barnett LB, Tyl RW, Shane BS, Shelby MD, Lewis SE., Environ. Mol. Mutagen. 40(4), 2002
PMID: 12489115
Mutagenic sensitivity of maturing germ cells in the male mouse
Bateman, Heredity 12(), 1958
Alterations in the reproductive patterns of female mice exposed to xenobiotics.
Bishop JB, Morris RW, Seely JC, Hughes LA, Cain KT, Generoso WM., Fundam Appl Toxicol 40(2), 1997
PMID: 9441715
Reproduction
Bronson, 1966
Functionality of the spindle checkpoint during the first meiotic division of mammalian oocytes.
Brunet S, Pahlavan G, Taylor S, Maro B., Reproduction 126(4), 2003
PMID: 14525526
Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect.
Buiting K, Gross S, Lich C, Gillessen-Kaesbach G, el-Maarri O, Horsthemke B., Am. J. Hum. Genet. 72(3), 2003
PMID: 12545427
Induction of translocations in mice by triethylenemelamine.
CATTANACH BM., Nature 180(4598), 1957
PMID: 13493527
Specific arrests of spermatogenesis in genetically modified and mutant mice.
de Rooij DG, de Boer P., Cytogenet. Genome Res. 103(3-4), 2003
PMID: 15051947
Long-term genetic effects of radiation exposure.
Dubrova YE., Mutat. Res. 544(2-3), 2003
PMID: 14644346
Monitoring of radiation-induced germline mutation in humans
Dubrova, Swiss Med. Weekly 133(), 2003
Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation.
Dubrova YE, Plumb M, Brown J, Fennelly J, Bois P, Goodhead D, Jeffreys AJ., Proc. Natl. Acad. Sci. U.S.A. 95(11), 1998
PMID: 9600951
Dominant lethal mutations in male mice.
Ehling UH., Arch. Toxicol. 38(1-2), 1977
PMID: 199138
Induction of gene mutations in germ cells of the mouse.
Ehling UH., Arch. Toxicol. 46(1-2), 1980
PMID: 7235989
From hazard identification to risk estimation of chemical mutagens
Ehling, 1982
Genetic risk assessment.
Ehling UH., Annu. Rev. Genet. 25(), 1991
PMID: 1812809
Procarbazine-induced specific-locus mutations in male mice.
Ehling UH, Neuhauser A., Mutat. Res. 59(2), 1979
PMID: 440322
Genetics of oocyte ageing.
Eichenlaub-Ritter U., Maturitas 30(2), 1998
PMID: 9871909
A sequential procedure for the detection of translocation heterozygotes in male mice
Generoso, Mutat. Res. 21(), 1973
Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death.
Generoso WM, Rutledge JC, Cain KT, Hughes LA, Braden PW., Mutat. Res. 176(2), 1987
PMID: 3807937
Mutagen-induced fetal anomalies and death following treatment of females within hours after mating.
Generoso WM, Rutledge JC, Cain KT, Hughes LA, Downing DJ., Mutat. Res. 199(1), 1988
PMID: 3362157
Concentration-response curves for ethylene-oxide-induced heritable translocations and dominant lethal mutations.
Generoso WM, Cain KT, Cornett CV, Cacheiro NL, Hughes LA., Environ. Mol. Mutagen. 16(2), 1990
PMID: 2209562
Developmental response of zygotes exposed to similar mutagens.
Generoso WM, Shourbaji AG, Piegorsch WW, Bishop JB., Mutat. Res. 250(1-2), 1991
PMID: 1944357
Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos.
Geuns E, De Rycke M, Van Steirteghem A, Liebaers I., Hum. Mol. Genet. 12(22), 2003
PMID: 14500540
Epigenetic reprogramming in mouse primordial germ cells.
Hajkova P, Erhardt S, Lane N, Haaf T, El-Maarri O, Reik W, Walter J, Surani MA., Mech. Dev. 117(1-2), 2002
PMID: 12204247
Sex matters in meiosis.
Hunt PA, Hassold TJ., Science 296(5576), 2002
PMID: 12077403
Female-specific dominant lethal effects in mice.
Katoh MA, Cain KT, Hughes LA, Foxworth LB, Bishop JB, Generoso WM., Mutat. Res. 230(2), 1990
PMID: 2374557
Reproductive epigenetics.
Kelly TL, Trasler JM., Clin. Genet. 65(4), 2004
PMID: 15025714
Meiotic micronuclei induced by X-rays in early spermatids of the rat.
