Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children

Kalbe E, Brand M, Thiel A, Kessler J, Markowitsch HJ (2008)
NEUROCASE 14(1): 15-28.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Kalbe, E.; Brand, M.; Thiel, A.; Kessler, J.; Markowitsch, Hans J.UniBi
Abstract / Bemerkung
We report a case of a delusional patient who had killed two of her children in an attempted 'extended suicide'. She was convinced of a genetic defect that caused autobiographical memory and emotional deficits and made life 'senseless'. Neuropsychological tests revealed dysfunctions in remembering emotional details of personal episodes and theory of mind. Water positron emission tomography (O-15) with a paradigm used in a former study by Fink et al. (1996) with healthy controls elicited abnormal activations during autobiographical memory retrieval characterised by a lack of prefrontal and limbic activity. We conclude that these imaging findings reflect neural correlates of the self-reported and objectified autobiographical dysfunctions. Furthermore, they indicate that beliefs or prejudices may have a major impact on the brain's processing of the personal past.
autobiographical memory; theory of mind; positron; emission tomography; neuroscience; crime
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Kalbe E, Brand M, Thiel A, Kessler J, Markowitsch HJ. Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children. NEUROCASE. 2008;14(1):15-28.
Kalbe, E., Brand, M., Thiel, A., Kessler, J., & Markowitsch, H. J. (2008). Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children. NEUROCASE, 14(1), 15-28.
Kalbe, E., Brand, M., Thiel, A., Kessler, J., and Markowitsch, Hans J. 2008. “Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children”. NEUROCASE 14 (1): 15-28.
Kalbe, E., Brand, M., Thiel, A., Kessler, J., and Markowitsch, H. J. (2008). Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children. NEUROCASE 14, 15-28.
Kalbe, E., et al., 2008. Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children. NEUROCASE, 14(1), p 15-28.
E. Kalbe, et al., “Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children”, NEUROCASE, vol. 14, 2008, pp. 15-28.
Kalbe, E., Brand, M., Thiel, A., Kessler, J., Markowitsch, H.J.: Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children. NEUROCASE. 14, 15-28 (2008).
Kalbe, E., Brand, M., Thiel, A., Kessler, J., and Markowitsch, Hans J. “Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children”. NEUROCASE 14.1 (2008): 15-28.

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Daten bereitgestellt von Europe PubMed Central.

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PMID: 21283572

114 References

Daten bereitgestellt von Europe PubMed Central.

Into the mind of a killer.
Abbott A., Nature 410(6826), 2001
PMID: 11268172


The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism.
Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I., J Child Psychol Psychiatry 42(2), 2001
PMID: 11280420

Bäumler, 1985
Persecutory delusions and the determination of self-relevance: an fMRI investigation.
Blackwood NJ, Bentall RP, Ffytche DH, Simmons A, Murray RM, Howard RJ., Psychol Med 34(4), 2004
PMID: 15099414

Bowers, 1998

Brand, 2003

Functional ("psychogenic") amnesia.
Brandt J, Van Gorp WG., Semin Neurol 26(3), 2006
PMID: 16791779

Breitenstein, Neurologie and Rehabilitation 2(), 1996

Brickenkamp, 1998
Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review.
Brower MC, Price BH., J. Neurol. Neurosurg. Psychiatry 71(6), 2001
PMID: 11723190
Cognitive and emotional influences in anterior cingulate cortex.
Bush G, Luu P, Posner MI., Trends Cogn. Sci. (Regul. Ed.) 4(6), 2000
PMID: 10827444
Functional neuroimaging of autobiographical memory.
Cabeza R, St Jacques P., Trends Cogn. Sci. (Regul. Ed.) 11(5), 2007
PMID: 17382578
Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm.
Cabeza R, Prince SE, Daselaar SM, Greenberg DL, Budde M, Dolcos F, LaBar KS, Rubin DC., J Cogn Neurosci 16(9), 2004
PMID: 15622612
Anterior cingulate cortex, error detection, and the online monitoring of performance.
Carter CS, Braver TS, Barch DM, Botvinick MM, Noll D, Cohen JD., Science 280(5364), 1998
PMID: 9563953
The construction of autobiographical memories in the self-memory system.
Conway MA, Pleydell-Pearce CW., Psychol Rev 107(2), 2000
PMID: 10789197
A positron emission tomography (PET) study of autobiographical memory retrieval.
Conway MA, Turk DJ, Miller SL, Logan J, Nebes RD, Meltzer CC, Becker JT., Memory 7(5-6), 1999
PMID: 10659092
Dysfunction in the neural circuitry of emotion regulation--a possible prelude to violence.
Davidson RJ, Putnam KM, Larson CL., Science 289(5479), 2000
PMID: 10915615

de, Journal of Clinical Child and Adolescent Psychology 32(), 2003
Facial emotion processing in criminal psychopathy. Preliminary functional magnetic resonance imaging study.
Deeley Q, Daly E, Surguladze S, Tunstall N, Mezey G, Beer D, Ambikapathy A, Robertson D, Giampietro V, Brammer MJ, Clarke A, Dowsett J, Fahy T, Phillips ML, Murphy DG., Br J Psychiatry 189(), 2006
PMID: 17139038

