Neural circuits of hierarchical visuo-spatial sequence processing

Bahlmann J, Schubotz RI, Mueller JL, Koester D, Friederici AD (2009)
Brain Research 1298: 161-170.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Bahlmann, Joerg; Schubotz, Ricarda I.; Mueller, Jutta L.; Koester, DirkUniBi ; Friederici, Angela D.
Abstract / Bemerkung
Sequence processing has been investigated in a number of studies using serial reaction time tasks or simple artificial grammar tasks. Little, however, is known about higher-order sequence processing entailing the hierarchical organization of events. Here, we manipulated the regularities within sequentially occurring, non-linguistic visual symbols by applying two types of prediction rules. In one rule (the adjacent dependency rule), the sequences consisted of alternating items from two different categories. In the second rule (the hierarchical dependency rule), a hierarchical structure was generated using the same set of item types. Thus, predictions about non-adjacent elements were required for the latter rule. Functional Magnetic Resonance Imaging (fMRI) was used to investigate the neural correlates of the application of the two prediction rules. We found that the hierarchical dependency rule correlated with activity in the pre-supplementary motor area, and the head of the caudate nucleus. in addition, in a hypothesis-driven ROI analysis in Broca's area (BA 44), we found a significantly higher hemodynamic response to the hierarchical dependency rule than to the adjacent dependency rule. These results suggest that this neural network supports hierarchical sequencing, possibly contributing to the integration of sequential elements into higher-order structural events. Importantly, the findings suggest that Broca's area is also engaged in hierarchical sequencing in domains other than language. (C) 2009 Elsevier B.V. All rights reserved.
Visual sequence processing; Hierarchy; Pre-SMA; Broca's area; fMRI
Brain Research
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Bahlmann J, Schubotz RI, Mueller JL, Koester D, Friederici AD. Neural circuits of hierarchical visuo-spatial sequence processing. Brain Research. 2009;1298:161-170.
Bahlmann, J., Schubotz, R. I., Mueller, J. L., Koester, D., & Friederici, A. D. (2009). Neural circuits of hierarchical visuo-spatial sequence processing. Brain Research, 1298, 161-170.
Bahlmann, Joerg, Schubotz, Ricarda I., Mueller, Jutta L., Koester, Dirk, and Friederici, Angela D. 2009. “Neural circuits of hierarchical visuo-spatial sequence processing”. Brain Research 1298: 161-170.
Bahlmann, J., Schubotz, R. I., Mueller, J. L., Koester, D., and Friederici, A. D. (2009). Neural circuits of hierarchical visuo-spatial sequence processing. Brain Research 1298, 161-170.
Bahlmann, J., et al., 2009. Neural circuits of hierarchical visuo-spatial sequence processing. Brain Research, 1298, p 161-170.
J. Bahlmann, et al., “Neural circuits of hierarchical visuo-spatial sequence processing”, Brain Research, vol. 1298, 2009, pp. 161-170.
Bahlmann, J., Schubotz, R.I., Mueller, J.L., Koester, D., Friederici, A.D.: Neural circuits of hierarchical visuo-spatial sequence processing. Brain Research. 1298, 161-170 (2009).
Bahlmann, Joerg, Schubotz, Ricarda I., Mueller, Jutta L., Koester, Dirk, and Friederici, Angela D. “Neural circuits of hierarchical visuo-spatial sequence processing”. Brain Research 1298 (2009): 161-170.

