Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics

Kleimann C, Sischka A, Spiering A, Tönsing K, Sewald N, Diederichsen U, Anselmetti D (2009)
Biophysical Journal 97(10): 2780-2784.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Kleimann, Christoph; Sischka, AndyUniBi; Spiering, Andre; Tönsing, KatjaUniBi; Sewald, NorbertUniBi ; Diederichsen, Ulf; Anselmetti, DarioUniBi
Einrichtung
Fakultät für Chemie > Organische Chemie III
SFB 613 Physik von Einzelmolekülprozessen/mol.Erkennung in organ.Sys.
Centrum für Biotechnologie > Arbeitsgruppe N. Sewald
Centrum für Biotechnologie > Institut für Biochemie und Biotechnik
Fakultät für Physik > AG Biophysik und angewandte Nanowissenschaften
Centrum für Biotechnologie > Arbeitsgruppe D. Anselmetti
Centrum für Biotechnologie > Institut für Biophysik und Nanowissenschaften
Abstract / Bemerkung
The binding kinetics of the intercalative binding of Triostin A to A-DNA was investigated by measuring the force extension response of the DNA-ligand complexes with an optical tweezers system. These force response curves, containing the information about different binding properties, were analyzed based on a recent method (put forth by another research group) for monointercalators that was extended to bisintercalators. Our binding analysis reveals an exponential dependence of the association constant on the applied external force as well as a decreasing binding site size. In general, our results are in agreement with those for the monointercalator ethidium. However, to explain the high-force binding site size, a new model for bisintercalation of Triostin A at high forces is proposed.
Erscheinungsjahr
2009
Zeitschriftentitel
Biophysical Journal
Band
97
Ausgabe
10
Seite(n)
2780-2784
ISSN
0006-3495
Page URI
https://pub.uni-bielefeld.de/record/1589614

Zitieren

Kleimann C, Sischka A, Spiering A, et al. Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal. 2009;97(10):2780-2784.
Kleimann, C., Sischka, A., Spiering, A., Tönsing, K., Sewald, N., Diederichsen, U., & Anselmetti, D. (2009). Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal, 97(10), 2780-2784. https://doi.org/10.1016/j.bpj.2009.09.001
Kleimann, Christoph, Sischka, Andy, Spiering, Andre, Tönsing, Katja, Sewald, Norbert, Diederichsen, Ulf, and Anselmetti, Dario. 2009. “Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics”. Biophysical Journal 97 (10): 2780-2784.
Kleimann, C., Sischka, A., Spiering, A., Tönsing, K., Sewald, N., Diederichsen, U., and Anselmetti, D. (2009). Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal 97, 2780-2784.
Kleimann, C., et al., 2009. Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal, 97(10), p 2780-2784.
C. Kleimann, et al., “Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics”, Biophysical Journal, vol. 97, 2009, pp. 2780-2784.
Kleimann, C., Sischka, A., Spiering, A., Tönsing, K., Sewald, N., Diederichsen, U., Anselmetti, D.: Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics. Biophysical Journal. 97, 2780-2784 (2009).
Kleimann, Christoph, Sischka, Andy, Spiering, Andre, Tönsing, Katja, Sewald, Norbert, Diederichsen, Ulf, and Anselmetti, Dario. “Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics”. Biophysical Journal 97.10 (2009): 2780-2784.

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