History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany)

Berg-Beckhoff G, Schuz J, Blettner M, Muenster E, Schlaefer K, Wahrendorf J, Schlehofer B (2009)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Berg-Beckhoff, GabrieleUniBi; Schuz, Joachim; Blettner, Maria; Muenster, Eva; Schlaefer, Klaus; Wahrendorf, Juergen; Schlehofer, Brigitte
Abstract / Bemerkung
The aim of the present analysis was to examine the association of a medical history of asthma, hay fever, eczema, or epilepsy with the risk of glioma and meningioma. Data of a German population-based case-control study included 381 meningioma cases, 366 glioma cases, and 1,494 controls. Participants' histories of asthma, hay fever, eczema, and epilepsy and the respective ages at onset were asked during a personal interview. A small inverse association between allergic condition and both glioma (odds ratio: 0.92; 95% CI: 0.70-1.22) and meningioma (odd ratio: 0.87; 95% CI: 0.66-1.14) was found. For glioma, this inverse association was more pronounced in persons reporting to have asthma compared to other allergic conditions. The positive association between epilepsy and particularly glioma suggests that epilepsy is an early symptom of the disease. As the association was seen also for epilepsies occurring more than a decade before the diagnosis of glioma, this might indicate either an aetiological role of epilepsy, or a relatively long preclinical phase. In conclusion our study confirms previous findings of case control studies but not those from cohort studies. However, possible selection bias in case control studies might not explain the different results in its entirety.
Epilepsy; Hay fever; Eczema; Glioma; Meningioma; Brain; tumour; Case control study; Allergy; Asthma
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Berg-Beckhoff G, Schuz J, Blettner M, et al. History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany). EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2009;24(8):433-440.
Berg-Beckhoff, G., Schuz, J., Blettner, M., Muenster, E., Schlaefer, K., Wahrendorf, J., & Schlehofer, B. (2009). History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany). EUROPEAN JOURNAL OF EPIDEMIOLOGY, 24(8), 433-440. https://doi.org/10.1007/s10654-009-9355-6
Berg-Beckhoff, G., Schuz, J., Blettner, M., Muenster, E., Schlaefer, K., Wahrendorf, J., and Schlehofer, B. (2009). History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany). EUROPEAN JOURNAL OF EPIDEMIOLOGY 24, 433-440.
Berg-Beckhoff, G., et al., 2009. History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany). EUROPEAN JOURNAL OF EPIDEMIOLOGY, 24(8), p 433-440.
G. Berg-Beckhoff, et al., “History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany)”, EUROPEAN JOURNAL OF EPIDEMIOLOGY, vol. 24, 2009, pp. 433-440.
Berg-Beckhoff, G., Schuz, J., Blettner, M., Muenster, E., Schlaefer, K., Wahrendorf, J., Schlehofer, B.: History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany). EUROPEAN JOURNAL OF EPIDEMIOLOGY. 24, 433-440 (2009).
Berg-Beckhoff, Gabriele, Schuz, Joachim, Blettner, Maria, Muenster, Eva, Schlaefer, Klaus, Wahrendorf, Juergen, and Schlehofer, Brigitte. “History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany)”. EUROPEAN JOURNAL OF EPIDEMIOLOGY 24.8 (2009): 433-440.