48 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

The right inferior frontal gyrus processes nested non-local dependencies in music.
Cheung VKM, Meyer L, Friederici AD, Koelsch S., Sci Rep 8(1), 2018
PMID: 29491454
Conserved Sequence Processing in Primate Frontal Cortex.
Wilson B, Marslen-Wilson WD, Petkov CI., Trends Neurosci 40(2), 2017
PMID: 28063612
Left posterior inferior frontal gyrus is causally involved in reordering during sentence processing.
Kuhnke P, Meyer L, Friederici AD, Hartwigsen G., Neuroimage 148(), 2017
PMID: 28069544
A revival of Homo loquens as a builder of labeled structures: Neurocognitive considerations.
Goucha T, Zaccarella E, Friederici AD., Neurosci Biobehav Rev 81(pt b), 2017
PMID: 28318539
Social Interaction Affects Neural Outcomes of Sign Language Learning As a Foreign Language in Adults.
Yusa N, Kim J, Koizumi M, Sugiura M, Kawashima R., Front Hum Neurosci 11(), 2017
PMID: 28408872
Learning Predictive Statistics: Strategies and Brain Mechanisms.
Wang R, Shen Y, Tino P, Welchman AE, Kourtzi Z., J Neurosci 37(35), 2017
PMID: 28760866
Neuronal bases of structural coherence in contemporary dance observation.
Bachrach A, Jola C, Pallier C., Neuroimage 124(pt a), 2016
PMID: 26348557
Disruption of Broca's Area Alters Higher-order Chunking Processing during Perceptual Sequence Learning.
Alamia A, Solopchuk O, D'Ausilio A, Van Bever V, Fadiga L, Olivier E, Zénon A., J Cogn Neurosci 28(3), 2016
PMID: 26765778
How the brain attunes to sentence processing: Relating behavior, structure, and function.
Fengler A, Meyer L, Friederici AD., Neuroimage 129(), 2016
PMID: 26777477
Fronto-Parietal Contributions to Phonological Processes in Successful Artificial Grammar Learning.
Goranskaya D, Kreitewolf J, Mueller JL, Friederici AD, Hartwigsen G., Front Hum Neurosci 10(), 2016
PMID: 27877120
Degree of automaticity and the prefrontal cortex.
Jeon HA, Friederici AD., Trends Cogn Sci 19(5), 2015
PMID: 25843542
Artificial grammar learning in individuals with severe aphasia.
Zimmerer VC, Cowell PE, Varley RA., Neuropsychologia 53(), 2014
PMID: 24184437
Chunking dynamics: heteroclinics in mind.
Rabinovich MI, Varona P, Tristan I, Afraimovich VS., Front Comput Neurosci 8(), 2014
PMID: 24672469
Fractal image perception provides novel insights into hierarchical cognition.
Martins MJ, Fischmeister FP, Puig-Waldmüller E, Oh J, Geissler A, Robinson S, Fitch WT, Beisteiner R., Neuroimage 96(), 2014
PMID: 24699014
Hierarchical processing in music, language, and action: Lashley revisited.
Fitch WT, Martins MD., Ann N Y Acad Sci 1316(), 2014
PMID: 24697242
Neural networks involved in learning lexical-semantic and syntactic information in a second language.
Mueller JL, Rueschemeyer SA, Ono K, Sugiura M, Sadato N, Nakamura A., Front Psychol 5(), 2014
PMID: 25400602
Syntax in a pianist's hand: ERP signatures of "embodied" syntax processing in music.
Sammler D, Novembre G, Koelsch S, Keller PE., Cortex 49(5), 2013
PMID: 22832238
Corticostriatal contributions to musical expectancy perception.
Seger CA, Spiering BJ, Sares AG, Quraini SI, Alpeter C, David J, Thaut MH., J Cogn Neurosci 25(7), 2013
PMID: 23410032
Deficit in complex sequence processing after a virtual lesion of left BA45.
Clerget E, Andres M, Olivier E., PLoS One 8(6), 2013
PMID: 23762232
Neurophysiological preconditions of syntax acquisition.
Friederici AD, Oberecker R, Brauer J., Psychol Res 76(2), 2012
PMID: 21706312
The cortical representation of simple mathematical expressions.
Maruyama M, Pallier C, Jobert A, Sigman M, Dehaene S., Neuroimage 61(4), 2012
PMID: 22521479
Pattern perception and computational complexity: introduction to the special issue.
Fitch WT, Friederici AD, Hagoort P., Philos Trans R Soc Lond B Biol Sci 367(1598), 2012
PMID: 22688630
Artificial grammar learning meets formal language theory: an overview.
Fitch WT, Friederici AD., Philos Trans R Soc Lond B Biol Sci 367(1598), 2012
PMID: 22688631
A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus.
Uddén J, Bahlmann J., Philos Trans R Soc Lond B Biol Sci 367(1598), 2012
PMID: 22688637
An approach to separating the levels of hierarchical structure building in language and mathematics.
Makuuchi M, Bahlmann J, Friederici AD., Philos Trans R Soc Lond B Biol Sci 367(1598), 2012
PMID: 22688638
Distinctive signatures of recursion.
Martins MD., Philos Trans R Soc Lond B Biol Sci 367(1598), 2012
PMID: 22688640
Levels of integration in cognitive control and sequence processing in the prefrontal cortex.
Bahlmann J, Korb FM, Gratton C, Friederici AD., PLoS One 7(8), 2012
PMID: 22952762
Implicit learning of recursive context-free grammars.
Rohrmeier M, Fu Q, Dienes Z., PLoS One 7(10), 2012
PMID: 23094021
Are left fronto-temporal brain areas a prerequisite for normal music-syntactic processing?
Sammler D, Koelsch S, Friederici AD., Cortex 47(6), 2011
PMID: 20570253
Intention processing in communication: a common brain network for language and gestures.
Enrici I, Adenzato M, Cappa S, Bara BG, Tettamanti M., J Cogn Neurosci 23(9), 2011
PMID: 20954937
The functional neuroanatomy of morphology in language production.
Koester D, Schiller NO., Neuroimage 55(2), 2011
PMID: 21109010
Altered motor network activation and functional connectivity in adult Tourette's syndrome.
Werner CJ, Stöcker T, Kellermann T, Bath J, Beldoch M, Schneider F, Wegener HP, Shah JN, Neuner I., Hum Brain Mapp 32(11), 2011
PMID: 21259388
Neural basis of linearization in speech production.
Ye Z, Habets B, Jansma BM, Münte TF., J Cogn Neurosci 23(11), 2011
PMID: 21557647
Role of Broca's area in motor sequence programming: a cTBS study.
Clerget E, Badets A, Duqué J, Olivier E., Neuroreport 22(18), 2011
PMID: 22089648

