Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)

Mbaze LM'a, Lado JA, Wansi J, Shiao TC, Chiozem DD, Mesaik MA, Choudhary MI, Lacaille-Dubois M-A, Wandji J, Roy R, Sewald N (2009)
Phytochemistry 70(11-12): 1442-1447.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Mbaze, Luc Meva'a; Lado, Jean Alexandre; Wansi, JeanUniBi; Shiao, Tze Chieh; Chiozem, David Dako; Mesaik, Muhammad Ahmed; Choudhary, Muhammad Iqbal; Lacaille-Dubois, Marie-Aleth; Wandji, Jean; Roy, Rene; Sewald, NorbertUniBi
Einrichtung
Centrum für Biotechnologie > Arbeitsgruppe N. Sewald
Centrum für Biotechnologie > Institut für Biochemie und Biotechnik
Fakultät für Chemie > Organische Chemie III
Abstract / Bemerkung
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC50 = 2.0-6.5 mu M, but no cytotoxic effect was observed (IC50 > 100 mu M). (C) 2009 Elsevier Ltd. All rights reserved.
Stichworte
Oxidative burst; Lignans; Phenylethanoids; Fagara heitzii; Amides; Cytotoxicity; inhibition
Erscheinungsjahr
2009
Zeitschriftentitel
Phytochemistry
Band
70
Ausgabe
11-12
Seite(n)
1442-1447
ISSN
0031-9422
Page URI
https://pub.uni-bielefeld.de/record/1589913

Zitieren

Mbaze LM'a, Lado JA, Wansi J, et al. Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). Phytochemistry. 2009;70(11-12):1442-1447.
Mbaze, L. M. 'a, Lado, J. A., Wansi, J., Shiao, T. C., Chiozem, D. D., Mesaik, M. A., Choudhary, M. I., et al. (2009). Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). Phytochemistry, 70(11-12), 1442-1447. https://doi.org/10.1016/j.phytochem.2009.08.007
Mbaze, Luc Meva'a, Lado, Jean Alexandre, Wansi, Jean, Shiao, Tze Chieh, Chiozem, David Dako, Mesaik, Muhammad Ahmed, Choudhary, Muhammad Iqbal, et al. 2009. “Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)”. Phytochemistry 70 (11-12): 1442-1447.
Mbaze, L. M. 'a, Lado, J. A., Wansi, J., Shiao, T. C., Chiozem, D. D., Mesaik, M. A., Choudhary, M. I., Lacaille-Dubois, M. - A., Wandji, J., Roy, R., et al. (2009). Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). Phytochemistry 70, 1442-1447.
Mbaze, L.M.'a, et al., 2009. Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). Phytochemistry, 70(11-12), p 1442-1447.
L.M.'a Mbaze, et al., “Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)”, Phytochemistry, vol. 70, 2009, pp. 1442-1447.
Mbaze, L.M.'a, Lado, J.A., Wansi, J., Shiao, T.C., Chiozem, D.D., Mesaik, M.A., Choudhary, M.I., Lacaille-Dubois, M.-A., Wandji, J., Roy, R., Sewald, N.: Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). Phytochemistry. 70, 1442-1447 (2009).
Mbaze, Luc Meva'a, Lado, Jean Alexandre, Wansi, Jean, Shiao, Tze Chieh, Chiozem, David Dako, Mesaik, Muhammad Ahmed, Choudhary, Muhammad Iqbal, Lacaille-Dubois, Marie-Aleth, Wandji, Jean, Roy, Rene, and Sewald, Norbert. “Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)”. Phytochemistry 70.11-12 (2009): 1442-1447.

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