Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C
Latajka R, Jewginski M, Makowski M, Paweiczak M, Huber T, Sewald N, Kafarski P (2008)
Journal of Peptide Science 14(10): 1084-1095.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Latajka, R.;
Jewginski, M.;
Makowski, M.;
Paweiczak, M.;
Huber, T.;
Sewald, NorbertUniBi 
;
Kafarski, P.
;
Kafarski, P.Einrichtung
Abstract / Bemerkung
Synthesis, structural and biological studies of pentapeptides containing two Delta Phe residues (Z and E isomers) in position 2 and 4 in peptide chain were performed. All the investigated peptides adopted bent conformation and majority of them could exist as two different. conformers in solution. Only pentapeptides. containing free N-termini appeared to act as weak inhibitors of cathepsin C with the slow-binding, competitive mechanism of inhibition. free acids being bound slightly better than their methyl esters. Results of Molecular modeling suggested significant difference between peptides, depending of the type of amino acid residue in position 5 in peptide chain. Dehydropeptides containing GIN, residue in this position may act as competitive slow-reacting substrates and therefore exhibit inhibitory-like properties. Copyright (C) 2008 European Peptide Society and John Wiley & Sons, Ltd.
Stichworte
conformation;
inhibitors of cathepsin C;
dehydropeptide
Erscheinungsjahr
2008
Zeitschriftentitel
Journal of Peptide Science
Band
14
Ausgabe
10
Seite(n)
1084-1095
ISSN
1075-2617
eISSN
1099-1387
Page URI
https://pub.uni-bielefeld.de/record/1585817
Zitieren
Latajka R, Jewginski M, Makowski M, et al. Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C. Journal of Peptide Science. 2008;14(10):1084-1095.
Latajka, R., Jewginski, M., Makowski, M., Paweiczak, M., Huber, T., Sewald, N., & Kafarski, P. (2008). Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C. Journal of Peptide Science, 14(10), 1084-1095. https://doi.org/10.1002/psc.1045
Latajka, R., Jewginski, M., Makowski, M., Paweiczak, M., Huber, T., Sewald, Norbert, and Kafarski, P. 2008. “Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C”. Journal of Peptide Science 14 (10): 1084-1095.
Latajka, R., Jewginski, M., Makowski, M., Paweiczak, M., Huber, T., Sewald, N., and Kafarski, P. (2008). Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C. Journal of Peptide Science 14, 1084-1095.
Latajka, R., et al., 2008. Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C. Journal of Peptide Science, 14(10), p 1084-1095.
R. Latajka, et al., “Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C”, Journal of Peptide Science, vol. 14, 2008, pp. 1084-1095.
Latajka, R., Jewginski, M., Makowski, M., Paweiczak, M., Huber, T., Sewald, N., Kafarski, P.: Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C. Journal of Peptide Science. 14, 1084-1095 (2008).
Latajka, R., Jewginski, M., Makowski, M., Paweiczak, M., Huber, T., Sewald, Norbert, and Kafarski, P. “Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C”. Journal of Peptide Science 14.10 (2008): 1084-1095.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
7 Zitationen in Europe PMC
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