58 References

Daten bereitgestellt von Europe PubMed Central.

Broca's region revisited: cytoarchitecture and intersubject variability.
Amunts K, Schleicher A, Burgel U, Mohlberg H, Uylings HB, Zilles K., J. Comp. Neurol. 412(2), 1999
PMID: 10441759
An fMRI study of canonical and noncanonical word order in German.
Bahlmann J, Rodriguez-Fornells A, Rotte M, Munte TF., Hum Brain Mapp 28(10), 2007
PMID: 17274018
Hierarchical artificial grammar processing engages Broca's area.
Bahlmann J, Schubotz RI, Friederici AD., Neuroimage 42(2), 2008
PMID: 18554927
Prefrontal connections of medial motor areas in the rhesus monkey.
Bates JF, Goldman-Rakic PS., J. Comp. Neurol. 336(2), 1993
PMID: 7503997
The neural reality of syntactic transformations: evidence from functional magnetic resonance imaging.
Ben-Shachar M, Hendler T, Kahn I, Ben-Bashat D, Grodzinsky Y., Psychol Sci 14(5), 2003
PMID: 12930473
Neural circuits subserving the retrieval and maintenance of abstract rules.
Bunge SA, Kahn I, Wallis JD, Miller EK, Wagner AD., J. Neurophysiol. 90(5), 2003
PMID: 12867532
Syntactic structure and artificial grammar learning: the learnability of embedded hierarchical structures.
de Vries MH, Monaghan P, Knecht S, Zwitserlood P., Cognition 107(2), 2007
PMID: 17963740
Is the human primary motor cortex involved in motor imagery?
Dechent P, Merboldt KD, Frahm J., Brain Res Cogn Brain Res 19(2), 2004
PMID: 15019710
Revisiting the role of Broca's area in sentence processing: syntactic integration versus syntactic working memory.
Fiebach CJ, Schlesewsky M, Lohmann G, von Cramon DY, Friederici AD., Hum Brain Mapp 24(2), 2005
PMID: 15455462
Learning-related neuronal responses in prefrontal cortex studied with functional neuroimaging.
Fletcher P, Buchel C, Josephs O, Friston K, Dolan R., Cereb. Cortex 9(2), 1999
PMID: 10220229
Neural correlates of artificial syntactic structure classification.
Forkstam C, Hagoort P, Fernandez G, Ingvar M, Petersson KM., Neuroimage 32(2), 2006
PMID: 16757182
Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold.
Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC., Magn Reson Med 33(5), 1995
PMID: 7596267
Location-probability profiles for the mouth region of human primary motor-sensory cortex: model and validation.
Fox PT, Huang A, Parsons LM, Xiong JH, Zamarippa F, Rainey L, Lancaster JL., Neuroimage 13(1), 2001
PMID: 11133322
The brain differentiates human and non-human grammars: functional localization and structural connectivity.
Friederici AD, Bahlmann J, Heim S, Schubotz RI, Anwander A., Proc. Natl. Acad. Sci. U.S.A. 103(7), 2006
PMID: 16461904
Mathematical logic in the human brain: syntax.
Friedrich R, Friederici AD., PLoS ONE 4(5), 2009
PMID: 19478999
Recursive syntactic pattern learning by songbirds.
Gentner TQ, Fenn KM, Margoliash D, Nusbaum HC., Nature 440(7088), 2006
PMID: 16641998
Partially overlapping neural networks for real and imagined hand movements.
Gerardin E, Sirigu A, Lehericy S, Poline JB, Gaymard B, Marsault C, Agid Y, Le Bihan D., Cereb. Cortex 10(11), 2000
PMID: 11053230
The role of rostral Brodmann area 6 in mental-operation tasks: an integrative neuroimaging approach.
Hanakawa T, Honda M, Sawamoto N, Okada T, Yonekura Y, Fukuyama H, Shibasaki H., Cereb. Cortex 12(11), 2002
PMID: 12379604
Training with cognitive sequences improves syntactic comprehension in agrammatic aphasics.
Hoen M, Golembiowski M, Guyot E, Deprez V, Caplan D, Dominey PF., Neuroreport 14(3), 2003
PMID: 12634511
