How T-cells use large deviations to recognize foreign antigens

Zint N, Baake E, den Hollander F (2008)
JOURNAL OF MATHEMATICAL BIOLOGY 57(6): 841-861.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ;
Abstract / Bemerkung
A stochastic model for the activation of T-cells is analysed. T-cells are part of the immune system and recognize foreign antigens against a background of the body's own molecules. The model under consideration is a slight generalization of a model introduced by Van den Berg et al. (J Theor Biol 209:465-486, 2001), and is capable of explaining how this recognition works on the basis of rare stochastic events. With the help of a refined large deviation theorem and numerical evaluation it is shown that, for a wide range of parameters, T-cells can distinguish reliably between foreign antigens and self-antigens.
Erscheinungsjahr
Zeitschriftentitel
JOURNAL OF MATHEMATICAL BIOLOGY
Band
57
Ausgabe
6
Seite(n)
841-861
ISSN
eISSN
PUB-ID

Zitieren

Zint N, Baake E, den Hollander F. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 2008;57(6):841-861.
Zint, N., Baake, E., & den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), 841-861. doi:10.1007/s00285-008-0191-1
Zint, N., Baake, E., and den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY 57, 841-861.
Zint, N., Baake, E., & den Hollander, F., 2008. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), p 841-861.
N. Zint, E. Baake, and F. den Hollander, “How T-cells use large deviations to recognize foreign antigens”, JOURNAL OF MATHEMATICAL BIOLOGY, vol. 57, 2008, pp. 841-861.
Zint, N., Baake, E., den Hollander, F.: How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 57, 841-861 (2008).
Zint, Natali, Baake, Ellen, and den Hollander, Frank. “How T-cells use large deviations to recognize foreign antigens”. JOURNAL OF MATHEMATICAL BIOLOGY 57.6 (2008): 841-861.

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Stochastic modelling of T-cell activation.
Mayer H, Bovier A., J Math Biol 70(1-2), 2015
PMID: 24500058
Chemodetection in fluctuating environments: receptor coupling, buffering, and antagonism.
Lalanne JB, François P., Proc Natl Acad Sci U S A 112(6), 2015
PMID: 25624502

27 References

Daten bereitgestellt von Europe PubMed Central.

A direct estimate of the human alphabeta T cell receptor diversity.
Arstila TP, Casrouge A, Baron V, Even J, Kanellopoulos J, Kourilsky P., Science 286(5441), 1999
PMID: 10542151

Chaganty, Ann. Probab. 21(), 1993
Activated TCRs remain marked for internalization after dissociation from pMHC.
Coombs D, Kalergis AM, Nathenson SG, Wofsy C, Goldstein B., Nat. Immunol. 3(10), 2002
PMID: 12244312

Hollander, 2000

Dembo, 2004

Ethier, 1986

Feller, 1971
Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry.
Hunt DF, Henderson RA, Shabanowitz J, Sakaguchi K, Michel H, Sevilir N, Cox AL, Appella E, Engelhard VH., Science 255(5049), 1992
PMID: 1546328

Janeway, 2005
Regulation of immune responses by T cells.
Jiang H, Chess L., N. Engl. J. Med. 354(11), 2006
PMID: 16540617
Probability model for molecular recognition in biological receptor repertoires: significance to the olfactory system.
Lancet D, Sadovsky E, Seidemann E., Proc. Natl. Acad. Sci. U.S.A. 90(8), 1993
PMID: 8475121
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.
Matsui K, Boniface JJ, Steffner P, Reay PA, Davis MM., Proc. Natl. Acad. Sci. U.S.A. 91(26), 1994
PMID: 7809136
Kinetic proofreading in T-cell receptor signal transduction.
McKeithan TW., Proc. Natl. Acad. Sci. U.S.A. 92(11), 1995
PMID: 7761445
How T cells count.
Rothenberg EV., Science 273(5271), 1996
PMID: 8658200
Serial triggering of many T-cell receptors by a few peptide-MHC complexes.
Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A., Nature 375(6527), 1995
PMID: 7753171
A reliable and safe T cell repertoire based on low-affinity T cell receptors.
Van Den Berg HA, Rand DA, Burroughs NJ., J. Theor. Biol. 209(4), 2001
PMID: 11319895
Quantifying the strength of ligand antagonism in TCR triggering.
Van Den Berg HA, Burroughs NJ, Rand DA., Bull. Math. Biol. 64(4), 2002
PMID: 12216421

Berg, J. Theor. Med 5(), 2003
Dynamics of T cell activation threshold tuning.
van den Berg HA, Rand DA., J. Theor. Biol. 228(3), 2004
PMID: 15135038
Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands.
van den Berg HA, Rand DA., J. Theor. Biol. 231(4), 2004
PMID: 15488530
T cell activation determined by T cell receptor number and tunable thresholds.
Viola A, Lanzavecchia A., Science 273(5271), 1996
PMID: 8658175

Wolfram, 2003
Two-step binding mechanism for T-cell receptor recognition of peptide MHC.
Wu LC, Tuot DS, Lyons DS, Garcia KC, Davis MM., Nature 418(6897), 2002
PMID: 12152083

AUTHOR UNKNOWN, 0

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 18560834
PubMed | Europe PMC

Suchen in

Google Scholar