Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons

Kurtz R, Beckers U, Hundsdoerfer B, Egelhaaf M (2009)
European Journal of Neuroscience 30(4): 567-577.

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In many neurons, strong excitatory stimulation causes an after-hyperpolarization (AHP) at stimulus offset, which might give rise to activity-dependent adaptation. Graded-potential visual motion-sensitive neurons of the fly Calliphora vicina respond with depolarization and hyperpolarization during motion in their preferred direction and their anti-preferred direction, respectively. A prominent after-response, opposite in sign to the response during motion, is selectively expressed after stimulation with preferred-direction motion. Previous findings suggested that this AHP is generated in the motion-sensitive neurons themselves rather than in presynaptic processing layers. However, it remained unknown whether the AHP is caused by membrane depolarization itself or by another process, e.g. a signaling cascade triggered by activity of excitatory input channels. Here we showed by current injections and voltage clamp that the AHP and a corresponding current are generated directly by depolarization. To test whether the generation of an AHP is linked to depolarization via a Ca(2+)-dependent mechanism, we used photoactivation of a high-affinity Ca(2+) buffer. In accordance with previous findings the AHP was insensitive to manipulation of cytosolic Ca(2+). We propose that membrane depolarization presents a more direction-selective mechanism for the control of AHP than other potential control parameters.
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European Journal of Neuroscience
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30
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4
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567-577
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Kurtz R, Beckers U, Hundsdoerfer B, Egelhaaf M. Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience. 2009;30(4):567-577.
Kurtz, R., Beckers, U., Hundsdoerfer, B., & Egelhaaf, M. (2009). Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience, 30(4), 567-577. doi:10.1111/j.1460-9568.2009.06854.x
Kurtz, R., Beckers, U., Hundsdoerfer, B., and Egelhaaf, M. (2009). Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience 30, 567-577.
Kurtz, R., et al., 2009. Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience, 30(4), p 567-577.
R. Kurtz, et al., “Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons”, European Journal of Neuroscience, vol. 30, 2009, pp. 567-577.
Kurtz, R., Beckers, U., Hundsdoerfer, B., Egelhaaf, M.: Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience. 30, 567-577 (2009).
Kurtz, Rafael, Beckers, Ulrich, Hundsdoerfer, Benjamin, and Egelhaaf, Martin. “Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons”. European Journal of Neuroscience 30.4 (2009): 567-577.
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