Patterns, chunks, and hierarchies in serial reaction-time tasks.
Koch I, Hoffmann J., Psychol Res 63(1), 2000
PMID: 10743384
Broca's area and the hierarchical organization of human behavior.
Koechlin E, Jubault T., Neuron 50(6), 2006
PMID: 16772176
Capturing regularities in event sequences: evidence for two mechanisms.
Koester D, Prinz W., Brain Res. 1180(), 2007
PMID: 17931608
An event-related fMRI study of artificial grammar learning in a balanced chunk strength design.
Lieberman MD, Chang GY, Chiao J, Bookheimer SY, Knowlton BJ., J Cogn Neurosci 16(3), 2004
PMID: 15072678
LIPSIA--a new software system for the evaluation of functional magnetic resonance images of the human brain.
Lohmann G, Muller K, Bosch V, Mentzel H, Hessler S, Chen L, Zysset S, von Cramon DY., Comput Med Imaging Graph 25(6), 2001
PMID: 11679206
Corticocortical connections of area F3 (SMA-proper) and area F6 (pre-SMA) in the macaque monkey.
Luppino G, Matelli M, Camarda R, Rizzolatti G., J. Comp. Neurol. 338(1), 1993
PMID: 7507940
Segregating the core computational faculty of human language from working memory.
Makuuchi M, Bahlmann J, Anwander A, Friederici AD., Proc. Natl. Acad. Sci. U.S.A. 106(20), 2009
PMID: 19416819
Broca's area and the language instinct.
Musso M, Moro A, Glauche V, Rijntjes M, Reichenbach J, Buchel C, Weiller C., Nat. Neurosci. 6(7), 2003
PMID: 12819784
Neural basis of processing sequential and hierarchical syntactic structures.
Opitz B, Friederici AD., Hum Brain Mapp 28(7), 2007
PMID: 17455365
Dissociable patterns of brain activity during comprehension of rapid and syntactically complex speech: evidence from fMRI.
Peelle JE, McMillan C, Moore P, Grossman M, Wingfield A., Brain Lang 91(3), 2004
PMID: 15533557
Striatum forever, despite sequence learning variability: a random effect analysis of PET data.
Peigneux P, Maquet P, Meulemans T, Destrebecqz A, Laureys S, Degueldre C, Delfiore G, Aerts J, Luxen A, Franck G, Van der Linden M, Cleeremans A., Hum Brain Mapp 10(4), 2000
PMID: 10949055
Imaging the premotor areas.
Picard N, Strick PL., Curr. Opin. Neurobiol. 11(6), 2001
PMID: 11741015
Implicit learning of artificial grammars
Reber, J. Verbal Learn. Verbal Behav. 6(), 1967
Neural representation of a rhythm depends on its interval ratio.
Sakai K, Hikosaka O, Miyauchi S, Takino R, Tamada T, Iwata NK, Nielsen M., J. Neurosci. 19(22), 1999
PMID: 10559415
Working memory and syntax interact in Broca's area.
Santi A, Grodzinsky Y., Neuroimage 37(1), 2007
PMID: 17560794
Prediction of external events with our motor system: towards a new framework.
Schubotz RI., Trends Cogn. Sci. (Regul. Ed.) 11(5), 2007
PMID: 17383218
Integrative models of Broca's area and the ventral premotor cortex
Schubotz, Cortex 42(), 2006
Neural activity differs between explicit and implicit learning of artificial grammar strings: an fMRI study
Seger, Psychobiology 28(), 2000
Neural correlates of artificial grammar learning.
Skosnik PD, Mirza F, Gitelman DR, Parrish TB, Mesulam MM, Reber PJ., Neuroimage 17(3), 2002
PMID: 12414270
Localization of syntactic comprehension by positron emission tomography.
Stromswold K, Caplan D, Alpert N, Rauch S., Brain Lang 52(3), 1996
PMID: 8653390

Talairach, 1988
Broca's area: a supramodal hierarchical processor?
Tettamanti M, Weniger D., Cortex 42(4), 2006
PMID: 16881256

A general statistical analysis for fMRI data.
Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, Morales F, Evans AC., Neuroimage 15(1), 2002
PMID: 11771969

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