Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana

Devkota KP, Lenta BN, Wansi J, Choudhary MI, Kisangau DP, Naz Q, Samreen ., Sewald N (2008)
JOURNAL OF NATURAL PRODUCTS 71(8): 1481-1484.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5 alpha-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known Compounds (3-10). The structures of I and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase IC50 8.1-48.5 mu M) and butyrylcholinesterase IC50 0.4-4.0 mu M). Compounds 1-10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.
Erscheinungsjahr
2008
Zeitschriftentitel
JOURNAL OF NATURAL PRODUCTS
Band
71
Ausgabe
8
Seite(n)
1481-1484
ISSN
0163-3864
eISSN
1520-6025
Page URI
https://pub.uni-bielefeld.de/record/1586629

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Devkota KP, Lenta BN, Wansi J, et al. Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS. 2008;71(8):1481-1484.
Devkota, K. P., Lenta, B. N., Wansi, J., Choudhary, M. I., Kisangau, D. P., Naz, Q., Samreen, ., et al. (2008). Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS, 71(8), 1481-1484. doi:10.1021/np800305b
Devkota, K. P., Lenta, B. N., Wansi, J., Choudhary, M. I., Kisangau, D. P., Naz, Q., Samreen, ., and Sewald, N. (2008). Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS 71, 1481-1484.
Devkota, K.P., et al., 2008. Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS, 71(8), p 1481-1484.
K.P. Devkota, et al., “Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana”, JOURNAL OF NATURAL PRODUCTS, vol. 71, 2008, pp. 1481-1484.
Devkota, K.P., Lenta, B.N., Wansi, J., Choudhary, M.I., Kisangau, D.P., Naz, Q., Samreen, ., Sewald, N.: Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS. 71, 1481-1484 (2008).
Devkota, Krishna P., Lenta, Bruno N., Wansi, Jean, Choudhary, Muhammad I., Kisangau, Daniel P., Naz, Qamar, Samreen, ., and Sewald, Norbert. “Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana”. JOURNAL OF NATURAL PRODUCTS 71.8 (2008): 1481-1484.

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