Ekman, 1975

Fast, 0

Fast, Zeitschrift für Neuropsychologie. (), 0
Cerebral representation of one's own past: neural networks involved in autobiographical memory.
Fink GR, Markowitsch HJ, Reinkemeier M, Bruckbauer T, Kessler J, Heiss WD., J. Neurosci. 16(13), 1996
PMID: 8753888
The mind's eye--precuneus activation in memory-related imagery.
Fletcher PC, Frith CD, Baker SC, Shallice T, Frackowiak RS, Dolan RJ., Neuroimage 2(3), 1995
PMID: 9343602
Brain activity during memory retrieval. The influence of imagery and semantic cueing.
Fletcher PC, Shallice T, Frith CD, Frackowiak RS, Dolan RJ., Brain 119 ( Pt 5)(), 1996
PMID: 8931582
Attention to action and awareness of other minds.
Frith C., Conscious Cogn 11(4), 2002
PMID: 12470618
The social brain?
Frith CD., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 362(1480), 2007
PMID: 17255010

Fujiwara, Cortex. (), 0
Prefrontal-cingulate interactions in action monitoring.
Gehring WJ, Knight RT., Nat. Neurosci. 3(5), 2000
PMID: 10769394
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis.
Greicius MD, Krasnow B, Reiss AL, Menon V., Proc. Natl. Acad. Sci. U.S.A. 100(1), 2002
PMID: 12506194
Brain connectivity related to working memory performance.
Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT., J. Neurosci. 26(51), 2006
PMID: 17182784

Hare, 2003
Schizophrenia, theory of mind, and persecutory delusions.
Harrington L, Langdon R, Siegert RJ, McClure J., Cogn Neuropsychiatry 10(2), 2005
PMID: 16571454
Theory of mind in schizophrenia: a critical review.
Harrington L, Siegert RJ, McClure J., Cogn Neuropsychiatry 10(4), 2005
PMID: 16571462

Härting, 2000

Horn, 1983
Neural correlates of self-reflection.
Johnson SC, Baxter LC, Wilder LS, Pipe JG, Heiserman JE, Prigatano GP., Brain 125(Pt 8), 2002
PMID: 12135971
DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia.
Kalbe E, Kessler J, Calabrese P, Smith R, Passmore AP, Brand M, Bullock R., Int J Geriatr Psychiatry 19(2), 2004
PMID: 14758579
Persecutory delusions and autobiographical memory.
Kaney S, Bowen-Jones K, Bentall RP., Br J Clin Psychol 38 ( Pt 1)(), 1999
PMID: 10212740
A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals.
Keedwell PA, Andrew C, Williams SC, Brammer MJ, Phillips ML., Biol. Psychiatry 58(6), 2005
PMID: 15993859
Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging.
Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, Liddle PF., Biol. Psychiatry 50(9), 2001
PMID: 11704074
Functional amnesia: clinical description and neuropsychological profile of 10 cases.
Kritchevsky M, Chang J, Squire LR., Learn. Mem. 11(2), 2004
PMID: 15054137
Telling truth from lie in individual subjects with fast event-related fMRI.
Langleben DD, Loughead JW, Bilker WB, Ruparel K, Childress AR, Busch SI, Gur RC., Hum Brain Mapp 26(4), 2005
PMID: 16161128
Mental state decoding abilities in clinical depression.
Lee L, Harkness KL, Sabbagh MA, Jacobson JA., J Affect Disord 86(2-3), 2005
PMID: 15935244

Leplow, Diagnostica 39(), 1993

Leplow, Zeitschrift für Neuropsychologie 8(), 1997

Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression.
Liotti M, Mayberg HS, McGinnis S, Brannan SL, Jerabek P., Am J Psychiatry 159(11), 2002
PMID: 12411216
Parietal cortex and representation of the mental Self.
Lou HC, Luber B, Crupain M, Keenan JP, Nowak M, Kjaer TW, Sackeim HA, Lisanby SH., Proc. Natl. Acad. Sci. U.S.A. 101(17), 2004
PMID: 15096584
Medial frontal cortex in action monitoring.
Luu P, Flaisch T, Tucker DM., J. Neurosci. 20(1), 2000
PMID: 10627622
Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval.
Maddock RJ, Garrett AS, Buonocore MH., Neuroscience 104(3), 2001
PMID: 11440800
Which brain regions are critically involved in the retrieval of old episodic memory?
Markowitsch HJ., Brain Res. Brain Res. Rev. 21(2), 1995
PMID: 8866670


Markowitsch, Neurology, Psychiatry and Brain Research 4(), 1996
Functional neuroimaging correlates of functional amnesia.
Markowitsch HJ., Memory 7(5-6), 1999
PMID: 10659087

