Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism

Brand M, Eggers C, Reinhold N, Fujiwara E, Kessler J, Heiss W-D, Markowitsch HJ (2009)
Psychiatry Research: Neuroimaging Section 174(1): 32-39.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Brand, MatthiasUniBi; Eggers, Carsten; Reinhold, NadineUniBi; Fujiwara, Esther; Kessler, Josef; Heiss, Wolf-Dieter; Markowitsch, Hans J.UniBi
Abstract / Bemerkung
Dissociative amnesia is a condition usually characterized by severely impaired retrograde memory functioning in the absence of structural brain damage. Recent case studies nevertheless found functional brain changes in patients suffering from autobiographical-episodic memory loss in the cause of dissociative amnesia. Functional changes were demonstrated in both resting state and memory retrieval conditions. In addition, some but not all cases also showed other neuropsychological impairments beyond retrograde memory deficits. However, there is no group study available that examined potential functional brain abnormalities and accompanying neuropsychological deteriorations in larger samples of patients with dissociative retrograde amnesia. We report functional imaging and neuropsychological data acquired in 14 patients with dissociative amnesia following stressful or traumatic events. All patients suffered from autobiographical memory loss. in addition, approximately half of the patients had deficits in anterograde memory and executive functioning. Accompanying functional brain changes were measured by [F-18] fluorodeoxyglucose positron emission tomography (FDG-PET). Regional glucose utilization of the patients was compared with that of 19 healthy subjects, matched for age and gender. We found significantly decreased glucose utilization in the right inferolateral prefrontal cortex in the patients. Hypometabolism in this brain region, known to be involved in retrieval of autobiographical memories and self-referential processing, may be a functional brain correlate of dissociative amnesia. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Stichworte
Psychogenic amnesia; Autobiographical memory; Functional neuroimaging; Mnestic block syndrome
Erscheinungsjahr
2009
Zeitschriftentitel
Psychiatry Research: Neuroimaging Section
Band
174
Ausgabe
1
Seite(n)
32-39
ISSN
0925-4927
Page URI
https://pub.uni-bielefeld.de/record/1589673

Zitieren

Brand M, Eggers C, Reinhold N, et al. Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism. Psychiatry Research: Neuroimaging Section. 2009;174(1):32-39.
Brand, M., Eggers, C., Reinhold, N., Fujiwara, E., Kessler, J., Heiss, W. - D., & Markowitsch, H. J. (2009). Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism. Psychiatry Research: Neuroimaging Section, 174(1), 32-39. https://doi.org/10.1016/j.pscychresns.2009.03.008
Brand, Matthias, Eggers, Carsten, Reinhold, Nadine, Fujiwara, Esther, Kessler, Josef, Heiss, Wolf-Dieter, and Markowitsch, Hans J. 2009. “Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism”. Psychiatry Research: Neuroimaging Section 174 (1): 32-39.
Brand, M., Eggers, C., Reinhold, N., Fujiwara, E., Kessler, J., Heiss, W. - D., and Markowitsch, H. J. (2009). Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism. Psychiatry Research: Neuroimaging Section 174, 32-39.
Brand, M., et al., 2009. Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism. Psychiatry Research: Neuroimaging Section, 174(1), p 32-39.
M. Brand, et al., “Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism”, Psychiatry Research: Neuroimaging Section, vol. 174, 2009, pp. 32-39.
Brand, M., Eggers, C., Reinhold, N., Fujiwara, E., Kessler, J., Heiss, W.-D., Markowitsch, H.J.: Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism. Psychiatry Research: Neuroimaging Section. 174, 32-39 (2009).
Brand, Matthias, Eggers, Carsten, Reinhold, Nadine, Fujiwara, Esther, Kessler, Josef, Heiss, Wolf-Dieter, and Markowitsch, Hans J. “Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism”. Psychiatry Research: Neuroimaging Section 174.1 (2009): 32-39.

