Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)

Mbaze LM'a, Lado JA, Wansi J, Shiao TC, Chiozem DD, Mesaik MA, Choudhary MI, Lacaille-Dubois M-A, Wandji J, Roy R, Sewald N (2009)
PHYTOCHEMISTRY 70(11-12): 1442-1447.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ; ; ; ; ;
Abstract / Bemerkung
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC50 = 2.0-6.5 mu M, but no cytotoxic effect was observed (IC50 > 100 mu M). (C) 2009 Elsevier Ltd. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
PHYTOCHEMISTRY
Band
70
Ausgabe
11-12
Seite(n)
1442-1447
ISSN
PUB-ID

Zitieren

Mbaze LM'a, Lado JA, Wansi J, et al. Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). PHYTOCHEMISTRY. 2009;70(11-12):1442-1447.
Mbaze, L. M. 'a, Lado, J. A., Wansi, J., Shiao, T. C., Chiozem, D. D., Mesaik, M. A., Choudhary, M. I., et al. (2009). Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). PHYTOCHEMISTRY, 70(11-12), 1442-1447. doi:10.1016/j.phytochem.2009.08.007
Mbaze, L. M. 'a, Lado, J. A., Wansi, J., Shiao, T. C., Chiozem, D. D., Mesaik, M. A., Choudhary, M. I., Lacaille-Dubois, M. - A., Wandji, J., Roy, R., et al. (2009). Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). PHYTOCHEMISTRY 70, 1442-1447.
Mbaze, L.M.'a, et al., 2009. Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). PHYTOCHEMISTRY, 70(11-12), p 1442-1447.
L.M.'a Mbaze, et al., “Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)”, PHYTOCHEMISTRY, vol. 70, 2009, pp. 1442-1447.
Mbaze, L.M.'a, Lado, J.A., Wansi, J., Shiao, T.C., Chiozem, D.D., Mesaik, M.A., Choudhary, M.I., Lacaille-Dubois, M.-A., Wandji, J., Roy, R., Sewald, N.: Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). PHYTOCHEMISTRY. 70, 1442-1447 (2009).
Mbaze, Luc Meva'a, Lado, Jean Alexandre, Wansi, Jean, Shiao, Tze Chieh, Chiozem, David Dako, Mesaik, Muhammad Ahmed, Choudhary, Muhammad Iqbal, Lacaille-Dubois, Marie-Aleth, Wandji, Jean, Roy, Rene, and Sewald, Norbert. “Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)”. PHYTOCHEMISTRY 70.11-12 (2009): 1442-1447.

12 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Synthetic studies on optically active furofuran and diarylbutane lignans.
Mori N., Biosci Biotechnol Biochem 82(1), 2018
PMID: 29207906
Experimental study of the anti-tumour activity and pharmacokinetics of arctigenin and its valine ester derivative.
Cai E, Song X, Han M, Yang L, Zhao Y, Li W, Han J, Tu S., Sci Rep 8(1), 2018
PMID: 29459629
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis.
Kärkäs MD, Porco JA, Stephenson CR., Chem Rev 116(17), 2016
PMID: 27120289
Identification of chemical constituents of Zanthoxylum heitzii stem bark and their insecticidal activity against the malaria mosquito Anopheles gambiae.
Moussavi N, Malterud KE, Mikolo B, Dawes D, Chandre F, Corbel V, Massamba D, Overgaard HJ, Wangensteen H., Parasit Vectors 8(), 2015
PMID: 26427956
Insecticidal activities of bark, leaf and seed extracts of Zanthoxylum heitzii against the African malaria vector Anopheles gambiae.
Overgaard HJ, Sirisopa P, Mikolo B, Malterud KE, Wangensteen H, Zou YF, Paulsen BS, Massamba D, Duchon S, Corbel V, Chandre F., Molecules 19(12), 2014
PMID: 25525826
The in vitro antisickling and antioxidant effects of aqueous extracts Zanthoxyllum heitzii on sickle cell disorder.
Pauline N, Cabral BN, Anatole PC, Jocelyne AM, Bruno M, Jeanne NY., BMC Complement Altern Med 13(), 2013
PMID: 23829696
Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides.
Boonen J, Bronselaer A, Nielandt J, Veryser L, De Tré G, De Spiegeleer B., J Ethnopharmacol 142(3), 2012
PMID: 22659196
Radical cation Diels-Alder cycloadditions by visible light photocatalysis.
Lin S, Ischay MA, Fry CG, Yoon TP., J Am Chem Soc 133(48), 2011
PMID: 22032252

23 References

Daten bereitgestellt von Europe PubMed Central.

