How T-cells use large deviations to recognize foreign antigens

Zint N, Baake E, den Hollander F (2008)
JOURNAL OF MATHEMATICAL BIOLOGY 57(6): 841-861.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
A stochastic model for the activation of T-cells is analysed. T-cells are part of the immune system and recognize foreign antigens against a background of the body's own molecules. The model under consideration is a slight generalization of a model introduced by Van den Berg et al. (J Theor Biol 209:465-486, 2001), and is capable of explaining how this recognition works on the basis of rare stochastic events. With the help of a refined large deviation theorem and numerical evaluation it is shown that, for a wide range of parameters, T-cells can distinguish reliably between foreign antigens and self-antigens.
Stichworte
antigen-presenting cells; foreign versus self; kinetics of stimulation; activation curves; T-cells; immune system; large deviations
Erscheinungsjahr
2008
Zeitschriftentitel
JOURNAL OF MATHEMATICAL BIOLOGY
Band
57
Ausgabe
6
Seite(n)
841-861
ISSN
0303-6812
eISSN
1432-1416
Page URI
https://pub.uni-bielefeld.de/record/1586423

Zitieren

Zint N, Baake E, den Hollander F. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 2008;57(6):841-861.
Zint, N., Baake, E., & den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), 841-861. doi:10.1007/s00285-008-0191-1
Zint, N., Baake, E., and den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY 57, 841-861.
Zint, N., Baake, E., & den Hollander, F., 2008. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), p 841-861.
N. Zint, E. Baake, and F. den Hollander, “How T-cells use large deviations to recognize foreign antigens”, JOURNAL OF MATHEMATICAL BIOLOGY, vol. 57, 2008, pp. 841-861.
Zint, N., Baake, E., den Hollander, F.: How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 57, 841-861 (2008).
Zint, Natali, Baake, Ellen, and den Hollander, Frank. “How T-cells use large deviations to recognize foreign antigens”. JOURNAL OF MATHEMATICAL BIOLOGY 57.6 (2008): 841-861.

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