How T-cells use large deviations to recognize foreign antigens

Zint N, Baake E, den Hollander F (2008)
JOURNAL OF MATHEMATICAL BIOLOGY 57(6): 841-861.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Zint, Natali; Baake, EllenUniBi; den Hollander, Frank
Einrichtung
Centrum für Biotechnologie > Institut für Bioinformatik
Technische Fakultät > AG Biomathematik und Theoretische Bioinformatik
Forschungsschwerpunkt Mathematisierung
Abstract / Bemerkung
A stochastic model for the activation of T-cells is analysed. T-cells are part of the immune system and recognize foreign antigens against a background of the body's own molecules. The model under consideration is a slight generalization of a model introduced by Van den Berg et al. (J Theor Biol 209:465-486, 2001), and is capable of explaining how this recognition works on the basis of rare stochastic events. With the help of a refined large deviation theorem and numerical evaluation it is shown that, for a wide range of parameters, T-cells can distinguish reliably between foreign antigens and self-antigens.
Stichworte
antigen-presenting cells; foreign versus self; kinetics of stimulation; activation curves; T-cells; immune system; large deviations
Erscheinungsjahr
2008
Zeitschriftentitel
JOURNAL OF MATHEMATICAL BIOLOGY
Band
57
Ausgabe
6
Seite(n)
841-861
ISSN
0303-6812
eISSN
1432-1416
Page URI
https://pub.uni-bielefeld.de/record/1586423

Zitieren

Zint N, Baake E, den Hollander F. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 2008;57(6):841-861.
Zint, N., Baake, E., & den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), 841-861. https://doi.org/10.1007/s00285-008-0191-1
Zint, Natali, Baake, Ellen, and den Hollander, Frank. 2008. “How T-cells use large deviations to recognize foreign antigens”. JOURNAL OF MATHEMATICAL BIOLOGY 57 (6): 841-861.
Zint, N., Baake, E., and den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY 57, 841-861.
Zint, N., Baake, E., & den Hollander, F., 2008. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), p 841-861.
N. Zint, E. Baake, and F. den Hollander, “How T-cells use large deviations to recognize foreign antigens”, JOURNAL OF MATHEMATICAL BIOLOGY, vol. 57, 2008, pp. 841-861.
Zint, N., Baake, E., den Hollander, F.: How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 57, 841-861 (2008).
Zint, Natali, Baake, Ellen, and den Hollander, Frank. “How T-cells use large deviations to recognize foreign antigens”. JOURNAL OF MATHEMATICAL BIOLOGY 57.6 (2008): 841-861.

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Stochastic modelling of T-cell activation.
Mayer H, Bovier A., J Math Biol 70(1-2), 2015
PMID: 24500058
Chemodetection in fluctuating environments: receptor coupling, buffering, and antagonism.
Lalanne JB, François P., Proc Natl Acad Sci U S A 112(6), 2015
PMID: 25624502
Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model.
Szomolay B, van den Berg HA., Integr Biol (Camb) 6(12), 2014
PMID: 25310311

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