Lahdetie J, Parvinen M., Mutat. Res. 81(1), 1981
PMID: 7254219
Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology.
Lucifero D, Chaillet JR, Trasler JM., Hum. Reprod. Update 10(1), 2004
PMID: 15005460
Mutation rates at a new set of specific loci in the mouse.
Lyon MF, Morris T., Genet. Res. 7(1), 1966
PMID: 5906488
Imprinting and assisted reproductive technology.
Maher ER., Hum. Mol. Genet. 14 Spec No 1(), 2005
PMID: 15809265
Preferential pericentric lesions and aneuploidy induced in mouse oocytes by the topoisomerase II inhibitor etoposide.
Mailhes JB, Marchetti F, Phillips GL Jr, Barnhill DR., Teratog., Carcinog. Mutagen. 14(1), 1994
PMID: 7910418
Differential diagnosis of hydrops fetalis.
Machin GA., Am. J. Med. Genet. 9(4), 1981
PMID: 6794370
The causes of malformations
Machin, 1991
PAINT/DAPI analysis of mouse zygotes to detect paternally transmitted chromosomal aberrations.
Marchetti F, Wyrobek AJ., Adv. Exp. Med. Biol. 518(), 2003
PMID: 12817682
Mechanisms and consequences of paternally-transmitted chromosomal abnormalities.
Marchetti F, Wyrobek AJ., Birth Defects Res. C Embryo Today 75(2), 2005
PMID: 16035041
Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse.
Marchetti F, Bishop JB, Lowe X, Generoso WM, Hozier J, Wyrobek AJ., Proc. Natl. Acad. Sci. U.S.A. 98(7), 2001
PMID: 11274416
Paternally transmitted chromosomal aberrations in mouse zygotes determine their embryonic fate.
Marchetti F, Bishop JB, Cosentino L, Moore D 2nd, Wyrobek AJ., Biol. Reprod. 70(3), 2003
PMID: 14585809
Spectrum of Bmp5 mutations from germline mutagenesis experiments in mice.
Marker PC, Seung K, Bland AE, Russell LB, Kingsley DM., Genetics 145(2), 1997
PMID: 9071596
Advances in the automated detection of metaphase chromosomes labeled with fluorescence dyes.
Mascio LN, Yuen BK, Kegelmeyer WP Jr, Matsumoto K, Briner J, Wyrobek AJ., Cytometry 33(1), 1998
PMID: 9725554
Spatial separation of parental genomes in preimplantation mouse embryos.
Mayer W, Smith A, Fundele R, Haaf T., J. Cell Biol. 148(4), 2000
PMID: 10684246
Remodelling the paternal chromatin at fertilization in mammals.
McLay DW, Clarke HJ., Reproduction 125(5), 2003
PMID: 12713425
Epigenetics and assisted reproductive technology: a call for investigation.
Niemitz EL, Feinberg AP., Am. J. Hum. Genet. 74(4), 2004
PMID: 14991528
The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis.
Odorisio T, Rodriguez TA, Evans EP, Clarke AR, Burgoyne PS., Nat. Genet. 18(3), 1998
PMID: 9500548
Micronucleus formation in 2-cell embryos after in vitro X-irradiation of mouse spermatozoa.
Pampfer S, Streffer C, Muller WU., Mutat. Res. 210(1), 1989
PMID: 2909867
Chromatin remodeling in mammalian zygotes.
Perreault SD., Mutat. Res. 296(1-2), 1992
PMID: 1279407
Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes.
Pogribny I, Raiche J, Slovack M, Kovalchuk O., Biochem. Biophys. Res. Commun. 320(4), 2004
PMID: 15249225
DNA methylation and human disease.
Robertson KD., Nat. Rev. Genet. 6(8), 2005
PMID: 16136652
Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes.
Roig I, Liebe B, Egozcue J, Cabero L, Garcia M, Scherthan H., Chromosoma 113(1), 2004
PMID: 15235794
Specific-locus mutation frequencies in mouse stem-cell spermatogonia at very low radiation dose rates.
Russell WL, Kelly EM., Proc. Natl. Acad. Sci. U.S.A. 79(2), 1982
PMID: 6952205
Spontaneous mutations recovered as mosaics in the mouse specific-locus test.