35 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma.
Fan HC, Chen CM, Chi CS, Tsai JD, Chiang KL, Chang YK, Lin SZ, Harn HJ., Int J Mol Sci 20(1), 2019
PMID: 30625996
Allergic Signs in Glioma Pathology: Current Knowledge and Future Perspectives.
Costanza M, Finocchiaro G., Cancers (Basel) 11(3), 2019
PMID: 30909395
Allergic conditions and risk of glioma and meningioma in the CERENAT case-control study.
Pouchieu C, Raherison C, Piel C, Migault L, Carles C, Fabbro-Perray P, Loiseau H, Guillamo JS, Lebailly P, Baldi I., J Neurooncol 138(2), 2018
PMID: 29500663
Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors.
Howell AE, Zheng J, Haycock PC, McAleenan A, Relton C, Martin RM, Kurian KM., Front Genet 9(), 2018
PMID: 30483309
Allergy reduces the risk of meningioma: a meta-analysis.
Wang PF, Ji WJ, Zhang XH, Li SW, Yan CX., Sci Rep 7(), 2017
PMID: 28071746
Allergy is associated with reduced risk of glioma: A meta-analysis.
Zhang C, Zhu QX., Allergol Immunopathol (Madr) 45(6), 2017
PMID: 28262389
Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study.
Amirian ES, Zhou R, Wrensch MR, Olson SH, Scheurer ME, Il'yasova D, Lachance D, Armstrong GN, McCoy LS, Lau CC, Claus EB, Barnholtz-Sloan JS, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Bernstein JL, Merrell RT, Davis FG, Lai R, Shete S, Amos CI, Melin BS, Bondy ML., Cancer Epidemiol Biomarkers Prev 25(2), 2016
PMID: 26908595
Association between cancer and allergies.
Kozłowska R, Bożek A, Jarząb J., Allergy Asthma Clin Immunol 12(), 2016
PMID: 27525013
Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma.
Wang G, Xu S, Cao C, Dong J, Chu Y, He G, Xu Z., Oncotarget 7(38), 2016
PMID: 27566584
Socioeconomic status and glioblastoma risk: a population-based analysis.
Porter AB, Lachance DH, Johnson DR., Cancer Causes Control 26(2), 2015
PMID: 25421378
Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk.
Guo J, Shi L, Li M, Xu J, Yan S, Zhang C, Sun G., Tumour Biol 35(1), 2014
PMID: 23979976
Allergic conditions reduce the risk of glioma: a meta-analysis based on 128,936 subjects.
Zhao H, Cai W, Su S, Zhi D, Lu J, Liu S., Tumour Biol 35(4), 2014
PMID: 24347487
A pilot case-cohort study of brain cancer in poultry and control workers.
Gandhi S, Felini MJ, Ndetan H, Cardarelli K, Jadhav S, Faramawi M, Johnson ES., Nutr Cancer 66(3), 2014
PMID: 24564367
Atopic conditions and brain tumor risk in children and adolescents--an international case-control study (CEFALO).
Shu X, Prochazka M, Lannering B, Schüz J, Röösli M, Tynes T, Kuehni CE, Andersen TV, Infanger D, Schmidt LS, Poulsen AH, Klaeboe L, Eggen T, Feychting M., Ann Oncol 25(4), 2014
PMID: 24608192
The epidemiology of glioma in adults: a "state of the science" review.
Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS., Neuro Oncol 16(7), 2014
PMID: 24842956
Drug allergy and the risk of lymph node metastasis in rectal cancer.
Gao C, Li JT, Fang L, Xu YY, Zhao HC., PLoS One 9(8), 2014
PMID: 25162236
Allergy and brain tumors in the INTERPHONE study: pooled results from Australia, Canada, France, Israel, and New Zealand.