New phenylethanoids from Buddleja cordata subsp. cordata.
Acevedo L, Martinez E, Castaneda P, Franzblau S, Timmermann BN, Linares E, Bye R, Mata R., Planta Med. 66(3), 2000
PMID: 10821053

AUTHOR UNKNOWN, 0

Asuman, 1984
A Contribution to the Phytochemistry of Zanthoxylum tessmannii1.
Ayofor JF, Ngadjui BT, Sondengam BL, Tsamo E., Planta Med. 50(3), 1984
PMID: 17340299
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.
Bartlett RR, Dimitrijevic M, Mattar T, Zielinski T, Germann T, Rude E, Thoenes GH, Kuchle CC, Schorlemmer HU, Bremer E., Agents Actions 32(1-2), 1991
PMID: 2058454
Constituents of Zanthoxylum heitzii
Bongui, Biochem. Syst. Ecol. 33(), 2005
Antifungal and antioxidant compounds from the root bark of Fagara zanthoxyloides.
Chaaib F, Queiroz EF, Ndjoko K, Diallo D, Hostettmann K., Planta Med. 69(4), 2003
PMID: 12709897
A new Flavonoid and other new components from Citrus plants
Chihiro, Chem. Pharmacol. Bull. 36(), 1988
Piperaceae alkaloids: Part IV structure and synthesis of cyclostachine A, cyclostachine B and cyclopiperstachine
Joshi, Helv. Chim. Acta 58(), 1975
Molluscicidal and insecticidal activities of isobutylamides isolated from Fagara macrophylla
Kubo, Experentia 40(), 1984
alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).
Mbaze LM, Poumale HM, Wansi JD, Lado JA, Khan SN, Iqbal MC, Ngadjui BT, Laatsch H., Phytochemistry 68(5), 2007
PMID: 17270224
Lignans and other constituents of Zanthoxylum heitzii
Ngouela, Phytochemistry 37(), 1994
A new phthalide and xanthones from Anthocleista djalonensis and Anthocleista vogelli
Okorie, Phytochemistry 15(), 1976
Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense.
Portet B, Fabre N, Roumy V, Gornitzka H, Bourdy G, Chevalley S, Sauvain M, Valentin A, Moulis C., Phytochemistry 68(9), 2007
PMID: 17397884
Flindersine from Fagara heitzii
Saboor, J. Nat. Prod. 47(), 1984
A Swedish collection of medicinal plants from Cameroon.
Sandberg F, Perera-Ivarsson P, El-Seedi HR., J Ethnopharmacol 102(3), 2005
PMID: 16098698

AUTHOR UNKNOWN, 0
New Novel synthesis and antibacterial activity of 1-(substituted phenyl)-2-phenyl-4-(3′-halo, 4′-hydroxy 5′-methoxy benzylidene)-imidazole-5-ones
Siddiqui, Bull. Korean Chem. Soc. 9(), 2001
Fatty acid esters of triterpenoids and steroid glycosides from Gambeya africana.
Wandji J, Tillequin F, Mulholland DA, Wansi JD, Fomum TZ, Fuendjiep V, Libot F, Tsabang N., Planta Med. 68(9), 2002
PMID: 12357395
Nigramides A-S, dimeric amide alkaloids from the roots of Piper nigrum.
Wei K, Li W, Koike K, Chen Y, Nikaido T., J. Org. Chem. 70(4), 2005
PMID: 15704948
Cytotoxicity of labdane-type diterpenoids from Hedychium forrestii.
Zhao Q, Qing C, Hao XJ, Han J, Zuo GY, Zou C, Xu GL., Chem. Pharm. Bull. 56(2), 2008
PMID: 18239312
In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria.
Zirihi GN, Mambu L, Guede-Guina F, Bodo B, Grellier P., J Ethnopharmacol 98(3), 2005
PMID: 15814260

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 19747699
PubMed | Europe PMC

Suchen in

Google Scholar