Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes

Vogt E, Kipp A, Eichenlaub-Ritter U (2009)
REPRODUCTIVE BIOMEDICINE ONLINE 19(3): 352-368.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ;
Abstract / Bemerkung
Aurora kinases comprise a family of phosphoproteins performing multiple functions in mitosis and meiosis. Because Aurora kinase B (AURKB) expression is altered in aged oocytes and there is only limited information on its function in meiosis, it was decided to study the spatial distribution and co-localization of AURKB with other regulatory proteins at centromeres during mouse oocyte maturation. AURKB associates with chromosomes after germinal vesicle breakdown, is enriched at centromeres from prometaphase I and transits to the spindle midzone at late anaphase I. Preferential inhibition of AURKB by low concentrations of ZM 447439 inhibitor prevents polar body formation and affects spindle formation and chromosome congression at meiosis I, associated with expression of BubR1 checkpoint protein at kinetochores. Release of cohesion between sister chromatids appears inhibited resulting in failure of chiasma resolution in oocytes progressing to anaphase I. Concomitantly, the inhibitor reduces histone H3 lysine 9 trimethylation at centromeric heterochromatin and affects chromosome condensation. The cytokinesis arrest protects young, healthy oocytes from errors in chromosome segregation although increasing polyploidy. This study shows that changes in activity of AURKB may increase risks for chromosome non-disjunction and aneuploidy in mammalian oocytes, irrespective of age.
Erscheinungsjahr
Zeitschriftentitel
REPRODUCTIVE BIOMEDICINE ONLINE
Band
19
Ausgabe
3
Seite(n)
352-368
ISSN
PUB-ID

Zitieren

Vogt E, Kipp A, Eichenlaub-Ritter U. Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes. REPRODUCTIVE BIOMEDICINE ONLINE. 2009;19(3):352-368.
Vogt, E., Kipp, A., & Eichenlaub-Ritter, U. (2009). Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes. REPRODUCTIVE BIOMEDICINE ONLINE, 19(3), 352-368. doi:10.1016/S1472-6483(10)60169-1
Vogt, E., Kipp, A., and Eichenlaub-Ritter, U. (2009). Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes. REPRODUCTIVE BIOMEDICINE ONLINE 19, 352-368.
Vogt, E., Kipp, A., & Eichenlaub-Ritter, U., 2009. Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes. REPRODUCTIVE BIOMEDICINE ONLINE, 19(3), p 352-368.
E. Vogt, A. Kipp, and U. Eichenlaub-Ritter, “Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes”, REPRODUCTIVE BIOMEDICINE ONLINE, vol. 19, 2009, pp. 352-368.
Vogt, E., Kipp, A., Eichenlaub-Ritter, U.: Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes. REPRODUCTIVE BIOMEDICINE ONLINE. 19, 352-368 (2009).
Vogt, E., Kipp, Alexandra, and Eichenlaub-Ritter, Ursula. “Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes”. REPRODUCTIVE BIOMEDICINE ONLINE 19.3 (2009): 352-368.

30 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.
Nguyen AL, Marin D, Zhou A, Gentilello AS, Smoak EM, Cao Z, Fedick A, Wang Y, Taylor D, Scott RT, Xing J, Treff N, Schindler K., Mol Hum Reprod 23(6), 2017
PMID: 28369513
PGRMC1 participates in late events of bovine granulosa cells mitosis and oocyte meiosis.
Terzaghi L, Tessaro I, Raucci F, Merico V, Mazzini G, Garagna S, Zuccotti M, Franciosi F, Lodde V., Cell Cycle 15(15), 2016
PMID: 27260975
Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes.
Demond H, Trapphoff T, Dankert D, Heiligentag M, Grümmer R, Horsthemke B, Eichenlaub-Ritter U., PLoS One 11(9), 2016
PMID: 27611906
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
Porcelli L, Guida G, Quatrale AE, Cocco T, Sidella L, Maida I, Iacobazzi RM, Ferretta A, Stolfa DA, Strippoli S, Guida S, Tommasi S, Guida M, Azzariti A., J Transl Med 13(), 2015
PMID: 25623468
Nucleosome functions in spindle assembly and nuclear envelope formation.
Zierhut C, Funabiki H., Bioessays 37(10), 2015
PMID: 26222742
Post-ovulatory ageing of mouse oocytes affects the distribution of specific spindle-associated proteins and Akt expression levels.
Cecconi S, Rossi G, Deldar H, Cellini V, Patacchiola F, Carta G, Macchiarelli G, Canipari R., Reprod Fertil Dev 26(4), 2014
PMID: 23622715
SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging.
Di Emidio G, Falone S, Vitti M, D'Alessandro AM, Vento M, Di Pietro C, Amicarelli F, Tatone C., Hum Reprod 29(9), 2014
PMID: 24963165
The impact of vitrification on murine germinal vesicle oocyte In vitro maturation and aurora kinase A protein expression.
Doyle JO, Lee HJ, Selesniemi K, Styer AK, Rueda BR., J Assist Reprod Genet 31(12), 2014
PMID: 25318984
Mutation screening of AURKB and SYCP3 in patients with reproductive problems.
López-Carrasco A, Oltra S, Monfort S, Mayo S, Roselló M, Martínez F, Orellana C., Mol Hum Reprod 19(2), 2013
PMID: 23100464
Spindle assembly checkpoint and its regulators in meiosis.
Sun SC, Kim NH., Hum Reprod Update 18(1), 2012
PMID: 22086113
Translation of incenp during oocyte maturation is required for embryonic development in Xenopus laevis.
Leblond GG, Sarazin H, Li R, Suzuki M, Ueno N, Liu XJ., Biol Reprod 86(5), 2012
PMID: 22378760
Polar body emission.
Liu XJ., Cytoskeleton (Hoboken) 69(10), 2012
PMID: 22730245
Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development.
Schindler K, Davydenko O, Fram B, Lampson MA, Schultz RM., Proc Natl Acad Sci U S A 109(33), 2012
PMID: 22778418
Environmental hazard in the aetiology of somatic and germ cell aneuploidy.
Pacchierotti F, Eichenlaub-Ritter U., Cytogenet Genome Res 133(2-4), 2011
PMID: 21228560
Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer.
Azzariti A, Bocci G, Porcelli L, Fioravanti A, Sini P, Simone GM, Quatrale AE, Chiarappa P, Mangia A, Sebastian S, Del Bufalo D, Del Tacca M, Paradiso A., Br J Cancer 104(5), 2011
PMID: 21304529
A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development.
Avo Santos M, van de Werken C, de Vries M, Jahr H, Vromans MJ, Laven JS, Fauser BC, Kops GJ, Lens SM, Baart EB., Hum Reprod 26(7), 2011
PMID: 21493633
Gamete competence assessment by polarizing optics in assisted reproduction.
Montag M, Köster M, van der Ven K, van der Ven H., Hum Reprod Update 17(5), 2011
PMID: 21531752
MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.
Vogt E, Sanhaji M, Klein W, Seidel T, Wordeman L, Eichenlaub-Ritter U., Mol Hum Reprod 16(9), 2010
PMID: 20406800
The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.
Sharif B, Na J, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM, Zernicka-Goetz M., J Cell Sci 123(pt 24), 2010
PMID: 21123620

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 19778480
PubMed | Europe PMC

arXiv: hep-th/9307195

Suchen in

Google Scholar