Turner MC, Krewski D, Armstrong BK, Chetrit A, Giles GG, Hours M, McBride ML, Parent MÉ, Sadetzki S, Siemiatycki J, Woodward A, Cardis E., Cancer Causes Control 24(5), 2013
PMID: 23443320
Epidemiology: allergy history, IgE, and cancer.
Turner MC., Cancer Immunol Immunother 61(9), 2012
PMID: 22183126
Eosinophils in glioblastoma biology.
Curran CS, Bertics PJ., J Neuroinflammation 9(), 2012
PMID: 22251275
Asthma and risk of brain cancer in children.
Roncarolo F, Infante-Rivard C., Cancer Causes Control 23(4), 2012
PMID: 22367725
Epidemiology of meningioma in the United Kingdom.
Cea-Soriano L, Wallander MA, García Rodríguez LA., Neuroepidemiology 39(1), 2012
PMID: 22777495
Allergy and risk of glioma: a meta-analysis.
Chen C, Xu T, Chen J, Zhou J, Yan Y, Lu Y, Wu S., Eur J Neurol 18(3), 2011
PMID: 20722711
Assessment of type of allergy and antihistamine use in the development of glioma.
McCarthy BJ, Rankin K, Il'yasova D, Erdal S, Vick N, Ali-Osman F, Bigner DD, Davis F., Cancer Epidemiol Biomarkers Prev 20(2), 2011
PMID: 21300619
Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system.
Kohler BA, Ward E, McCarthy BJ, Schymura MJ, Ries LA, Eheman C, Jemal A, Anderson RN, Ajani UA, Edwards BK., J Natl Cancer Inst 103(9), 2011
PMID: 21454908
Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.
Wiemels JL, Wrensch M, Sison JD, Zhou M, Bondy M, Calvocoressi L, Black PM, Yu H, Schildkraut JM, Claus EB., Int J Cancer 129(8), 2011
PMID: 21520030
Inverse association between eczema and meningioma: a meta-analysis.
Wang M, Chen C, Qu J, Xu T, Lu Y, Chen J, Wu S., Cancer Causes Control 22(10), 2011
PMID: 21710191
Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort.
Schlehofer B, Siegmund B, Linseisen J, Schüz J, Rohrmann S, Becker S, Michaud D, Melin B, Bas Bueno-de-Mesquita H, Peeters PH, Vineis P, Tjonneland A, Olsen A, Overvad K, Romieu I, Boeing H, Aleksandrova K, Trichopoulou A, Bamia C, Lagiou P, Sacerdote C, Palli D, Panico S, Sieri S, Tumino R, Sanchez MJ, Rodriguez L, Dorronsoro M, Duell EJ, Chirlaque MD, Barricarte A, Borgquist S, Manjer J, Gallo V, Allen NE, Key TJ, Riboli E, Kaaks R, Wahrendorf J., Allergy 66(11), 2011
PMID: 21726235
Family and personal medical history and risk of meningioma.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M., J Neurosurg 115(6), 2011
PMID: 21780859
The Rotterdam Study: 2012 objectives and design update.
Hofman A, van Duijn CM, Franco OH, Ikram MA, Janssen HL, Klaver CC, Kuipers EJ, Nijsten TE, Stricker BH, Tiemeier H, Uitterlinden AG, Vernooij MW, Witteman JC., Eur J Epidemiol 26(8), 2011
PMID: 21877163
Eczema and cancer risk: a critical appraisal and review of the literature.
Wedgeworth E, Powell AM, Flohr C., Br J Dermatol 165(3), 2011
PMID: 21884041
Season of birth and risk for adult onset glioma.
Efird JT., Int J Environ Res Public Health 7(5), 2010
PMID: 20623001
Epidemiology and etiology of meningioma.
Wiemels J, Wrensch M, Claus EB., J Neurooncol 99(3), 2010
PMID: 20821343
The Generation R Study: design and cohort update 2010.
Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A., Eur J Epidemiol 25(11), 2010
PMID: 20967563
New studies, technology, and the progress of epidemiology.
Hofman A., Eur J Epidemiol 25(12), 2010
PMID: 21153562