26 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Psychogenic amnesia: syndromes, outcome, and patterns of retrograde amnesia.
Harrison NA, Johnston K, Corno F, Casey SJ, Friedner K, Humphreys K, Jaldow EJ, Pitkanen M, Kopelman MD., Brain 140(9), 2017
PMID: 29050391
Grey matter alterations in patients with depersonalization disorder: a voxel-based morphometry study.
Daniels JK, Gaebler M, Lamke JP, Walter H., J Psychiatry Neurosci 40(1), 2015
PMID: 25285875
A case of dissociative fugue and general amnesia with an 11-year follow-up.
Helmes E, Brown JM, Elliott L., J Trauma Dissociation 16(1), 2015
PMID: 25365262
Transient epileptic amnesia: Update on a slowly emerging epileptic syndrome.
Felician O, Tramoni E, Bartolomei F., Rev Neurol (Paris) 171(3), 2015
PMID: 25724712
The lesson for us in a bipolar disorder patient comorbid with dissociative amnesia.
Wang JK, Hu LY, Lee YT., Aust N Z J Psychiatry 49(12), 2015
PMID: 26238383
FDG-PET Contributions to the Pathophysiology of Memory Impairment.
Segobin S, La Joie R, Ritz L, Beaunieux H, Desgranges B, Chételat G, Pitel AL, Eustache F., Neuropsychol Rev 25(3), 2015
PMID: 26319237
Functional (Psychogenic) Cognitive Disorders: A Perspective from the Neurology Clinic.
Stone J, Pal S, Blackburn D, Reuber M, Thekkumpurath P, Carson A., J Alzheimers Dis 48 Suppl 1(), 2015
PMID: 26445274
Conversion, dissociative amnesia, and Ganser syndrome in a case of "chameleon" syndrome: anatomo-functional findings.
Magnin E, Thomas-Antérion C, Sylvestre G, Haffen S, Magnin-Feysot V, Rumbach L., Neurocase 20(1), 2014
PMID: 23075263
Neurophysiological correlates of dissociative symptoms.
van der Kruijs SJ, Bodde NM, Carrette E, Lazeron RH, Vonck KE, Boon PA, Langereis GR, Cluitmans PJ, Feijs LM, Hofman PA, Backes WH, Jansen JF, Aldenkamp AP., J Neurol Neurosurg Psychiatry 85(2), 2014
PMID: 23175855
Gray matter volume alterations related to trait dissociation in PTSD and traumatized controls.
Nardo D, Högberg G, Lanius RA, Jacobsson H, Jonsson C, Hällström T, Pagani M., Acta Psychiatr Scand 128(3), 2013
PMID: 23113800
Transient amnesic syndromes.
Bartsch T, Butler C., Nat Rev Neurol 9(2), 2013
PMID: 23296343
Perspectives on episodic-like and episodic memory.
Pause BM, Zlomuzica A, Kinugawa K, Mariani J, Pietrowsky R, Dere E., Front Behav Neurosci 7(), 2013
PMID: 23616754
Memory and self-neuroscientific landscapes.
Markowitsch HJ., ISRN Neurosci 2013(), 2013
PMID: 24967303
An interesting case of barbiturate automatism and review of literature.
Gokhale S, Ramos-Estebanez C., Case Rep Neurol Med 2013(), 2013
PMID: 24222872
The dissociative subtype of posttraumatic stress disorder: rationale, clinical and neurobiological evidence, and implications.
Lanius RA, Brand B, Vermetten E, Frewen PA, Spiegel D., Depress Anxiety 29(8), 2012
PMID: 22431063
The remains of the day in dissociative amnesia.
Staniloiu A, Markowitsch HJ., Brain Sci 2(2), 2012
PMID: 24962768
Amnesic disorders.
Markowitsch HJ, Staniloiu A., Lancet 380(9851), 2012
PMID: 22503117
Psychogenic amnesia and self-identity: a multimodal functional investigation.
Arzy S, Collette S, Wissmeyer M, Lazeyras F, Kaplan PW, Blanke O., Eur J Neurol 18(12), 2011
PMID: 21554495
Mutism and amnesia following high-voltage electrical injury: psychogenic symptomatology triggered by organic dysfunction?
Mishra NK, Russmann H, Granziera C, Maeder P, Annoni JM., Eur Neurol 66(4), 2011
PMID: 21952143
Losing memories overnight: a unique form of human amnesia.
Smith CN, Frascino JC, Kripke DL, McHugh PR, Treisman GJ, Squire LR., Neuropsychologia 48(10), 2010
PMID: 20493889
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