Markowitsch, 1999

Markowitsch, 2000

Markowitsch, 2003
Psychogenic amnesia.
Markowitsch HJ., Neuroimage 20 Suppl 1(), 2003
PMID: 14597306

Markowitsch, 2007
Psychic trauma causing grossly reduced brain metabolism and cognitive deterioration.
Markowitsch HJ, Kessler J, Van Der Ven C, Weber-Luxenburger G, Albers M, Heiss WD., Neuropsychologia 36(1), 1998
PMID: 9533390
Right amygdalar and temporofrontal activation during autobiographic, but not during fictitious memory retrieval.
Markowitsch HJ, Thiel A, Reinkemeier M, Kessler J, Koyuncu A, Heiss WD., Behav Neurol 12(4), 2000
PMID: 11568430
Engagement of lateral and medial prefrontal areas in the ecphory of sad and happy autobiographical memories.
Markowitsch HJ, Vandekerckhove MM, Lanfermann H, Russ MO., Cortex 39(4-5), 2003
PMID: 14584547
Decreased activation of anterior cingulate cortex in the working memory of the elderly.
Otsuka Y, Osaka N, Morishita M, Kondo H, Osaka M., Neuroreport 17(14), 2006
PMID: 16957592
Differential remoteness and emotional tone modulate the neural correlates of autobiographical memory.
Piefke M, Weiss PH, Zilles K, Markowitsch HJ, Fink GR., Brain 126(Pt 3), 2003
PMID: 12566286
Gender differences in the functional neuroanatomy of emotional episodic autobiographical memory.
Piefke M, Weiss PH, Markowitsch HJ, Fink GR., Hum Brain Mapp 24(4), 2005
PMID: 15704151
Prefrontal glucose deficits in murderers lacking psychosocial deprivation.
Raine A, Phil D, Stoddard J, Bihrle S, Buchsbaum M., Neuropsychiatry Neuropsychol Behav Neurol 11(1), 1998
PMID: 9560822
Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder.
Raine A, Lencz T, Bihrle S, LaCasse L, Colletti P., Arch. Gen. Psychiatry 57(2), 2000
PMID: 10665614
Neurocognitive impairments in boys on the life-course persistent antisocial path.
Raine A, Moffitt TE, Caspi A, Loeber R, Stouthamer-Loeber M, Lynam D., J Abnorm Psychol 114(1), 2005
PMID: 15709810

Reduced levels of specific autobiographical memories in schizophrenia.
Riutort M, Cuervo C, Danion JM, Peretti CS, Salame P., Psychiatry Res 117(1), 2003
PMID: 12581819
Pure retrograde amnesia following a mild head trauma: a neuropsychological and metabolic study.
Sellal F, Manning L, Seegmuller C, Scheiber C, Schoenfelder F., Cortex 38(4), 2002
PMID: 12465665
Impaired strategic regulation of contents of conscious awareness in schizophrenia.
Sonntag P, Gokalsing E, Olivier C, Robert P, Burglen F, Kauffmann-Muller F, Huron C, Salame P, Danion JM., Conscious Cogn 12(2), 2003
PMID: 12763004
Behavioural and functional anatomical correlates of deception in humans.
Spence SA, Farrow TF, Herford AE, Wilkinson ID, Zheng Y, Woodruff PW., Neuroreport 12(13), 2001
PMID: 11588589

Strauss, 2006
The functional neuroanatomy of autobiographical memory: a meta-analysis.
Svoboda E, McKinnon MC, Levine B., Neuropsychologia 44(12), 2006
PMID: 16806314
Plasticity of language networks in patients with brain tumors: a positron emission tomography activation study.
Thiel A, Herholz K, Koyuncu A, Ghaemi M, Kracht LW, Habedank B, Heiss WD., Ann. Neurol. 50(5), 2001
PMID: 11706968
Episodic memory: from mind to brain.
Tulving E., Annu Rev Psychol 53(), 2002
PMID: 11752477

Tulving, 2005
Self-face recognition activates a frontoparietal "mirror" network in the right hemisphere: an event-related fMRI study.
Uddin LQ, Kaplan JT, Molnar-Szakacs I, Zaidel E, Iacoboni M., Neuroimage 25(3), 2005
PMID: 15808992
Bi-hemispheric engagement in the retrieval of autobiographical episodes.
Vandekerckhove MM, Markowitsch HJ, Mertens M, Woermann FG., Behav Neurol 16(4), 2005
PMID: 16518010

Viard, Cerebral Cortex (), 2007
Neural correlates of first-person perspective as one constituent of human self-consciousness.
Vogeley K, May M, Ritzl A, Falkai P, Zilles K, Fink GR., J Cogn Neurosci 16(5), 2004
PMID: 15200709
The possible contribution of the septal region to memory.
von Cramon DY, Markowitsch HJ, Schuri U., Neuropsychologia 31(11), 1993
PMID: 8107978



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