31 References

Daten bereitgestellt von Europe PubMed Central.

ML, Cancer 113(Suppl. 7), 2008
Environmental risk factors for brain tumors.
Connelly JM, Malkin MG., Curr Neurol Neurosci Rep 7(3), 2007
PMID: 17488586
Epidemiology and etiology of gliomas.
Ohgaki H, Kleihues P., Acta Neuropathol. 109(1), 2005
PMID: 15685439

M, Neuro-oncol 4(), 2002
Epidemiology and etiology of intracranial meningiomas: a review.
Bondy M, Ligon BL., J. Neurooncol. 29(3), 1996
PMID: 8858525
Atopy and risk of brain tumors: a meta-analysis.
Linos E, Raine T, Alonso A, Michaud D., J. Natl. Cancer Inst. 99(20), 2007
PMID: 17925535
Allergic conditions and brain tumor risk.
Wigertz A, Lonn S, Schwartzbaum J, Hall P, Auvinen A, Christensen HC, Johansen C, Klaeboe L, Salminen T, Schoemaker MJ, Swerdlow AJ, Tynes T, Feychting M., Am. J. Epidemiol. 166(8), 2007
PMID: 17646205
Cohort studies of association between self-reported allergic conditions, immune-related diagnoses and glioma and meningioma risk.
Schwartzbaum J, Jonsson F, Ahlbom A, Preston-Martin S, Lonn S, Soderberg KC, Feychting M., Int. J. Cancer 106(3), 2003
PMID: 12845684
Incidence of cancer among patients with atopic dermatitis.
Hagstromer L, Ye W, Nyren O, Emtestam L., Arch Dermatol 141(9), 2005
PMID: 16172309
Cancer mortality among US men and women with asthma and hay fever.
Turner MC, Chen Y, Krewski D, Ghadirian P, Thun MJ, Calle EE., Am. J. Epidemiol. 162(3), 2005
PMID: 15987724
Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management.
van Breemen MS, Wilms EB, Vecht CJ., Lancet Neurol 6(5), 2007
PMID: 17434097
Role of medical history in brain tumour development. Results from the international adult brain tumour study.
Schlehofer B, Blettner M, Preston-Martin S, Niehoff D, Wahrendorf J, Arslan A, Ahlbom A, Choi WN, Giles GG, Howe GR, Little J, Menegoz F, Ryan P., Int. J. Cancer 82(2), 1999
PMID: 10389745
Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls.
Wrensch M, Lee M, Miike R, Newman B, Barger G, Davis R, Wiencke J, Neuhaus J., Am. J. Epidemiol. 145(7), 1997
PMID: 9098174
Prevalence and prognostic significance of epilepsy in patients with gliomas.
Lote K, Stenwig AE, Skullerud K, Hirschberg H., Eur. J. Cancer 34(1), 1998
PMID: 9624245
Prior hospitalization for epilepsy, diabetes, and stroke and subsequent glioma and meningioma risk.
Schwartzbaum J, Jonsson F, Ahlbom A, Preston-Martin S, Malmer B, Lonn S, Soderberg K, Feychting M., Cancer Epidemiol. Biomarkers Prev. 14(3), 2005
PMID: 15767344
The INTERPHONE study: design, epidemiological methods, and description of the study population.
Cardis E, Richardson L, Deltour I, Armstrong B, Feychting M, Johansen C, Kilkenny M, McKinney P, Modan B, Sadetzki S, Schuz J, Swerdlow A, Vrijheid M, Auvinen A, Berg G, Blettner M, Bowman J, Brown J, Chetrit A, Christensen HC, Cook A, Hepworth S, Giles G, Hours M, Iavarone I, Jarus-Hakak A, Klaeboe L, Krewski D, Lagorio S, Lonn S, Mann S, McBride M, Muir K, Nadon L, Parent ME, Pearce N, Salminen T, Schoemaker M, Schlehofer B, Siemiatycki J, Taki M, Takebayashi T, Tynes T, van Tongeren M, Vecchia P, Wiart J, Woodward A, Yamaguchi N., Eur. J. Epidemiol. 22(9), 2007
PMID: 17636416
Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany).
Schuz J, Bohler E, Berg G, Schlehofer B, Hettinger I, Schlaefer K, Wahrendorf J, Kunna-Grass K, Blettner M., Am. J. Epidemiol. 163(6), 2006
PMID: 16443797
Reduced immunoglobulin E and allergy among adults with glioma compared with controls.
Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barger G, Wrensch M., Cancer Res. 64(22), 2004
PMID: 15548720
History of allergies among adults with glioma and controls.
Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M., Int. J. Cancer 98(4), 2002
PMID: 11920623
History of allergies and autoimmune diseases and risk of brain tumors in adults.
Brenner AV, Linet MS, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD., Int. J. Cancer 99(2), 2002
PMID: 11979441
Nonoccupational risk indicators of glioblastoma in adults.
Hochberg F, Toniolo P, Cole P, Salcman M., J. Neurooncol. 8(1), 1990
PMID: 2319291
History of allergies and risk of glioma in adults.
Schoemaker MJ, Swerdlow AJ, Hepworth SJ, McKinney PA, van Tongeren M, Muir KR., Int. J. Cancer 119(9), 2006
PMID: 16823851
Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.
Schwartzbaum J, Ahlbom A, Malmer B, Lonn S, Brookes AJ, Doss H, Debinski W, Henriksson R, Feychting M., Cancer Res. 65(14), 2005
PMID: 16024651
An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.
Schwartzbaum JA, Ahlbom A, Lonn S, Malmer B, Wigertz A, Auvinen A, Brookes AJ, Collatz Christensen H, Henriksson R, Johansen C, Salminen T, Schoemaker MJ, Swerdlow AJ, Debinski W, Feychting M., Cancer Epidemiol. Biomarkers Prev. 16(11), 2007
PMID: 18006935
Long-term anti-inflammatory and antihistamine medication use and adult glioma risk.
Scheurer ME, El-Zein R, Thompson PA, Aldape KD, Levin VA, Gilbert MR, Weinberg JS, Bondy ML., Cancer Epidemiol. Biomarkers Prev. 17(5), 2008
PMID: 18483351

JL, Cancer Epidemiol Biomarker Prev 16(), 2007
Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma.
Brenner AV, Butler MA, Wang SS, Ruder AM, Rothman N, Schulte PA, Chanock SJ, Fine HA, Linet MS, Inskip PD., Carcinogenesis 28(12), 2007
PMID: 17916900
History of allergic disease and risk of meningioma.
Schoemaker MJ, Swerdlow AJ, Hepworth SJ, van Tongeren M, Muir KR, McKinney PA., Am. J. Epidemiol. 165(5), 2006
PMID: 17182979

E, Gesundheitswesen 61(), 1999


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