Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics

Kleimann C, Sischka A, Spiering A, Tönsing K, Sewald N, Diederichsen U, Anselmetti D (2009)
Biophysical Journal 97(10): 2780-2784.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Kleimann, Christoph; Sischka, AndyUniBi; Spiering, Andre; Tönsing, KatjaUniBi; Sewald, NorbertUniBi ; Diederichsen, Ulf; Anselmetti, DarioUniBi
Einrichtung
Fakultät für Chemie > Organische Chemie III
Centrum für Biotechnologie > Institut für Biochemie und Biotechnik
SFB 613 Physik von Einzelmolekülprozessen/mol.Erkennung in organ.Sys.
Centrum für Biotechnologie > Institut für Biophysik und Nanowissenschaften
Centrum für Biotechnologie > Arbeitsgruppe N. Sewald
Centrum für Biotechnologie > Arbeitsgruppe D. Anselmetti
Fakultät für Physik > AG Biophysik und angewandte Nanowissenschaften
Abstract / Bemerkung
The binding kinetics of the intercalative binding of Triostin A to A-DNA was investigated by measuring the force extension response of the DNA-ligand complexes with an optical tweezers system. These force response curves, containing the information about different binding properties, were analyzed based on a recent method (put forth by another research group) for monointercalators that was extended to bisintercalators. Our binding analysis reveals an exponential dependence of the association constant on the applied external force as well as a decreasing binding site size. In general, our results are in agreement with those for the monointercalator ethidium. However, to explain the high-force binding site size, a new model for bisintercalation of Triostin A at high forces is proposed.
Erscheinungsjahr
2009
Zeitschriftentitel
Biophysical Journal
Band
97
Ausgabe
10
Seite(n)
2780-2784
ISSN
0006-3495
Page URI
https://pub.uni-bielefeld.de/record/1589614

Zitieren

Kleimann C, Sischka A, Spiering A, et al. Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal. 2009;97(10):2780-2784.
Kleimann, C., Sischka, A., Spiering, A., Tönsing, K., Sewald, N., Diederichsen, U., & Anselmetti, D. (2009). Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal, 97(10), 2780-2784. https://doi.org/10.1016/j.bpj.2009.09.001
Kleimann, Christoph, Sischka, Andy, Spiering, Andre, Tönsing, Katja, Sewald, Norbert, Diederichsen, Ulf, and Anselmetti, Dario. 2009. “Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics”. Biophysical Journal 97 (10): 2780-2784.
Kleimann, C., Sischka, A., Spiering, A., Tönsing, K., Sewald, N., Diederichsen, U., and Anselmetti, D. (2009). Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal 97, 2780-2784.
Kleimann, C., et al., 2009. Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal, 97(10), p 2780-2784.
C. Kleimann, et al., “Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics”, Biophysical Journal, vol. 97, 2009, pp. 2780-2784.
Kleimann, C., Sischka, A., Spiering, A., Tönsing, K., Sewald, N., Diederichsen, U., Anselmetti, D.: Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal. 97, 2780-2784 (2009).
Kleimann, Christoph, Sischka, Andy, Spiering, Andre, Tönsing, Katja, Sewald, Norbert, Diederichsen, Ulf, and Anselmetti, Dario. “Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics”. Biophysical Journal 97.10 (2009): 2780-2784.

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PMID: 27028636
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PMID: 27085806
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Wu H, Mitra M, Naufer MN, McCauley MJ, Gorelick RJ, Rouzina I, Musier-Forsyth K, Williams MC., Nucleic Acids Res 42(4), 2014
PMID: 24293648
Biosynthetic modularity rules in the bisintercalator family of antitumor compounds.
Fernández J, Marín L, Alvarez-Alonso R, Redondo S, Carvajal J, Villamizar G, Villar CJ, Lombó F., Mar Drugs 12(5), 2014
PMID: 24821625
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15 References

Daten bereitgestellt von Europe PubMed Central.

Molecular mechanisms and kinetics between DNA and DNA binding ligands.
Sischka A, Toensing K, Eckel R, Wilking SD, Sewald N, Ros R, Anselmetti D., Biophys. J. 88(1), 2004
PMID: 15516529
Single-molecule manipulation of double-stranded DNA using optical tweezers: interaction studies of DNA with RecA and YOYO-1.
Bennink ML, Scharer OD, Kanaar R, Sakata-Sogawa K, Schins JM, Kanger JS, de Grooth BG, Greve J., Cytometry 36(3), 1999
PMID: 10404969
Mapping the phase diagram of single DNA molecule force-induced melting in the presence of ethidium.
Vladescu ID, McCauley MJ, Rouzina I, Williams MC., Phys. Rev. Lett. 95(15), 2005
PMID: 16241765
DNA mechanics affected by small DNA interacting ligands
Husale S., Grange W., Hegner M.., 2002
Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules.
Smith SB, Cui Y, Bustamante C., Science 271(5250), 1996
PMID: 8628994
Stretching DNA
Marko J.F., Siggia E.D.., 1995
Thermodynamics of DNA interactions from single molecule stretching experiments.
Williams MC, Rouzina I, Bloomfield VA., Acc. Chem. Res. 35(3), 2002
PMID: 11900519
Bifunctional intercalation and sequence specificity in the binding of quinomycin and triostin antibiotics to deoxyribonucleic acid.
Lee JS, Waring MJ., Biochem. J. 173(1), 1978
PMID: 687363
Preparation and DNA-binding properties of substituted triostin antibiotics.
Cornish A, Fox KR, Waring MJ., Antimicrob. Agents Chemother. 23(2), 1983
PMID: 6838186
Compact, microscope based optical tweezers system for molecular manipulation
Sischka A., Eckel R., Tönsing K., Ros R., Anselmetti D.., 2003
Quantifying force-dependent and zero-force DNA intercalation by single-molecule stretching.
Vladescu ID, McCauley MJ, Nunez ME, Rouzina I, Williams MC., Nat. Methods 4(6), 2007
PMID: 17468764
Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.
McGhee JD, von Hippel PH., J. Mol. Biol. 86(2), 1974
PMID: 4416620
Mechanical processes in biochemistry.
Bustamante C, Chemla YR, Forde NR, Izhaky D., Annu. Rev. Biochem. 73(), 2004
PMID: 15189157
Calculation of binding isotherms for heterogenous polymers.
Crothers DM., Biopolymers 6(4), 1968
PMID: 5644787
The molecular structure of a DNA-triostin A complex.
Wang AH, Ughetto G, Quigley GJ, Hakoshima T, van der Marel GA, van Boom JH, Rich A., Science 225(4667), 1984
PMID: 6474168
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