Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart

Gawlowski T, Stratmann B, Stork I, Engelbrecht B, Brodehl A, Niehaus K, Koerfer R, Tschoepe D, Milting H (2009)
Hormone and Metabolic Research 41(08): 594-599.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Chronic conditions like diabetes mellitus (DM) leading to altered metabolism might cause cardiac dysfunction. Hyperglycemia plays an important role in the pathogenesis of diabetic complications including accumulation of methylglyoxal (MG), a highly reactive alpha-dicarbonyl metabolite of glucose degradation pathways and increased generation of advanced glycation endproducts (AGEs). The aim of this investigation was to study the extent of the MG-modification argpyrimidine in human diabetic heart and in rat cardiomyoblasts grown under hyperglycemic conditions. Left ventricular myocardial samples from explanted hearts of patients with cardiomyopathy with (n=8) or without DM (n=8) as well as nonfailing donor organs (n=6), and rat cardiac myoblasts H9c2 treated with glucose were screened for the MG-modification argpyrimidine. The small heat shock protein 27 (Hsp27) revealed to be the major argpyrimidine containing protein in cardiac tissue. Additionally, the modification of arginine leading to argpyrimidine and the phosphorylation of Hsp27 are increased in the myocardium of patients with DM. In H9c2 cells hyperglycemia leads to a decrease of the Hsp27-expression and an increase in argpyrimidine content and phosphorylation of Hsp27, which was accompanied by the induction of oxidative stress and apoptosis. This study shows an association between diabetes and increased argpyrimidine-modification of myocardial Hsp27, a protein which is involved in apoptosis, oxidative stress, and cytoskeleton stabilization.
Stichworte
methylglyoxal; argpyrimidine; heart failure; Hsp27; diabetes mellitus
Erscheinungsjahr
2009
Zeitschriftentitel
Hormone and Metabolic Research
Band
41
Ausgabe
08
Seite(n)
594-599
ISSN
0018-5043
eISSN
1439-4286
Page URI
https://pub.uni-bielefeld.de/record/1591138

Zitieren

Gawlowski T, Stratmann B, Stork I, et al. Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research. 2009;41(08):594-599.
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, K., Koerfer, R., et al. (2009). Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research, 41(08), 594-599. doi:10.1055/s-0029-1216374
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, K., Koerfer, R., Tschoepe, D., and Milting, H. (2009). Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research 41, 594-599.
Gawlowski, T., et al., 2009. Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research, 41(08), p 594-599.
T. Gawlowski, et al., “Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart”, Hormone and Metabolic Research, vol. 41, 2009, pp. 594-599.
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, K., Koerfer, R., Tschoepe, D., Milting, H.: Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research. 41, 594-599 (2009).
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, Karsten, Koerfer, R., Tschoepe, D., and Milting, H. “Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart”. Hormone and Metabolic Research 41.08 (2009): 594-599.

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