Russell LB, Russell WL., Proc. Natl. Acad. Sci. U.S.A. 93(23), 1996
PMID: 8917546
The mouse specific-locus test with agents other than radiations: interpretation of data and recommendations for future work.
Russell LB, Selby PB, von Halle E, Sheridan W, Valcovic L., Mutat. Res. 86(3), 1981
PMID: 7029264
Chlorambucil effectively induces deletion mutations in mouse germ cells.
Russell LB, Hunsicker PR, Cacheiro NL, Bangham JW, Russell WL, Shelby MD., Proc. Natl. Acad. Sci. U.S.A. 86(10), 1989
PMID: 2726748
Factors affecting the nature of induced mutations
Russell, 1990
Chlorambucil and bleomycin induce mutations in the specific-locus test in female mice.
Russell LB, Hunsicker PR, Shelby MD., Mutat. Res. 358(1), 1996
PMID: 8921974
Bleomycin, unlike other male-mouse mutagens, is most effective in spermatogonia, inducing primarily deletions.
Russell LB, Hunsicker PR, Kerley MK, Johnson DK, Shelby MD., Mutat. Res. 469(1), 2000
PMID: 10946246
X-ray-induced mutations in mice.
RUSSELL WL., Cold Spring Harb. Symp. Quant. Biol. 16(), 1951
PMID: 14942747
Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens.
Rutledge JC, Generoso WM, Shourbaji A, Cain KT, Gans M, Oliva J., Mutat. Res. 296(1-2), 1992
PMID: 1279403
Female-specific mutagenic response of mice to hycanthone.
Sudman PD, Generoso WM., Mutat. Res. 246(1), 1991
PMID: 1986266
Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes.
Sun F, Betzendahl I, Shen Y, Cortvrindt R, Smitz J, Eichenlaub-Ritter U., Mutagenesis 19(1), 2004
PMID: 14681309
In vivo transgenic mutation assays.
Thybaud V, Dean S, Nohmi T, de Boer J, Douglas GR, Glickman BW, Gorelick NJ, Heddle JA, Heflich RH, Lambert I, Martus HJ, Mirsalis JC, Suzuki T, Yajima N., Mutat. Res. 540(2), 2003
PMID: 14550498
Micronuclei and developmental abnormalities in 4-day mouse embryos after paternal treatment with acrylamide.
Titenko-Holland N, Ahlborn T, Lowe X, Shang N, Smith MT, Wyrobek AJ., Environ. Mol. Mutagen. 31(3), 1998
PMID: 9585259
Induction and transmission of chromosome aberrations in mouse oocytes after treatment with butadiene diepoxide.
Tiveron C, Ranaldi R, Bassani B, Pacchierotti F., Environ. Mol. Mutagen. 30(4), 1997
PMID: 9435881
Induction of micronuclei in human sperm-hamster egg hybrids at the two-cell stage after in vitro gamma-irradiation of human spermatozoa.
Tusell L, Alvarez R, Caballin MR, Genesca A, Miro R, Ribas M, Egozcue J., Environ. Mol. Mutagen. 26(4), 1995
PMID: 8575420
Ovarian follicle bioassay reveals adverse effects of diazepam exposure upon follicle development and oocyte quality.
Van Wemmel K, Gobbers E, Eichenlaub-Ritter U, Smitz J, Cortvrindt R., Reprod. Toxicol. 20(2), 2005
PMID: 15907652
Germline mutation induction at mouse repeat DNA loci by chemical mutagens.
Vilarino-Guell C, Smith AG, Dubrova YE., Mutat. Res. 526(1-2), 2003
PMID: 12714184
End-sequence profiling: sequence-based analysis of aberrant genomes.
Volik S, Zhao S, Chin K, Brebner JH, Herndon DR, Tao Q, Kowbel D, Huang G, Lapuk A, Kuo WL, Magrane G, De Jong P, Gray JW, Collins C., Proc. Natl. Acad. Sci. U.S.A. 100(13), 2003
PMID: 12788976
Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxymethylacrylamide in the mouse dominant lethal assay.
Witt KL, Hughes LA, Burka LT, McFee AF, Mathews JM, Black SL, Bishop JB., Environ. Mol. Mutagen. 41(2), 2003
PMID: 12605380

AUTHOR UNKNOWN, 0
A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells.
Yauk CL, Gingerich JD, Soper L, MacMahon A, Foster WG, Douglas GR., Mutat. Res. 578(1-2), 2005
PMID: 16039675
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